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    • 33. 发明授权
    • Cationic cellulose derivatives of controlled charge density useful in
cosmetic preparations
    • 具有控制电荷密度的阳离子纤维素衍生物可用于化妆品制剂
    • US6071505A
    • 2000-06-06
    • US286814
    • 1999-04-06
    • Melissa A. Manuszak-GuerriniDoris A. CulbersonWilliam H. Daly
    • Melissa A. Manuszak-GuerriniDoris A. CulbersonWilliam H. Daly
    • A01N43/16A61K8/73A61Q5/02A61Q5/06A61Q5/12C08B11/193C08B11/20C08B15/06A61K7/06C07H5/04C07H11/02C08B15/04
    • A61Q5/02A01N43/16A61K8/731A61Q5/06A61Q5/12C08B11/193C08B11/20C08B15/06A61K2800/5426
    • Water-soluble quaternary ammonium cellulosic derivatives of controlled charge density are disclosed. These derivatives are useful in cosmetic preparations, such as hair and skin formulations, for example hair conditioners. These quaternized cellulosic derivatives are useful as thickeners, conditioners, film formers, fixatives, emulsifiers, or additives in hair or skin formulations to improve combing, manageability, body, curl retention, moisture resistance, and binding of ingredients to keratin. Compared to existing agents, these compounds have improved temperature stability, improved interactions with surfactants (such as in shampoos), improved binding to keratin, improved mechanical properties, and can mend split ends on hair. A major advantage of these compounds is that they may be applied to hair directly from an aqueous solution, and do not require a volatile organic compound solvent as carrier. Alternatively, smaller amounts of VOC's may be used than is the case in current products, to improve drying times for the formulations. The compounds are also useful as antistatic agents, bactericides, flocculating agents, and as drug binding or drug delivery agents.
    • 公开了具有受控电荷密度的水溶性季铵纤维素衍生物。 这些衍生物可用于化妆品制剂,例如头发和皮肤制剂,例如头发调理剂。 这些季铵化的纤维素衍生物可用作毛发或皮肤制剂中的增稠剂,调理剂,成膜剂,固定剂,乳化剂或添加剂,以改善组合,可管理性,身体,卷曲保留性,耐湿性和成分与角蛋白的结合。 与现有的试剂相比,这些化合物具有改善的温度稳定性,改善与表面活性剂的相互作用(如洗发剂),改善的与角蛋白的结合,改进的机械性能,以及修补头发上的分叉端。 这些化合物的主要优点是它们可以直接从水溶液中施用于毛发,并且不需要挥发性有机化合物溶剂作为载体。 或者,可以使用比当前产品更小量的VOC,以改善制剂的干燥时间。 这些化合物也可用作抗静电剂,杀菌剂,絮凝剂,以及药物结合或药物递送剂。
    • 35. 发明授权
    • Bioactive conjugates of cellulose with amino compounds
    • 纤维素与氨基化合物的生物活性偶联物
    • US5855987A
    • 1999-01-05
    • US416351
    • 1995-04-04
    • Shlomo MargelSophia Sturchak
    • Shlomo MargelSophia Sturchak
    • A61K38/00A61K38/46A61K45/00A61K47/48A61L15/40A61L15/44A61L26/00A61P43/00C08B15/06C08B37/00B32B3/00B32B27/14
    • A61K47/4823A61L15/40A61L26/0057Y10S530/815Y10T428/24802Y10T428/24893Y10T442/2525
    • Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound, e.g. pyridine, pyrrole, pyridazine, their partially or fully hydrogenated analogs and any of these which may be substituted, in a pre-activation step prior to reaction with reactant for free hydroxy groups in the polymer, the polymer-bound residue of which reactant may be thereafter reacted in turn with amino compounds containing at least one unsubstituted N-attached hydrogen atom, e.g. proteins, thereby to form amine-polymer conjugates. The invention further relates to a powder, bandage, patch or like cover for application to wounds which has been manufactured from polymer containing a plurality of hydroxy groups by a process which includes the step of providing an amine conjugated to the polymer; the amine may be, e.g., trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.
    • 含有多个游离羟基的聚合物,如纤维素,琼脂糖或聚乙烯醇,在不存在羟基反应物的情况下,与至少一种N-杂环化合物 吡啶,吡咯,哒嗪,它们的部分或完全氢化的类似物和它们中的任何一个可以被取代,在与反应物反应之前的预活化步骤中,聚合物中游离羟基的反应物,其中聚合物结合的残基可以是 然后依次与含有至少一个未取代的N-连接的氢原子的氨基化合物反应, 蛋白质,从而形成胺 - 聚合物共轭物。 本发明还涉及一种用于应用于伤口的粉末,绷带,贴剂或类似的覆盖物,其通过包括提供与所述聚合物缀合的胺的步骤的方法由含有多个羟基的聚合物制成, 胺可以是例如胰蛋白酶,糜蛋白酶,溶菌酶,胶原酶,白蛋白和透明质酸酶。
    • 40. 发明授权
    • Process for the production of cellulose carbamate
    • 生产纤维素氨基甲酸酯的方法
    • US5378827A
    • 1995-01-03
    • US122244
    • 1993-09-16
    • Gerhard KeuneckeAdolf ArnoldSabine Butzke
    • Gerhard KeuneckeAdolf ArnoldSabine Butzke
    • C08B15/06C08B5/00
    • C08B15/06
    • A process for the production of cellulose carbamate from cellulose and urea through the conversion of the cellulose with excess urea in an inert liquid organic reaction carrier at a temperature in the range of 130 .degree. to 160.degree. C., separation of the reaction carrier from the reaction mixture and washing of the reaction mixture with water. The cellulose is intimately mixed with an aqueous urea solution. Then the water in the solution is replaced with the organic reaction carrier, and the reaction of urea and cellulose is carried out in the presence of an inert gaseous carrier to remove the by-product ammonia. Thereafter, the organic reaction carrier remaining in the reaction product is replaced with an aqueous urea solution and the resulting suspension of cellulose carbamate in the urea solution is filtered and washed free of urea with water. No liquid ammonia is required in this process.
    • 在惰性液体有机反应载体中,在130〜160℃的温度范围内,通过纤维素与过量尿素的转化,从纤维素和尿素生产纤维素氨基甲酸酯的方法,将反应载体与 反应混合物并用水洗涤反应混合物。 纤维素与尿素水溶液紧密混合。 然后用有机反应载体代替溶液中的水,尿素和纤维素的反应在惰性气态载体的存在下进行以除去副产物氨。 此后,将残留在反应产物中的有机反应载体用尿素水溶液代替,将所得到的尿素溶液中的氨基甲酸纤维素悬浮液过滤并用水洗涤尿素。 在这个过程中不需要液氨。