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31. 发明申请

US20110015409A1 SYNTHESIS OF CYCLIC CARBONATES 审中-公开
公开(公告)号：US20110015409A1
公开(公告)日：2011-01-20
申请号：US12921264
申请日：2009-03-06
申请人： Michael North
发明人： Michael North
IPC分类号： C07D317/38 , C07F5/06
CPC分类号： C07D317/38 , C07B2200/11 , C07D317/34 , C07D317/36 , C07F5/069
摘要： A dimeric aluminium(salen) catalyst of formula I: wherein: Y-Q is CRC1═N or CRC1RC2—NRN1, where RC1, RC2 and RN1 are independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, ether and nitro; each of the substituents R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16, is independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, ether and nitro; X1 and X2 are independently either (i) a C2-5 alkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl, or a C1-3 bisoxyalkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl or (ii) represent a divalent group selected from C5-7 arylene, C5-7 cyclic alkylene and C3-7 heterocyclylene, which may be optionally substituted; (i) (a) at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is selected from L-A, where L is a single bond or a C1-10 alkylene group and A is an ammonium group paired with a counterion selected from Cl, Br and I; and/or (b) at least one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen atom paired with a counterion selected from Cl, Br and I; and/or (c) at least one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A, where Q is either —C(═O)—O—, —C(═O)—NH—, or a single bond; and/or (ii) (a) one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is L-A′, where L is as defined above and A′ is a ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (b) one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen forming part of an ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (c) one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A′.

32. 发明申请

US20060205195A1 Method of forming an ohmic contact in wide band semiconductor 有权
标题翻译：在宽带半导体中形成欧姆接触的方法
公开(公告)号：US20060205195A1
公开(公告)日：2006-09-14
申请号：US11159264
申请日：2005-06-23
申请人： Rajesh Malhan , Yuichi Takeuchi , Irina Nikitina , Konstantin Vassilevski , Nicholas Wright , Alton Horsfall
发明人： Rajesh Malhan , Yuichi Takeuchi , Irina Nikitina , Konstantin Vassilevski , Nicholas Wright , Alton Horsfall
IPC分类号： H01L21/28
CPC分类号： H01L29/7802 , H01L21/0485 , H01L29/41766 , H01L29/45 , H01L29/66068 , H01L29/7395
摘要： A method of forming an ohmic contact on a substrate composed of a wide-band gap semiconductor material includes: depositing a transition metal group metal on the substrate; annealing the substrate at a high temperature to cause a solid state chemical reaction between the substrate and the deposited metal that forms a modified layer in the substrate having modified properties different than the substrate, and by-products composed of a silicide and a nanocrystalline graphite layer; selectively etching the substrate to remove one or more of the by-products of the solid state chemical reaction from a surface of the substrate; and depositing a metal film composed of a transition group metal over the modified layer on the substrate to form the ohmic contact. The modified layer permits formation of the ohmic contact without high temperature annealing after depositing the metal film.
摘要翻译：在由宽带隙半导体材料构成的衬底上形成欧姆接触的方法包括：在衬底上沉积过渡金属组金属; 在高温下使基板退火，从而在基板和沉积金属之间产生固态化学反应，所述金属在衬底中形成改性的特性，其具有不同于衬底的改性，以及由硅化物和纳米晶体石墨层组成的副产物 ; 选择性地蚀刻所述基板以从所述基板的表面去除所述固态化学反应的一种或多种副产物; 以及在所述基板上在所述改性层上沉积由过渡金属组成的金属膜以形成欧姆接触。在沉积金属膜之后，改性层允许形成欧姆接触而不进行高温退火。

33. 发明公开

US20230305022A1 Biomarkers in Primary Biliary Cholangitis 审中-公开
公开(公告)号：US20230305022A1
公开(公告)日：2023-09-28
申请号：US18041267
申请日：2021-08-10
申请人： University of Newcastle upon Tyne
发明人： David Jones , Steve Rushton
IPC分类号： G01N33/68 , A61K31/575
CPC分类号： G01N33/6863 , A61K31/575 , G01N2333/7155 , G01N2333/7158 , G01N2800/085 , G01N2800/52
摘要： The present invention provides methods for predicting whether or not a test subject having primary biliary cholangitis (PBC) will benefit from advanced treatment in the form of a second-line agent used in addition to, or as an alternative to, ursodeoxycholic acid (UDCA). Associated methods for determining the therapeutic effect of a treatment regimen for PBC, methods for monitoring PBC progression, methods of PBC treatment, kits and assay devices are also provided.

34. 发明授权

US11590357B2 Optogenetic system and method 有权
公开(公告)号：US11590357B2
公开(公告)日：2023-02-28
申请号：US16321389
申请日：2017-07-28
申请人： University of Newcastle Upon Tyne
发明人： Andrew Jackson , Mark Cunningham , Stuart Baker , Patrick Degenaar
IPC分类号： A61N5/06 , A61B5/00 , A61B5/291 , A61B5/01
摘要： An optogenetic system and method for preventing or halting seizures. The system and method use a sensor for monitoring the activity of a neural network containing a group of target neurons, and generating an input signal indicative of said activity, the target neurons being excitatory neurons. Excitatory stimulation is delivered in the form of an optical signal by an optical stimulator to the target neurons, the optical signal being determined based on the input signal, to reduce the overall activity of the target neurons.

35. 发明授权

US11478180B2 Probe response signals 有权
公开(公告)号：US11478180B2
公开(公告)日：2022-10-25
申请号：US15768460
申请日：2016-10-12
申请人： University of Newcastle Upon Tyne
发明人： Roger Whittaker , Anthony O'Neill , Stuart Baker , Bashar Awwad Shiekh Hasan , Enrique Escobedo-Cousin
IPC分类号： A61B5/00 , A61B18/14 , A61B5/296 , A61B5/30 , A61B18/00
摘要： A method and apparatus are disclosed for simultaneously providing a plurality of probe response signals indicative of electrical activity at a respective plurality of locations in a patient. The apparatus comprises a rigid needle shaft element comprising a piercing tip and a substrate supporting a plurality of electrode tracks, secured to the needle shaft element and extending along the shaft element away from the piercing tip. Each electrode track extends from a sensing end region arranged for providing a respective probe response signal responsive to localised electrical activity, along the region of the substrate, to a respective bond pad connection region. Recording surface regions of the plurality of electrode tracks are spaced apart in a plurality of substantially linear spaced apart configurations along the substrate.

36. 发明申请

US20220229006A1 A SENSOR DEVICE 有权
公开(公告)号：US20220229006A1
公开(公告)日：2022-07-21
申请号：US17610842
申请日：2020-05-13
申请人： University of Newcastle Upon Tyne
发明人： Marloes Peeters
IPC分类号： G01N27/12
摘要： A thermistor comprising a functionalised nanoparticle coating bonded thereto, which may be in the form of a nanoscale molecularly imprinted polymer. The thermistor may form part of a device for detecting molecules and a used in a method therefor.

37. 发明申请

US20210379068A1 METHODS AND MATERIALS FOR TREATING NEUROPSYCHIATRIC DISORDERS 有权
公开(公告)号：US20210379068A1
公开(公告)日：2021-12-09
申请号：US17288258
申请日：2019-12-18
申请人： Mayo Foundation for Medical Education and Research , University of Newcastle Upon Tyne
发明人： James L. Kirkland , Mikolaj B. Ogrodnik , Tamar Tchkonia , Diana Jurk , Thomas von Zglinicki
IPC分类号： A61K31/506 , A61K31/352 , A61P25/28
摘要： This document provides methods and materials for treating obesity-induced neuropsychiatric disorders. For example, one or more senotherapeutic agents can be administered to a mammal having, or at risk of developing, an obesity-induced neuropsychiatric disorder (e.g., obesity-induced anxiety) to treat the mammal.

38. 发明申请

US20210255199A1 PREDICTION OF DRUG-FREE REMISSION IN RHEUMATOID ARTHRITIS 有权
公开(公告)号：US20210255199A1
公开(公告)日：2021-08-19
申请号：US17045428
申请日：2019-03-28
申请人： University of Newcastle Upon Tyne
发明人： Kenneth Baker , John Isaacs , Arthur Pratt
IPC分类号： G01N33/68 , G01N33/50
摘要： Certain embodiments of the present invention relate to methods and products for use in the determination of treatment of rheumatoid arthritis (RA). Particularly, although not exclusively, embodiments of the present invention relate to predicting the likelihood of a patient suffering from rheumatoid arthritis maintaining remission following cessation of disease-modifying anti-rheumatic drugs (DMARDs). Certain embodiments of the present invention are based on the determination of certain biomarkers of drug-free remission in RA following cessation of DMARD therapy.

39. 发明授权

US10820816B2 System for a brain-computer interface 有权
公开(公告)号：US10820816B2
公开(公告)日：2020-11-03
申请号：US15115616
申请日：2015-01-29
申请人： UNIVERSITY OF LEICESTER , UNIVERSITY OF NEWCASTLE UPON TYNE , IP2IPO INNOVATIONS LIMITED
发明人： Andrew Jackson , Tim Constandinou , Amir Eftekhar , Rodrigo Quian Quiroga , Joaquin Navajas Ahumada
IPC分类号： A61B5/04 , A61B5/00 , G06F3/01
摘要： The invention provides a two-step approach to providing a BCI system. In a first step the invention provides a low-power implantable platform for amplifying and filtering the extracellular recording, performing analogue to digital conversion (ADC) and detecting action potentials in real-time, which is connected to a remote device capable of performing the processor-intensive tasks of feature extraction and spike classification, thus generating a plurality of predetermined templates for each neuron to be used in a second processing step. In the second step the low-power implantable platform amplifies and filters the extracellular recording, performs ADC and detects action potentials, which can be matched on-chip to the predetermined templates generated by the external receiver in the first step. This two-step approach exploits the advantages of both offline and online processing, providing an effective and safe method for performing multiple recordings of single-neuron activity, for research or monitoring applications or for control of a remote device.

40. 发明授权

US10680825B2 Authentication of physical object using internal structure 有权
公开(公告)号：US10680825B2
公开(公告)日：2020-06-09
申请号：US15972922
申请日：2018-05-07
申请人： University of Newcastle Upon Tyne
发明人： Feng Hao , Ehsan Toreini , Siamak F. Shahandashti
IPC分类号： H04L29/06 , H04L9/32 , G06K9/00 , G09C5/00 , H04L9/08
摘要： A method for preventing counterfeiting of an object (e.g. paper) is described. The method comprises capturing an image of at least a portion of the object, wherein the portion of the object whose image is captured is at least partially transparent, and wherein the captured image includes features of the internal structure of the object (e.g. the texture of the paper resulting from the arrangement of fibres from which the paper is made). The method further comprises generating, based on the image, a code that encodes features of the internal structure of the object, and recording the code. Generating the code may comprise applying a filter to the image to obtain a filtered image, and processing the filtered image to obtain a binary code. The filter may be a Gabor filter, and processing the filtered image may comprise applying a Gray code to the filtered image. The method may further comprise encrypting the binary code, and recording the code may comprise recording the encrypted binary code. A method for authenticating an object is also described. The method comprises capturing an image of at least a portion of the object, wherein the portion of the object whose image is captured is at least partially transparent, and wherein the captured image includes features of the internal structure of the object. The method further comprises generating, based on the image, a code that encodes features of the internal structure of the object, reading one or more reference values comprising at least a reference code, and authenticating the object based on the code and the reference code.

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