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41. 发明授权

US10102261B2 System and method for correlating cloud-based big data in real-time for intelligent analytics and multiple end uses 有权
公开(公告)号：US10102261B2
公开(公告)日：2018-10-16
申请号：US15900329
申请日：2018-02-20
申请人： Leidos, Inc.
发明人： Thomas James Cannaliato , Joshua A. Decker , Matthew William Vahlberg
IPC分类号： G06F17/30 , G16H10/60 , G06F21/62 , G06F19/00
摘要： A processing platform integrates ETL (extract, transform, and load), real time stream processing, and “big data” data stores into a high performance analytic system that runs in a public or private cloud. The platform performs real time pre-storage enrichment of data records to form a single comprehensive record usable for analytics, searching and alerting. The platform further supports sharing of components and plug-ins and performs automatic scaling of resources based on real time resource monitoring and analysis.

42. 发明申请

US20180185474A1 PD-1 Peptide Inhibitors 审中-公开
公开(公告)号：US20180185474A1
公开(公告)日：2018-07-05
申请号：US15908861
申请日：2018-03-01
申请人： Leidos, Inc.
发明人： Gabriel M. Gutierrez , Vinayaka Kotraiah , James Pannucci , Ramses Ayala
IPC分类号： A61K39/39 , C07K7/08 , A61K39/015 , A61K38/10 , A61K39/00 , A61K38/16
摘要： This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

43. 发明授权

US09943580B2 Malaria vaccine 有权
公开(公告)号：US09943580B2
公开(公告)日：2018-04-17
申请号：US15023653
申请日：2014-09-11
申请人： STC.UNM , LEIDOS, INC
发明人： David S. Peabody , Bryce Chackerian , James Pannucci , Gabriel M. Gutierrez , Amy Rene Noe , Scott Budd Winram , Steve Chienwen Huang
IPC分类号： A61K39/39 , A61K39/015 , C12N7/00 , C12N15/10 , A61K39/00 , A61K35/76
CPC分类号： A61K39/015 , A61K35/76 , A61K39/39 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , C07K2319/40 , C12N7/00 , C12N15/1037 , C12N2795/18122 , C12N2795/18123 , C12N2795/18134 , Y02A50/412
摘要： Embodiments are directed to malaria vaccines comprising a bacteriophage VLP displaying a heterologous peptide identified by affinity selection as an anti-malaria mimotope.

44. 发明申请

US20180071385A1 PD-1 Peptide Inhibitors 审中-公开
公开(公告)号：US20180071385A1
公开(公告)日：2018-03-15
申请号：US15705333
申请日：2017-09-15
申请人： Leidos, Inc.
发明人： Gabriel M. Gutierrez , Vinayaka Kotraiah , James Pannucci , Ramses Ayala
IPC分类号： A61K39/39 , A61K38/16 , A61K39/00 , A61K39/015
CPC分类号： A61K39/39 , A61K38/10 , A61K38/16 , A61K39/0011 , A61K39/015 , A61K2039/55516 , C07K7/08
摘要： This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

45. 发明授权

US09908064B2 Portable fluidic platform for rapid cell-free production of protein biologics 有权
公开(公告)号：US09908064B2
公开(公告)日：2018-03-06
申请号：US15010528
申请日：2016-01-29
申请人： Leidos, Inc.
发明人： John Dresios , Richard Holmes Griffey , Challise J. Sullivan , Erik D. Pendleton , Henri M. Sasmor , William L. Hicks , Eric M. Amendt
IPC分类号： B01D15/36 , B01D15/14 , C12M1/12 , C12N9/12 , C07K14/505 , C07K14/535 , C12M1/40 , C12M1/00 , C12M1/36 , C12M3/00 , B01D15/12 , B01D15/10 , B01D15/22 , B01D15/38 , B01D15/34 , C12P21/02
CPC分类号： B01D15/361 , B01D15/10 , B01D15/12 , B01D15/14 , B01D15/22 , B01D15/34 , B01D15/3804 , C07K14/505 , C07K14/535 , C12M21/18 , C12M23/28 , C12M23/44 , C12M29/00 , C12M41/48 , C12M47/10 , C12N9/1223 , C12N9/1252 , C12P21/02 , C12Y207/03002 , C12Y207/07007
摘要： A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements. Protein synthesis and purification modules are integrated into self-contained disposable fluidic cartridge that eliminates cross-contamination between runs. The platform allows for flexible production of protein biologics within 24 hours (from DNA to purified product).

46. 发明授权

US09864069B2 Switching frequency extended range geiger detection system and method 有权
公开(公告)号：US09864069B2
公开(公告)日：2018-01-09
申请号：US15040384
申请日：2016-02-10
申请人： Leidos, Inc.
发明人： Eric Matthew Amendt , Ryan Shyffer
IPC分类号： G01T1/18 , H03B5/20 , H03B5/32
CPC分类号： G01T1/18 , H03B5/20 , H03B5/32
摘要： A Geiger-Mueller charge particle rate measurement system includes a clock management unit in combination with multiple oscillators and rate feedback controller to allow for reactive switching between the different oscillator frequencies to optimize system use. Controlling the clock management unit to send the appropriate frequency (clock signal) to the timers in response to measured rate date from the rate feedback controller facilitates operation at different clock speeds, which helps reduce power consumption when operated at lower speeds.

47. 发明申请

US20170225760A1 System and Method For Fusion of Sensor Data to Support Autonomous Maritime Vessels 有权
公开(公告)号：US20170225760A1
公开(公告)日：2017-08-10
申请号：US14968161
申请日：2015-12-14
申请人： Leidos, Inc.
发明人： Nahid Sidki , Shen Weicheng , Suk Lee , Andrew Genduso
IPC分类号： B63H25/04 , G05D1/00 , G05D1/02 , B63B35/00 , G08G3/02
CPC分类号： B63H25/04 , B63B35/00 , B63B2035/007 , G05D1/0088 , G05D1/0206 , G08G3/02
摘要： A system of modular components can be used with existing sensor suites to fuse data and determine the operating environment (surface contacts/tracks) for an autonomous marine vehicle and feed an autonomy decision engine to improve the vessel arbitration process in deciding which way to turn, how fast to go, obstacle avoidance, and mission monitoring. The system includes the ability to obey the set of navigation rules published by the International Maritime Organization. Generally referred to as COLREGS (collision regulations).

48. 发明申请

US20170123100A1 Method For Autonomous Self-Blanking by Radiation Portal Monitors to Minimize the Interference From Pulsed X-Rays Radiation 有权
公开(公告)号：US20170123100A1
公开(公告)日：2017-05-04
申请号：US15409205
申请日：2017-01-18
申请人： Leidos, Inc.
发明人： Adrian Stoian , Gregory Alan Greenwood
IPC分类号： G01V5/00
CPC分类号： G01V5/0016 , G01T1/17 , G01V5/0008 , G01V5/0066
摘要： A system and associated method for isolating intended radiation signals for determining target characteristics includes multiple detectors for detecting radiation signals having varying energies, delay modules for delaying the detected radiation signals and a discriminator associated with the multiple detectors for determining if detected radiation signals include unintended radiation signals, e.g., x-rays, and provided blanking signals to a switch in order to effectively remove the unintended radiation signals from the data that is presented to the processor for determining target characteristics.

49. 发明申请

US20170059301A1 System and Method For a Self-Referencing Interferometer 审中-公开
标题翻译：自参考干涉仪的系统和方法
公开(公告)号：US20170059301A1
公开(公告)日：2017-03-02
申请号：US15348113
申请日：2016-11-10
申请人： Leidos, Inc.
发明人： Troy Rhoadarmer , Eric Berg
IPC分类号： G01B9/02
CPC分类号： G01B9/02097 , G01B9/02081 , G01B2290/70
摘要： Systems and methods are described herein for a self-referencing interferometer. The interferometer can comprise an improved spatial phase shifter that reduces the number of components, size and complexity of the spatial phase shifter and maintains a common path for a combined reference beam and signal beam. The self-referencing interferometer further comprises a single mode fiber shunt for filtering the reference beam and further reducing the size of the interferometer. The angle of the reference beam can be tilted before being recombined with the single beam which further simplifies the spatial phase shifting component of the interferometer.
摘要翻译：这里描述了用于自参考干涉仪的系统和方法。干涉仪可以包括改进的空间移相器，其减少空间移相器的分量的数量，大小和复杂度，并且为组合的参考光束和信号光束保持公共路径。自参考干涉仪还包括用于对参考光束进行滤波的单模光纤分流器，并进一步减小干涉仪的尺寸。参考光束的角度可以在与单个光束重新组合之前倾斜，这进一步简化了干涉仪的空间相移分量。

50. 发明授权

US09503310B1 Methods and systems of dynamic management of resources in a virtualized environment 有权
标题翻译：在虚拟化环境中动态管理资源的方法和系统
公开(公告)号：US09503310B1
公开(公告)日：2016-11-22
申请号：US14082895
申请日：2013-11-18
申请人： Leidos, Inc.
发明人： Kurt R. Hawkes , Christina L. Bouwens , James E. Shiflett , Michael R. Macedonia
IPC分类号： H04L12/24 , H04L12/26
CPC分类号： H04L67/1008 , G06F9/45558 , G06F9/4881 , G06F2009/45575 , H04L41/00 , H04L43/00 , H04L67/1031
摘要： The methods and systems described herein centralize simulation resources and effectively delivering training and simulation services to a broad set of distributed users at both the enterprise and operational levels. The cloud-based delivery of simulation applications described herein enables on-demand network access to a shared pool of configurable computing resources (e.g., networks, servers, storage, applications, and services) that can be rapidly provisioned and released with minimal management effort or service provider interaction. In exemplary systems, users may provision computing capabilities, such as server time and network storage, as needed, automatically without requiring human interaction.
摘要翻译：本文描述的方法和系统集中了模拟资源，并在企业和运营层面为广泛的分布式用户群提供培训和仿真服务。本文描述的模拟应用程序的基于云的传送使得能够以最少的管理努力快速地供应和发布的可配置计算资源（例如，网络，服务器，存储，应用和服务）的共享池进行按需网络访问，服务提供商的互动。在示例性系统中，用户可以根据需要自动地提供诸如服务器时间和网络存储的计算能力，而不需要人的交互。

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