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51. 发明申请

US20070287842A1 Conjugated Thiophenes Having Conducting Properties and Synthesis of Same 失效
标题翻译：具有导电性能的共轭噻吩及其合成
公开(公告)号：US20070287842A1
公开(公告)日：2007-12-13
申请号：US10597722
申请日：2005-02-02
申请人： William Skene
发明人： William Skene
IPC分类号： C08G12/26 , C07C249/00 , C07D333/20 , C07D333/36 , H01L51/30 , H01L33/00 , C07D409/00 , C07D495/02
CPC分类号： C08G73/00 , C07D333/38 , C08G61/126 , H01L51/0036 , Y02E10/549
摘要： The present invention relates to conjugated oligomers and polymers comprising aromatic thiophene cores. The conjugated materials are obtained by simple and efficient condensation of an aryl diamine and an aryl dialdehyde or a bifunctional aryl moiety comprising both an aldehyde and an amine. Condensation of the complementary moieties at temperatures ranging from ambient to refluxing temperatures in various solvents resulted in conjugated oligomers and polymers that can subsequently be cast into thin films. Oligomerization and polymerization can be done under mild conditions with removal of the resulting water bi-product responsible for shifting the equilibrium in favour of the conjugated products. The resulting conjugated compounds can be made conducting with dopants affording electrically conducting materials of either p-type or n-type conductors depending on the dopant selected.
摘要翻译：本发明涉及包含芳族噻吩核的共轭低聚物和聚合物。共轭材料通过芳基二胺和芳基二醛或包含醛和胺的双官能芳基部分的简单而有效的缩合获得。互补部分在各种溶剂中的环境温度至回流温度范围内的缩合产生可以随后浇铸成薄膜的共轭低聚物和聚合物。低聚和聚合可以在温和的条件下进行，除去所得的水双组分负责转移有利于共轭产物的平衡。所得到的共轭化合物可以通过掺杂剂进行导电，所述掺杂剂根据所选择的掺杂剂提供p型或n型导体的导电材料。

52. 发明申请

US20070276030A1 Pyranobenzothiophene derivatives to treat infection with hepatitis c virus 审中-公开
标题翻译：苯并噻吩衍生物用于治疗丙型肝炎病毒感染
公开(公告)号：US20070276030A1
公开(公告)日：2007-11-29
申请号：US10567649
申请日：2004-08-13
申请人： Ariamala Gopalsamy
发明人： Ariamala Gopalsamy
IPC分类号： A61K31/381 , C07D495/02
CPC分类号： C07D495/04 , A61K31/381
摘要： The invention is directed to a compound of the formula: wherein substitutions fat R1, R2, R3-R12, and Y are set forth in the specification; pharmaceutical compositions comprising said compound, methods of treating or preventing a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of said compound or pharmaceutical compositions including said compound and methods of inhibiting replication of a Hepatitis C virus comprising contacting the HCV virus with an effective amount of said compound or pharmaceutical compositions including said compound.
摘要翻译：本发明涉及下式化合物：其中取代脂肪R 1，R 2，R 3，R 12， / SUP>和Y在说明书中列出; 包含所述化合物的药物组合物，治疗或预防哺乳动物中丙型肝炎病毒感染的方法，包括使哺乳动物与有效量的所述化合物或包含所述化合物的药物组合物和抑制丙型肝炎病毒复制的方法接触，包括接触HCV 病毒与有效量的所述化合物或包含所述化合物的药物组合物。

53. 发明申请

US20070120113A1 Supramolecular structures and method for forming the same 审中-公开
标题翻译：超分子结构及其形成方法
公开(公告)号：US20070120113A1
公开(公告)日：2007-05-31
申请号：US11287309
申请日：2005-11-28
申请人： King-Fu Lin , Chi-Chun Hsieh
发明人： King-Fu Lin , Chi-Chun Hsieh
IPC分类号： H01L51/00 , C07D495/02 , C07D409/14
CPC分类号： C07C309/32
摘要： A primary supramolecular structure is described. The primary supramolecular structure has a shape of ring-like disk. The shape of ring-like disk has a diameter of about 10 nanometers to about 60 nanometers. The mentioned primary supramolecular structure is formed by self-assembly of amphiphilic conjugate molecules. Moreover, a secondary supramolecular structure is described. The secondary supramolecular structure has a shape of ring-like disk. The shape of ring-like disk has a diameter of about 100 nanometers to about 300 nanometers. The mentioned secondary supramolecular structure is formed by self-assembly of amphiphilic conjugate molecules hybrid with metal alkoxides or non-metal alkoxides.
摘要翻译：描述了一个主要的超分子结构。主要的超分子结构具有环状盘的形状。环形盘的形状具有约10纳米至约60纳米的直径。所述的主要超分子结构通过两亲性共轭分子的自组装形成。此外，描述了次级超分子结构。次级超分子结构具有环状圆盘形状。环形盘的形状具有约100纳米至约300纳米的直径。所述的次级超分子结构通过与金属醇盐或非金属醇盐杂交的两亲性缀合物分子的自组装形成。

54. 发明申请

US20060149083A1 Method for the decarboxylation of dicarboxylic acids 失效
标题翻译：二羧酸脱羧的方法
公开(公告)号：US20060149083A1
公开(公告)日：2006-07-06
申请号：US10538995
申请日：2003-12-04
申请人： Sigurd Buchholz , Alexander Klausener , Reinhard Langer , Leslaw Mleczko , Gunter Leverkusen
发明人： Sigurd Buchholz , Alexander Klausener , Reinhard Langer , Leslaw Mleczko , Gunter Leverkusen
IPC分类号： C07D495/02
CPC分类号： C07D495/04 , C07D333/38 , Y02P20/582
摘要： The invention relates to a method for the thermal decarboxylation of dicarboxylic acids, in particular to 3,4-ethylene dioxythiophene-2,5-dicarboxylic acid as an educt. According to said method the educt is used in solid form and/or the reaction is carried out in the presence of a plurality of fluidised bed bodies. No solvents are used in the reaction and the decarboxylation product that is formed during the reaction is carried away from the reaction zone in gaseous form.
摘要翻译：本发明涉及一种二羧酸热脱羧的方法，特别涉及作为溶出物的3,4-亚乙基二氧噻吩-2,5-二羧酸的热脱羧方法。根据所述方法，溶出物以固体形式使用和/或反应在多个流化床体的存在下进行。在反应中没有使用溶剂，并且在反应期间形成的脱羧产物以气态形式从反应区带走。

55. 发明授权

US07029606B2 Hyperpolarizable organic chromophores 失效
标题翻译：超极化有机发色团
公开(公告)号：US07029606B2
公开(公告)日：2006-04-18
申请号：US09912444
申请日：2001-07-24
申请人： Larry R. Dalton , Kwan-Yue Jen , Timothy Londergan , William Brenden Carlson , Gregory Phelan , Diyun Huang , Daniel Casmier , Todd Ewy , Nicholas Buker
发明人： Larry R. Dalton , Kwan-Yue Jen , Timothy Londergan , William Brenden Carlson , Gregory Phelan , Diyun Huang , Daniel Casmier , Todd Ewy , Nicholas Buker
IPC分类号： G02F1/061 , C07D409/02 , C07D307/00 , C07D409/14 , C07D495/02
CPC分类号： C07D307/56 , C07D307/36 , C07D307/54 , C07D307/66 , C07D319/06 , C07D333/24 , C07D409/06 , C07D495/04 , C07F7/0814 , C09B23/0075 , C09B23/105 , C09B69/105
摘要： A dihydrofuran-containing nonlinear optical chromophore having a π-electron donor group conjugated to the dihydrofuran group through a π-electron conjugated bridge group. The nonlinear optical chromophore is a hyperpolarizable chromophore that can be used as an electro-optic modulator in electro-optic devices.
摘要翻译：具有通过π-电子共轭桥基与二氢呋喃基结合的π-电子给体基团的含二氢呋喃的非线性光学发色团。非线性光学发色团是可以用作电光器件中的电光调制器的超极化发色团。

56. 发明申请

US20050171138A1 Flavone acetic acid analogs and methods of use thereof 审中-公开
标题翻译：黄酮乙酸类似物及其使用方法
公开(公告)号：US20050171138A1
公开(公告)日：2005-08-04
申请号：US11091054
申请日：2005-03-28
申请人： Kuo-Hsiung Lee , Yi Xia , Zheng-Yu Yang , Kenneth Bastow , Sheng-Chu Kuo
发明人： Kuo-Hsiung Lee , Yi Xia , Zheng-Yu Yang , Kenneth Bastow , Sheng-Chu Kuo
IPC分类号： C07D215/22 , C07D215/233 , A61K31/4741 , A61K31/353 , A61K31/382 , C07D491/02 , C07D495/02
CPC分类号： C07D215/233
摘要： Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n is from 1 to 5; R1 and R3 are each independently selected from the group consisting of H, hydroxy, lower alkyl, lower alkoxy, halo, amino, aminoalkyl, nitro, heteroaryl, —OC(═O)R6, —O(C═O)OR6; and —O(C═O)N(R6)2; and R2 is side chain such as an acetic acid side chain, where p is O to 4, R5 is hydroxy, alkoxy or amino, and R6 is H or lower alkyl, or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer.
摘要翻译：描述具有根据式I或式II的结构的化合物：其中：X选自O，NH和S; Y选自O和S; m为1〜3; n为1〜5; R 1和R 3各自独立地选自H，羟基，低级烷基，低级烷氧基，卤素，氨基，氨基烷基，硝基，杂芳基，-OC （-O）R 6，-O（CO）OR 6; 和-O（C-O）N（R 6）2。并且R 2是侧链，例如乙酸侧链，其中p为0至4，R 5为羟基，烷氧基或氨基，R 6 或其低级烷基或其药学上可接受的盐。该化合物可用于治疗癌症。

57. 发明申请

US20050171091A1 Thienodibenzoazulene compounds as tumor necrosis factor inhibitors 审中-公开
标题翻译：噻吩并苯并薁类化合物作为肿瘤坏死因子抑制剂
公开(公告)号：US20050171091A1
公开(公告)日：2005-08-04
申请号：US11090743
申请日：2005-03-25
申请人： Mladen Mercep , Milan Mesic , Dijana Pesic , Zeljko Zupanovic , Boska Hrvacic
发明人： Mladen Mercep , Milan Mesic , Dijana Pesic , Zeljko Zupanovic , Boska Hrvacic
IPC分类号： A61K31/381 , A61K31/55 , A61P1/04 , A61P11/06 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07B61/00 , C07D495/04 , C07D495/02 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
摘要翻译：本发明涉及由式I表示的二苯并薁化合物及其在所有疾病和病症中抑制哺乳动物的肿瘤坏死因子α（TNF-α）和白细胞介素1（IL-1）的药物制剂，其中这些介质过度分泌。本发明的化合物还表现出止痛作用，可用于缓解疼痛。

58. 发明申请

US20040229846A1 P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions 有权
标题翻译： P-手性磷脂和磷酸环化合物及其在不对称催化反应中的应用
公开(公告)号：US20040229846A1
公开(公告)日：2004-11-18
申请号：US10856014
申请日：2004-05-28
申请人： The Penn State Research Foundation
发明人： Xumu Zhang , Wenjun Tang
IPC分类号： A61K031/675 , A61K031/4741 , A61K031/407 , C07D495/02
CPC分类号： C07C45/505 , C07B31/00 , C07B53/00 , C07B2200/07 , C07C5/333 , C07C41/20 , C07C45/69 , C07C45/72 , C07C51/36 , C07C67/283 , C07C67/303 , C07C231/18 , C07C2531/24 , C07D217/04 , C07D307/42 , C07D333/24 , C07F1/005 , C07F7/003 , C07F9/005 , C07F9/65683 , C07F9/6571 , C07F11/005 , C07F13/005 , C07F15/0033 , C07F15/004 , C07F15/0046 , C07F15/0053 , C07F15/006 , C07F15/0066 , C07F15/0073 , C07F15/008 , C07F15/0086 , C07F15/0093 , C07F15/04 , C07F15/045 , C07F17/02 , C07C15/12 , C07C55/02 , C07C69/007 , C07C69/616 , C07C69/612 , C07C69/734 , C07C69/34 , C07C69/65 , C07C233/47 , C07C69/157 , C07C43/205
摘要： Chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic alkylation, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, olefin metathesis, hydrocarboxylation, isomerization, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition; epoxidation, kinetic resolution and nullmnullnnull cycloaddition. Processes for the preparation of the ligands are also described.
摘要翻译：公开了基于用于不对称催化的这种手性配体的手性配体和金属络合物。根据本发明的金属络合物可用作不对称反应中的催化剂，例如氢化，氢化物转移，烯丙基烷基化，氢化硅烷化，氢硼化，氢化乙烯化，加氢甲酰化，烯烃复分解，加氢羧化，异构化，环丙烷化，Diels-Alder反应，Heck 反应异构化，醛醇反应，迈克尔加成; 环氧化，动力学拆分和[m + n]环加成。还描述了制备配体的方法。

59. 发明申请

US20040147580A1 Fab I inhibitors 有权
标题翻译： Fab I抑制剂
公开(公告)号：US20040147580A1
公开(公告)日：2004-07-29
申请号：US10474315
申请日：2003-10-06
发明人： Walter J. Burgess , Dalia Jakas , William F Huffmann , William H Miller , Kenneth A Newlander , Mark A Seefeld , Irene N Uzinskas
IPC分类号： C07D495/02 , C07D215/12 , A61K031/47 , A61K031/416 , A61K031/381 , A61K031/16
CPC分类号： C07D213/73 , A61K31/16 , A61K31/381 , A61K31/416 , A61K31/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04 , Y02A50/473
摘要： Compounds are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
摘要翻译：公开了作为Fab I抑制剂并且可用于治疗细菌感染的化合物。

60. 发明申请

US20030055130A1 New thiophenes and polymers derived therefrom 失效
标题翻译：新的噻吩和衍生自其的聚合物
公开(公告)号：US20030055130A1
公开(公告)日：2003-03-20
申请号：US10104266
申请日：2002-03-22
申请人： AGFA-GEVAERT
发明人： Lambertus Groenendaal , Frank Louwet , Gianni Zotti
IPC分类号： C08G075/00 , C07D495/02
CPC分类号： C07D495/04 , C08G61/126 , H01G11/48 , H01G11/56 , Y02E60/13
摘要： A thiophene compound represented by formula (I): 1 in which: A represents a C2-C5 alkylene bridge; R represents a stereoselectively substituted, linear or branched C2-C24 alkyl, C3-C18 cycloalkyl, C1-C18 alkoxy or polyethyleneoxide group, optionally substituted with at least one substituent selected from the group consisting of an alcohol, amide, ether, ester or sulfonate group; or an optionally substituted aryl group having at least one chiral centre substituted at said C2-C5 alkylene bridge; polymers derived therefrom; a process for polymerizing a thiophene according to formula (I), optionally chemically or electrochemically; and dispersions, pastes and layers containing polymers derived therefrom.
摘要翻译：由式（I）表示的噻吩化合物：其中：A表示C2-C5亚烷基桥; R表示立体选择性取代的直链或支链C 2 -C 24烷基，C 3 -C 18环烷基，C 1 -C 18烷氧基或聚环氧乙烷基团，任选被至少一个选自醇，酰胺，醚，酯或磺酸盐的取代基取代组; 或在所述C 2 -C 5亚烷基桥上具有至少一个手性中心取代的任选取代的芳基; 衍生自其的聚合物; 根据式（I）聚合噻吩的方法，任选化学或电化学方法; 以及含有由其衍生的聚合物的分散体，糊剂和层。

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