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31. 发明授权

US08910288B2 Network managed antivirus appliance 有权
标题翻译：网络管理防病毒设备
公开(公告)号：US08910288B2
公开(公告)日：2014-12-09
申请号：US13020900
申请日：2011-02-04
申请人： Alan G. Young , Paul L. Bartruff , Eric E. Brown , Michael P. Miley
发明人： Alan G. Young , Paul L. Bartruff , Eric E. Brown , Michael P. Miley
IPC分类号： G06F11/00 , G06F12/14 , G06F21/55 , G06F21/56
CPC分类号： H04L63/1416 , G06F21/552 , G06F21/564 , H04L63/0861
摘要： Data can be scanned using a network managed appliance. The network managed appliance may integrate commercial hardware elements connected through a basic or simplified operating system environment expressly developed for the appliance, thus being more malware resistant and less vulnerable to attacks from the scanned data or other sources. The network managed appliance may be a self-contained apparatus with an integrated chassis, designed and configured as “single-purpose” device. Such appliances may be connected to an appliance management network including central management servers in communication with appliances in remote locations. The central management servers may ensure that scanning software and the definitions lists for each of the appliances are current and match an enterprise-approved configuration.
摘要翻译：可以使用网络管理的设备扫描数据。网络管理设备可以集成通过为设备明确开发的基本或简化的操作系统环境连接的商业硬件元件，从而更具恶意软件，并且更不易受来自扫描数据或其他来源的攻击。网络管理设备可以是具有集成机箱的独立设备，被设计和配置为“单用途”设备。这样的设备可以连接到设备管理网络，包括与远程位置的设备通信的中央管理服务器。中央管理服务器可以确保扫描软件和每个设备的定义列表是最新的，并且符合企业认可的配置。

32. 发明授权

US08866328B1 System and method for generated power from wave action 有权
标题翻译：波动作用产生电力的系统和方法
公开(公告)号：US08866328B1
公开(公告)日：2014-10-21
申请号：US13453761
申请日：2012-04-23
申请人： Steven C. Hench , Charles R. Fralick , Christopher J. Eckert
发明人： Steven C. Hench , Charles R. Fralick , Christopher J. Eckert
IPC分类号： F03B13/10 , F03B13/12 , H02P9/04
CPC分类号： F03B13/20 , E02B9/08 , F05B2240/93 , F05B2260/406 , F15B11/08 , F15B2211/2053 , F15B2211/7058 , Y02E10/38
摘要： Wave energy conversion systems are provided utilizing a mass of water entrained in a collapsible water mass enclosure that is suspended beneath a float (e.g., a vehicle, buoy, platform, etc.) to provide an inertial force in opposition to the rising heave-induced acceleration of the float. The water mass enclosure is in communication with a generator, such as by tethering one end of a tethering component to the generator and the other to the enclosure. The enclosure may be placed in communication with an intermediary hydraulic system, which is also in communication with the generator. In certain embodiments, the system will include a reel system for deploying and retrieving the water masse enclosure.
摘要翻译：提供了波浪能量转换系统，其利用悬挂在浮动体（例如，车辆，浮标，平台等）下方的可折叠水体箱体中的大量水，以提供与上升起伏引起的相反的惯性力加速浮子。水体外壳与发生器连通，例如通过将束缚组件的一端束缚到发生器，另一端连接到外壳。外壳可以放置成与中间液压系统连通，中间液压系统也与发电机连通。在某些实施例中，该系统将包括一个用于展开和取回水闸外壳的卷轴系统。

33. 发明公开

US20240229017A1 Optical Methods For DNA Assembly For Computer Data Storage 审中-公开
公开(公告)号：US20240229017A1
公开(公告)日：2024-07-11
申请号：US18616933
申请日：2024-03-26
申请人： Leidos, Inc.
发明人： Steven Gerald Haupt , Stephen Alan Chappell
IPC分类号： C12N15/10 , G16B50/00
CPC分类号： C12N15/1068 , G16B50/00
摘要： An array-based system of assembled DNA for computer data storage is described. An array surface contains immobilized seed DNA initially having with blunt (or blocked) ends with a photocleavable optical linker at a forward end thereof holding the last few base pairs. A light source is light is applied to break the linker, generating a sticky end which allows for hybridization. Data-bearing DNA cassettes are introduced to the array and attach via their sticky ends to the unblock sites on the array surface. The attachment is made permanent via ligase.

34. 发明授权

US11970696B1 Optical methods and systems for DNA assembly for computer data storage 有权
公开(公告)号：US11970696B1
公开(公告)日：2024-04-30
申请号：US17004675
申请日：2020-08-27
申请人： Leidos, Inc.
发明人： Steven Gerald Haupt , Stephen Alan Chappell
IPC分类号： C12N15/10 , G16B50/00
CPC分类号： C12N15/1068 , G16B50/00
摘要： An array-based system of assembled DNA for computer data storage is described. An array surface contains immobilized seed DNA initially having with blunt (or blocked) ends with a photocleavable optical linker at a forward end thereof holding the last few base pairs. A light source is light is applied to break the linker, generating a sticky end which allows for hybridization. Data-bearing DNA cassettes are introduced to the array and attach via their sticky ends to the unblock sites on the array surface. The attachment is made permanent via ligase.

35. 发明授权

US11793856B2 PD-1 peptide inhibitors 有权
公开(公告)号：US11793856B2
公开(公告)日：2023-10-24
申请号：US17015658
申请日：2020-09-09
申请人： Leidos, Inc.
发明人： Gabriel M. Gutierrez , Vinayaka Kotraiah , James Pannucci , Ramses Ayala
IPC分类号： A61K38/10 , A61K39/015 , A61K38/16 , A61K39/00 , A61K35/17 , A61K38/19 , A61P33/06 , A61P31/20 , A61P37/04 , A61P35/04 , A61K45/06 , C07K7/08 , C07K14/00 , A61K39/39 , A61K48/00
CPC分类号： A61K38/10 , A61K35/17 , A61K38/16 , A61K38/19 , A61K39/0011 , A61K39/015 , A61K39/39 , A61K45/06 , A61P31/20 , A61P33/06 , A61P35/04 , A61P37/04 , C07K7/08 , C07K14/00 , A01K2227/105 , A01K2267/0331 , A01K2267/0337 , A61K48/00
摘要： This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

36. 发明授权

US11578102B2 LAG3 binding peptides 有权
公开(公告)号：US11578102B2
公开(公告)日：2023-02-14
申请号：US17386637
申请日：2021-07-28
申请人： Leidos, Inc.
发明人： Gabriel M. Gutierrez , James Pannucci , Vinayaka Kotraiah , Timothy W. Phares , Cecilie D. Browne
IPC分类号： C07K7/08 , A61K38/10 , A61K45/06
摘要： This disclosure provides peptides that bind to LAG3 and can be used to block its interaction with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides, with their demonstrated activity and short half-life, can be used to activate cellular immunity while significantly reducing the potential for adverse events that is often associated with the antibody-based checkpoint inhibitors. The peptides can be used as stand-alone therapeutics or can be used as immune modulators in combination with other therapies.

37. 发明申请

US20230010033A1 Method and System For Accelerating Rapid Class Augmentation for Object Detection in Deep Neural Networks 有权
公开(公告)号：US20230010033A1
公开(公告)日：2023-01-12
申请号：US17840238
申请日：2022-06-14
申请人： Leidos, Inc.
发明人： Hanna Witzgall
IPC分类号： G06T3/40 , G06T7/194
摘要： Object detection architectures for detecting and classifying objects in an image are modified to incorporate an extending Rapid Class Augmentation (XRCA) progressive learning algorithm with its defining aspect of memory built into its optimizer which allows joint optimization over both the old and the classes using just the new class data and eliminates the issues associated with catastrophic forgetting.

38. 发明申请

US20210379189A1 Immunomodulatory Compounds 有权
公开(公告)号：US20210379189A1
公开(公告)日：2021-12-09
申请号：US17337489
申请日：2021-06-03
申请人： Leidos, Inc.
发明人： Gabriel M. Gutierrez , James Pannucci , Vinayaka Kotraiah , Timothy W. Phares , Cecille D. Browne
IPC分类号： A61K47/62 , A61K38/10 , A61K47/60
摘要： This disclosure provides peptide conjugates that are useful for inhibiting the progression of a hyperproliferative disorder, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, enhancing a response to a vaccine, or inhibiting the progression of a synucleinopathy.

39. 发明申请

US20210109044A1 CONTACT IMAGING SENSOR HEAD FOR COMPUTED RADIOGRAPHY 有权
公开(公告)号：US20210109044A1
公开(公告)日：2021-04-15
申请号：US17107096
申请日：2020-11-30
申请人： Leidos, Inc.
发明人： Rex David Richardson , William L. Hicks , Mark Alan Peressini
IPC分类号： G01N23/22
摘要： A scan head design uses 1:1 (one-to-one) imaging micro-lens arrays to transfer the object plane X-ray image from a CR-plate onto a linear photosensor. The scan-head includes a housing having therein, an array of red light emitting diodes (LEDs), a microlens array, and a sensor. The housing faces the CR-plate and the scan-head is translated across the CR-plate to read out the X-ray image therein. The scan head is compact and provides for improved spatial resolution and reduced power requirements.

40. 发明授权

US10876981B2 Contact imaging sensor head for computed radiography 有权
公开(公告)号：US10876981B2
公开(公告)日：2020-12-29
申请号：US16667298
申请日：2019-10-29
申请人： Leidos, Inc.
发明人： Rex David Richardson , William L. Hicks , Mark Alan Peressini
IPC分类号： G01N23/22
CPC分类号： G01N23/22 , G01N2223/407 , G01N2223/5015
摘要： A scan head design uses 1:1 (one-to-one) imaging micro-lens arrays to transfer the object plane X-ray image from a CR-plate onto a linear photosensor. The scan-head includes a housing having therein, an array of red light emitting diodes (LEDs), a red-absorbing filter, a microlens array, an infrared-filter, and a sensor. The housing faces the CR-plate and the scan-head is translated across the CR-plate to read out the X-ray image therein. The scan head is compact and provides for improved spatial resolution and reduced power requirements.

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