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51. 发明授权

US09388155B1 Coumarin derivatives for cancer therapy 有权
公开(公告)号：US09388155B1
公开(公告)日：2016-07-12
申请号：US14213181
申请日：2014-03-14
申请人： Wellesley College
发明人： Dora Carrico-Moniz
IPC分类号： A61K31/35 , C07D311/18
CPC分类号： C07D311/18 , C07D311/14
摘要： The disclosure provides methods and compositions for treating and preventing cancer using 6-substituted coumarin derivatives. The coumarin derivatives of the disclosure have substituents at the 6-position with five carbon atoms or greater. The coumarin derivatives may be further substituted and may be 3,4-dihydrocoumarins. In preferred embodiments, the coumarin derivatives of the disclosure are used to treat pancreatic cancer.

52. 发明授权

US09381286B2 Graft for use with counterpulsation device 有权
标题翻译：用于反搏装置的移植物
公开(公告)号：US09381286B2
公开(公告)日：2016-07-05
申请号：US14360470
申请日：2012-11-21
申请人： Abiomed, Inc.
发明人： Paul Spence , Rob Dowling , Robert T. V. Kung , Caitlyn Hastie , Thorsten Siess , Eric Gratz , Gerd Spanier
IPC分类号： A61M1/10 , A61M1/12 , A61B17/062 , A61B17/11
CPC分类号： A61M1/1086 , A61B17/062 , A61B2017/1107 , A61B2017/1135 , A61M1/10 , A61M1/1008 , A61M1/1037 , A61M1/1044 , A61M1/106 , A61M1/1062 , A61M1/107 , A61M1/12 , A61M1/122 , A61M2205/3337 , A61M2205/502 , A61M2230/06
摘要： An apparatus is disclosed for attaching a counter pulsation device (CPD) to a blood vessel in a human or animal subject, the apparatus including: an interposition graft having a first end configured to be attached to the blood vessel, a second end, and an interior passage providing fluid connection between the first end and the second end; and a pump graft having first end attached to the second end of the interposition graft, a second end configured to be attached to the CPD, and an interior passage providing fluid connection between the first end and the second end In some embodiments, the interior passage of the interposition graft includes a rough surface configured to promote biological growth on the surface, and the interior passage of the pump graft includes a smooth surface configured to inhibit biological growth on the surface.
摘要翻译：公开了一种用于将反搏脉动装置（CPD）附接到人或动物对象中的血管的装置，该装置包括：插入移植物，其具有构造成附接到血管的第一端，第二端和内部通道，在第一端和第二端之间提供流体连接; 以及泵移植物，其具有连接到插入物移植物的第二端的第一端，构造成连接到CPD的第二端和在第一端和第二端之间提供流体连接的内部通道。在一些实施例中，插入移植物包括构造成促进表面上的生物生长的粗糙表面，并且泵移植物的内部通道包括被配置为抑制表面上的生物生长的光滑表面。

53. 发明授权

US09372858B1 Systems and methods to present automated suggestions in a document 有权
标题翻译：在文档中呈现自动化建议的系统和方法
公开(公告)号：US09372858B1
公开(公告)日：2016-06-21
申请号：US14104640
申请日：2013-12-12
申请人： Google Inc.
发明人： Vance Julius Vagell , Peter James Solderitsch , Fil Zembowicz , Samuel Benjamin Messing , Luiz Do Amaral De Franca Pereira Filho
IPC分类号： G06F7/00 , G06F17/30 , G06F17/24
CPC分类号： G06F17/24 , G06F17/274
摘要： A method for providing automated suggestions in a document stored on a cloud computing service includes providing collaborators with access to the document, who may each insert suggested edits into the document. The cloud computing service provides a plurality of suggestion robots for the collaborators to activate within the document, where each suggestion robot has an associated editing objective. The cloud computing service receives a request from a first collaborator to activate a first suggestion robot and activates the robot to present to the first collaborator a plurality of suggested edits of the document according to the editing objective of the robot, where the plurality of suggested edits by the first suggestion robot are displayed with any suggested edits by the one or more collaborators, and the first collaborator may accept or reject each of the plurality of suggested edits of the robot and the collaborators.
摘要翻译：用于在存储在云计算服务上的文档中提供自动化建议的方法包括向协作者提供对文档的访问，谁可以将建议的编辑插入到文档中。云计算服务提供多个建议机器人，用于协作者在文档内激活，其中每个建议机器人具有相关联的编辑目标。云计算服务接收来自第一协作者的请求以激活第一建议机器人并激活机器人以根据机器人的编辑目标向第一协作者呈现多个建议的文档编辑，其中多个建议的编辑所述第一建议机器人由所述一个或多个协作者进行任何建议的编辑显示，并且所述第一协作者可以接受或拒绝所述多个所述建议的所述机器人和所述协作者的编辑。

54. 发明授权

US09369741B2 Interactive television systems with digital video recording and adjustable reminders 有权
公开(公告)号：US09369741B2
公开(公告)日：2016-06-14
申请号：US14741034
申请日：2015-06-16
申请人： Rovi Guides, Inc.
发明人： Michael D. Ellis
IPC分类号： H04N7/173 , H04N21/231 , H04N21/4147 , H04N21/242
CPC分类号： H04N21/4882 , H04N5/44543 , H04N21/23113 , H04N21/242 , H04N21/262 , H04N21/2747 , H04N21/4147 , H04N21/4312 , H04N21/4335 , H04N21/4343 , H04N21/4383 , H04N21/4438 , H04N21/4583 , H04N21/472 , H04N21/47214 , H04N21/47217 , H04N21/4821 , H04N21/6587 , H04N21/84
摘要： An interactive television system is provided in which an interactive television application is used to support network-based or local personal video recorder capabilities. A user may use this application to view lists of program listings. The user may select a program listing of interest. The interactive television application may allow the user to set a reminder for the selected program at the scheduled broadcast time. This application may also allow the user to set a reminder for the selected program at a later time at which the program is not scheduled to be broadcast. The user may be provided with a reminder at this later time. In response, the user may direct the network-based or local personal video recorder to play back the program or may defer the reminder again. The interactive television application may collect information on program usage and popularity to determine how long to retain certain programming.

55. 发明授权

US09364987B2 Systems and methods for cooling extruded materials 有权
标题翻译：用于冷却挤压材料的系统和方法
公开(公告)号：US09364987B2
公开(公告)日：2016-06-14
申请号：US13650972
申请日：2012-10-12
申请人： Manchester Copper Products, LLC
发明人： Charles L. Stewart , Mark R. Denison , Robert Wessner
IPC分类号： B29C47/00 , B29C47/88 , B29C47/86
CPC分类号： B29C47/0085 , B21C29/003 , B29C47/0004 , B29C47/0016 , B29C47/0019 , B29C47/0021 , B29C47/864 , B29C47/868 , B29C47/8815 , B29C47/882 , B29C47/8835 , C21D1/667 , C22F1/002
摘要： Systems, devices, and methods are described for cooling extruded materials. In certain embodiments, a quench tube is provided that includes an inner wall and an outer wall having a channel therebetween for transporting cooling fluid along the quench tube. A passage within the inner surface of the inner wall receives an extruded material through a nozzle formed at an end of the quench tube that delivers the cooling fluid to the extruded material. The channel may be angled at the nozzle to deliver the cooling fluid at an angle with respect to the quench tube, and the quench tube is configured to extend at least in part within an extrusion die.
摘要翻译：描述了用于冷却挤压材料的系统，装置和方法。在某些实施例中，提供了一种淬火管，其包括内壁和外壁，其中具有用于沿着骤冷管输送冷却流体的通道。在内壁的内表面内的通道通过形成在骤冷管的端部处的喷嘴接收挤出的材料，该喷嘴将冷却流体输送到挤出的材料。通道可以在喷嘴处成角度以相对于骤冷管以一定角度输送冷却流体，并且骤冷管构造成至少部分地在挤出模具内延伸。

56. 发明授权

US09353356B2 Activin-actriia antagonists for treating a follicle-stimulating horomone-secreting pituitary tumor 有权
标题翻译：活化激活素拮抗剂用于治疗促卵泡激素分泌性垂体肿瘤
公开(公告)号：US09353356B2
公开(公告)日：2016-05-31
申请号：US13754234
申请日：2013-01-30
申请人： Acceleron Pharma, Inc.
发明人： John Knopf , Jasbir Seehra , Matthew L. Sherman
IPC分类号： C12N9/12 , A61K38/17
CPC分类号： C12N9/12 , A61K38/179 , C07K14/71 , C07K2319/30 , C12Y207/1103
摘要： In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.
摘要翻译：在某些方面，本发明提供用于降低患者中FSH水平的组合物和方法。患者可能例如被诊断患有FSH相关疾病或延迟或抑制生殖细胞成熟的欲望。

57. 发明授权

US09351929B2 Antibiotic formulations, unit doses, kits, and methods 有权
公开(公告)号：US09351929B2
公开(公告)日：2016-05-31
申请号：US13471126
申请日：2012-05-14
申请人： Chatan Charan , Sarvajna Dwivedi
发明人： Chatan Charan , Sarvajna Dwivedi
IPC分类号： A61K9/12 , A61K31/7036 , A61M16/14 , A61K9/00 , A61K31/573 , A61K31/7034 , A61K9/08 , A61K9/19
CPC分类号： A61K31/7036 , A61J1/065 , A61J1/1412 , A61K9/0019 , A61K9/0078 , A61K9/08 , A61K9/19 , A61K31/573 , A61K31/7034 , A61M11/001 , A61M16/04 , A61M2202/064
摘要： An aqueous or powder composition includes anti-gram-negative antibiotic or salt thereof being present at an amount ranging from about 100 mg/ml to about 200 mg/ml. Another aqueous or powder composition includes anti-gram-positive antibiotic or salt thereof being present at a concentration ranging from about 0.6 to about 0.9 of the water solubility limit, at 25° C. and 1.0 atmosphere, of the anti-gram-positive antibiotic or salt thereof. Other embodiments include unit doses, kits, and methods.

58. 发明授权

US09348803B2 Systems and methods for providing just-in-time preview of suggestion resolutions 有权
标题翻译：提供即时预览建议决议的系统和方法
公开(公告)号：US09348803B2
公开(公告)日：2016-05-24
申请号：US14060059
申请日：2013-10-22
申请人： Google Inc.
发明人： Vance Julius Vagell , Ian Gunn
IPC分类号： G06F17/24 , G06F17/21
CPC分类号： G06F17/24 , G06F17/212
摘要： Systems and methods are disclosed herein for providing a preview of an editor action related to a suggested edit of an electronic document. A first user provides a suggested edit to the electronic document, and the suggested edit to the electronic document is displayed to a second user of the electronic document. The second user provides a user input that is indicative of a desire to preview a result of the editor action on the suggested edit, such as an acceptance or a rejection of the suggested edit. Then, before the second user performs the editor action, a preview of the result of the editor action is provided to the second user in response to detecting the user input.
摘要翻译：本文公开了用于提供与电子文档的建议编辑相关的编辑器动作的预览的系统和方法。第一用户提供对电子文档的建议编辑，并且向电子文档的第二用户显示对电子文档的建议编辑。第二用户提供用户输入，其表示希望预览关于所建议编辑的编辑器动作的结果，例如接受或拒绝所建议的编辑。然后，在第二用户执行编辑器动作之前，响应于检测到用户输入，向第二用户提供编辑器动作的结果的预览。

59. 发明授权

US09344768B2 Program guide system with real-time data sources 有权
标题翻译：具有实时数据源的程序指南系统
公开(公告)号：US09344768B2
公开(公告)日：2016-05-17
申请号：US14049804
申请日：2013-10-09
申请人： Rovi Guides, Inc.
发明人： Edward B. Knudson , David M. Rudnick , Michael D. Ellis , Daniel C. Hagenbuch , Joel G. Hassell , Robert A. Knee , Steven J. Reynolds
IPC分类号： H04N5/445 , H04N7/173 , H04N21/488 , H04N21/235 , H04N21/435 , H04N21/482 , H04N21/472 , H04N21/4725 , H04N21/81 , H04N21/478
CPC分类号： H04N21/4886 , H04N21/23113 , H04N21/235 , H04N21/26613 , H04N21/435 , H04N21/47202 , H04N21/47211 , H04N21/4725 , H04N21/478 , H04N21/482 , H04N21/4821 , H04N21/812 , H04N21/8126 , H04N21/8133
摘要： A program guide system in which an interactive television program guide that is implemented at least partially on user television equipment receives program listings data and real-time data such as sports scores, news data, etc. The real-time data may be stored in a database maintained by the program guide. Updated program listings information may be provided to the program guide as part of the data stream in which the real-time data is provided. Unique keys may be generated for the program listings data and real-time data associated with each live event. The keys may be compared at the program guide to determine which program listings correspond to which items of real-time data.
摘要翻译：一种节目指南系统，其中至少部分地在用户电视设备上实现的交互式电视节目指南接收节目列表数据和诸如运动分数，新闻数据等的实时数据。实时数据可以存储在数据库由程序指南维护。更新的节目列表信息可以作为提供实时数据的数据流的一部分提供给节目指南。可以为节目列表数据和与每个实况事件相关联的实时数据生成唯一的密钥。可以在节目指南处对密钥进行比较，以确定哪些节目列表对应于哪个实时数据项。

60. 发明授权

US09328741B2 Pump arrangement 有权
标题翻译：泵排列
公开(公告)号：US09328741B2
公开(公告)日：2016-05-03
申请号：US13261515
申请日：2011-05-16
申请人： Reiner Liebing
发明人： Reiner Liebing
IPC分类号： A61M1/12 , F04F5/10 , A61M1/10
CPC分类号： F04F5/10 , A61M1/1008 , A61M1/101 , A61M1/1024 , A61M1/1034 , A61M1/1082 , A61M1/1084 , A61M1/122 , A61M1/125 , F04D3/00 , F04D7/00 , F04D29/026 , F04D29/181 , F04D29/528
摘要： The subject matter of the present invention is a pump arrangement, in particular for use in the body's own vessels, having a pump and a sheath receiving the pump, bounding a flow passage and having a distal intake opening and a proximal outflow opening for producing a driving flow by means of the pump, wherein the pump is arranged in a first fluid-tight section having the distal intake opening and a second fluid-tight section includes the proximal outflow opening. In accordance with the invention, a further inlet opening is present between the first section, and the second section and is arranged between the intake opening and the outflow opening, with the first section and the second section being arranged with respect to one another such that the inlet opening opens into the flow proximal to the pump.
摘要翻译：本发明的主题是一种泵装置，特别是在身体本身的容器中使用，具有容纳泵的泵和护套，其包围流动通道并且具有远端进气口和近侧流出口，用于产生通过泵驱动流动，其中泵布置在具有远端进气口的第一流体密封部分中，而第二流体密封部分包括近侧流出口。根据本发明，在第一部分和第二部分之间存在进一步的入口，并且布置在进气口和流出口之间，第一部分和第二部分相对于彼此布置，使得入口开口通向靠近泵的流体。

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