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31. 发明申请

US20210294083A1 PREDICTIVE FOCUS TRACKING APPARATUS AND METHODS 有权
公开(公告)号：US20210294083A1
公开(公告)日：2021-09-23
申请号：US17339587
申请日：2021-06-04
申请人： ILLUMINA, INC.
发明人： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
IPC分类号： G02B21/00 , G01N21/64 , G02B21/26 , G02B21/24 , G02B7/09
摘要： An imaging system may include a sample stage comprising a surface to support a sample container, the sample container including a sample having a plurality of sample locations; an optical stage to image the sample at the plurality of sample locations; one or more actuators physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location of the plurality of sample locations; a first light source to illuminate the current sample location; a second light source to project a pair of spots on a next sample location of the plurality of sample locations; and a controller to determine, based on an image of the pair of spots projected on the next sample location, a focus setting for the next sample location.

32. 发明申请

US20210266469A1 IMAGING METHOD, DEVICE AND SYSTEM 有权
公开(公告)号：US20210266469A1
公开(公告)日：2021-08-26
申请号：US17262663
申请日：2019-07-23
申请人： GeneMind Biosciences Company Limited
发明人： Linsen LI , Ruitao SUN , Jiahong XU , Zhiliang ZHOU , Zefei JIANG , Qin YAN
IPC分类号： H04N5/232 , G02B21/24
摘要： The present disclosure discloses a method and a system for imaging. The method for imaging objects using the system for imaging. The system for imaging comprises a lens. The objects comprise a first object, a second object and a third object located at different positions on a first preset track. The method for imaging comprises: allowing the lens and the first preset track to move relatively in a first predetermined relationship to acquire a clear image of the third object using the system for imaging without focusing, the first predetermined relationship is determined by a focal plane position of the first object and a focal plane position of the second object. The aforementioned method for imaging is high in imaging efficiency and is capable of fast focusing according to the first predetermined relationship even if focus tracking fails so that the blurring of a photographed image due to defocusing is avoided.

33. 发明授权

US11092791B2 Method and device for scanning wells in a multi-well plate 有权
公开(公告)号：US11092791B2
公开(公告)日：2021-08-17
申请号：US16423063
申请日：2019-05-27
申请人： IDEA BIOMEDICAL LTD.
发明人： Shlomo Turgeman , Yael Paran , Alex Efros
IPC分类号： G02B21/00 , G02B21/24 , G02B21/06 , G02B21/33 , G02B21/34
摘要： An auto-focusing method for determining an in-focus position of a plurality of wells in at least a portion of a multi-well plate, the method including using a first objective lens having a first magnification to identify, in each of at least three wells of a selected subset of the plurality of wells, an in-focus position of each well with respect to the first objective lens, on the basis of at least three the in-focus positions, computing a plane along which the at least three wells will be in focus with respect to at least one objective lens having a second magnification that is not greater than the first magnification, and using the at least one objective lens to scan, along the plane, at least some of the plurality of wells in the portion of the plate.

34. 发明授权

US11045089B2 Automatic lens to cornea standoff control for non-contact visualization 有权
公开(公告)号：US11045089B2
公开(公告)日：2021-06-29
申请号：US15979798
申请日：2018-05-15
申请人： Novartis AG
发明人： Steven T. Charles
IPC分类号： G02B21/00 , A61B3/13 , A61B3/00 , A61B90/50 , G02B21/24 , A61B90/25 , A61B3/14
摘要： Systems, methods, and computer-readable media for automatically controlling a lens to cornea standoff. Automatic lens to cornea standoff control can include an ophthalmic microscope with a lens arrangement configured for viewing images of an eye, a front lens assembly with a high diopter lens for resolving an image of a posterior portion of the eye, and a sensor to monitor a distance between the high diopter lens and a surface of the eye. Automatic lens to cornea standoff control can also include a control system for receiving distance information and an actuator for the front lens assembly back to the threshold standoff distance, past the threshold standoff distance, etc.

35. 发明申请

US20210173192A1 MICROSCOPE DEVICE 有权
公开(公告)号：US20210173192A1
公开(公告)日：2021-06-10
申请号：US17267879
申请日：2019-08-12
申请人： Miltenyi Biotec B.V. & CO. KG
发明人： Rainer UHL
IPC分类号： G02B21/24 , G02B21/02 , G02B21/08 , G02B21/26 , G02B27/14
摘要： There is provided a microscope device comprising: an objective (1); an actuator (6) for adjustment of a distance between the objective and a sample (3) in a focusing direction z during a focusing action to reach and hold a desired focus position, an absolute z-position detector (7) for measuring a z-position of the actuator in the focusing direction, an autofocus light source (11); a first optical arrangement (12, 13) for generating a focused spot (31) of autofocus light from the light source in the backfocal plane (14) of the objective (1) at a position offset from the optical axis of the objective by a lateral offset distance (of), such that the objective generates a collimated incoming beam (22) of autofocus light, which is directed at an oblique angle (13) relative to the optical axis (15) of the objective onto the substrate; and a second optical arrangement (13, 16) for generating collimated outgoing beams (34, 35) of autofocus light from the collimated incoming beam as reflected by a substrate surface (4, 5) through the objective and directing the collimated outgoing beam onto a detector-array (17). The device further comprises a relative z-position detector (20) comprising the sensor-array (17) configured to detect the wandering position of the outgoing collimated autofocus light beam (34, 35) on the detector during the focusing action, the wandering position reflecting a change in the distance between the objective and the reflecting substrate surface (4, 5) in the z-direction; and a central control unit (8, 10) configured to control the actuator based on signals from the absolute z-position detector and the relative z-position detector, wherein the signal of the relative z-position detector is used to dynamically recalibrate the absolute z-position detector during focus-find and focus-hold activities.

36. 发明申请

US20210173191A1 SYSTEMS AND METHODS FOR ACTIVE VIBRATION REDUCTION OF A SURGICAL MICROSCOPE 有权
公开(公告)号：US20210173191A1
公开(公告)日：2021-06-10
申请号：US17181341
申请日：2021-02-22
申请人： Alcon Inc.
发明人： Jiansheng Zhou
IPC分类号： G02B21/24 , G02B27/64 , G01P15/18 , G02B21/00 , A61B90/20 , G01P13/00 , A61B3/13 , G02B7/00 , A61B34/20
摘要： The present disclosure provides a system for active vibration reduction of a surgical microscope. The system includes a surgical microscope with an optical head connected to a control device that adjusts the position of the optical head in any of the X, Y, and Z-directions. The system also includes a processor and an accelerometer that detects motion of the optical head and generates data relating to the motion. The disclosure also provides a method for active vibration reduction, which includes receiving data relating to motion of an optical head of a surgical microscope, determining whether the motion is a vibration event or an intentional movement, determining a distance and direction the optical head must be adjusted to reduce the vibration caused by the motion detected, and generating and transmitting a control signal to adjust the position of the optical head to reduce the vibration of the vibration event.

37. 发明授权

US11029486B2 Microscope and observation method 有权
公开(公告)号：US11029486B2
公开(公告)日：2021-06-08
申请号：US16055457
申请日：2018-08-06
申请人： FUJIFILM Corporation
发明人： Kenta Matsubara
IPC分类号： G02B7/28 , G02B21/26 , G02B7/36 , G02B21/24 , G02B21/06 , G03B13/32 , H04N5/232
摘要： A microscope includes an illumination light emission unit 10 that emits illumination light, a stage 61 on which a culture container 60 is placed, an objective lens 31 on which the illumination light having passed through the culture container 60 and the stage 61 is incident, a focusing light emission unit 70 that emits focusing light, a reflected light detection unit 75 that detects reflected light due to emission of the focusing light, a distance changing unit 34 that changes a distance between the objective lens 31 and the stage 61, an autofocus control unit 51 that performs autofocus control based on the reflected light, and a focus control information acquisition unit 53 that acquires focus control information including information of the culture container 60, the amount of culture solution C, and the magnification of the objective lens 31.

38. 发明授权

US10983305B2 Methods for correctly orienting a substrate in a microscope 有权
公开(公告)号：US10983305B2
公开(公告)日：2021-04-20
申请号：US16512856
申请日：2019-07-16
申请人： Abbott Laboratories
发明人： Trevor David Shields , Robert John Fahey , Damian J. Verdnik , Svitlana Y. Berezhna , Mahmoud Janbakhsh , Koshy T. Chacko
IPC分类号： G02B7/38 , G02B21/08 , G02B21/24
摘要： Methods, systems and devices for automatically focusing a microscope on a specimen and collecting a focused image of the specimen are provided. Aspects of the methods include detecting the presence of a substrate in a microscope, determining whether the substrate is in a correct orientation for imaging, focusing the microscope on a specimen that is placed on the substrate, and collecting one or more images of the specimen. Systems and devices for carrying out the subject methods are also provided.

39. 发明申请

US20210109336A1 VARIABLE FOCAL LENGTH LENS DEVICE AND CONTROL METHOD OF VARIABLE FOCAL LENGTH LENS DEVICE 有权
公开(公告)号：US20210109336A1
公开(公告)日：2021-04-15
申请号：US17065079
申请日：2020-10-07
申请人： MITUTOYO CORPORATION
发明人： Yuki KURAHASHI
IPC分类号： G02B21/24 , G02B3/14 , G02B26/00 , G02B21/06
摘要： A variable focal length lens device includes: a variable focal length lens whose focal length cyclically changes in accordance with an inputted drive signal; an image detector configured to detect an image of a measurement target through the variable focal length lens; a pulsed light illuminator configured to emit a pulsed light to illuminate the measurement target; and an illumination controller configured to control the pulsed light illuminator so that the pulsed light is emitted twice in one cycle of the drive signal based on two detection phases corresponding to a designated focal distance of the variable focal length lens.

40. 发明申请

US20210103134A1 REAL-TIME AUTOFOCUS SCANNING 有权
公开(公告)号：US20210103134A1
公开(公告)日：2021-04-08
申请号：US17105251
申请日：2020-11-25
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
IPC分类号： G02B21/24 , G02B21/00 , G06T7/50
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.

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