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41. 发明授权

US08135474B1 Cochlear implant for an implantable cochlear stimulation system and method of assembly 有权
标题翻译：用于植入式耳蜗刺激系统的耳蜗植入物和组装方法
公开(公告)号：US08135474B1
公开(公告)日：2012-03-13
申请号：US12329338
申请日：2008-12-05
申请人： Jian Xie
发明人： Jian Xie
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/0541 , A61N1/36036 , A61N1/37229 , A61N1/3752 , A61N1/3754
摘要： A cochlear implant for a cochlear stimulation system and method of assembling the implant comprising an implantable sealed housing comprising a metal feedthrough case and a metal bottom cover and containing cochlea stimulation circuitry, the feedthrough case comprising silicone enclosed feedthrough pins for connecting an electrical lead of a cochlear electrode to the stimulation circuitry, and a moisture absorbing material comprising calcium oxide secured within the housing and sufficient in quantity to absorb moisture released by the circuitry materials and leaking into the feedthrough case at leak rates of about 1×10−7 atm cc/s to maintain the cochlear implant within acceptable internal moisture limits for at least about 60 years.
摘要翻译：用于耳蜗刺激系统的耳蜗植入物和组装植入物的方法包括可植入密封壳体，其包括金属馈通壳体和金属底盖并且包含耳蜗刺激电路，所述馈通壳体包括用于连接耳蜗电极到刺激电路，以及吸湿材料，其包含固定在壳体内的氧化钙，并且其量足以吸收由电路材料释放的水分并以大约1×10 -7 atm cc / 以将耳蜗植入物保持在可接受的内部水分限度内至少约60年。

42. 发明授权

US08121698B2 Outer hair cell stimulation model for the use by an intra-cochlear implant 有权
标题翻译：用于耳蜗植入物的外毛细胞刺激模型
公开(公告)号：US08121698B2
公开(公告)日：2012-02-21
申请号：US12728722
申请日：2010-03-22
申请人： Gene Y. Fridman , Leonid M. Litvak
发明人： Gene Y. Fridman , Leonid M. Litvak
IPC分类号： A61N1/08
CPC分类号： H04S3/002 , A61N1/36036 , G10L21/02 , G10L2021/065
摘要： Contrast between various frequency components of sound is enhanced through a lateral suppression strategy to provide increased speech perception in the electrically stimulated cochlea. A received audio signal is divided into a plurality of input signals, wherein each input signal is associated with a frequency band. A plurality of envelope signals are generated by determining the envelope of each of a plurality of the input signals. At least one of the envelope signals is scaled in accordance with a scaling factor to generate at least one scaled envelope signal. An output signal is generated by combining at least one envelope signal with at least one scaled envelope signal, and the cochlea is stimulated based on the generated output signal. The lateral suppression strategy can be applied to one or more frequency bands using scaled amplitude signals associated with one or more neighboring frequency bands.
摘要翻译：通过横向抑制策略来增强声音的各种频率分量之间的对比，以在电刺激的耳蜗中提供增加的语音感知。接收到的音频信号被分成多个输入信号，其中每个输入信号与频带相关联。通过确定多个输入信号中的每一个的包络来生成多个包络信号。根据缩放因子来缩放包络信号中的至少一个，以产生至少一个缩放的包络信号。通过将至少一个包络信号与至少一个缩放的包络信号组合来产生输出信号，并且基于所生成的输出信号来刺激耳蜗。横向抑制策略可以使用与一个或多个相邻频带相关联的缩放振幅信号应用于一个或多个频带。

43. 发明申请

US20120035615A1 Composite Stylet 审中-公开
标题翻译：复合探针
公开(公告)号：US20120035615A1
公开(公告)日：2012-02-09
申请号：US12470990
申请日：2009-05-22
申请人： Kurt J. Koester , Chuladatta Thenuwara , Timothy Beerling
发明人： Kurt J. Koester , Chuladatta Thenuwara , Timothy Beerling
IPC分类号： A61B17/00 , A61N1/05
CPC分类号： A61B17/3468 , A61N1/0541
摘要： A composite stylet for facilitating insertion of an implantable electrode array into either a left or right cochlea comprises a composite having a glass transition temperature between room temperature and body temperature. While relatively stiff and straight at room temperature, the composite stylet is slidably inserted into a longitudinal lumen of the electrode array. The electrode array is then inserted into the cochlea. As the composite stylet within the electrode array warms to body temperature, it becomes compliant, allowing the electrode array to assume a spiral shape. The proximal end of the composite stylet, which is not inserted into the body, retains its stiffness to aid the implanter in inserting the electrode array.
摘要翻译：用于促进可植入电极阵列插入左耳蜗或右耳蜗的复合探针包括具有室温和体温之间的玻璃化转变温度的复合物。虽然在室温下相对刚性和直线，但是复合探针可滑动地插入电极阵列的纵向内腔中。然后将电极阵列插入耳蜗。由于电极阵列内的复合管心针加热到体温，所以它变得顺从，允许电极阵列呈现螺旋状。未插入到主体中的复合管心针的近端保持其刚度以帮助注入机插入电极阵列。

44. 发明申请

US20110319965A1 Optimizing Pitch Allocation in a Cochlear Stimulation System 有权
标题翻译：优化耳蜗刺激系统中的音高分配
公开(公告)号：US20110319965A1
公开(公告)日：2011-12-29
申请号：US13225981
申请日：2011-09-06
申请人： Gene Y. Fridman , Leonid M. Litvak
发明人： Gene Y. Fridman , Leonid M. Litvak
IPC分类号： A61F11/04
CPC分类号： A61N1/36036
摘要： Optimizing pitch allocation in a cochlear stimulation system may include implanting an electrode array having a plurality of electrodes into the cochlea of a patient, where the electrode array has an associated implant fitting characteristic that defines a relationship between the implanted electrode array and audio frequencies, presenting sounds through the electrode array to the patient, receiving from the patient a selection of one of the sounds that most closely conforms to a single note, and determining a slope of the implant fitting characteristic of the electrode array based on the sound selected by the patient. Each sound may include a fundamental frequency and one or more harmonics. The optimization may also include changing a center frequency of a band pass filter associated with each electrode based on the determined slope.
摘要翻译：在耳蜗刺激系统中优化音调分配可以包括将具有多个电极的电极阵列植入到患者的耳蜗中，其中电极阵列具有限定植入的电极阵列和音频之间的关系的相关联的植入拟合特征，呈现通过电极阵列向患者发出声音，从患者接收最接近于单个音符的声音之一的选择，以及基于由患者选择的声音来确定电极阵列的植入物拟合特征的斜率。每个声音可以包括基频和一个或多个谐波。优化还可以包括基于确定的斜率改变与每个电极相关联的带通滤波器的中心频率。

45. 发明授权

US08027734B1 Methods and systems of optimizing stimulation current applied to a cochlear implant patient 有权
标题翻译：优化施加到耳蜗植入患者的刺激电流的方法和系统
公开(公告)号：US08027734B1
公开(公告)日：2011-09-27
申请号：US12059358
申请日：2008-03-31
申请人： Aniket Saoji , Leonid M. Litvak
发明人： Aniket Saoji , Leonid M. Litvak
IPC分类号： A61N1/08
CPC分类号： A61N1/36036
摘要： Methods of optimizing stimulation current applied to a cochlear implant patient include determining a plurality of narrowband spectral modulation detection thresholds for the patient and adjusting a stimulation current applied to the patient in accordance with the narrowband spectral modulation detection thresholds. Systems for optimizing stimulation current applied to a cochlear implant patient include an electrode array having a plurality of electrodes disposed thereon, an implantable cochlear stimulator coupled to the electrode array and configured to apply a stimulation current to one or more locations along a cochlea of a patient via one or more of the electrodes, and a fitting station communicatively coupled to the implantable cochlear stimulator. The fitting station is configured determine a plurality of narrowband spectral modulation detection thresholds and adjust the stimulation current in accordance with the narrowband spectral modulation detection thresholds.
摘要翻译：优化施加到耳蜗植入患者的刺激电流的方法包括确定患者的多个窄带频谱调制检测阈值，并根据窄带频谱调制检测阈值调整施加到患者的刺激电流。用于优化施加到耳蜗植入物患者的刺激电流的系统包括具有布置在其上的多个电极的电极阵列，耦合到电极阵列并被配置为将刺激电流施加到沿着患者的耳蜗的一个或多个位置的可植入耳蜗刺激器通过一个或多个电极，以及通信地耦合到可植入耳蜗刺激器的装配台。配置站配置确定多个窄带频谱调制检测阈值，并根据窄带频谱调制检测阈值调整刺激电流。

46. 发明申请

US20110166626A1 Methods and Apparatus For Cochlear Implant Signal Processing 失效
标题翻译：人工耳蜗信号处理方法与装置
公开(公告)号：US20110166626A1
公开(公告)日：2011-07-07
申请号：US13050805
申请日：2011-03-17
申请人： Gene Y. Fridman
发明人： Gene Y. Fridman
IPC分类号： A61F11/04
CPC分类号： A61N1/36032 , A61N1/0541 , A61N1/36036
摘要： A cochlear implant processing strategy increases speech clarity and higher temporal performance. The strategy determines the power spectral component within each channel, and dynamically selects or de-selects the channels through which a stimulation pulse is provided as a function of whether the spectral power of the channel is high or low. “High” and “low” are estimated relative to a selected spectral power, for example. The selected spectral power can be estimated by signal average or mean, or by other criteria. Once a selection of the channels to stimulate has been made, the system can decide that only those channels are stimulated, and stimulation is removed from the other channels. The selected channels are the ones on which the spectral power is above the mean of all the available channels. Fewer channels are stimulated at any time and the contrast of the stimulation is enhanced. Also, the temporal resolution increases as the number of channels that must be stimulated on a given frame decreases. This way, the channels which are presented to the patient are fewer in number and contain more temporal information.
摘要翻译：耳蜗植入物处理策略增加了语音清晰度和更高的时间性能。该策略确定每个通道内的功率谱分量，并且根据信道的频谱功率是高还是低来动态选择或取消选择提供刺激脉冲的信道。例如，相对于所选择的光谱功率来估计“高”和“低”。所选频谱功率可以通过信号平均值或平均值或其他标准来估计。一旦选择了要刺激的通道，系统就可以决定只刺激那些通道，并从其他通道中去除刺激。所选频道是频谱功率高于所有可用频道平均值的频道。任何时候都会刺激更少的通道，增强刺激的对比度。此外，时间分辨率随着给定帧上必须被刺激的信道数量的减少而增加。这样，呈现给患者的信道数量较少，并且包含更多的时间信息。

47. 发明授权

US07953491B1 Auto-referencing mixed-mode phase locked loop for audio playback applications 有权
标题翻译：用于音频播放应用的自动参考混合模式锁相环
公开(公告)号：US07953491B1
公开(公告)日：2011-05-31
申请号：US12861746
申请日：2010-08-23
申请人： Lee F Hartley
发明人： Lee F Hartley
IPC分类号： A61N1/36
CPC分类号： H04R25/70 , A61N1/36036 , H04R25/554 , H04R25/606
摘要： Audio streaming is made available throughout the signal processing path of the speech processor of a cochlear implant or other audio signal processor. Audio streaming comprises the digitally phase locked playback of a real time n-bit digital audio stream, where n may be a large number, e.g., 8, 12, 16, 24 or 32, that emanates (unsolicited) from an operating speech processor. A number of sample points are made available long the processing chain of a digital signal processor (DSP) used within the speech processor of the cochlear implant. Audio streaming may occur at any sample point. The signal at a selected sample point may be selectively monitored in order to allow appropriate diagnostics to be performed. Audio streaming utilizes an auto-referencing mixed-mode phase locked loop. Such phase locked loop processes an asynchronous stream of digital audio samples that arrive at a designated location, e.g., a selected sample point, at a consistent, but unknown, average rate. Once the stream of asynchronous audio samples are received, the average sample rate is extracted, and a local clock is generated at the average frequency. The incoming audio streaming samples are then re-synchronized with the local clock. in order to allow digitally phase locked playback of the audio stream.
摘要翻译：在耳蜗植入物或其他音频信号处理器的语音处理器的整个信号处理路径中，音频流可用。音频流包括实时n位数字音频流的数字相位锁定重放，其中n可以是从操作语音处理器发出（非请求）的大数量，例如8,12,16,24或32。在耳蜗植入物的语音处理器中使用的数字信号处理器（DSP）的处理链之前，多个采样点可用。音频流可能发生在任何采样点。可以选择性地监视所选择的采样点处的信号，以便执行适当的诊断。音频流使用自动参考混合模式锁相环。这种锁相环处理以一致但未知的平均速率到达指定位置（例如，选定的采样点）的数字音频采样的异步流。一旦接收到异步音频采样流，则提取平均采样率，并以平均频率产生本地时钟。传入的音频流采样然后与本地时钟重新同步。以便允许音频流的数字锁相播放。

48. 发明申请

US20110098785A1 Fully Implantable Cochlear Implant Systems Including Optional External Components and Methods for Using the Same 有权
标题翻译：全植入人工耳蜗系统包括可选的外部组件和使用它的方法
公开(公告)号：US20110098785A1
公开(公告)日：2011-04-28
申请号：US12910389
申请日：2010-10-22
申请人： Lakshmi N. Mishra
发明人： Lakshmi N. Mishra
IPC分类号： A61F11/04 , A61N1/36
CPC分类号： A61N1/36032 , A61N1/0541 , A61N1/36036
摘要： An exemplary cochlear implant system includes an external module configured to be positioned external to and worn by a patient, the external module having an external microphone configured to detect an input audio signal presented to the patient, and an external speaker configured to acoustically transmit an audio signal representative of the input audio signal. The exemplary cochlear implant system further includes an implantable module configured to be implanted within the patient, the implantable module having an internal microphone configured to detect the acoustically transmitted audio signal, an internal sound processor configured to generate one or more stimulation parameters based on the acoustically transmitted audio signal, and an internal cochlear stimulator configured to apply electrical stimulation representative of the input audio signal to one or more stimulation sites within the patient in accordance with the one or more stimulation parameters. Corresponding methods and systems are also disclosed.
摘要翻译：示例性的人工耳蜗植入系统包括外部模块，该外部模块被配置为被定位在病人的外部并由患者佩戴，所述外部模块具有被配置为检测呈现给患者的输入音频信号的外部麦克风和被配置为声学地传输音频的外部扬声器信号代表输入音频信号。示例性耳蜗植入系统还包括被配置为植入患者体内的可植入模块，所述可植入模块具有被配置为检测所述声学传输的音频信号的内部麦克风，内部声音处理器，被配置为基于所述声学信号产生一个或多个刺激参数被配置为根据一个或多个刺激参数将表示输入音频信号的电刺激施加到患者体内的一个或多个刺激部位。还公开了相应的方法和系统。

49. 发明授权

US07925350B1 Systems and methods for detecting an error associated with an implantable device 有权
标题翻译：用于检测与可植入装置相关的错误的系统和方法
公开(公告)号：US07925350B1
公开(公告)日：2011-04-12
申请号：US12879174
申请日：2010-09-10
申请人： Logan P. Palmer
发明人： Logan P. Palmer
IPC分类号： A61N1/08
CPC分类号： A61N1/37252 , A61N1/36036 , A61N1/3787
摘要： Methods of detecting an error associated with an implantable device include powering up the implantable device with an external device, disabling a back-telemetry transmitter within the implanted device after the implanted device is powered up, detecting an error with the implanted device, generating a fault signal corresponding to the error with the implanted device, turning on the back-telemetry transmitter after the fault signal has been generated, and transmitting the fault signal to the external device with the back-telemetry transmitter.
摘要翻译：检测与可植入装置相关联的误差的方法包括用外部装置上电可植入装置，在植入装置上电之后禁用植入装置内的背部遥测发射器，检测植入装置的错误，产生故障信号对应于植入装置的误差，在产生故障信号后打开后置遥测发射器，并用后置遥测发射机将故障信号发送到外部设备。

50. 发明授权

US07916823B1 Auto-referencing mixed-mode phase locked loop for audio playback applications 有权
标题翻译：用于音频播放应用的自动参考混合模式锁相环
公开(公告)号：US07916823B1
公开(公告)日：2011-03-29
申请号：US11381719
申请日：2006-05-04
申请人： Lee F Hartley
发明人： Lee F Hartley
IPC分类号： H03D3/24
CPC分类号： H04R25/70 , A61N1/36036 , H04R25/554 , H04R25/606
摘要： Audio streaming is made available throughout the signal processing path of a speech (or audio) processor of a cochlear implant system. Audio streaming allows one to “listen in” to what a cochlear implant patient may be hearing. As an audio signal stream is received and digitally processed, it may be sampled at any of a number of sample points. The signal at a selected sample point allows appropriate diagnostics to be performed. An auto-referencing mixed-mode phase locked loop processes an asynchronous stream of digital audio samples that arrive at a consistent, but unknown, average rate. Once received, the average sample rate is extracted, and a local clock is generated at the average frequency. The incoming audio streaming samples are then re-synchronized with the local clock in order to allow digitally phase locked playback of the audio stream.
摘要翻译：在耳蜗植入系统的语音（或音频）处理器的整个信号处理路径中，音频流可用。音频流式传输允许人们“听取”什么是耳蜗植入物患者可能听到的。当音频信号流被接收和数字处理时，可以在多个采样点中的任一个采样。所选采样点的信号允许执行适当的诊断。自动参考混合模式锁相环处理以一致但未知的平均速率达到的数字音频样本的异步流。一旦接收到，则提取平均采样率，并以平均频率产生本地时钟。接收的音频流采样然后与本地时钟重新同步，以便允许音频流的数字锁相播放。

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