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71. 发明授权

US10948558B2 Method of performing magnetic resonance imaging and a magnetic resonance apparatus 有权
公开(公告)号：US10948558B2
公开(公告)日：2021-03-16
申请号：US16108531
申请日：2018-08-22
申请人： Siemens Healthcare Limited , King's College London
发明人： Radhouene Neji , Sebastien Roujol , Rene Botnar
IPC分类号： G01R33/50 , A61B5/055 , G01R33/54 , A61B5/0456 , G01R33/565 , G01R33/24 , A61B5/00 , G01R33/567
摘要： In a method of performing magnetic resonance imaging and a magnetic resonance apparatus, first MR data are acquired of a region of interest of a subject in the absence of a B1 field. Second MR data are acquired of the region of interest in the presence of a B1 field, and within a short time interval after generation of the B1 field. The first and second MR data are processed to determine a B1 field map, and a T1 map is generated using the B1 field map. The T1 map is a B1 corrected T1 map. The first and second MR data 103, 109 may be acquired as part of a T1 mapping sequence, such as a MOLLI or SASHA type cardiac T1 mapping sequence.

72. 发明授权

US10900914B2 Authenticating an article 有权
公开(公告)号：US10900914B2
公开(公告)日：2021-01-26
申请号：US15534966
申请日：2015-12-11
申请人： KING'S COLLEGE LONDON
发明人： Kaspar Althoefer , Jamie Barras , David Nugent
IPC分类号： G01N24/00 , G07D7/06 , G06F21/32 , G01R33/44
摘要： A method of authenticating an article, the method comprising: reading a label associated with the article, the label comprising article fingerprint information; retrieving, in dependence on the article fingerprint information, an article fingerprint, the fingerprint describing the resonance response of the article to an excitation signal; applying an excitation signal to the article; receiving the resonance response of the article to the excitation signal; comparing the resonance response to the fingerprint; and determining in dependence on the comparison whether the article is authentic.

73. 发明授权

US10775465B2 Method for use in correcting a magnetic relaxation time constant value 有权
公开(公告)号：US10775465B2
公开(公告)日：2020-09-15
申请号：US16668089
申请日：2019-10-30
申请人： Siemens Healthcare GmbH , King's College London
发明人： Sebastien Roujol , Radhouene Neji , Li Huang
IPC分类号： G01R33/56 , G01R33/567
摘要： Techniques are disclosed for determining coefficients for use in correcting a magnetic relaxation time constant, T, value obtained via magnetic resonance imaging when a pulse rate was at a first pulse rate value to a T value reflecting the T value that would have been obtained if the pulse rate was at a second pulse rate value. The technique includes, for each region of interest, pairing an obtained derivative, m, and an obtained offset, c, as an ordered pair (c, m). The technique further includes fitting the obtained plurality of ordered pairs (c, m) to a polynomial function, and determining the values of the coefficients from the polynomial function.

74. 发明授权

US10753991B2 Method and system for magnetic resonance imaging 有权
公开(公告)号：US10753991B2
公开(公告)日：2020-08-25
申请号：US16093265
申请日：2017-04-06
申请人： King's College London
发明人： Shaihan Malik , Francesco Padormo , Joseph Hajnal , Felipe Godinez
IPC分类号： G01R33/28 , G01R33/36 , G01R33/561
摘要： Parallel transmit Magnetic Resonance MR scanner used to image a conductive object such as an interventional device like a guidewire within a subject. This is achieved by determining which Radio Frequency RF transmission modes produced by the parallel RF transmission elements couple with the conductive object and then transmitting at significantly reduced power so as to prevent excessive heating of the conductive object to an extent that would damage the surrounding tissue of the subject, for example, the coupling RF transmission modes may be generated at less than 30%, preferably around 10% of the normal power levels that would conventionally be used for MR imaging. However, even at these low power levels sufficient electric currents are induced in the conductive device to cause detectable MR signals; the location of the conductive object within the subject can thus be visualised. By fast alternate, or simultaneous, iterative application of low-power coupling mode and normal-power non-coupling modes, both the subject and the conductive object can be imaged. During the calibration step of determining which RF transmission modes couples with the conductive object, instead of physically measuring the current induced in the conductive object using sensors, imaging the conductive object using additional very short series of flip angle RF pulses (vLFA) gives a good approximation of the coupling matrix.

75. 发明申请

US20200241096A1 METHOD OF RECONSTRUCTING MAGNETIC RESONANCE IMAGE DATA 审中-公开
公开(公告)号：US20200241096A1
公开(公告)日：2020-07-30
申请号：US16750423
申请日：2020-01-23
申请人： Siemens Healthcare Limited , King's College London
发明人： Aurelien Bustin , Rene Botnar , Claudia Prieto , Radhouene Neji
IPC分类号： G01R33/48 , G01R33/56 , G06T9/00
摘要： A plurality of sets of k-space data each of the same image region of a subject but having different contrasts are obtained. A sparse image coding procedure is performed to reconstruct a plurality of MR images each corresponding to one of the sets of k-space data. This involves solving an optimization problem comprising a data consistency iteration step used to generate the reconstructed MR images; and a denoising iteration step applied to the reconstructed MR images generated during the data consistency iteration step. The denoising iteration step includes performing a 2D/3D block matching operation to identify similar patches across the reconstructed MR images, and using the similar patches across the reconstructed MR images in a sparsifying operation to provide sparse representations of the reconstructed MR images. The sparse representations are used as an input to the data consistency iteration step.

76. 发明授权

US10443054B2 Methods for identifying and treating invasive/metastatic breast cancers 有权
公开(公告)号：US10443054B2
公开(公告)日：2019-10-15
申请号：US15451374
申请日：2017-03-06
申请人： Massachusetts Institute of Technology , King's College London
发明人： Frank B. Gertler , Guillaume Carmona , Matthias Krause , Upamali Perera
IPC分类号： C12N15/113 , C12Q1/6886 , G01N33/574 , G01N30/88
摘要： Cancer invasion is a hallmark of metastasis. The mesenchymal mode of cancer cell invasion is mediated by elongated membrane protrusions driven by the assembly of branched F-actin networks. Described herein are compositions and methods for assessing and treating a subject having metastatic cancer or at risk of developing metastatic cancer, e.g., metastatic breast cancer, through the determination of Lamellipodin protein or gene expression levels in the subject.

77. 发明授权

US10273549B2 Engineered skin equivalent, method of manufacture thereof and products derived therefrom 有权
公开(公告)号：US10273549B2
公开(公告)日：2019-04-30
申请号：US15493083
申请日：2017-04-20
申请人： VitroLabs Inc , King's College London
发明人： Ingvar Helgason , Dusko Ilic
IPC分类号： C14C3/02 , C12N5/071 , C14C13/00
摘要： Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.

78. 发明授权

US09994559B2 Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists 有权
公开(公告)号：US09994559B2
公开(公告)日：2018-06-12
申请号：US15533492
申请日：2015-12-16
申请人： King's College London
发明人： Alan David Borthwick , Mark Trevor Mills , Jane Theresa Brown , Jonathan Patrick Thomas Corcoran , Maria Beatriz De Castro Vasconcelos Goncalves , Sarkis Barret Kalindjian
IPC分类号： C07D413/04 , C07D417/04 , A61K31/41 , A61P25/16 , A61P25/14 , A61P25/02
CPC分类号： C07D413/04 , C07D417/04
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as “BHBA compounds”), which, inter alia, are (selective) retinoic acid receptor beta (RARβ) (e.g., RARβ2) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARβ (e.g., RARβ2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RARβ (e.g., RARβ2), that are ameliorated by the activation of RARβ (e.g., RARβ2), etc., including, e.g., neurological injuries such as spinal cord injuries.

79. 发明授权

US09940741B2 Delay coordinate analysis of periodic data 有权
公开(公告)号：US09940741B2
公开(公告)日：2018-04-10
申请号：US15118405
申请日：2015-02-16
申请人： University of Surrey , King's College London
发明人： Philip Aston , Mark Christie , Manasi Nandi
IPC分类号： G06T11/20 , A61B5/00 , A61B5/04 , A61B5/021
CPC分类号： G06T11/206 , A61B5/021 , A61B5/04012 , A61B5/412 , A61B5/7253 , A61B5/7445 , G06F19/00 , G06K9/0053 , G06K9/00557 , G06K9/6232
摘要： Periodic data is analyzed by obtaining a vector of delay coordinates for each one of a plurality of samples of the periodic data in a time window, and transforming each of the vectors into a coordinate system comprising a plurality of predefined vectors, to obtain a projection of an attractor of the periodic data along one of the predefined vectors. The periodic data may be physiological data. Information representing one or more characteristics of the obtained attractor, which is of diagnostic value, is then displayed to enable a diagnosis.

80. 发明授权

US09861606B2 Therapeutic for treating inflammatory lung disorders 有权
公开(公告)号：US09861606B2
公开(公告)日：2018-01-09
申请号：US14431382
申请日：2013-09-25
申请人： University College Cardiff Consultants Limited , King's College London
发明人： Daniela Riccardi , Paul Jeffrey Kemp , Christopher John Corrigan , Jeremy Patrick Thomas Ward
IPC分类号： A61K31/277 , A61K45/06 , A61K9/00
CPC分类号： A61K31/277 , A61K9/0075 , A61K9/0078 , A61K45/06 , A61K2300/00
摘要： A calcium/cation-sensing receptor (CaSR) antagonist to treat an inflammatory lung disorder is described. Methods of treatment including the antagonist, combination therapeutics including the antagonist and at least one other agent, and nebulizers or inhalers including the antagonist are also described.

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