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51. 发明申请

US20130240734A1 APPARATUS AND METHOD FOR PERFORMING SURFACE PLASMON RESONANCE (SPR) SPECTROSCOPY WITH AN INFRARED (IR) SPECTROMETER 有权
标题翻译：用红外（IR）光谱仪实现表面等离子体共振（SPR）光谱的装置和方法
公开(公告)号：US20130240734A1
公开(公告)日：2013-09-19
申请号：US13812323
申请日：2011-07-28
申请人： Karl Booksh , Nicola Menegazzo , Yoon-Chang Kim , Laurel Kegel , Derrick Allen
发明人： Karl Booksh , Nicola Menegazzo , Yoon-Chang Kim , Laurel Kegel , Derrick Allen
IPC分类号： G01J3/02 , G02B5/20 , G01J3/42
CPC分类号： G01J3/0205 , G01J3/42 , G01N21/35 , G01N21/553 , G02B5/208
摘要： Methods of measuring a sample characteristic and accessories for infrared (IR) spectrometers are provided. An accessory includes an input port and an output port having an optical path therebetween, a surface plasmon resonance (SPR) structure for contacting a sample, a mirror system, and an optical element for producing collimated light. The SPR structure produces internally reflected light responsive to broadband IR light, modified by a SPR between the SPR structure and the sample. The mirror system directs the broadband IR light from the input port to the SPR structure and directs the internally reflected light from the SPR structure to the output port, producing output light indicative of a characteristic of the sample associated with the SPR. The optical element is disposed along the optical path between the input port and the output port.
摘要翻译：提供了测量红外（IR）光谱仪的样品特性和附件的方法。一个附件包括一个输入端口和一个具有光路的输出端口，用于接触样品的表面等离子体共振（SPR）结构，镜子系统和用于产生准直光的光学元件。 SPR结构产生内部反射光，响应宽带IR光，由SPR结构和样品之间的SPR进行修改。镜系统将宽带IR光从输入端口引导到SPR结构，并将内部反射光从SPR结构引导到输出端口，产生指示与SPR相关联的样本特征的输出光。光学元件沿着输入端口和输出端口之间的光路布置。

52. 发明授权

US08538570B2 Process and system for manufacturing a customized orthosis 有权
标题翻译：制造定制矫形器的工艺和系统
公开(公告)号：US08538570B2
公开(公告)日：2013-09-17
申请号：US12879805
申请日：2010-09-10
申请人： Steven J. Stanhope , Elisa Schrank
发明人： Steven J. Stanhope , Elisa Schrank
IPC分类号： G06F19/00
CPC分类号： G06F17/50 , B33Y50/00 , G01B5/008 , G06T19/00 , G06T2210/41
摘要： A process and system for fitting, customizing and manufacturing an orthosis for a subject. 3-dimensional coordinates for a plurality of landmarks corresponding to anatomical characteristics of the subject, means for attachment of the orthosis to the subject, and a reference plane are digitally acquired. Then, coordinates of one or more virtual landmarks corresponding to one or more anatomical joint centers or joint projection locations are calculated. The landmarks are clinically aligned in a reference position of one of the anatomical joint centers and a customized digital model of the orthosis is created using the clinically aligned landmarks. Finally, the orthosis is fabricated using a computer aided manufacturing process, based upon an output from the customized digital model.
摘要翻译：用于安装，定制和制造主题矫形器的过程和系统。对应于对象的解剖特征的多个地标的三维坐标，用于将矫形器附接到对象的装置和参考平面被数字地获取。然后，计算与一个或多个解剖关节中心或联合投影位置对应的一个或多个虚拟界标的坐标。地标在临床上在解剖关节中心之一的参考位置对齐，并且使用临床对准的地标创建矫形器的定制数字模型。最后，根据定制数字模型的输出，使用计算机辅助制造过程制造矫形器。

53. 发明授权

US08409827B2 Nitrate reductase fusion proteins and uses thereof 有权
标题翻译：硝酸还原酶融合蛋白及其用途
公开(公告)号：US08409827B2
公开(公告)日：2013-04-02
申请号：US13184037
申请日：2011-07-15
申请人： Jennifer J. Stewart , Kathryn J. Coyne
发明人： Jennifer J. Stewart , Kathryn J. Coyne
IPC分类号： C12P21/04 , C12N9/00
CPC分类号： C07K14/805 , C07K2319/00 , C12N9/0044 , C12P3/00 , C12Y107/01001
摘要： The present invention relates to a novel fusion protein comprising a nitrate reductase (NR) and a truncated hemoglobin N (trHbN) domain. The fusion protein may be used for bioremediation of nitric oxide.
摘要翻译：本发明涉及包含硝酸还原酶（NR）和截短的血红蛋白N（trHbN）结构域的新型融合蛋白。融合蛋白可用于一氧化氮的生物修复。

54. 发明授权

US08409118B2 Upper arm wearable exoskeleton 失效
标题翻译：上臂可穿戴外骨骼
公开(公告)号：US08409118B2
公开(公告)日：2013-04-02
申请号：US12568541
申请日：2009-09-28
申请人： Sunil Agrawal , Venketesh Dubey , John Gangloff , Elizabeth Brackbill
发明人： Sunil Agrawal , Venketesh Dubey , John Gangloff , Elizabeth Brackbill
IPC分类号： A61H1/00 , A61H1/02 , A61H5/00
CPC分类号： A61H1/0237 , A61H1/0274 , A61H2201/165 , A61H2201/5007 , B25J9/0006 , B25J9/104
摘要： An exoskeleton having a first cuff adapted to be coupled to a user's lower limb is disclosed. The exoskeleton also includes a second cuff adapted to be coupled to the user's upper limb and a third cuff adapted to be coupled to the user's body. A first motor is mounted on the third cuff and has a first motor output coupled to the first cuff. A second motor is mounted on the third cuff and has a second motor output coupled to the second cuff. A processor is operatively coupled to the first and second motors to manipulate the first cuff and the second cuff relative to the third cuff such that the first cuff and the second cuff are able to move the user's lower limb and upper limb. A method of operating the exoskeleton is also disclosed.
摘要翻译：公开了具有适于联接到使用者的下肢的第一箍的外骨骼。外骨骼还包括适于联接到使用者的上肢的第二箍和适于联接到使用者身体的第三箍。第一电动机安装在第三袖带上，并且具有耦合到第一袖带的第一电动机输出。第二电动机安装在第三袖带上，并具有耦合到第二袖带的第二电动机输出。处理器可操作地耦合到第一和第二电动机以相对于第三袖口操纵第一袖带和第二袖带，使得第一袖带和第二袖口能够移动使用者的下肢和上肢。还公开了操作外骨骼的方法。

55. 发明申请

US20120209561A1 METHODS AND SYSTEMS FOR IDENTIFYING A POINT OF INTEREST ON THE PERIPHERY OF AN OBJECT 审中-公开
标题翻译：用于识别对象周边的兴趣点的方法和系统
公开(公告)号：US20120209561A1
公开(公告)日：2012-08-16
申请号：US13370803
申请日：2012-02-10
申请人： John Toland Van Stan, II , Matthew T. Jarvis , Delphis F. Levia, JR.
发明人： John Toland Van Stan, II , Matthew T. Jarvis , Delphis F. Levia, JR.
IPC分类号： G06F15/00
CPC分类号： G01B5/0035 , G06T7/66 , G06T2207/30188
摘要： Methods and systems for identifying a point of interest on the periphery of an object are disclosed. A system comprises a track, a carriage, an advancement mechanism, a non-contact measurement device, and a processor. The advancement mechanism is configured to advance the carriage along the path defined by the track. The measurement device comprises a transmitter configured to transmit a beam of radiation toward the periphery of the object and a detector configured to detect at least a portion of the radiation reflected from the periphery of the object. The processor is programmed to (i) advance the carriage along the path, (ii) measure a distance between the periphery of the object and the measurement device, (iii) calculate a center of mass of the object from the measured distances, and (iv) determine the point of interest on the periphery of the object using the calculated center of mass of the object.
摘要翻译：公开了用于识别物体周边上的感兴趣点的方法和系统。系统包括轨道，托架，前进机构，非接触测量装置和处理器。推进机构被配置为沿着由轨道限定的路径推进托架。测量装置包括发射器，其被配置为朝向物体的周边传送辐射束;以及检测器，被配置为检测从物体周边反射的辐射的至少一部分。处理器被编程为（i）沿着路径推进托架，（ii）测量物体的周边与测量装置之间的距离，（iii）根据测量的距离计算物体的质心，和（ iv）使用所计算的物体的质心来确定对象周边上的兴趣点。

56. 发明授权

US08236949B2 Tetrazine-based bio-orthogonal coupling reagents and methods 有权
标题翻译：基于四氮嗪的生物正交偶联试剂和方法
公开(公告)号：US08236949B2
公开(公告)日：2012-08-07
申请号：US12174913
申请日：2008-07-17
申请人： Joseph Michael Fox , Melissa Blackman , Maksim Royzen , Ni Yan
发明人： Joseph Michael Fox , Melissa Blackman , Maksim Royzen , Ni Yan
IPC分类号： C07D257/08 , C07D243/10 , C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14
CPC分类号： C07D263/22 , C07C59/62 , C07C2601/02 , C07C2601/10 , C07D203/02 , C07D207/448 , C07D225/02 , C07D249/06 , C07D249/18 , C07D263/58 , C07D401/14 , C07D403/12 , C07D413/06 , C07D498/02
摘要： Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and/or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.
摘要翻译：通过使1,2,4,5-四嗪与亲二烯体接触来进行适用于有机或水性介质的偶联反应。亲二烯体可以共价键合到蛋白质上，并且偶联反应可以在生物培养基如含有细胞或细胞裂解物的培养基中进行。反应可以在伯胺，硫醇，乙炔，叠氮化物，膦和Staudinger和/或Sharpless-Huisgen反应的产物存在下进行。新型3-取代的环丙烯化合物和反式环辛烯是这些反应的示例性亲环体。

57. 发明申请

US20120064587A1 RECOMBINANT CLOSTRIDIA THAT FIX CO2 AND CO AND USES THEREOF 有权
标题翻译：二氧化碳和二氧化碳的重组螯合物及其用途
公开(公告)号：US20120064587A1
公开(公告)日：2012-03-15
申请号：US13229033
申请日：2011-09-09
申请人： Eleftherios T. Papoutsakis , Mohab Ali Al-Hinai , Shawn William Jones , Dinesh Chanukya Indurthi , Daniel Knox Mitchell , Alan Fast
发明人： Eleftherios T. Papoutsakis , Mohab Ali Al-Hinai , Shawn William Jones , Dinesh Chanukya Indurthi , Daniel Knox Mitchell , Alan Fast
IPC分类号： C12P7/54 , C12P7/16 , C12P7/40 , C12P7/26 , C12N1/21 , C12P7/06
CPC分类号： C12P7/16 , C07K14/33 , C12N9/1007 , C12N15/52 , C12P7/065 , C12P7/28 , C12P7/52 , C12P7/54 , C12Y201/01013 , Y02E50/10 , Y02E50/17
摘要： The present invention relates a recombinant Clostridium expressing one or more heterologous Wood-Ljungdahl (WL) genes. In particular, the recombinant Clostridium produces a metabolite at an increased level. The present invention also relates to a method for producing a metabolite by the recombinant Clostridium.
摘要翻译：本发明涉及表达一种或多种异源Wood-Ljungdahl（WL）基因的重组梭状芽胞杆菌。特别地，重组梭菌产生增加水平的代谢物。本发明还涉及通过重组梭菌产生代谢物的方法。

58. 发明申请

US20120059548A1 POWERED MOBILITY SYSTEMS AND METHODS 有权
标题翻译：动力移动系统和方法
公开(公告)号：US20120059548A1
公开(公告)日：2012-03-08
申请号：US13222437
申请日：2011-08-31
申请人： Sunil K. Agrawal , James C. Galloway , Xi Chen , Christina B. Ragonesi , Sherry Liang , Stephen Dolph , Zachary R. Schoepflin
发明人： Sunil K. Agrawal , James C. Galloway , Xi Chen , Christina B. Ragonesi , Sherry Liang , Stephen Dolph , Zachary R. Schoepflin
IPC分类号： G05D1/00 , B62D6/00 , G06F19/00
CPC分类号： A61G5/04 , A61F5/0102 , A61G2200/14 , A61G2200/325 , A61G2200/34 , A61G2203/10 , A61G2203/36
摘要： Powered mobility systems and methods are disclosed. A powered mobility system includes a mobile unit, a support frame, a plurality of markers, a motion capture device, and a processor. The mobile unit is operable to move the powered mobility system. The support frame is adapted to support a user. The plurality of markers are configured to be attached to the user. The motion capture device is configured to detect movement of the plurality of markers. The processor is programmed to receive signals from the motion capture device, translate the signals into instructions for moving the mobile unit, and transmit the instructions to the mobile unit. A powered mobility method includes placing a user in a support frame, attaching a plurality of markers to the user, detecting movement of the plurality of the markers, and generating movement of the mobile unit based on the movement of the plurality of the markers.
摘要翻译：公开了动力移动系统和方法。动力移动系统包括移动单元，支撑框架，多个标记，运动捕捉设备和处理器。移动单元可操作以移动动力移动系统。支撑框架适于支持用户。多个标记被配置为附接到用户。运动捕捉装置被配置为检测多个标记的移动。处理器被编程为从运动捕获装置接收信号，将信号转换成用于移动移动单元的指令，并将指令发送到移动单元。动力移动方法包括将用户放置在支撑框架中，将多个标记附接到使用者，检测多个标记的移动，以及基于多个标记的移动来产生移动单元的移动。

59. 发明申请

US20120054921A1 Corn Variety DE811ASR(BC5) 有权
标题翻译：玉米品种DE811ASR（BC5）
公开(公告)号：US20120054921A1
公开(公告)日：2012-03-01
申请号：US13270722
申请日：2011-10-11
申请人： Karen E. Broglie , Karlene H. Butler , Marymar G. Butruille , Alexandre da Silva Conceição , Travis James Frey , James A. Hawk , Jennifer S. Jaqueth , Elizabeth S. Jones , Dilbag Singh Multani , Petra Johanna Christina Cecilia Wolters
发明人： Karen E. Broglie , Karlene H. Butler , Marymar G. Butruille , Alexandre da Silva Conceição , Travis James Frey , James A. Hawk , Jennifer S. Jaqueth , Elizabeth S. Jones , Dilbag Singh Multani , Petra Johanna Christina Cecilia Wolters
IPC分类号： A01H5/00 , C12N5/10 , A01H5/10
CPC分类号： C12Q1/6895 , A01H1/04 , A01H5/10 , C07K14/415 , C12N15/8282 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen Colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen Colletotrichum, and processes of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently introgress the gene from corn lines carrying said gene into other corn lines that do not carry said gene, in order to make them resistant to Colletotrichum and resistant to stalk rot.
摘要翻译：本发明涉及编码能够赋予植物病原体Colletotrichum的抗性的基因的多核苷酸序列，其导致炭疽病腐烂，叶枯病和玉米和其他谷物中的顶部枯萎病。它进一步涉及携带包含所述多核苷酸序列的嵌合基因的植物的植物和种子，其增强或赋予对植物病原体Colletotrichum的抗性，以及制备所述植物和种子的过程。本发明还提供可用作分子标记的序列，其又可用于鉴定由新杂交产生的玉米品系中的感兴趣区域，并快速且有效地将携带所述基因的玉米品系的基因从其它玉米品系不携带所述基因，以使它们抵抗Colletotrichum并且抵抗茎腐烂。

60. 发明授权

US08114279B2 Removal of microorganisms and disinfection byproduct precursors using elemental iron or aluminum 失效
标题翻译：使用元素铁或铝去除微生物和消毒副产物前体
公开(公告)号：US08114279B2
公开(公告)日：2012-02-14
申请号：US11375206
申请日：2006-03-15
申请人： Yan Jin , Pei Chiu
发明人： Yan Jin , Pei Chiu
IPC分类号： C02F1/50 , C02F1/28
CPC分类号： A61L9/16 , C02F1/001 , C02F1/281 , C02F1/288 , C02F1/50 , C02F1/505
摘要： A process for removing microorganisms and/or precursors of disinfection by-products from a medium sought to be treated comprising treating the medium with one or more elements capable of forming an oxide, a hydroxide, and/or an oxyhydroxide through corrosion is disclosed. A system for effecting the removal or inactivation of microorganisms and/or disinfection by-product precursors is also contemplated.
摘要翻译：公开了一种从寻求待处理的介质中除去消毒副产物的微生物和/或前体的方法，包括用能够通过腐蚀形成氧化物，氢氧化物和/或羟基氧化物的一种或多种元素处理介质。还考虑了用于除去或灭活微生物和/或消毒副产物前体的系统。

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