专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US09034877B2 Bifunctional/polyfunctional dopamine D2/D3 agonist as neuroprotective agents for treatment of neurodegenerative diseases 有权
标题翻译：双功能/多官能多巴胺D2 / D3激动剂作为治疗神经变性疾病的神经保护剂
公开(公告)号：US09034877B2
公开(公告)日：2015-05-19
申请号：US13264505
申请日：2010-04-21
申请人： Aloke K. Dutta
发明人： Aloke K. Dutta
IPC分类号： C07D215/26 , C07D215/20 , C07D215/22 , C07D215/227 , C07D215/233 , C07D417/12 , A61K31/50 , C07D209/08 , C07D215/38 , C07D215/46 , C07D215/54 , C07D231/56 , C07D277/82 , C07D307/85 , C07D333/70
CPC分类号： A61K31/50 , C07D209/08 , C07D215/26 , C07D215/38 , C07D215/46 , C07D215/54 , C07D231/56 , C07D277/82 , C07D307/85 , C07D333/70 , C07D417/12
摘要： A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an amidate-derived ligand. A process of forming a thin film using the precursors is also provided.
摘要翻译：提供了通过原子层沉积沉积薄膜的前体。化合物具有式MxLy，其中M是金属，L是氨基腙衍生的配体或酰胺化物衍生的配体。还提供了使用前体形成薄膜的工艺。

82. 发明申请

US20150080365A1 HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT 有权
标题翻译：具有循环桥单元的HETEROARYL化合物
公开(公告)号：US20150080365A1
公开(公告)日：2015-03-19
申请号：US14387437
申请日：2013-03-27
申请人： Intervet Inc.
发明人： Michael Berger , Marko Eck , Christopher Kern
IPC分类号： C07D487/08 , C07D401/04 , C07D277/46 , C07D215/38 , C07D271/07 , C07D401/12 , C07D239/42
CPC分类号： C07D487/08 , C07D213/74 , C07D213/82 , C07D213/85 , C07D213/89 , C07D215/38 , C07D239/42 , C07D271/07 , C07D271/113 , C07D277/42 , C07D277/46 , C07D277/56 , C07D401/04 , C07D401/12
摘要： This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.
摘要翻译：本发明涉及用作药物的某些杂芳基化合物，更具体地涉及用于治疗动物的药物。药物可用于治疗蠕虫感染和治疗由蠕虫感染引起的寄生虫病。本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。本发明还涉及包含该化合物的药物组合物和试剂盒。

83. 发明授权

US08975278B2 8-hydroxy quinoline derivatives 有权
公开(公告)号：US08975278B2
公开(公告)日：2015-03-10
申请号：US11901941
申请日：2007-09-19
申请人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Guy Krippner
发明人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Guy Krippner
IPC分类号： A01N43/42 , A61K31/47 , C07D215/00 , C07D215/38 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/26 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
摘要： The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.

84. 发明申请

US20150051245A1 KINASE PROTEIN BINDING INHIBITORS 有权
标题翻译：激酶蛋白结合抑制剂
公开(公告)号：US20150051245A1
公开(公告)日：2015-02-19
申请号：US13261870
申请日：2012-11-13
申请人： ROSWELL PARK CANCER INSTITUTE
发明人： William G. Cance , Ravindra K. Pandey , Elena V. Kurenova , Manivannan Ethirajan
IPC分类号： C07D215/38 , C07D213/74
CPC分类号： C07D215/38 , A61K31/337 , A61K31/4188 , A61K31/513 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K45/06 , C07C211/45 , C07D207/34 , C07D209/40 , C07D213/74 , A61K2300/00
摘要： The invention relates to protein binding inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating cell proliferative disorders, especially cancer.
摘要翻译：本发明涉及蛋白质结合抑制剂化合物及其鉴定和使用方法。本发明还涉及用于治疗细胞增殖性疾病，特别是癌症的药物组合物和方法。

85. 发明授权

US08940764B2 Compositions and methods of treating retinal disease 有权
公开(公告)号：US08940764B2
公开(公告)日：2015-01-27
申请号：US11920866
申请日：2006-05-26
申请人： Thomas A. Jordan , John E. Dowling , John Clifford Chabala
发明人： Thomas A. Jordan , John E. Dowling , John Clifford Chabala
IPC分类号： A61K31/47 , A61K31/425 , A61K31/42 , C07C229/56 , A61K31/41 , A61K31/423 , A61K31/426 , A61K31/435 , A61K31/4706 , C07C215/68 , C07C229/60 , C07D215/38 , C07D277/40 , C07D277/56
CPC分类号： C07D215/38 , A61K31/41 , A61K31/423 , A61K31/426 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/4706 , C07C215/68 , C07C229/56 , C07C229/60 , C07D277/40 , C07D277/56
摘要： Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.

86. 发明申请

US20150025067A1 USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67 (PHOX) 有权
标题翻译：使用小分子抑制剂来预防RAC GTPASE和P67（PHOX）之间的相互作用
公开(公告)号：US20150025067A1
公开(公告)日：2015-01-22
申请号：US14378089
申请日：2013-02-13
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER
发明人： Yi Zheng , Prakash Jagtap , Emily E. Bosco , Jaroslaw Meller , Marie-Dominique Filippi
IPC分类号： C07D491/052 , C07D215/36 , C07D491/048 , C07D401/04 , C07D215/48 , C07D409/04 , C07D215/06 , C07D498/04 , C07D215/38
CPC分类号： C07D498/04 , A61K31/473 , A61K31/4738 , A61K31/5365 , A61K31/5377 , C07D215/06 , C07D215/36 , C07D215/38 , C07D215/48 , C07D221/12 , C07D221/16 , C07D401/04 , C07D409/04 , C07D491/04 , C07D491/048 , C07D491/052
摘要： Inhibitors of p67phox protein are provided herein, as well as pharmaceutical compositions and methods relating thereto.
摘要翻译：本文提供了p67phox蛋白的抑制剂，以及与之有关的药物组合物和方法。

87. 发明授权

US08921392B2 6-aminoisoquinoline compounds 有权
标题翻译： 6-氨基异喹啉化合物
公开(公告)号：US08921392B2
公开(公告)日：2014-12-30
申请号：US13723811
申请日：2012-12-21
申请人： Aerie Pharmaceuticals, Inc.
发明人： Mitchell A. deLong , Susan M. Royalty , Jill Marie Sturdivant , Geoffrey Richard Heintzelman
IPC分类号： C07D217/02 , A61K31/472 , C07D215/38
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译：提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。

88. 发明授权

US08889872B2 Bisazole-based compound and group VIII transition metal complex 有权
标题翻译：基于双唑的化合物和第VIII族过渡金属络合物
公开(公告)号：US08889872B2
公开(公告)日：2014-11-18
申请号：US13668025
申请日：2012-11-02
申请人： Yun Chi , Hsiu-Hsuan Yeh , Shu-Te Ho , Shih-Han Chang
发明人： Yun Chi , Hsiu-Hsuan Yeh , Shu-Te Ho , Shih-Han Chang
IPC分类号： C07D215/38
CPC分类号： C07D231/12 , C07D249/08 , C07D409/14 , C07F15/0026 , C07F15/0053
摘要： A bisazole-based compound is represented by formula (I): wherein X represents C—R3 or nitrogen, R1 and R2 independently represent a haloalkyl group, R3 represents H or F. A transition metal complex is represented by formula (II): ML1L2L3 (II) wherein M is a transition metal, L1 represents in which X represents C—R31 or nitrogen, R11 and R21 independently represent a haloalkyl group, and R31 represents H or F; and L2 and L3 independently represent a dipyridine-based ligand.
摘要翻译：由式（I）表示的基于双唑的化合物：其中X表示C-R3或氮，R1和R2分别表示卤代烷基，R3表示H或F.过渡金属配合物由式（II）表示：ML1L2L3 （II）其中M是过渡金属，L1表示其中X表示C-R31或氮，R11和R21独立地表示卤代烷基，R31表示H或F; L2和L3独立地表示基于二吡啶的配体。

89. 发明授权

US08871937B2 8-hydroxy-quinoline derivatives 有权
标题翻译： 8-羟基 - 喹啉衍生物
公开(公告)号：US08871937B2
公开(公告)日：2014-10-28
申请号：US13696541
申请日：2011-05-06
申请人： Laszlo Puskas , Csaba Szabo , Ivan Kanizsai , Mario Gyuris , Ramona Madacsi , Bela Ozsvari , Liliana Feher , Gabor Tamas
发明人： Laszlo Puskas , Csaba Szabo , Ivan Kanizsai , Mario Gyuris , Ramona Madacsi , Bela Ozsvari , Liliana Feher , Gabor Tamas
IPC分类号： C07D215/38 , C07D401/10 , C07D401/06 , C07D401/14 , C07D413/12 , C07D401/12 , C07D215/26
CPC分类号： C07D413/12 , C07D215/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14
摘要： The invention relates to compounds of the general formula (I) and their pharmaceutically acceptable salts (in which formula R1 represents a hydrogen atom, lower alkyl group, lower alkenyl group, lower cycloalkyl group, aryl group, aralkyl group or heterocyclic group, wherein, the above groups are optionally substituted in ortho, meta and/or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R2 represents a hydrogen atom, lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted with one or more halogen atoms; R3 represents a lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted in ortho, meta or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R4 represents a hydrogen atom, lower alkyl group or any acidic functional group; n is 1 or 2). The compounds according to the invention can be used in the medicine mainly for the treatment of diseases associated with neurological and/or oxidative stress.
摘要翻译：本发明涉及通式（I）的化合物及其药学上可接受的盐（式中R1表示氢原子，低级烷基，低级烯基，低级环烷基，芳基，芳烷基或杂环基，其中，上述基团任选在邻位，间位和/或对位用1,2,3或4个吸电子基团或给电子基团取代; R 2表示氢原子，低级烷基，芳基，芳烷基或杂环基，其中上述基团任选被一个或多个卤素原子取代; R 3表示低级烷基，芳基，芳烷基或杂环基，其中上述基团在邻位，间位或对位任选被取代1,2,3或4 吸电子基团或给电子基团; R 4表示氢原子，低级烷基或任何酸性官能团; n为1或2）。根据本发明的化合物可用于药物中，主要用于治疗与神经和/或氧化应激有关的疾病。

90. 发明申请

US20140309257A1 TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译： TOPOISOMERASE抑制剂及其制备方法和用作治疗药物
公开(公告)号：US20140309257A1
公开(公告)日：2014-10-16
申请号：US14357249
申请日：2012-11-13
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate
发明人： Daniel V. Labarbera
IPC分类号： C07D401/12 , C07D215/44 , A61K31/4706 , A61N5/10 , C07D215/48 , A61K31/47 , C07D215/38 , A61K45/06 , A61K31/475
CPC分类号： C07D401/12 , A61K31/47 , A61K31/4706 , A61K31/475 , A61K45/06 , A61N5/10 , C07D215/38 , C07D215/44 , C07D215/48 , C07D471/04 , C07D471/16
摘要： The invention provides methods of inhibiting the growth or metastasis of cancer in a mammal by inhibiting TopoIIa in the mammal. The invention also provides small molecule inhibitors of TopoIIa useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds and methods of using the same.
摘要翻译：本发明提供通过抑制哺乳动物中的TopoIIa来抑制哺乳动物癌症生长或转移的方法。本发明还提供了可用于本发明方法的TopoIIa的小分子抑制剂和含有治疗有效化合物的药物组合物及其使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式