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1. 发明授权

US08535294B2 Carotid sheath with flexible distal section 有权
标题翻译：颈动脉鞘与柔性远端部分
公开(公告)号：US08535294B2
公开(公告)日：2013-09-17
申请号：US13150308
申请日：2011-06-01
申请人： Robert E. Fischell , Timothy J. Lynch , Tim A. Fischell
发明人： Robert E. Fischell , Timothy J. Lynch , Tim A. Fischell
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/0045 , A61M25/005
摘要： The present invention is a carotid sheath that has a proximal portion that is stiffer than the distal portion of the sheath as a result of the proximal portion having a higher durometer of the outer plastic coating of the sheath's proximal portion with a lower durometer for the plastic coating on the more flexible distal portion of the sheath. Another means to increase the flexibility of the sheath's distal portion compared to a stiffer proximal portion is by having a slightly smaller outside diameter for the outer plastic coating of the distal portion of the sheath. A more flexible distal portion of the sheath allows easier access for angiography, angioplasty or stenting when the sheath is used to access the tortuous path encountered when entering the carotid arteries.
摘要翻译：本发明是一种颈动脉鞘，其具有比鞘的远端部更硬的近端部分，因为近端部分具有较高硬度的护套近端部分的塑料涂层，其中较低的硬度计用于塑料涂覆在护套的更柔性的远端部分上。与较硬的近端部分相比，增加护套远端部分的灵活性的另一种手段是通过对鞘的远侧部分的外部塑料涂层具有略小的外径。当护套用于进入进入颈动脉期间遇到的曲折路径时，鞘的更柔性的远侧部分允许更容易地进行血管造影，血管成形术或支架置入。

2. 发明申请

US20130079746A1 INTRODUCER SHEATH WITH THIN-WALLED SHAFT 有权
标题翻译：介绍带有薄壁轴的井
公开(公告)号：US20130079746A1
公开(公告)日：2013-03-28
申请号：US13431526
申请日：2012-03-27
申请人： Robert E. Fischell , Tim A. Fischell , David R. Fischell
发明人： Robert E. Fischell , Tim A. Fischell , David R. Fischell
IPC分类号： A61M25/01 , B21C37/04 , A61M25/00
CPC分类号： A61M25/01 , A61M25/0012 , A61M25/005 , A61M25/0108 , A61M25/02 , A61M25/0662 , A61M39/0606 , A61M2025/0266 , A61M2025/028 , A61M2025/0286 , B21C37/042
摘要： A thin-walled introducer sheath is described. In some embodiments, the introducer sheath includes structural support components, such as wires, used in connection with a polymeric inner coating, a polymeric outer coating, or both. Further, in some embodiments, the wire components are annealed to reduce cold-work-related stresses and hardness. Use of annealed components may enable a reduction in the thickness of the polymeric outer coating in some applications.
摘要翻译：描述了薄壁导引鞘。在一些实施例中，引入器护套包括与聚合物内涂层，聚合物外涂层或两者结合使用的结构支撑部件，例如导线。此外，在一些实施例中，将线材部件退火以减少与冷加工有关的应力和硬度。在一些应用中，退火组分的使用可以使聚合物外涂层的厚度减小。

3. 发明授权

US09119935B2 Carotid sheath with entry and tracking rapid exchange dilators and method of use 有权
标题翻译：颈动脉鞘与进入和跟踪快速交换扩张器及使用方法
公开(公告)号：US09119935B2
公开(公告)日：2015-09-01
申请号：US14297903
申请日：2014-06-06
申请人： Fischell Innovations, LLC
发明人： Robert E. Fischell , Tim A. Fischell
IPC分类号： A61M29/00 , A61M25/01 , A61M25/06
CPC分类号： A61M29/00 , A61M25/0662 , A61M2025/0183 , A61M2025/0188 , A61M2025/0681
摘要： Dilators and sheaths for use in minimally invasive vascular therapy are disclosed. In some embodiments, the dilators include a slot that accesses a guidewire lumen within the dilator. These slots facilitate rapid exchange of one dilator for another. In another embodiment, a dilator is sufficiently stiff to facilitate entry, but also designed to facilitate placement of the dilator along a tortuous path.
摘要翻译：公开了用于微创血管治疗的扩张器和护套。在一些实施例中，扩张器包括进入扩张器内的导丝管腔的狭槽。这些插槽可以方便快速更换一个扩张器。在另一个实施例中，扩张器足够坚硬以便于进入，而且还设计成便于扩张器沿曲折路径放置。

4. 发明授权

US08591495B2 Introducer sheath with thin-walled shaft 有权
标题翻译：导管护套带薄壁轴
公开(公告)号：US08591495B2
公开(公告)日：2013-11-26
申请号：US13431526
申请日：2012-03-27
申请人： Robert E. Fischell , Tim A. Fischell , David R. Fischell
发明人： Robert E. Fischell , Tim A. Fischell , David R. Fischell
IPC分类号： A61M25/00
CPC分类号： A61M25/01 , A61M25/0012 , A61M25/005 , A61M25/0108 , A61M25/02 , A61M25/0662 , A61M39/0606 , A61M2025/0266 , A61M2025/028 , A61M2025/0286 , B21C37/042
摘要： A thin-walled introducer sheath is described. In some embodiments, the introducer sheath includes structural support components, such as wires, used in connection with a polymeric inner coating, a polymeric outer coating, or both. Further, in some embodiments, the wire components are annealed to reduce cold-work-related stresses and hardness. Use of annealed components may enable a reduction in the thickness of the polymeric outer coating in some applications.
摘要翻译：描述了薄壁导引鞘。在一些实施例中，引入器护套包括与聚合物内涂层，聚合物外涂层或两者结合使用的结构支撑部件，例如导线。此外，在一些实施例中，将线材部件退火以减少与冷加工有关的应力和硬度。在一些应用中，退火组分的使用可以使聚合物外涂层的厚度减小。

5. 发明申请

US20120271301A1 EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权
标题翻译：膀胱注射和肌肉和神经纤维的放大导管系统
公开(公告)号：US20120271301A1
公开(公告)日：2012-10-25
申请号：US13092363
申请日：2011-04-22
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00375 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/143 , A61M5/00
摘要： At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.
摘要翻译：目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。这些系统是昂贵的并且花费耗时的使用。本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的资本设备。针的膨胀通过自膨胀或球囊可膨胀结构来实现。本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。还包括限制针头进入左心房壁的距离的成员。本发明还可用于消除肾动脉口周围的组织用于治疗高血压。

6. 发明申请

US20120271277A1 EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权
标题翻译：膀胱注射和肌肉和神经纤维的放大导管系统
公开(公告)号：US20120271277A1
公开(公告)日：2012-10-25
申请号：US13196104
申请日：2011-08-02
申请人： DAVID R. FISCHELL , TIM A. FISCHELL
发明人： DAVID R. FISCHELL , TIM A. FISCHELL
IPC分类号： A61M29/00
CPC分类号： A61B18/06 , A61B5/042 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/22038 , A61B2017/22068 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00375 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00839 , A61B2018/143 , A61B2018/1475 , A61B2090/3966 , A61M2025/0087
摘要： At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.
摘要翻译：目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。这些系统是昂贵的并且花费耗时的使用。本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的资本设备。针的膨胀通过自膨胀或球囊可膨胀结构来实现。本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。还包括限制针穿入左心房壁或主动脉壁的距离的构件。本发明还具有重要的应用，用于消除一个或两个肾动脉周围的组织，用于消除去往或来自每个肾脏的交感神经纤维和/或其他传入或传出神经以治疗高血压。

7. 发明授权

US08747428B2 Carotid sheath with entry and tracking rapid exchange dilators and method of use 有权
标题翻译：颈动脉鞘与进入和跟踪快速交换扩张器及使用方法
公开(公告)号：US08747428B2
公开(公告)日：2014-06-10
申请号：US13349060
申请日：2012-01-12
申请人： Robert E. Fischell , Tim E. Fischell
发明人： Robert E. Fischell , Tim E. Fischell
IPC分类号： A61M29/00
CPC分类号： A61M29/00 , A61M25/0662 , A61M2025/0183 , A61M2025/0188 , A61M2025/0681
摘要： Dilators and sheaths for use in minimally invasive vascular therapy are disclosed. In some embodiments, the dilators include a slot that accesses a guidewire lumen within the dilator. These slots facilitate rapid exchange of one dilator for another. In another embodiment, a dilator is sufficiently stiff to facilitate entry, but also designed to facilitate placement of the dilator along a tortuous path.
摘要翻译：公开了用于微创血管治疗的扩张器和护套。在一些实施例中，扩张器包括进入扩张器内的导丝管腔的槽。这些插槽可以方便快速更换一个扩张器。在另一个实施例中，扩张器足够坚硬以便于进入，而且还设计成便于扩张器沿曲折路径放置。

8. 发明授权

US08348925B2 Introducer sheath with thin-walled shaft and improved means for attachment to the skin 有权
标题翻译：引导器鞘与薄壁轴和改进的附着到皮肤的手段
公开(公告)号：US08348925B2
公开(公告)日：2013-01-08
申请号：US13032876
申请日：2011-02-23
申请人： Robert E. Fischell , Tim A. Fischell , David R. Fischell , Scott J. S. Fischell
发明人： Robert E. Fischell , Tim A. Fischell , David R. Fischell , Scott J. S. Fischell
IPC分类号： A61M25/00
CPC分类号： A61M25/0662 , A61M5/1418 , A61M25/005 , A61M25/0108 , A61M25/02 , A61M2025/0266 , A61M2025/028 , A61M2025/0286 , A61M2209/088
摘要： An introducer sheath for placement into the vascular system of a human subject. The introducer sheath has a tubular shaft, a side arm, and a hemostasis valve with an integrated attachment mechanism for attaching and detaching a proximal end of the introducer sheath to and from the skin of the human subject.
摘要翻译：用于放置在人类受试者的血管系统中的导引鞘。引导器护套具有管状轴，侧臂和具有集成附接机构的止血阀，用于将引导器护套的近端附接到人类受试者的皮肤和从皮肤脱离皮肤。

9. 发明申请

US20120310212A1 CAROTID SHEATH WITH FLEXIBLE DISTAL SECTION 有权
标题翻译： CAROTID SHEATH与柔性的远程部分
公开(公告)号：US20120310212A1
公开(公告)日：2012-12-06
申请号：US13150308
申请日：2011-06-01
申请人： ROBERT E. FISCHELL , TIMOTHY J. LYNCH , TIM A. FISCHELL
发明人： ROBERT E. FISCHELL , TIMOTHY J. LYNCH , TIM A. FISCHELL
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/0045 , A61M25/005
摘要： The present invention is a carotid sheath that has a proximal portion that is stiffer than the distal portion of the sheath as a result of the proximal portion having a higher durometer of the outer plastic coating of the sheath's proximal portion with a lower durometer for the plastic coating on the more flexible distal portion of the sheath. Another means to increase the flexibility of the sheath's distal portion compared to a stiffer proximal portion is by having a slightly smaller outside diameter for the outer plastic coating of the distal portion of the sheath. A more flexible distal portion of the sheath allows easier access for angiography, angioplasty or stenting when the sheath is used to access the tortuous path encountered when entering the carotid arteries.
摘要翻译：本发明是一种颈动脉鞘，其具有比鞘的远端部更硬的近端部分，因为近端部分具有较高硬度的护套近端部分的塑料涂层，其中较低的硬度计用于塑料涂覆在护套的更柔性的远端部分上。与较硬的近端部分相比，增加护套远端部分的灵活性的另一种手段是通过对鞘的远侧部分的外部塑料涂层具有略小的外径。当护套用于进入进入颈动脉期间遇到的曲折路径时，鞘的更柔性的远侧部分允许更容易地进行血管造影，血管成形术或支架置入。

10. 发明授权

US08262625B1 Introducer sheath having a hemostasis valve with an adhesive means for attachment to the skin 有权
标题翻译：引导器护套具有止血阀，其具有用于附接到皮肤的粘合装置
公开(公告)号：US08262625B1
公开(公告)日：2012-09-11
申请号：US13105043
申请日：2011-05-11
申请人： Robert E. Fischell , Scott J. S. Fischell
发明人： Robert E. Fischell , Scott J. S. Fischell
IPC分类号： A61M5/32 , A61M5/178
CPC分类号： A61M25/0662 , A61M25/0097 , A61M25/02 , A61M2025/0266 , A61M2025/028
摘要： An introducer sheath for placement of a tubular shaft into the vascular system of a human subject. The introducer sheath has a tubular shaft, a side arm, and a hemostasis valve placed at a proximal portion of the introducer sheath. The hemostasis valve has an adhesive pad formed integral with the shell of the hemostasis valve. The adhesive pad is designed to attach and detach a proximal section of the introducer sheath to and from the skin of the human subject.
摘要翻译：用于将管状轴放置到人类受试者的血管系统中的导引鞘。引导器鞘具有管状轴，侧臂和放置在导引鞘的近端部分处的止血阀。止血阀具有与止血阀壳体一体形成的粘合垫。粘合垫被设计成将引导器护套的近端部分附着和分离到人类受试者的皮肤上和从皮肤上分离。

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