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41. 发明申请

US20100158150A1 MAX-LOG STACK DECODER 有权
标题翻译：最大日志堆栈解码器
公开(公告)号：US20100158150A1
公开(公告)日：2010-06-24
申请号：US12549574
申请日：2009-08-28
申请人： Narayan Prasad , Xiaodong Wang , Sampath Rangarajan
发明人： Narayan Prasad , Xiaodong Wang , Sampath Rangarajan
IPC分类号： H04L5/12 , H04L27/06
CPC分类号： H04L25/03318 , H04L25/0204 , H04L25/0246 , H04L25/03203 , H04L2025/0342 , H04L2025/03426
摘要： A method for demodulating signals in a multi-input multi-output (MIMO) receiver includes obtaining a transformed vector by a coordinate transformation of a received observation vector using a unitary matrix determined through QR decomposition of an estimated channel matrix; maintaining a list containing nodes along with a cost metric for each node; using the list to generate soft-outputs in the form of log-likelihood ratios (LLRs) for selected symbols of interest, based on the transformed vector and a lower triangular matrix determined through QR decomposition of the estimated channel matrix and the constellations to which the input symbols belong.
摘要翻译：一种用于在多输入多输出（MIMO）接收机中解调信号的方法，包括：使用通过估计的信道矩阵的QR分解确定的酉矩阵，通过接收到的观测向量的坐标变换来获得变换矢量; 维护包含节点的列表以及每个节点的成本度量; 使用该列表基于经变换的矢量以及通过估计的信道矩阵的QR分解确定的下一个三角矩阵和所选择的星座的星座，以所选择的感兴趣的符号的对数似然比（LLR）的形式产生软输出输入符号属于。

42. 发明授权

US07732446B1 Dipeptidyl peptidase inhibitors 失效
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US07732446B1
公开(公告)日：2010-06-08
申请号：US11077487
申请日：2005-03-09
申请人： Stephen L. Gwaltney , Jeffrey A. Stafford , Michael B. Wallace , Laurence E. Burgess , Scott D. Cowen , Stephen S. Gonzales , Ellen R. Laird , Xiaodong Wang
发明人： Stephen L. Gwaltney , Jeffrey A. Stafford , Michael B. Wallace , Laurence E. Burgess , Scott D. Cowen , Stephen S. Gonzales , Ellen R. Laird , Xiaodong Wang
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： A61K31/47 , C07D217/16 , C07D217/22 , C07D217/26 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formulae: where the substituents are as described herein.
摘要翻译：提供化合物，药物，试剂盒和方法用于包含式的DPP-IV抑制剂：其中取代基如本文所述。

43. 发明授权

US07709533B2 Imines as ion channel modulators 失效
标题翻译：作为离子通道调节剂
公开(公告)号：US07709533B2
公开(公告)日：2010-05-04
申请号：US11346546
申请日：2006-02-01
申请人： Xiaodong Wang , Alan Bradley Fulp , Darrick Seconi
发明人： Xiaodong Wang , Alan Bradley Fulp , Darrick Seconi
IPC分类号： A61K31/13 , C07C249/02
CPC分类号： C07D213/54 , C07C251/40 , C07C251/80 , C07C257/06 , C07C257/14 , C07C257/22 , C07C259/12 , C07C259/14 , C07D213/58 , C07D413/06 , C07F9/12
摘要： The present invention provides a class of chemical compounds useful in the treatment of sickle cell disease, diseases characterized by unwanted or abnormal cell proliferation and for the treatment of ocular disorders such as glaucoma. The active compounds are tri-(aryl or heteroaryl) methane compounds or analogues thereof which further comprise an imine moiety and where the tertiary carbon atom can be replaced with a different atom such as Si, Ge, N or P. The compounds enhance resistance to degradation in a biological medium, inhibit potassium flux in a cell, reduce mammalian cell proliferation, reduce the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.
摘要翻译：本发明提供了一类用于治疗镰状细胞病，特征在于不想要的或异常细胞增殖的疾病和用于治疗眼部疾病如青光眼的化合物。活性化合物是三（芳基或杂芳基）甲烷化合物或其类似物，其还包含亚胺部分，其中叔碳原子可被不同的原子如Si，Ge，N或P替代。化合物增强了对在生物培养基中降解，抑制细胞内的钾通量，减少哺乳动物细胞增殖，减少红细胞的Gardos通道，减少镰状红细胞脱水和/或延缓红细胞镰状或变形的发生。

44. 发明授权

US07704764B2 Fabrication method of GaN power LEDs with electrodes formed by composite optical coatings 有权
标题翻译：具有由复合光学涂层形成的电极的GaN功率LED的制造方法
公开(公告)号：US07704764B2
公开(公告)日：2010-04-27
申请号：US12110428
申请日：2008-04-28
申请人： Jinmin Li , Xiaodong Wang , Guohong Wang , Liangchen Wang , Fuhua Yang
发明人： Jinmin Li , Xiaodong Wang , Guohong Wang , Liangchen Wang , Fuhua Yang
IPC分类号： H01L21/00
CPC分类号： H01L33/405 , H01L33/42 , H01L33/46
摘要： Fabrication method of GaN power LED with electrodes formed by composite optical coatings, comprising epitaxially growing N—GaN, active, and P—GaN layers successively on a substrate; depositing a mask layer thereon; coating the mask layer with photoresist; etching the mask layer into an N—GaN electrode pattern; etching through that electrode pattern to form an N—GaN electrode region; removing the mask layer and cleaning; forming a transparent, electrically conductive film simultaneously on the P—GaN and N—GaN layers; forming P—GaN and N—GaN transparent, electrically conductive electrodes by lift-off; forming bonding pad pattern for the P—GaN and N—GaN electrodes by photolithography process; simultaneously forming thereon bonding pad regions for the P—GaN and N—GaN electrodes by stepped electron beam evaporation; forming an antireflection film pattern by photolithography process; forming an antireflection film; thinning and polishing the backside of the substrate, then forming a reflector thereon; and completing the process after scribing, packaging and testing.
摘要翻译：具有通过复合光学涂层形成的电极的GaN功率LED的制造方法，包括在衬底上连续地外延生长N-GaN，有源和P-GaN层; 在其上沉积掩模层; 用光刻胶涂覆掩模层; 将掩模层蚀刻成N-GaN电极图案; 蚀刻该电极图案以形成N-GaN电极区域; 去除掩模层并进行清洗; 在P-GaN和N-GaN层上同时形成透明导电膜; 通过剥离形成P-GaN和N-GaN透明导电电极; 通过光刻工艺形成用于P-GaN和N-GaN电极的焊盘图案; 同时通过阶梯式电子束蒸发在其上形成用于P-GaN和N-GaN电极的焊盘区域; 通过光刻工艺形成抗反射膜图案; 形成抗反射膜; 对衬底的背面进行稀疏和抛光，然后在其上形成反射器; 并在划线，包装和测试后完成该过程。

45. 发明申请

US20100081656A1 COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS 失效
标题翻译：用于调节C-kit和PDGFR受体的组合物和方法
公开(公告)号：US20100081656A1
公开(公告)日：2010-04-01
申请号：US12629665
申请日：2009-12-02
申请人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
发明人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
IPC分类号： A61K31/5377 , A61K31/496 , C07D413/14 , C07D401/14 , C07D471/04 , A61P25/22 , A61K31/4375 , A61P25/28 , A61P25/16 , A61P3/10 , A61P3/04
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit，PDGFRα，PDGFR和bgr，CSF1R，Abl，BCR-Abl，CSK，JNK1，JNK2，p38异常活化的疾病或病症的方法，p70S6K，TGF-bgr，SRC，EGFR，trkB，FGFR3，FLT3，Fes，Lck，Syk，RAF，MKK4，MKK6，SAPK2＆bgr，BRK，KDR，c-raf或b-raf激酶或其突变形式。

46. 发明授权

US07660360B2 Peak-to-average power ratio reduction with threshold limited selection for coded OFDM systems 有权
标题翻译：峰值与平均功率比降低与编码OFDM系统的阈值限制选择
公开(公告)号：US07660360B2
公开(公告)日：2010-02-09
申请号：US11536263
申请日：2006-09-28
申请人： Guosen Yue , Xiaodong Wang , Mohammad Madihian
发明人： Guosen Yue , Xiaodong Wang , Mohammad Madihian
IPC分类号： H04K1/10 , H04L27/28
CPC分类号： H04L27/2618 , H04L1/0043 , H04L1/0057 , H04L1/0066 , H04L27/2617
摘要： Disclosed is a coded orthogonal frequency-division multiplexing (OFDM) system and method for reducing a peak-to-average power ratio (PAPR). The system and method include a modulator configured to modulate (e.g., using quadrature amplitude modulation (QAM)) coded bits into symbols. The system and method also include an inverse discrete fourier transform (IDFT) module to perform an IDFT on the symbols to produce an OFDM signal. The system and method measure the PAPR of the OFDM signal and transmit the signal to a receiver if the PAPR of the signal is less than a threshold PAPR.
摘要翻译：公开了用于降低峰均功率比（PAPR）的编码正交频分复用（OFDM）系统和方法。该系统和方法包括配置成将（例如，使用正交幅度调制（QAM））编码比特调制成符号的调制器。该系统和方法还包括对码元执行IDFT以产生OFDM信号的反离散傅里叶变换（IDFT）模块。如果信号的PAPR小于阈值PAPR，则该系统和方法测量OFDM信号的PAPR并将该信号发送到接收机。

47. 发明授权

US07655641B2 Sulfonamide derivatives as PPAR modulators 失效
标题翻译：磺酰胺衍生物作为PPAR调节剂
公开(公告)号：US07655641B2
公开(公告)日：2010-02-02
申请号：US10542579
申请日：2004-02-10
申请人： Scott Eugene Conner , Lynn Stacy Gossett , Jonathan Edward Green , Winton Dennis Jones, Jr. , Nathan Bryan Mantlo , Donald Paul Matthews , Daniel Ray Mayhugh , Daryl Lynn Smith , Jennifer Ann Vance , Xiaodong Wang , Alan M Warshawsky , Leonard Larry Winneroski, Jr. , Yanping Xu , Guoxin Zhu
发明人： Scott Eugene Conner , Lynn Stacy Gossett , Jonathan Edward Green , Winton Dennis Jones, Jr. , Nathan Bryan Mantlo , Donald Paul Matthews , Daniel Ray Mayhugh , Daryl Lynn Smith , Jennifer Ann Vance , Xiaodong Wang , Alan M Warshawsky , Leonard Larry Winneroski, Jr. , Yanping Xu , Guoxin Zhu
IPC分类号： A61K31/66 , A61K31/38 , C07D409/12 , C07D209/04
CPC分类号： C07D207/08 , A61K31/00 , A61K45/06 , C07C311/13 , C07C311/17 , C07C311/19 , C07C311/29 , C07C317/14 , C07C323/49 , C07C323/52 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D209/48 , C07D213/64 , C07D213/71 , C07D213/74 , C07D215/36 , C07D231/12 , C07D231/18 , C07D263/32 , C07D271/12 , C07D277/36 , C07D307/79 , C07D307/82 , C07D319/18 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/12 , C07D413/04 , A61K2300/00
摘要： The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，溶剂合物，水合物或立体异构体，其可用于治疗或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，例如综合征X型 II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化以及与X综合症和心血管疾病有关的其他疾病。

48. 发明申请

US20090312379A1 Dimeric Small Molecule Potentiators of Apoptosis 有权
标题翻译：二聚体小分子细胞凋亡电位
公开(公告)号：US20090312379A1
公开(公告)日：2009-12-17
申请号：US12509190
申请日：2009-07-24
申请人： Patrick G. Harran , Xiaodong Wang , Jef D. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
发明人： Patrick G. Harran , Xiaodong Wang , Jef D. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
IPC分类号： A61K31/422 , C07D417/14 , C12N5/00 , C07D403/14 , A61K31/41 , A61K31/4192 , A61P35/00
CPC分类号： C07D413/14 , A61K31/41 , A61K31/422 , C07D207/08 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/14 , C07D495/04 , C07K5/06026 , C07K5/06034
摘要： Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要翻译：使用通式M1-L-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。接触步骤可以通过给予包含治疗有效量的复合模拟物的药物组合物来实现，其中个体可以同时或先前放射或化疗用于治疗新生血管病变。

49. 发明申请

US20090262872A1 RECEIVER WITH PREFILTERING FOR DISCRETE FOURIER TRANSFORM-SPREAD-ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING (DFT-S-OFDM) BASED SYSTEMS 有权
标题翻译：用于离散傅里叶变换扩展正交频分多址（DFT-S-OFDM）的系统的接收器
公开(公告)号：US20090262872A1
公开(公告)日：2009-10-22
申请号：US12425080
申请日：2009-04-16
申请人： Narayan Prasad , Xiaodong Wang , Shuangquan Wang
发明人： Narayan Prasad , Xiaodong Wang , Shuangquan Wang
IPC分类号： H04L27/06
CPC分类号： H04L27/2647 , H04L25/03159 , H04L25/067
摘要： A receiver for discrete Fourier transform-spread-orthogonal frequency division multiplexing (DFT-S-OFDM) based systems, including a prefilter for received signal codeword(s); and a log-likelihood ratio LLR module responsive to the prefilter; wherein the prefilter includes a pairing and whitening module that based on channel estimates and data rate enables the LLR module to perform either a Serial-In-Serial-Out (SISO) based log likelihood ratio processing of an output from the paring and whitening module or a two-symbol max-log soft output demodulator (MLSD) based log likelihood ratio processing of an output from the pairing and whitening module.
摘要翻译：一种用于离散傅里叶变换扩展正交频分复用（DFT-S-OFDM）系统的接收机，包括用于接收信号码字的预滤波器; 以及响应于所述预过滤器的对数似然比LLR模块; 其中所述预过滤器包括配对和增白模块，其基于信道估计和数据速率使得所述LLR模块能够执行基于串行输出（SISO）的对数似然比处理来自所述配对和增白模块的输出，来自配对和增白模块的输出的基于双符号最大对数软输出解调器（MLSD）的对数似然比处理。

50. 发明授权

US07544812B2 Peroxisome proliferator activated receptor agonists 失效
标题翻译：过氧化物酶体增殖物激活受体激动剂
公开(公告)号：US07544812B2
公开(公告)日：2009-06-09
申请号：US10496770
申请日：2002-11-26
申请人： Tracey Ann Gibson , Richard Duane Johnston , Nathan Bryan Mantlo , Richard Craig Thompson , Leonard Larry Winneroski , Yanping Xu , Xiaodong Wang
发明人： Tracey Ann Gibson , Richard Duane Johnston , Nathan Bryan Mantlo , Richard Craig Thompson , Leonard Larry Winneroski , Yanping Xu , Xiaodong Wang
IPC分类号： A61K31/4166 , C07D233/32
CPC分类号： C07D401/06 , C07D233/32 , C07D233/70 , C07D233/76 , C07D403/12 , C07D405/06 , C07D405/12
摘要： The present invention is directed to compounds represented by the following structural Formula (I), (a) R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl, and —CH2—C(O)—R17-R18, wherein R17 is O or NH and R18 is optionally substituted benzyl; (b) R2 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkenyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, C1-C4 alkyl sulfonamide, C1-C4 alkyl amide, OR10 and C3-C6 cycloalkyl; (c) W is O or S; (d) X is an optionally substituted C1-C5 alkylene linker wherein one carbon atom of the linker may optionally be replaced with O, NH, S, and optionally two carbons together may form a double bond; (e) Y is selected from the group consisting of C, O, S, NH and a single bond; and (f) E is selected from the group consisting of C(R3)(R4)A, A, and a substituted or unsubstituted group selected from the group consisting of (CH2)n COOR19.
摘要翻译：本发明涉及由以下结构式（I）表示的化合物，（a）R 1选自氢，取代或未取代的选自C 1 -C 8烷基，芳基-C 0-4 - 烷基，杂芳基 C 0-4烷基，C 3 -C 6环烷基芳基-C 0-2 - 烷基和-CH 2 -C（O）-R 17 -R 18，其中R 17是O或NH，R 18是任选取代的苄基; （b）R 2选自C 1 -C 6烷基，C 1 -C 6烯基，芳基-C 0-4 - 烷基，杂芳基-C 0-4 - 烷基，C 1 -C 4烷基磺酰胺，C 1 -C 4烷基酰胺，OR 10 和C 3 -C 6环烷基; （c）W为O或S; （d）X是任选取代的C1-C5亚烷基连接体，其中连接体的一个碳原子可以任选地被O，NH，S取代，并且任选地两个碳可以一起形成双键; （e）Y选自C，O，S，NH和单键; 和（f）E选自C（R 3）（R 4）A，A和选自（CH 2）n COOR 19的取代或未取代的基团。

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