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81. 发明申请

US20230138619A1 GAME PRACTICING APPARATUS AND SYSTEM 有权
公开(公告)号：US20230138619A1
公开(公告)日：2023-05-04
申请号：US17515604
申请日：2021-11-01
申请人： Bolt Sports Co LLC
发明人： Eric Eustace , Benjamin Dolgin-Gardner
IPC分类号： A63B71/06 , A63B69/00 , A63B63/00
摘要： A game practicing system for practicing a game involving propelling a playing piece into a goal of a goal post, by a player, includes one or more game practicing apparatus, and a user interactive device. The game practicing apparatus includes a target member having a target face, a target indicative lighting, and a vibration sensor. The target indicative lighting is configured to be illuminated to indicate the player to propel the playing piece on the target face. The vibration sensor to detect if the playing piece hits the target face. The user interactive device is wirelessly coupled to the practicing apparatus to: illuminate the target indicative lighting of game practicing apparatus to indicate the player to propel the playing piece on the target face; and detect if the playing piece hits the target face of the illuminated target indicative lighting.

82. 发明申请

US20230138583A1 SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS 有权
公开(公告)号：US20230138583A1
公开(公告)日：2023-05-04
申请号：US17841938
申请日：2022-06-16
申请人： Ohio State Innovation Foundation , North Carolina State University
发明人： John Gunn , Laura Kuo , Christian Melander , William M. Huggins
IPC分类号： A61K31/4184
摘要： In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

83. 发明申请

US20230138576A1 USE OF DIHYDROBERBERINE OR ITS DERIVATIVES TO ENHANCE MUSCLE FUNCTION 有权
公开(公告)号：US20230138576A1
公开(公告)日：2023-05-04
申请号：US17976066
申请日：2022-10-28
申请人： NANJING NUTRABUILDING BIO-TECH CO., LTD.
发明人： Mingru WANG , Ronghua YI , Shawn WELLS , Kylin LIAO
IPC分类号： A61K31/4375 , A61P21/00
摘要： The present invention provides novel methods for enhancing muscle function in a mammal, the method includes administration to the mammal of a composition comprising therapeutically effective amount of dihydroberberine (DHB) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. The present invention also provides a composition including therapeutically effective amount of dihydroberberine (DHB) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for enhancing muscle function. In addition, the present invention provides methods for preparing any compositions disclosed herein.

84. 发明申请

US20230138572A1 METHOD FOR DETERMINING THE LIKELIHOOD THAT A SUBJECT HAS OR WILL DEVELOP CANCER 有权
公开(公告)号：US20230138572A1
公开(公告)日：2023-05-04
申请号：US17822720
申请日：2022-08-26
申请人： GMDX CO PTY LTD
发明人： Robyn Alice Lindley
IPC分类号： C12Q1/6886 , A61N5/10
摘要： A method determines the likelihood that a subject has or will develop cancer. The method is based on identifying whether targeted somatic mutagenesis of a nucleic acid molecule by a mutagenic agent has occurred. The mutations are at one or more motifs recognized or targeted by the mutagenic agent such as AID, an APOBEC cytidine deaminase or aflatoxin, The nucleic acid molecule includes the whole exome. The cancer can be any of breast, prostate, liver, colon, pancreatic, skin, cervical, lymphoid, hematopoietic and ovarian cancer; and the biological sample comprises, respectively, breast, prostate, liver, colon, pancreatic, skin, cervical, lymphoid, hematopoietic or ovarian tissue or cells.

85. 发明申请

US20230138559A1 MULTIFUNCTIONAL SURGICAL INSTRUMENT 有权
公开(公告)号：US20230138559A1
公开(公告)日：2023-05-04
申请号：US17925292
申请日：2021-05-12
申请人： Christos Panotopoulos
发明人： Christos Panotopoulos
IPC分类号： A61B18/14
摘要： A multifunctional surgical instrument (1) is provided. The multifunctional surgical instrument (1) comprises a proximal portion (13) and two legs (14), each leg comprising a distal end (11, 12), wherein a default position of the multifunctional surgical instrument is an open position, wherein the distal ends (11, 12) of the legs (14) do not meet in the open position, characterized in that each leg (14) comprises an aspiration half-channel (26, 27), the proximal portion (13) comprises an aspiration connection (29) and at least one of the distal ends (11, 12) comprises at least one aspiration orifice (28), wherein the two half-channels (26, 27) are configured to form an air-tight and water-tight continuous channel (25) connecting the at least one aspiration orifice (28) to the aspiration connection (29) when the multifunctional surgical instrument is in a fully closed position and are configured to open the aspiration channel (25) when the multifunctional surgical instrument is not in the fully closed position.

86. 发明申请

US20230138533A1 INFORMATION PROCESSING APPARATUS AND GAME IMAGE DISTRIBUTING METHOD 有权
公开(公告)号：US20230138533A1
公开(公告)日：2023-05-04
申请号：US17911767
申请日：2021-03-19
申请人： Sony Interactive Entertainment Inc.
发明人： Masahiro Fujihara
IPC分类号： A63F13/53 , A63F13/213 , A63F13/87
摘要： A message generation unit generates a notification message. A setting unit registers setting information determining whether or not a camera image is to be included in a distribution image. A distribution processing unit distributes a distribution image. When the camera image is set to be included in the distribution image, an image processing unit generates the distribution image including a region in which the notification message is superimposed. When the camera image is set not to be included in the distribution image, the image processing unit generates the distribution image not including the region in which the notification message is superimposed.

87. 发明申请

US20230138532A1 DEVICE FOR IMPROVING CARDIAC FUNCTION 有权
公开(公告)号：US20230138532A1
公开(公告)日：2023-05-04
申请号：US18089497
申请日：2022-12-27
申请人： Cardiac Success Ltd.
发明人： David Neustadter
IPC分类号： A61F2/24 , A61M25/10 , A61M25/09
摘要： The present disclosure provides methods of improving cardiac function, including transcutaneously inserting at least one catheter into a heart, delivering a band to a ventricle of the heart via the at least one catheter, guiding the band through a plurality of spaces among a trabeculae in the ventricle, tightening the band in a single loop, locking the band in a loop, and removing the at least one catheter from the heart.

88. 发明申请

US20230138531A1 SYSTEM AND APPARATUS FOR INTELLIGENT VAPORIZER 有权
公开(公告)号：US20230138531A1
公开(公告)日：2023-05-04
申请号：US17515559
申请日：2021-11-01
申请人： Patrick Tidalgo
发明人： Patrick Tidalgo
IPC分类号： A24F40/53 , A24F40/42 , A24F40/10 , A24F40/51 , A24F40/57 , A24F40/65 , A61M11/04 , G05B15/02
摘要： An intelligent vaporizing system includes a vaporizing device having a cartridge detachably coupled with a main body, the cartridge includes: a container configured to receive a liquid; a sensor for detecting a user’s action of inhalation; and a memory chip embedded inside the cartridge and communicated with the sensor, the memory chip configured to: record collected data from the sensor; receive associated data from an application; and transfer the collected data to the application; wherein the main body includes a heating element configured to heat the liquid to form a vaporized form; and a controller configured to receive the collected data and activate the heating element for heating the liquid.

89. 发明申请

US20230138509A1 GLOVE HAVING DETECTABLE MARKS 有权
公开(公告)号：US20230138509A1
公开(公告)日：2023-05-04
申请号：US17696106
申请日：2022-03-16
申请人： Acushnet Company
发明人： Donald F. Zabkar, JR.
IPC分类号： A41D19/00
摘要： Gloves including one or more layers having at least one radar detectable mark formed of radar detectable material and/or an infrared detectable mark formed of infrared absorbing ink disposed on the surface thereof are provided.

90. 发明申请

US20230138507A1 ALPHA-2A ADRENERGIC RECEPTOR (ADRA2A) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF 有权
公开(公告)号：US20230138507A1
公开(公告)日：2023-05-04
申请号：US17907741
申请日：2021-04-01
申请人： ALNYLAM PHARMACEUTICALS, INC.
发明人： BRET L. BOSTWICK , JAMES D. MCININCH , ADAM CASTORENO
IPC分类号： C12N15/113 , A61K47/54
摘要： The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an alpha-2A adrenergic receptor (ADRA2A) gene, as well as methods of inhibiting expression of an ADRA2A gene and methods of treating subjects having an ADRA2A-associated disease or disorder, e.g., a primary tauopathy or Alzheimer's disease, using such dsRNAi agents and compositions.

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