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51. 发明申请

US20170001170A1 METHOD, SYNTHESIS, ACTIVATION PROCEDURE AND CHARACTERIZATION OF AN OXYGEN RICH ACTIVATED POROUS CARBON SORBENT FOR SELECTIVE REMOVAL OF CARBON DIOXIDE WITH ULTRA HIGH CAPACITY 审中-公开
标题翻译：方法，合成，活化程序和氧化活性多孔碳分子的选择性去除二氧化碳超高容量的特征
公开(公告)号：US20170001170A1
公开(公告)日：2017-01-05
申请号：US15200632
申请日：2016-07-01
申请人： William Marsh Rice University , Apache Corporation
发明人： Saunab Ghosh , Andrew R. Barron , Jason Ho
IPC分类号： B01J20/20 , C10L3/10 , B01J20/30 , B01D53/04 , C01B31/12 , B01J20/28
CPC分类号： B01J20/20 , B01D53/02 , B01D2253/102 , B01D2253/306 , B01D2253/311 , B01D2256/245 , B01D2257/504 , B01J20/28066 , B01J20/28076 , B01J20/3078 , C01B32/342 , C10L3/104 , C10L2290/541 , Y02C10/04 , Y02C10/08 , Y02P20/152
摘要： The present disclosure pertains to materials for CO2 adsorption at pressures above 1 bar, where the materials include a porous carbon material with a surface area of at least 2800 m2/g, a total pore volume of at least 1.35 cm3/g, and a carbon content of 80%-95%. The porous carbon material is prepared by heating organic polymer precursors or biological materials in the presence of KOH at 700° C.-800° C. The present disclosure also pertains to materials for the separation of CO2 from natural gas at partial pressures above 1 bar, where the material includes a porous carbon material with a surface area of at least 2000 m2/g, a total pore volume of at least 1.00 cm3/g, and a carbon content of greater than 90%. The porous carbon materials can be prepared by heating organic polymer precursors or biological materials in the presence of KOH at 600° C.-700° C.
摘要翻译：本公开涉及在高于1巴的压力下进行CO 2吸附的材料，其中材料包括表面积至少为2800m 2 / g，总孔体积至少为1.35cm 3 / g的多孔碳材料，以及碳含量80％-95％。多孔碳材料通过在KOH存在下在700℃-800℃下加热有机聚合物前体或生物材料来制备。本公开还涉及用于在高于1巴的分压下从天然气分离CO 2的材料其中该材料包括表面积至少为2000m 2 / g，总孔体积至少为1.00cm 3 / g，碳含量大于90％的多孔碳材料。多孔碳材料可以通过在KOH存在下在600℃-700℃下加热有机聚合物前体或生物材料来制备。

52. 发明授权

US09532875B2 Combined space maintenance and bone regeneration system for the reconstruction of large osseous defects 有权
标题翻译：组合空间维护和骨再生系统重建大骨缺损
公开(公告)号：US09532875B2
公开(公告)日：2017-01-03
申请号：US14491681
申请日：2014-09-19
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： Antonios G. Mikos , Mark E. Wong , Simon W. Young , James D. Kretlow , Meng Shi , F. Kurtis Kasper , Patrick Spicer
IPC分类号： A61F2/28 , A61L27/16 , A61L27/36 , A61L27/56
CPC分类号： A61F2/28 , A61F2/2803 , A61F2210/0085 , A61L27/16 , A61L27/3608 , A61L27/56 , A61L2430/02 , C08L33/12
摘要： Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided.
摘要翻译：提供了可用于治疗创伤性骨损伤的系统，方法和组合物。在一个实施方案中，一种骨重建系统，包括空间维持组合物，其包含多孔聚甲基丙烯酸甲酯; 并且提供了包含包含一种或多种骨发生材料的聚甲基丙烯酸甲酯室的骨骼产生构建体。还提供了相关的组合物和方法。

53. 发明申请

US20160237237A1 GRAPHENE NANORIBBON-BASED GAS BARRIER COMPOSITES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：基于纳米比亚的基于石墨烯的气体阻隔复合材料及其制备方法
公开(公告)号：US20160237237A1
公开(公告)日：2016-08-18
申请号：US15024560
申请日：2014-09-30
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： James M. Tour , Changsheng Xiang
IPC分类号： C08K3/04 , C08L75/04
CPC分类号： C08K3/04 , C08K3/043 , C08K9/04 , C08K2201/008 , C08K2201/011 , C08L75/04
摘要： In some embodiments, the present disclosure pertains to gas barrier composites that include a polymer matrix and graphene nanoribbons dispersed in the polymer matrix. The polymer matrix can include a phase-separated block copolymer with a hard phase domain and a soft phase domain. Like-wise, the functionalized graphene nanoribbons can include edge-functionalized graphene nanoribbons with concentrations that range from about 0.1% by weight to about 5% by weight of the gas barrier composites. In some embodiments, the present disclosure pertains to methods of making gas barrier composites by dispersing graphene nanoribbons in a polymer matrix. In some embodiments, the dispersing lowers the permeability of a gas through the gas barrier composite and causes phase separation of block copolymers in the polymer matrix. In some embodiments, the dispersion of graphene nanoribbons in the polymer matrix lowers the gas effective diffusivity of the gas barrier composite by three orders of magnitude.
摘要翻译：在一些实施方案中，本公开涉及包含聚合物基质和分散在聚合物基质中的石墨烯纳米带的气体阻隔复合物。聚合物基质可包括具有硬相结构域和软相结构域的相分离嵌段共聚物。类似地，官能化石墨烯纳米带可以包括边界官能化的石墨烯纳米带，其浓度范围为阻气复合材料的约0.1重量％至约5重量％。在一些实施方案中，本公开涉及通过将石墨烯纳米带分散在聚合物基质中制备阻气复合材料的方法。在一些实施方案中，分散降低气体通过气体阻隔复合材料的渗透性，并导致聚合物基质中嵌段共聚物的相分离。在一些实施方案中，石墨烯纳米带在聚合物基质中的分散将气体阻隔复合材料的气体有效扩散率降低三个数量级。

54. 发明申请

US20160223669A1 MINIATURIZED DIRECT DIGITAL-TO-IMPULSE RADAR SENSORS IN SILICON 审中-公开
标题翻译： MINIATURIZED直接数字到脉冲雷达传感器在硅中
公开(公告)号：US20160223669A1
公开(公告)日：2016-08-04
申请号：US15021978
申请日：2014-09-29
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： M. Mahdi Assefzadeh , Aydin Babakhani
IPC分类号： G01S13/89 , G01S7/41 , G01V3/30 , G01S7/03 , G01S7/282
CPC分类号： G01S13/89 , E21B47/0002 , E21B47/122 , G01N22/00 , G01S7/032 , G01S7/038 , G01S7/282 , G01S7/411 , G01S13/0209 , G01V3/30 , H01Q1/38
摘要： A radar system may comprise a trigger, driver, switching circuit, and antenna for generating an ultra-short impulse without utilizing an oscillator. A radar imaging system for imaging a formation or a cross section of a pipeline may include at least one radar sensor. The system may transmit a high-frequency, short impulse signal to a formation or pipeline and measure a reflected signal. A high speed impulse generator may allow the short impulse signals to be generated. This impulse generator may utilize a switching circuit and digital driver to provide the short impulse signals. The images provide useful information about complex permittivity of the formation, the geometry of the pipeline, deposition thickness of asphaltenes and wax, velocity of the fluid, as well as size, type, concentration of gas bubbles, water, or solid particles in the flow, or combinations thereof.
摘要翻译：雷达系统可以包括用于在不利用振荡器的情况下产生超短脉冲的触发器，驱动器，开关电路和天线。用于对管道的地层或横截面进行成像的雷达成像系统可以包括至少一个雷达传感器。系统可以将高频，短脉冲信号发送到地层或管道并测量反射信号。高速脉冲发生器可以允许产生短脉冲信号。该脉冲发生器可以利用开关电路和数字驱动器来提供短脉冲信号。这些图像提供了关于地层复杂介电常数，管道几何形状，沥青质和蜡沉积厚度，流体速度以及流体中气泡，水或固体颗粒的大小，类型，浓度，，或其组合。

55. 发明申请

US20160215201A1 COMPOSITION AND METHOD FOR ENHANCED HYDROCARBON RECOVERY 审中-公开
标题翻译：用于增强油气回收的组合物和方法
公开(公告)号：US20160215201A1
公开(公告)日：2016-07-28
申请号：US15024421
申请日：2014-09-24
申请人： SHELL OIL COMPANY , WILLIAM MARSH RICE UNIVERSITY
发明人： Julian Richard BARNES , Clarence Alphonso MILLER , George Jiro HIRASAKI , Maura Camps PUERTO , Sheila Teresa DUBEY , Carmen Geraldine REZNIK
IPC分类号： C09K8/584
CPC分类号： C09K8/584
摘要： The invention relates to a hydrocarbon recovery composition, which composition contains: a) a first anionic surfactant which is selected from the group consign of a propoxylated primary alcohol carboxylate or a propoxylated primary alcohol glycerol sulfonate; and b) a second anionic surfactant which is an alkoxylated primary alcohol carboxylate or an alkoxylated primary alcohol glycerol sulfonate selected from the group consisting of (i) an ethoxylated primary alcohol carboxylate, (ii) an ethoxylated-propoxylated primary alcohol carboxylate, (iii) an ethoxylated primary alcohol glycerol sulfonate and (iv) an ethoxylated-propoxylated primary alcohol glycerol sulfonate. Further, the invention relates to an injectable liquid containing the hydrocarbon recovery composition and a method for treating a hydrocarbon containing formation.
摘要翻译：本发明涉及一种烃回收组合物，该组合物含有：a）选自丙氧基化伯醇羧酸酯或丙氧基化伯醇甘油磺酸酯的第一种阴离子表面活性剂; 和b）第二阴离子表面活性剂，其是烷氧基化伯醇羧酸盐或烷氧基化伯醇甘油磺酸盐，其选自（i）乙氧基化伯醇羧酸盐，（ii）乙氧基化丙氧基化伯醇羧酸盐，（iii）乙氧基化伯醇甘油磺酸盐和（iv）乙氧基化丙氧基化伯醇甘油磺酸盐。此外，本发明涉及含有烃回收组合物的可注射液体和含烃地层的处理方法。

56. 发明申请

US20160185791A1 DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS 有权
标题翻译： UNCIALAMYCIN的衍生物，合成方法及其作为抗肿瘤剂的用途
公开(公告)号：US20160185791A1
公开(公告)日：2016-06-30
申请号：US14911881
申请日：2014-08-14
申请人： WILLIAM MARSH RICE UNIVERSITY , BRISTOL-MYERS SQUIBB COMPANY , THE SCRIPPS RESEARCH INSTITUTE
发明人： Kyriacos C. NICOLAOU , Min LU , Debashis MANDAL , Sanjeev GANGWAR , Naidu S. CHOWDARI , Yam B. POUDEL
IPC分类号： C07D491/08 , A61K47/48
CPC分类号： C07D491/08 , A61K47/6803 , A61K47/6851
摘要： In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
摘要翻译：一方面，本公开提供式（I）和（II）的新型类似物。本公开还提供了获得非丝氨酸霉素及其类似物的新型合成途径。另外，本公开还描述了使用非丝氨酸霉素及其类似物的方法。另一方面，本公开提供包含式（I）和（II）化合物的抗体 - 药物偶联物。

57. 发明申请

US20160136613A1 POROUS CARBON MATERIALS FOR CO2 SEPARATION IN NATURAL GAS 有权
公开(公告)号：US20160136613A1
公开(公告)日：2016-05-19
申请号：US15001835
申请日：2016-01-20
申请人： William Marsh Rice University
发明人： James M. Tour , Desmond E. Schipper , Chih-Chau Hwang , Josiah Tour , Almaz S. Jalilov , Gedeng Ruan , Yilun Li
IPC分类号： B01J20/20 , B01J20/28
CPC分类号： B01J20/20 , B01D53/02 , B01D2253/102 , B01D2257/304 , B01D2257/504 , B01J20/28011 , B01J20/28066 , B01J20/2808 , B01J20/28083 , B01J20/3078 , B01J20/3416 , B01J20/3483 , B01J20/3491 , B01J2220/4825 , B01J2220/4837 , B01J2220/485 , B01J2220/4893 , C01B32/00 , C01B32/30 , C01B32/50 , C01P2004/80 , Y02C10/08 , Y02C20/20 , Y02P20/152
摘要： In some embodiments, the present disclosure pertains to materials for use in CO2 capture in high pressure environments. In some embodiments, the materials include a porous carbon material containing a plurality of pores for use in a high pressure environment. Additional embodiments pertain to methods of utilizing the materials of the present disclosure to capture CO2 from various environments. In some embodiments, the materials of the present disclosure selectively capture CO2 over hydrocarbon species in the environment.

58. 发明授权

US09283299B2 Injectable hydrogels 有权
标题翻译：注射水凝胶
公开(公告)号：US09283299B2
公开(公告)日：2016-03-15
申请号：US14298170
申请日：2014-06-06
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： Antonios G. Mikos , F. Kurtis Kasper , Adam K. Ekenseair , Tiffany N. Vo , Kristel W. M. Boere , Tyler J. Touchet
IPC分类号： A61L27/18 , A61K38/18 , A61K35/28 , A61K9/00 , A61K47/18 , A61K9/06 , A61L27/54 , C08L33/26 , A61L27/52
CPC分类号： A61L27/18 , A61K9/0024 , A61K9/06 , A61K35/28 , A61K38/18 , A61K47/18 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/64 , A61L2400/06 , A61L2430/34 , C08L33/26
摘要： The present disclosure generally relates to injectable compositions. More particularly, the present disclosure relates to injectable, thermogelling hydrogels and associated methods. In one embodiment, the present disclosure provides for a composition comprising a poly(N-isopropylacrylamide)-based macromer and a polyamidoamine-based macromer.
摘要翻译：本公开一般涉及可注射组合物。更具体地，本公开涉及可注射的，热凝胶化水凝胶和相关方法。在一个实施方案中，本公开提供了包含基于聚（N-异丙基丙烯酰胺）的大分子单体和基于聚酰胺胺的大分子单体的组合物。

59. 发明申请

US20150225753A1 HYDROXY- AND DICARBOXYLIC-FAT SYNTHSIS BY MICROBES 有权
标题翻译：微生物的羟基和二甲氧基 - 脂肪酸合成
公开(公告)号：US20150225753A1
公开(公告)日：2015-08-13
申请号：US14607624
申请日：2015-01-28
申请人： William Marsh Rice University
发明人： Ka-Yiu SAN , Xixian XIE , Leepika TULI , Hui WU
IPC分类号： C12P7/64 , C12N9/02 , C07K14/195 , C12N9/16
CPC分类号： C12P7/6409 , C12N9/16 , C12N15/52 , C12P7/42 , C12P7/44 , C12Y301/02014 , Y02P20/52
摘要： Systems, methods and microbes that allow the biological production of hydroxy fatty acids and dicarboxylic fatty acids are provided. Specifically, hydroxy fatty acids and dicarboxylic fatty acids are produced by microbes that have been engineered to overexpress acyl ACP thioesterase plus an alkane degration pathway, such as AlkBGT or AlkJH These can be in separate microbes or the same microbe, and separate microbes can be co-cultured or sequentially cultured. Continuously fed systems transferring secreted fats from one microbial culture to another can also be used.
摘要翻译：提供允许生物制备羟基脂肪酸和二羧酸脂肪酸的系统，方法和微生物。具体地说，羟基脂肪酸和二羧酸脂肪酸是由已被改造过表达酰基ACP硫酯酶加上烷烃降解途径的微生物产生的，如AlkBGT或AlkJH。这些可以分开的微生物或相同的微生物，分离的微生物可以是共同的培养或依次培养。也可以使用将分泌的脂肪从一种微生物培养物转移到另一种微生物培养基的连续进料系统。

60. 发明申请

US20150072337A1 THERANOSTIC METHODS AND SYSTEMS FOR DIAGNOSIS AND TREATMENT OF MALARIA 审中-公开
标题翻译：用于诊断和治疗疟疾的治疗方法和系统
公开(公告)号：US20150072337A1
公开(公告)日：2015-03-12
申请号：US14333145
申请日：2014-07-16
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： Dmitri Lapotko , Katsiaryna Hleb , Janet Braam , John S. Olson
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , A61B5/0095 , A61B5/14546 , A61B5/1455 , A61N5/0624 , A61N5/0625 , A61N2005/0627 , A61N2005/0662 , A61N2005/067 , G01N21/49 , G01N21/636 , G01N21/6458 , G01N2021/6439
摘要： Methods, systems, and apparatuses for employing nanobubbles for theranostic purposes are provided. In one embodiment, a method comprising introducing a photothermal nanobubble into a malaria-infected red blood cell is provided.
摘要翻译：提供了用于纳入气泡的方法，系统和装置。在一个实施方案中，提供了一种包括将光热纳米气泡引入疟疾感染的红细胞的方法。

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