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81. 发明申请

US20170219611A1 BIOMARKERS AND METHODS RELATING TO ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：US20170219611A1
公开(公告)日：2017-08-03
申请号：US15104149
申请日：2014-12-12
申请人： Electrophoretics Limited , King's College London
发明人： Malcolm Andrew Ward , Abdul Hye , Simon Harold Lovestone , Richard James Butler Dobson
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2814 , G01N2800/2821 , G01N2800/52
摘要： Alzheimer's disease, the most common cause of dementia in older individuals, is a debilitating neurodegenerative disease for which there is currently no cure. In the past, AD could only be definitively diagnosed by brain biopsy or upon autopsy after a patient died. These methods, which demonstrate the presence of the characteristic plaque and tangle lesions in the brain, are still considered the gold standard for the pathological diagnoses of AD. However, in the clinical setting brain biopsy is rarely performed and diagnosis depends on a battery of neurological, psychometric and biochemical tests, including the measurement of biochemical markers such as the ApoE and tau proteins or the beta-amyloid peptide in cerebrospinal fluid and blood. The present invention discloses and describes panels of makers that are differentially expressed in the disease state relative to their expression in the normal state and, in particular, identifies and describes panels of makers associated with neurocognitive disorders. Such biomarker panel might have considerable value in triaging patients with early memory disorders to yet more specific but more invasive and costly approaches such as molecular markers in CSF and on PET imaging in clinical trials and possibly in clinical practice.

82. 发明授权

US08976977B2 Microphone array 有权
标题翻译：麦克风阵列
公开(公告)号：US08976977B2
公开(公告)日：2015-03-10
申请号：US12905415
申请日：2010-10-15
申请人： Enzo De Sena , Hüseyin Hacihabibo{hacek over (g)}lu , Zoran Cvetković
发明人： Enzo De Sena , Hüseyin Hacihabibo{hacek over (g)}lu , Zoran Cvetković
IPC分类号： H04R3/00
CPC分类号： H04R3/005 , H04R2201/401 , H04R2430/21 , H04S2400/15
摘要： A microphone array, comprising N microphones, wherein N is greater than or equal to 3 is provided. The microphones are substantially equiangularly arranged over a circular arc subtending an angle ε, wherein ε is less than or equal to 2π, with the directional axes of the N microphones facing substantially radially outwards. Each of the N microphones have a substantially common directivity function Γ(θ) defining the directional response of the microphone, wherein θ=0 is the directional axis, and the directivity function Γ(θ) is arranged such that a sound source in acoustical free field is effectively captured by no more than two consecutive microphones in the array. By arranging the directivity function in this manner crosstalk between non-adjacent microphones can be minimized, which has been shown to improve auditory localization performance.
摘要翻译：提供了包括N个麦克风的麦克风阵列，其中N大于或等于3。麦克风基本上等角地布置在对着角度的圆弧上，其中，小于或等于2＆pgr; N个麦克风的方向轴面向大致径向向外。 N个麦克风中的每一个具有定义麦克风的方向响应的基本上共同的方向性函数＆G;（＆amp; t），其中＆amp; t = 0是方向轴，并且方向性函数＆Ggr;（＆Theta）被布置成使得在声学自由场中的声源被阵列中不超过两个连续的麦克风有效地捕获。通过以这种方式布置方向性函数，可以使非相邻麦克风之间的串扰最小化，这已经显示出改善听觉定位性能。

83. 发明申请

US20150051097A1 Methods for Screening Inhibitors of Tau Phosphorylation By Casein Kinase I 审中-公开
标题翻译：筛选酪蛋白激酶Tau磷酸化抑制剂的方法I
公开(公告)号：US20150051097A1
公开(公告)日：2015-02-19
申请号：US14339538
申请日：2014-07-24
申请人： Proteome Sciences PLC , King's College London
发明人： Brian Anderton , Diane Hanger , Malcolm Ward , Helen Byers
IPC分类号： G01N33/573 , C12Q1/42 , G01N33/68 , C12Q1/48
CPC分类号： G01N33/573 , C12Q1/42 , C12Q1/485 , G01N33/6896 , G01N2333/4709 , G01N2333/9121 , G01N2500/02
摘要： Methods of screening for candidate compounds capable of inhibiting activity of fyn in phosphorylating tau protein at Y394 or binding to fyn to inhibit interaction with tau protein at Y394, including determining whether, and optionally the extent, the candidate compounds have these capabilities under conditions where fyn has these capabilities in the absence of the candidate compound. Methods of screening for substances capable of promoting dephosphorylation of tau protein by a phosphatase at a site of tau protein including contacting a candidate substance, the tau protein and a phosphatase capable of dephosphorylating the tau protein under conditions where the phosphatase is capable of dephosphorylating the site in absence of the candidate substance, where the kinase is fyn; determining whether, and optionally the extent, the candidate substance promotes dephosphorylation of the tau protein at the site; and selecting the candidate substance which promotes dephosphorylation of the tau protein the sites.
摘要翻译：筛选能够抑制Y39磷酸化tau蛋白的活性的候选化合物的方法或结合Fyn以抑制与Y394的tau蛋白相互作用的候选化合物的方法，包括确定候选化合物在任何条件下是否具有这些能力在没有候选化合物的情况下具有这些能力。筛选能够通过磷酸酶促进tau蛋白的位点促进tau蛋白去磷酸化的物质的方法，包括使候选物质，tau蛋白和能够使磷酸酶脱磷酸化的磷酸酶在磷酸酶能够使磷酸化位点脱磷的条件下接触在没有候选物质的情况下，激酶是fyn; 确定候选物质是否促进tau蛋白的去磷酸化以及任选的程度; 并选择促进tau蛋白去磷酸化位点的候选物质。

84. 发明授权

US08908875B2 Electronic device with digital reverberator and method 有权
标题翻译：具有数字混响器和方法的电子设备
公开(公告)号：US08908875B2
公开(公告)日：2014-12-09
申请号：US13364998
申请日：2012-02-02
申请人： Enzo De Sena , Zoran Cvetkovic , Huseyin Hacihabiboglu
发明人： Enzo De Sena , Zoran Cvetkovic , Huseyin Hacihabiboglu
IPC分类号： H03G3/00
CPC分类号： G10K15/12 , H04S7/305
摘要： Electronic devices having digital reverberators are disclosed, together with a method of reproducing sound for a user with the digital reverberator. The digital reverberator uses digital surface absorption filters positioned in the reverberator to simulate absorption of energy as digital audio data samples are reflected from virtual surfaces. The position of the digital surface absorption filters enables known frequency-dependent surface absorption characteristics of real materials to be directly implemented using the filter coefficients of each digital surface absorption filter. This enables virtual acoustic spaces to be designed quickly without the need for the digital reverberator to be manually tuned for each space.
摘要翻译：公开了具有数字混响器的电子设备，以及用数字混响器再现用户声音的方法。数字混响器使用位于混响器中的数字表面吸收滤光器来模拟吸收能量，因为数字音频数据采样从虚拟表面反射。数字表面吸收滤光片的位置可以使用每个数字表面吸收滤光片的滤光系数直接实现真实材料的已知频率相关表面吸收特性。这使得能够快速设计虚拟声学空间，而不需要为每个空间手动调谐数字混响器。

85. 发明授权

US08906383B2 T cell receptor having binding affinity for a peptide-MHC complex and uses thereof 有权
标题翻译：对肽-MHC复合物具有结合亲和力的T细胞受体及其用途
公开(公告)号：US08906383B2
公开(公告)日：2014-12-09
申请号：US12666416
申请日：2008-06-27
申请人： Mark Peakman , Ruben Varela Calvino
发明人： Mark Peakman , Ruben Varela Calvino
IPC分类号： A61K39/00 , G01N33/50 , G01N33/68 , C07K7/06 , C07K14/62 , A61K38/00
CPC分类号： C07K14/62 , A61K38/00 , C07K7/06 , G01N33/505 , G01N33/6893 , G01N2800/042
摘要： The present disclosure provides isolated preproinsulin-derived peptides of 8 or 9 amino acids, comprising the amino acid sequence WGPDPAA (SEQ ID NO: 1), isolated Class I peptide-HLA complexes presenting said peptides and isolated molecules having binding affinity for said peptides and/or said peptide-HLA complexes. Such compositions are useful in the treatment of type 1 diabetes mellitus (T1DM). Such isolated molecules can include a T cell receptor (TCR) having specific binding affinity for a peptide-MHC complex wherein the MHC is an HLA Class I molecule and the peptide is a preproinsulin-derived peptide of 8 to 10 amino acids, comprising the amino acid sequence WGPDPAA (SEQ ID NO: 1).
摘要翻译：本公开提供了8或9个氨基酸的分离的前胰岛素原衍生肽，其包含氨基酸序列WGPDPAA（SEQ ID NO：1），呈现所述肽的分离的I型肽-HAH复合物和对所述肽具有结合亲和力的分离的分子， /或所述肽-HAA复合物。这样的组合物可用于治疗1型糖尿病（T1DM）。这种分离的分子可以包括对MHC复合物具有特异性结合亲和力的T细胞受体（TCR），其中MHC是HLA I类分子，该肽是8至10个氨基酸的前胰岛素原衍生肽，其包含氨基酸序列WGPDPAA（SEQ ID NO：1）。

86. 发明申请

US20140322246A1 IGE ANTI-HMW-MAA Antibody 有权
标题翻译： IGE抗HMW-MAA抗体
公开(公告)号：US20140322246A1
公开(公告)日：2014-10-30
申请号：US14348997
申请日：2011-10-04
申请人： Sophia Karagiannis , Andrew Beavil , Frank Nestle
发明人： Sophia Karagiannis , Andrew Beavil , Frank Nestle
IPC分类号： C07K16/30 , A61K47/48
CPC分类号： C07K16/3053 , A61K47/6865 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/732
摘要： In one aspect, there is provided an antibody or a functional fragment thereof, wherein the antibody or functional fragment thereof is capable of binding specifically to high molecular weight melanoma associated antigen (HMW-MAA), and binding to an Fcε receptor.
摘要翻译：一方面，提供了一种抗体或其功能片段，其中所述抗体或其功能片段能够特异性结合高分子量黑素瘤相关抗原（HMW-MAA），并且与FcγR结合。受体。

87. 发明申请

US20140018256A1 METHOD OF DIAGNOSING AUTISM SPECTRUM DISORDER 审中-公开
标题翻译：诊断光谱异常的方法
公开(公告)号：US20140018256A1
公开(公告)日：2014-01-16
申请号：US13981244
申请日：2012-01-23
申请人： Patrick Johnston , David Hardoon , Declan Murphy , John Powell , Christine Ecker
发明人： Patrick Johnston , David Hardoon , Declan Murphy , John Powell , Christine Ecker
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16
摘要： The present invention provides a method for diagnosing an autism spectrum disorder (ASD), or predisposition to develop an ASD, in a subject, which comprises the step of investigating a set of single nucleotide polymorphisms (SNPs) in a sample from the subject, wherein the number of SNPs in the set is such that the method can diagnose ASD with at least 70% accuracy. The invention also provides a kit for diagnosing an ASD, or predisposition to develop an ASD, in a subject, which comprises a plurality of primer pairs or probes capable of investigating such a set of SNPs in a sample from a subject, and a method for making such a kit.
摘要翻译：本发明提供一种用于诊断受试者中的自闭症谱系障碍（ASD）或开发ASD的倾向性的方法，其包括研究来自受试者的样品中的一组单核苷酸多态性（SNP）的步骤，其中组中的SNP数量使得该方法能够以至少70％的准确度来诊断ASD。本发明还提供了一种用于诊断受试者的ASD或ASD发病倾向的试剂盒，其包含能够研究来自受试者的样品中的这样一组SNP的多个引物对或探针，以及用于制作这样一个工具包。

88. 外观设计

USD685529S1 Mouthpiece 有权
公开(公告)号：USD685529S1
公开(公告)日：2013-07-02
申请号：US29426110
申请日：2012-06-29
申请人： Garrit Koller , Richard Cook , Timothy Watson
设计人： Garrit Koller , Richard Cook , Timothy Watson

89. 发明申请

US20130017562A1 Assay for Vascular Calcification 有权
标题翻译：测定血管钙化
公开(公告)号：US20130017562A1
公开(公告)日：2013-01-17
申请号：US13577978
申请日：2011-02-11
申请人： Catherine M. Shanahan , Alexander N. Kapustin
发明人： Catherine M. Shanahan , Alexander N. Kapustin
IPC分类号： G01N33/84 , G01N21/25 , G01N33/566 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/323
摘要： An assay for identifying an individual having or at risk of developing vascular calcification, said assay comprising obtaining a blood sample from an individual and measuring the level of a vesicular compound in a matrix vesicle present in the blood sample from said individual; wherein an increased level of said compound indicates an individual at risk of developing vascular calcification.
摘要翻译：用于鉴定具有或有发生血管钙化风险的个体的测定法，所述测定法包括从个体获得血液样品并测量来自所述个体的血液样品中存在的基质囊泡中的囊泡化合物的水平; 其中所述化合物的水平升高表示存在发生血管钙化风险的个体。

90. 发明申请

US20120269736A1 MICELLAR COMPOSITIONS FOR USE IN BIOLOGICAL APPLICATIONS 有权
标题翻译：用于生物应用的MICELLAR组合物
公开(公告)号：US20120269736A1
公开(公告)日：2012-10-25
申请号：US13499098
申请日：2010-09-28
申请人： Mark Green , Philip Howes
发明人： Mark Green , Philip Howes
IPC分类号： A61K49/12 , G01N21/64 , G01N24/00 , B82Y5/00
CPC分类号： G01N33/586 , A61K49/0002 , A61K49/0019 , A61K49/0054 , A61K49/0082 , A61K49/1806 , A61K49/1818 , B82Y5/00
摘要： This invention relates to a composition comprising a micelle for use in biological applications, the micelle comprising: a substantially water-insoluble conjugated polymer which exhibits luminescence or fluorescence from about 300 nm to about 1500 nm of the electromagnetic spectrum: a biocompatible surfactant and/or lipid: and a MRI active agent.
摘要翻译：本发明涉及一种包含用于生物应用的胶束的组合物，所述胶束包括：基本上不溶于水的共轭聚合物，其表现出约300nm至约1500nm的电磁光谱的发光或荧光：生物相容性表面活性剂和/或脂质和MRI活性剂。

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