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41. 发明申请

US20050251216A1 Method and device for electronically controlling the beating of a heart 有权
公开(公告)号：US20050251216A1
公开(公告)日：2005-11-10
申请号：US11112730
申请日：2005-04-22
申请人： Michael Hill , Kenneth Jonkman
发明人： Michael Hill , Kenneth Jonkman
IPC分类号： A61B17/00 , A61B17/02 , A61B17/34 , A61N1/05 , A61N1/36 , A61N1/362 , A61N1/38 , A61N1/39
CPC分类号： A61N1/36114 , A61B17/3417 , A61B2017/00243 , A61B2017/00969 , A61B2017/0243 , A61B2017/3445 , A61B2017/3449 , A61N1/056 , A61N1/362 , A61N1/385 , A61N1/3962
摘要： An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.

42. 发明申请

US20050245852A1 System and method for providing therapy to an area of a body 审中-公开
标题翻译：用于向身体区域提供治疗的系统和方法
公开(公告)号：US20050245852A1
公开(公告)日：2005-11-03
申请号：US10835938
申请日：2004-04-30
申请人： Kimberly Ellefson , MeeWha Lee , James Milner
发明人： Kimberly Ellefson , MeeWha Lee , James Milner
IPC分类号： A61F7/10 , A61K9/70 , A61F5/00 , A61N1/36 , A61N1/38
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092
摘要： In some example embodiments, the present invention relates to a system for providing therapy to a body. The system includes a first patch that applies a first therapy to the body when the first patch is placed near the body. The first patch is customized to fit on a first area of the body. The system further includes a second patch that applies a second therapy to the body when the second patch is placed near the body. The second patch may be a different size than the first patch such that the second patch is customized to fit on a second area of the body and is detachably secured to the first patch to form a third patch that is a combination of the first patch and the second patch. In some embodiments, the first therapy may be different than the second therapy.
摘要翻译：在一些示例性实施例中，本发明涉及一种用于向身体提供治疗的系统。该系统包括当第一贴片放置在身体附近时将第一疗法应用于身体的第一贴片。第一个补丁是定制适合身体的第一个区域。该系统还包括第二贴片，当第二贴片放置在身体附近时，第二贴片将第二疗法应用于身体。第二贴片可以是与第一贴片不同的尺寸，使得第二贴片定制成适合于身体的第二区域，并且可拆卸地固定到第一贴片以形成第三贴片，其是第一贴片和第二个补丁。在一些实施方案中，第一疗法可以不同于第二疗法。

43. 发明授权

US06912419B2 Method and device for electronically controlling the beating of a heart 有权
标题翻译：用于电子控制心脏跳动的方法和装置
公开(公告)号：US06912419B2
公开(公告)日：2005-06-28
申请号：US10387280
申请日：2003-03-12
申请人： Michael R. S. Hill , Kenneth R. Jonkman
发明人： Michael R. S. Hill , Kenneth R. Jonkman
IPC分类号： A61B17/00 , A61B17/02 , A61B17/34 , A61N1/05 , A61N1/36 , A61N1/362 , A61N1/38 , A61N1/39 , A61N1/18
CPC分类号： A61N1/36114 , A61B17/3417 , A61B2017/00243 , A61B2017/00969 , A61B2017/0243 , A61B2017/3445 , A61B2017/3449 , A61N1/056 , A61N1/362 , A61N1/385 , A61N1/3962
摘要： An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.
摘要翻译：电刺激装置包括一对电极，用于连接到体内至少一个影响或调节心跳的位置。电刺激装置既电气阻止心跳并刺激心跳。提供一对电极用于连接到体内至少一个影响或调节心跳的位置。该对电极可以连接到静脉导管，用于适当神经的经静脉刺激。第一开关连接在电源和电极之间，用于选择性地从电源向电极提供电流，以增加对心脏的任何自然刺激，从而阻止心脏跳动。第二开关连接在电源和电极之间，用于选择性地从电源向电极提供电流以提供人造刺激以启动心跳。另一方面，本发明涉及一种用于在生物体中阻止心脏的搏动的方法，包括以下步骤：将一对电极连接到体内至少一个位置，其影响或调节心跳并提供电流到足够的幅度和持续时间的电极以阻止心跳。该装置还可以通过输入呼吸器或在外科手术期间刺激膈神经而服用于肺。

44. 发明申请

US20050137639A1 Method and apparatus for actively determining a coupling interval corresponding to a cardiac vulnerable zone 有权
标题翻译：用于主动确定对应于心脏易感区的耦合间隔的方法和装置
公开(公告)号：US20050137639A1
公开(公告)日：2005-06-23
申请号：US10745035
申请日：2003-12-23
申请人： William Havel
发明人： William Havel
IPC分类号： A61N1/38 , A61N1/39 , A61N1/37
CPC分类号： A61N1/3962 , A61N1/3937
摘要： A method and apparatus for actively determining a coupling interval corresponding to a cardiac vulnerable zone associated with a therapy of an implantable medical device that includes a timing and control unit delivering, via electrodes of a plurality of electrodes, a first pulse train and a first pulse signal at a predetermined time interval from delivery of a last pulse of the first pulse train. A sensor determines an evoked response corresponding to the first pulse signal, and a microprocessor compares the evoked response to a prior determined evoked response and sets the coupling interval equal to the predetermined time interval in response to the evoked response having increased by a first predetermined amount, and reduces the predetermined time interval by a second predetermined amount in response to the evoked response not having increased by the first predetermined amount.
摘要翻译：一种用于主动地确定与可植入医疗装置的治疗相关联的心脏脆弱区域的耦合间隔的方法和装置，其包括定时和控制单元，其经由多个电极的电极传送第一脉冲串和第一脉冲以从第一脉冲序列的最后脉冲的传送起的预定时间间隔发出信号。传感器确定对应于第一脉冲信号的诱发响应，并且微处理器将诱发响应与先前确定的诱发响应进行比较，并且响应于已经增加了第一预定量的诱发响应将耦合间隔设置为等于预定时间间隔并且响应于没有增加第一预定量的诱发响应，将预定时间间隔减小第二预定量。

45. 再颁专利

USRE38705E1 Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers 有权
标题翻译：用神经纤维静脉电刺激电子控制心跳的方法和装置
公开(公告)号：USRE38705E1
公开(公告)日：2005-02-22
申请号：US10004182
申请日：2001-11-15
申请人： Michael R. S. Hill , Kenneth R. Jonkman
发明人： Michael R. S. Hill , Kenneth R. Jonkman
IPC分类号： A61N1/05 , A61N1/36 , A61N1/362 , A61N1/38 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/362 , A61N1/385 , A61N1/3956
摘要： An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.

46. 发明授权

US5871517A Convulsive therapy apparatus to stimulate and monitor the extent of therapeutic value of the treatment 失效
标题翻译：惊厥治疗仪刺激和监测治疗价值的程度
公开(公告)号：US5871517A
公开(公告)日：1999-02-16
申请号：US784128
申请日：1997-01-15
申请人： Richard Stephen Abrams , Conrad Melton Swartz
发明人： Richard Stephen Abrams , Conrad Melton Swartz
IPC分类号： A61N1/38 , A61N2/04 , A61N1/32 , A61N1/36
CPC分类号： A61N1/38 , A61B5/0476 , A61B5/0484 , A61B5/4094 , A61B5/4833
摘要： In medical convulsive therapy (CV), comprising electroconvulsive therapy (ECT) and magnetoconvulsive therapy (MCT), a computer system is used to analyze the effectiveness of the treatment. In one embodiment the effectiveness is determined by measuring the physiological effects on the heart (ECG) muscles (EMG) and brain (EEG).
摘要翻译：在包括电惊厥治疗（ECT）和磁震惊治疗（MCT）的医学惊厥治疗（CV）中，使用计算机系统来分析治疗的有效性。在一个实施例中，通过测量对心脏（ECG）肌肉（EMG）和脑（EEG）的生理作用来确定有效性。

47. 发明授权

US5843133A Dynamic bandwidth control in an implantable medical cardiac stimulator 失效
标题翻译：植入式医疗心脏刺激器中的动态带宽控制
公开(公告)号：US5843133A
公开(公告)日：1998-12-01
申请号：US843236
申请日：1997-04-14
申请人： Andre Routh , Annette Bruls , Drury Woodson, III , Joseph Vandegriff , Yves Verboven
发明人： Andre Routh , Annette Bruls , Drury Woodson, III , Joseph Vandegriff , Yves Verboven
IPC分类号： A61N1/362 , A61N1/37 , A61N1/38 , A61N1/39 , A61N1/18
CPC分类号： A61N1/3622 , A61N1/3704 , A61N1/385 , A61N1/3962 , A61N1/395
摘要： An implantable medical device for electrically stimulating the heart to beat includes a sense circuit for detecting cardiac electrical activity. The sense circuit includes a band pass filter with an adjustable frequency response. The frequency response can be repeatedly adjusted after implantation of the medical device and preferably is adjusted upon detection of the loss of normal sinus rhythm (NSR) in the heart's atria. The loss of NSR often indicates atrial fibrillation (AF), and the filter's frequency response is adjusted to increase the sensitivity of the sense circuit to the cardiac electrical activity typical during AF. The medical device is calibrated during implantation or at subsequent doctor visits with the aid of a calibration device external to the body. Cardiac electrical activity in the form of an electrogram is transmitted from the medical device to the external calibration device. The transmitted electrogram preferably includes both NSR and AF rhythms. The calibration device computes two sets of filter coefficients; one set for increased filter sensitivity during NSR and another set for increased sensitivity during AF. The coefficients are transmitted to the medical device which uses the appropriate set of coefficients to increase the filter's frequency response during both NSR and AF.
摘要翻译：用于电刺激心脏跳动的可植入医疗装置包括用于检测心脏电活动的感测电路。感测电路包括具有可调频率响应的带通滤波器。可以在植入医疗装置之后重复地调整频率响应，并且优选地在检测到心脏心房中的正常窦性心律（NSR）的损失时进行调整。 NSR的损失经常表明心房颤动（AF），并且调整滤波器的频率响应以增加感觉电路对AF期间典型的心脏电活动的灵敏度。借助于身体外部的校准装置，在植入期间或随后的医生访问期间校准医疗装置。以电图形式的心脏电活动从医疗装置传输到外部校准装置。传输的电描记图优选地包括NSR和AF节奏。校准装置计算两组滤波器系数; 一组用于在NSR期间增加滤波器灵敏度，另一组用于在AF期间增加灵敏度。这些系数被传送到使用适当的系数集合的医疗设备，以在NSR和AF期间增加滤波器的频率响应。

48. 发明授权

US5824018A Fibrillation induction method and system for implantable devices 失效
标题翻译：用于植入式装置的颤动感应方法和系统
公开(公告)号：US5824018A
公开(公告)日：1998-10-20
申请号：US642806
申请日：1996-05-03
申请人： Robert Dreher , Brian Kuhnley , Conrad L. Sowder
发明人： Robert Dreher , Brian Kuhnley , Conrad L. Sowder
IPC分类号： A61N1/37 , A61N1/38 , A61N1/39 , A61N1/36
CPC分类号： A61N1/37 , A61N1/385 , A61N1/3943 , A61N1/3906
摘要： A method and apparatus for generating a multiphasic defibrillation/cardioversion waveform as well as a multiphasic fibrillation inducing pulse train. The multiphasic fibrillation inducing waveform being applied to the same electrodes as the defibrillation/cardioversion waveform.
摘要翻译：一种用于产生多相除颤/心脏复律波形的方法和装置以及多相原纤颤诱导脉冲串。多相纤维诱导波形被施加到与除颤/心律转换波形相同的电极。

49. 发明授权

US5814086A Perex respiratory system stimulation upon tachycardia detection 失效
标题翻译：佩雷克斯呼吸系统刺激对心动过速检测
公开(公告)号：US5814086A
公开(公告)日：1998-09-29
申请号：US950138
申请日：1997-10-14
申请人： Jakub Hirschberg , Hans Strandberg
发明人： Jakub Hirschberg , Hans Strandberg
IPC分类号： A61N1/365 , A61N1/36 , A61N1/372 , A61N1/38
CPC分类号： A61N1/3601
摘要： A tachycardia eliminating apparatus includes a heartbeat detector which detects heartbeats in an input heart activity signal which delivers an output heartbeat signal indicating each detected heartbeat, a tachycardia detector coupled to the output of the heartbeat detector which generates a tachycardia indication signal in response to a detected tachycardia status of a heart as reflected in the heartbeat signal, and a respiratory system stimulator coupled to the output of the tachycardia detector and generating an output respiratory system stimulation signal for stimulating a respiratory system to achieve a stimulated breathing rate, with the ratio of the detected heartbeat rate to the stimulated breathing rate corresponding to a predetermined value.
摘要翻译：心动过速消除装置包括心跳检测器，该心跳检测器检测输入心跳活动信号中的心跳，该信号传送指示每个检测到的心跳的输出心跳信号，耦合到心跳检测器的输出的心动过速检测器，其响应于检测到的心跳过程指示信号而产生心动过速指示信号在心跳信号中反映的心脏的心动过速状态，以及耦合到心动过速检测器的输出的呼吸系统刺激器，并且产生用于刺激呼吸系统以产生刺激呼吸频率的输出呼吸系统刺激信号，检测到对应于预定值的刺激呼吸频率的心跳速率。

50. 发明授权

US5679022A Universal cable connector for temporarily connecting implantable stimulation leads and implantable stimulation devices with a non-implantable system analyzer 失效
标题翻译：通用电缆连接器，用于临时连接植入式刺激引线和具有非植入式系统分析仪的可植入刺激装置
公开(公告)号：US5679022A
公开(公告)日：1997-10-21
申请号：US502592
申请日：1995-07-14
申请人： Armando M. Cappa , Warren R. Heer
发明人： Armando M. Cappa , Warren R. Heer
IPC分类号： A61N1/05 , A61N1/08 , A61N1/372 , A61N1/375 , A61N1/38 , H01R11/24 , H01R4/40
CPC分类号： A61N1/375 , A61N1/05 , A61N1/0587 , A61N1/372 , A61N1/3752 , A61N1/385 , H01R11/24 , A61N2001/083 , H01R2201/12 , Y10S439/909
摘要： A universal cable connector for use between an external system analyzer (54) and an implantable stimulation device includes a multi-conductor cable (60) and a universal connector block (52) having plurality of different sized female connectors adapted to mate with the proximal connectors of different sized implantable pacing leads (33, 34 or 38) and defibrillation leads (48, 50). The universal connector block (52) attaches to the system analyzer and enables the system analyzer to interface with whatever implantable stimulation leads are connected to the connector block, thereby allowing the system analyzer to perform desired tests, such as threshold-determining tests, using the implanted stimulation leads. An adapter cable (96) and clamp (94) are also provided that allow an electrical connection of the proper polarity to be established between an implantable stimulation device (24), e.g., an implantable cardioverter-defibrillator (ICD), and the universal connector block while the implantable stimulation device is connected to a patient via shocking leads (e.g., 48 and 50) and is operating, thereby permitting the system analyzer to monitor the performance of the implantable stimulation device.
摘要翻译：用于在外部系统分析器（54）和可植入刺激装置之间使用的通用电缆连接器包括多导体电缆（60）和通用连接器块（52），其具有多个不同尺寸的阴连接器，适于与近端连接器不同尺寸的可植入起搏引线（33,34或38）和除颤引线（48,50）。通用连接器块（52）连接到系统分析器，使得系统分析仪能够与任何可植入的刺激引线连接到连接器块，从而允许系统分析仪执行期望的测试，例如阈值确定测试，使用植入刺激引线。还提供了适配器电缆（96）和夹具（94），其允许在植入式刺激装置（例如植入式心律转复除颤器（ICD））和通用连接器（ICD）之间建立适当极性的电连接当可植入刺激装置通过震动引线（例如，48和50）连接到患者并且正在操作时，从而允许系统分析仪监测可植入刺激装置的性能。

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