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71. 发明授权

US06897338B2 Methods of making intermediates from polyhydroxyalkanoates 有权
标题翻译：从聚羟基链烷酸酯制备中间体的方法
公开(公告)号：US06897338B2
公开(公告)日：2005-05-24
申请号：US10326442
申请日：2002-12-18
申请人： Luhua Zhong , Robert S. Whitehouse
发明人： Luhua Zhong , Robert S. Whitehouse
IPC分类号： C07C29/136 , C07C31/20 , C07C51/00 , C07C51/09 , C07C57/04 , C07C67/02 , C07C69/02 , C07C69/66 , C07C231/02 , C07C235/04 , C07D207/26 , C08G63/06 , C08J11/04
CPC分类号： C07C51/377 , C07C29/149 , C07C51/09 , C07C67/03 , C07C235/06 , C07C2601/14 , C07C31/207 , C07C31/205 , C07C31/202 , C07C31/20 , C07C57/08 , C07C69/675
摘要： Methods of forming acrylic acid from a PHA, such as, for example, poly 3-hydroxypropionate or a 3-hydroxypropionate containing polymer are disclosed. The methods can include, for example, heating a biomass containing the PHA to form acrylic acid. The methods can include, for example, heating the PHA to a temperature of at least about 200° C. to form acrylic acid. The methods can include for example, heating a mixture containing a first portion of the PHA to form a first portion of acrylic acid, and then adding a second portion of the PHA to the mixture.
摘要翻译：公开了从PHA形成丙烯酸的方法，例如聚3-羟基丙酸酯或含3-羟丙酸酯的聚合物。所述方法可以包括例如加热含有PHA的生物质以形成丙烯酸。该方法可以包括例如将PHA加热到至少约200℃的温度以形成丙烯酸。所述方法可以包括例如加热含有PHA的第一部分的混合物以形成丙烯酸的第一部分，然后向混合物中加入第二部分PHA。

72. 发明授权

US06858232B2 Topical transdermal treatments 有权
标题翻译：局部透皮治疗
公开(公告)号：US06858232B2
公开(公告)日：2005-02-22
申请号：US09795589
申请日：2001-02-28
申请人： Anthony J. Verbiscar
发明人： Anthony J. Verbiscar
IPC分类号： A61P31/22 , A01N25/00 , A01N31/00 , A61F13/02 , A61F15/00 , A61K20060101 , A61K31/00 , A61K31/045 , A61K31/355 , A61K31/60 , A61K31/612 , A61K35/12 , A61K35/52 , A61K36/00 , A61P17/00 , A61P31/12 , C07C27/02 , C07C29/136 , C07C29/147 , C07C33/025 , A61K35/78
CPC分类号： C07C255/00
摘要： Jojoba alcohol, a mixture of long chain monounsaturated alcohols, is an oily liquid at moderate ambient temperatures. It is readily absorbed by human skin where it relieves irritation and inhibits the formation of lesions caused by viruses. The inhibitory action is applicable to enveloped viruses such as herpes simplex, which express as sores at dermal surfaces in humans. When applied topically to an incipent herpes episode, it will quickly penetrate the epidermis to the subdermal vascular cells and suppress viral replication which leads to inflammation and the formation of blisters on the face, genital and other skin and mucosal areas. Compositions of certain low molecular weight organic acids in jojoba alcohol enhance antiviral activity. Jojoba alcohol is a carrier and transdermal delivery system for these and other pharmacologically active agents for the relief of pain and treatment of other conditions which occur at or under the surface of the skin. Topically applied jojoba alcohol is non-toxic and safe for animals and humans.
摘要翻译：荷荷巴醇，长链单不饱和醇的混合物，在中等环境温度下为油状液体。它容易被人体皮肤吸收，从而缓解刺激并抑制病毒引起的病变形成。抑制作用适用于包膜病毒如单纯疱疹，其表达为人类真皮表面的疮。当局部应用于初生疱疹发作时，它将迅速穿透表皮到皮下血管细胞，并抑制病毒复制，导致炎症和脸部，生殖器和其他皮肤和粘膜区域上的水疱形成。荷荷巴醇中某些低分子量有机酸的组合增强抗病毒活性。荷荷巴醇是这些和其他药理学活性剂的载体和透皮递送系统，用于缓解疼痛和治疗其它发生在皮肤表面或其下表面的病症。局部应用霍霍巴醇对动物和人体无毒，安全。

73. 发明授权

US06844447B2 Methods of making intermediates from polyhydroxyalkanoates 有权
标题翻译：从聚羟基链烷酸酯制备中间体的方法
公开(公告)号：US06844447B2
公开(公告)日：2005-01-18
申请号：US10326413
申请日：2002-12-18
申请人： Luhua Zhong , Edward M. Muller , James J. Barber , Joseph Pugach
发明人： Luhua Zhong , Edward M. Muller , James J. Barber , Joseph Pugach
IPC分类号： C07C29/136 , C07C31/20 , C07C51/00 , C07C51/09 , C07C57/04 , C07C67/02 , C07C69/02 , C07C69/66 , C07C231/02 , C07C235/04 , C07D207/26 , C08G63/06 , C08J11/04
CPC分类号： C07C51/377 , C07C29/149 , C07C51/09 , C07C67/03 , C07C235/06 , C07C2601/14 , C07C31/207 , C07C31/205 , C07C31/202 , C07C31/20 , C07C57/08 , C07C69/675
摘要： Methods of forming intermediates from PHAs are disclosed. In general, the methods include forming a pyrrolidone from a PHA, such as poly 4-hydroxybutyrate or a 4-hydroxybutyrate containing polymer. The methods can include, for example, treating (e.g., heating) the PHA to form a pyrrolidone. The methods can include, for example, treating a biomass containing the PHA to form a pyrrolidone. The methods can include, for example, heating the PHA to a temperature of at most about 90° C. to form a pyrrolidone, wherein the percent yield of the pyrrolidone is at least about 50%.
摘要翻译：公开了从PHAs形成中间体的方法。通常，所述方法包括由PHA形成吡咯烷酮，例如聚4-羟基丁酸酯或含4-羟基丁酸酯的聚合物。所述方法可以包括例如处理（例如加热）PHA以形成吡咯烷酮。所述方法可以包括例如处理含有PHA的生物质以形成吡咯烷酮。该方法可以包括例如将PHA加热到至多约90℃的温度以形成吡咯烷酮，其中吡咯烷酮的产率为至少约50％。

74. 发明授权

US6166260A Tandem reduction and host-guest complexation 失效
标题翻译：串联还原和宿主 - 复合
公开(公告)号：US6166260A
公开(公告)日：2000-12-26
申请号：US369732
申请日：1999-08-06
申请人： Glenn L. Heise
发明人： Glenn L. Heise
IPC分类号： C07B53/00 , C07B57/00 , C07C29/143 , C07C213/00 , C07C215/32 , C07C249/02 , C07C251/24 , C07F9/34 , C07F9/36 , C07C29/136 , C07C29/78 , C07C29/92
CPC分类号： C07C213/00 , C07B53/00 , C07B57/00 , C07B2200/07 , C07B2200/09 , C07C29/143 , C07C249/02 , C07C2601/02 , C07C2601/14 , C07F9/34 , C07F9/36 , C07C215/32 , C07C251/24 , C07C33/20
摘要： The present invention relates to a tandem process of reduction and host-guest complexation using metal-hydride complexes to reduce chemical entities bearing carbonyl groups or their equivalents, and host-guest complexation to achieve improved optical resolution of the reduction product. In the complexation step, the reduction product is optically resolved via inclusion into the crystalline complex where it resides as guest and another complex component acts as host. Additional crystallization stages are performed if further improvements in the enantiomeric excess is desired.
摘要翻译：本发明涉及使用金属氢化物络合物还原和主客体络合的串联方法以减少带有羰基或其等同物的化学物质，以及主体 - 客体络合以实现还原产物的改进的光学拆分。在络合步骤中，还原产物通过包含在其中作为客体存在的结晶配合物中被光学拆分，另一个复合组分作为主体。如果需要进一步改善对映体过量，则进行额外的结晶阶段。

75. 发明授权

US6100410A Process for the production of 1,4-butanediol, .gamma.-butyrolactone and tetrahydrofuran 有权
标题翻译：生产1,4-丁二醇，γ-丁内酯和四氢呋喃的方法
公开(公告)号：US6100410A
公开(公告)日：2000-08-08
申请号：US180769
申请日：1998-11-12
申请人： Michael William Marshall Tuck , Michael Anthony Wood , Andrew George Hiles
发明人： Michael William Marshall Tuck , Michael Anthony Wood , Andrew George Hiles
IPC分类号： C07B61/00 , C07C29/149 , C07C29/17 , C07C31/20 , C07C33/035 , C07C67/08 , C07C69/60 , C07D307/08 , C07D307/33 , C07D315/00 , C07C27/06 , C07C29/136
CPC分类号： C07D307/33 , C07C29/149 , C07C29/177 , C07D307/08 , C07D315/00
摘要： A process for the production of at least one C.sub.4 compound selected from butane-1,4-diol, .gamma.-butyrolactone and tetrahydrofuran comprises contacting a vaporous stream containing maleic anhydride vapour, water vapour, and carbon oxides in an absorption zone with a high boiling organic solvent thereby to form a solution of maleic anhydride in the high boiling organic solvent. Maleic anhydride in this solution is reacted under esterification conditions in an esterification zone with a C.sub.1 to C.sub.4 alkanol to form a solution of the corresponding di-(C.sub.1 to C.sub.4 alkyl) maleate in the high boiling solvent. This solution of the di-(C.sub.1 to C.sub.4 alkyl) maleate in the high boiling solvent is contacted with a gaseous stream containing hydrogen thereby to strip di-(C.sub.1 to C.sub.4 alkyl) maleate therefrom and to form a vaporous stream comprising hydrogen and di-(C.sub.1 to C.sub.4 alkyl) maleate. Material of this vaporous stream is contacted in a hydrogenation zone under ester hydrogenation conditions in the presence of a heterogeneous ester hydrogenation catalyst thereby to convert di-(C.sub.1 to C.sub.4 alkyl) maleate to at least one C.sub.4 compound selected from butane-1,4-diol, .gamma.-butyrolactone and tetrahydrofuran which is recovered from the hydrogenation zone in the resulting product stream. The high boiling solvent has a boiling point at atmospheric pressure that is at least about 30.degree. C. higher than that of the di-(C.sub.1 to C.sub.4 alkyl) maleate.
摘要翻译： PCT No.PCT / GB97 / 01285 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月12日PCT公布。公开号WO97 / 43242 日期1997年11月20日制备选自丁烷-1,4-二醇，γ-丁内酯和四氢呋喃中的至少一种C 4化合物的方法包括使含有马来酸酐蒸气，水蒸汽和碳氧化物的蒸汽流在吸收区域，由此形成马来酸酐在高沸点有机溶剂中的溶液。该溶液中的马来酸酐在酯化条件下在酯化区与C1至C4链烷醇反应，以在高沸点溶剂中形成相应的二（C1至C4烷基）马来酸酯的溶液。马来酸二（C1-C4烷基）酯在高沸点溶剂中的溶液与含有氢气的气流接触，从而从其中剥离二（C1至C4烷基）马来酸酯，并形成含有氢和二 - （C1-C4烷基）马来酸酯。在异构酯加氢催化剂存在下，在氢化反应条件下，在氢化反应区中使该气态物质接触，从而将马来酸二 - （C 1 -C 4烷基）酯转化为至少一种选自丁烷-1,4- 二醇，γ-丁内酯和四氢呋喃，其从所得产物流中的氢化区回收。高沸点溶剂的沸点在大气压下至少比二（C1-C4烷基）马来酸酯高约30℃。

76. 发明授权

US5728896A Process for the preparation of hydroxymethyl-cyclopropane 失效
标题翻译：制备羟甲基环丙烷的方法
公开(公告)号：US5728896A
公开(公告)日：1998-03-17
申请号：US601931
申请日：1996-02-15
申请人： Lutz Frohn , Reinhard Langer , Gerhard Darsow , Eberhard Zirngiebl , Jorg-Dietrich Jentsch , Bernd Pennemann , Christoph Tiburtius
发明人： Lutz Frohn , Reinhard Langer , Gerhard Darsow , Eberhard Zirngiebl , Jorg-Dietrich Jentsch , Bernd Pennemann , Christoph Tiburtius
IPC分类号： B01J23/06 , C07B61/00 , C07C27/02 , C07C29/149 , C07C31/133 , C07C29/136
CPC分类号： C07C29/149 , B01J23/06 , C07C2101/02
摘要： Hydroxymethyl-cyclopropane (cyclopropyl-methanol) can be obtained in a manner which is both economical and environment-friendly by catalytic hydrogenation of cyclopropanecarboxylic acid alkyl esters under increased pressure at elevated temperature if a chromium-free zinc oxide catalyst is employed as the catalyst.
摘要翻译：如果使用无铬氧化锌催化剂作为催化剂，可以通过环烷基羧酸烷基酯在升高的压力下在升高的温度下的催化氢化，以经济和环境友好的方式获得羟甲基 - 环丙烷（环丙基甲醇）。

77. 发明授权

US5414159A Process 失效
标题翻译：处理
公开(公告)号：US5414159A
公开(公告)日：1995-05-09
申请号：US174320
申请日：1993-12-30
申请人： Paul Appleton , Michael A. Wood
发明人： Paul Appleton , Michael A. Wood
IPC分类号： B01J23/889 , C07B61/00 , C07C27/02 , C07C29/149 , C07C31/27 , C07C35/14 , C07C29/136 , C07C31/20
CPC分类号： C07C35/14 , C07C29/149 , C07C2101/14
摘要： A process is described for the production of cyclohexanedimethanol by hydrogenation of a dialkyl cyclohexanedicarboxylate which comprises the steps of:(a) providing a hydrogenation zone containing a charge of a granular reduced manganese promoted copper catalyst;(b) forming a vaporous feed stream of a hydrogenatable material comprising a dialkyl cyclohexanedicarboxylate and from about 0.1 wt % up to about 15 wt % of an acidic material at a feed temperature which is in the range of from about 150.degree. C. to about 350.degree. C. and which is above the dew point of the feed stream and at a feed pressure which is in the range of from about 150 psia (about 10.34 bar) up to about 2000 psia (about 137.90 bar), said vaporous mixture having a known hydrogen-containing gas:dialkyl cyclohexanedicarboxylate ratio;(c) supplying the vaporous feed stream to the hydrogenation zone;(d) maintaining hydrogenation conditions in the hydrogenation zone which are effective to maintain the reaction mixture in contact with the catalyst above its dew point;(e) passing the vaporous feed stream through the hydrogenation zone: and(f) recovering from the hydrogenation zone a product stream comprising cyclohexanedimethanol.
摘要翻译：描述了通过氢化环己烷二羧酸二烷基酯制备环己烷二甲醇的方法，该方法包括以下步骤：（a）提供含有粒状还原锰促进铜催化剂装料的氢化区; （b）在约150℃至约20℃的进料温度下，形成包含环己烷二羧酸二烷基酯和约0.1重量％至约15重量％酸性物质的可氢化材料的气态进料流 350℃，高于进料流的露点，进料压力在约150psia（约10.34巴）至约2000psia（约137.90巴）的范围内，所述蒸气混合物具有已知的含氢气体：环己烷二羧酸二烷基酯比例; （c）将蒸气进料流供应到氢化区; （d）保持加氢区中的氢化条件，其有效地使反应混合物与催化剂接触高于其露点; （e）使气态进料流通过氢化区;和（f）从氢化区回收包含环己烷二甲醇的产物流。

78. 发明授权

US5382717A Process of controlling the rate at which used catalyst is recycled to hydrogenating means for preparing fatty alcohols from fatty acid derivatives 失效
标题翻译：控制使用的催化剂再循环到用于由脂肪酸衍生物制备脂肪醇的氢化装置的速率的方法
公开(公告)号：US5382717A
公开(公告)日：1995-01-17
申请号：US195854
申请日：1994-02-10
申请人： Hans-Martin Stonner , Henning Buchold
发明人： Hans-Martin Stonner , Henning Buchold
IPC分类号： B01J23/72 , C07B61/00 , C07C29/136 , C07C29/149 , C07C31/125
CPC分类号： C07C29/149 , Y02P20/584
摘要： Fatty acids and/or fatty acid derivatives as well as hydrogen, fresh catalyst and a dispersion which contains used catalyst are supplied to the hydrogenating means, which are operated at temperatures in the range from 100.degree. to 400.degree. C. and under pressures in the range from 20 to 400 bars to produce a product stream, which contains fatty alcohols and used catalyst. A part of the product stream is circulated. A first partial stream Is withdrawn at a controllable rate from the circulating stream and is passed through a separator. A product which is rich in fatty alcohol and a dispersion which contains used catalyst are separately delivered by the separator. The dispersion is recycled to the hydrogenating means. A second partial stream is withdrawn at a controllable rate from the circulating product stream. Used catalyst is separated from the second partial stream and is removed from the process. The rate at which used catalyst is fed to the hydrogenating means can be increased in that the rate of the second partial stream is decreased.
摘要翻译：将含有使用的催化剂的脂肪酸和/或脂肪酸衍生物以及氢气，新鲜催化剂和分散体供给到氢化装置，其在100-400℃的温度和在范围为20至400巴，以产生含有脂肪醇和用过的催化剂的产品流。产品流的一部分流通。第一部分流以可控速率从循环流中取出并通过分离器。富含脂肪醇的产物和含有使用的催化剂的分散体由分离器分开输送。将分散体再循环至氢化装置。以可控速率从循环产物流中取出第二部分流。使用的催化剂与第二部分流分离并从该方法中除去。使用的催化剂进料到氢化装置的速率可以增加，因为第二部分流的速率降低。

79. 发明授权

US5306847A Manufacture of 1,2-propylene glycol 失效
标题翻译： 1,2-丙二醇的制造
公开(公告)号：US5306847A
公开(公告)日：1994-04-26
申请号：US981318
申请日：1992-11-25
申请人： Eugen Gehrer , Wolfgang Harder
发明人： Eugen Gehrer , Wolfgang Harder
IPC分类号： B01J23/88 , C07B61/00 , C07C29/136 , C07C29/60 , C07C31/20 , C07C29/132 , C07C31/18
CPC分类号： C07C29/60
摘要： A process for the manufacture of 1,2-propylene glycol, wherein dihydroxyacetone is hydrogenolytically converted to 1,2-propylene glycol in a single stage using a catalyst.
摘要翻译：制备1,2-丙二醇的方法，其中使用催化剂在一个阶段中将二羟基丙酮氢解转化为1,2-丙二醇。

80. 发明授权

US5128488A Process for the asymmetric hydrogenation of carbonyl compounds obtained 失效
标题翻译：获得的羰基化合物的不对称加氢方法
公开(公告)号：US5128488A
公开(公告)日：1992-07-07
申请号：US515314
申请日：1990-04-27
申请人： Andre Mortreux , Francis Petit
发明人： Andre Mortreux , Francis Petit
IPC分类号： C07B41/02 , B01J31/22 , C07B31/00 , C07B53/00 , C07B61/00 , C07C29/136 , C07C67/00 , C07C231/12 , C07C233/00 , C07C233/11 , C07C235/36 , C07C237/04 , C07D307/32 , C07D307/33 , C07D307/60
CPC分类号： C07C231/12 , B01J31/189 , C07B41/02 , C07B53/00 , C07D307/32 , C07D307/33 , B01J2231/643 , B01J2531/822
摘要： The asymmetric hydrogenation of carbonyl compounds is carried out in the presence of at least one transition metal complex MZq(M=metal of group VIII of the Periodic Classication; Z=ligand selected among the atoms and the molecules which may complex the metal M; and q=degree of corrdination of M) and of at least one chiral phosphorous-containing ligand having formula (I), wherein R is hydrocarbonated radical (alkyl, cycloalkyl and aryl); R.sup.1 is H, hydrocarbonated radical or PR.sub.2 ; R.sup.2 is H or hydrocarbonated radical R.sup.3,R.sup.4, necessarily different, are H and optionally functionalized hydrocarbonated radicals; R.sup.5 and R.sup.6 are H and optionally functionalized hydrocarbonated radicals; one of the radicals R.sup.3 and R.sup.4 possibly carrying a function - OPR.sub.2 or NPR.sub.2, R.sup.5 and R.sup.6 being in this case H when R.sup.1 is PR.sub.2 ; R.sup.2 and R.sup.3 and the atoms of N and C which cary them respectively forming a heterocycle; or R.sup.2 and R.sup.5, the atoms of N and C which carry them respectively and the intermediate C atom possibly forming a heterocycle. ##STR1##
摘要翻译： PCT No.PCT / FR87 / 00238 Sec。 371日期：1988年4月1日 102（e）日期1988年4月1日PCT提交1987年6月22日PCT公布。公开号WO87 / 07889 日期为1987年12月30日。羰基化合物的不对称氢化在至少一种过渡金属络合物MZq（M =元素周期分类的VIII族金属; Z =选自原子和分子中的配体）存在下进行可以使金属M复合; q = M的修饰度和至少一种具有式（I）的手性含磷配体，其中R是烃基（烷基，环烷基和芳基）; R1是H，烃基或PR2; R2是H或烃基R3，R4必定不同，是H和任选官能化的烃基; R5和R6是H和任选的官能化烃基; R3和R4之一可能具有功能 - OPR2或NPR2，R5和R6在这种情况下为R1，当R1为PR2时; R2和R3以及分别形成杂环的N和C的原子; 或R2和R5分别携带它们的N和C的原子和可能形成杂环的中间体C原子。（一）

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