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1. 发明授权

US11376419B2 Dynamic HQ for closed loop control 有权
公开(公告)号：US11376419B2
公开(公告)日：2022-07-05
申请号：US17017873
申请日：2020-09-11
申请人： HeartWare, Inc.
发明人： Carlos Reyes , Fernando Casas
IPC分类号： A61M60/50 , A61M60/148 , A61M60/419 , A61M60/857
摘要： A method of controlling a blood pump having a predefined hydraulic performance including at least from the group consisting of estimating and measuring an instantaneous flow rate during operation of the blood pump at a predetermined rotational speed of an impeller of the blood pump, the instantaneous flow rate including a plurality of flow rate data points. The plurality of flow rate data points define a trajectory around at least one from the group consisting of an operational point of a predefined pressure-flow curve associated with the predetermined rotational speed of the impeller of the blood pump and a target operational point of a target pressure-flow curve different than the predefined pressure-flow curve. The predetermined rotational speed of the impeller is adjusted until the plurality of flow rate data points define a predetermined trajectory around at least one of the operational point and the target operational point.

2. 发明申请

US20220203083A1 HEART RATE MEASUREMENT USING BLOOD PUMP IMPELLER LOCATION 有权
公开(公告)号：US20220203083A1
公开(公告)日：2022-06-30
申请号：US17654724
申请日：2022-03-14
申请人： HeartWare, Inc.
发明人： Justin Wolman , Fernando Casas , Carlos Reyes
IPC分类号： A61M60/122 , A61M60/50 , A61M60/148 , A61M60/422
摘要： A method of determining a heart rate of a patient having an implanted blood pump including applying a voltage to a plurality of coils of a stator of the blood pump to produce an electromagnetic force to rotate a rotor in communication with the plurality of coils; displaying a waveform associated with a back electromotive force in the plurality of coils of the blood pump, the waveform being proportional to an axial position of the rotor relative to the stator; determining a time interval between a first alteration in the waveform relative to a baseline and a second alteration in the waveform relative to the baseline; and determining the heart rate of the patient based on the time interval.

3. 发明申请

US20220157448A1 DETECTION OF ABNORMAL CHANGES IN FLOW PULSATILITY CLINICALLY CORRELATED WITH ADVERSE EVENTS USING LOGFILE DATA 有权
公开(公告)号：US20220157448A1
公开(公告)日：2022-05-19
申请号：US17097169
申请日：2020-11-13
申请人： HeartWare, Inc.
发明人： Neethu Lekshmi Jalaja Vasudevan
IPC分类号： G16H40/67 , A61M1/12 , A61M1/10 , A61B8/06 , G16H15/00 , G06F17/18
摘要： A method of determining adverse events from log file data from operation of an implantable blood pump. The method includes measuring a flow pulsatility from flow rate data recorded in a log file. A moving mean of the measured flow pulsatility is calculated. A moving standard deviation of the measured flow pulsatility is calculated. A difference between the moving mean of the measured pulsatility and the moving standard deviation of the measured flow pulsatility is calculated. If the difference is less than a first predetermined threshold, an alert is generated as the presence of an adverse event.

4. 发明授权

US11273300B2 Magnetically suspended blood driving piston circulatory assist device 有权
公开(公告)号：US11273300B2
公开(公告)日：2022-03-15
申请号：US16143984
申请日：2018-09-27
申请人： HeartWare, Inc.
发明人： David A. Schafir
IPC分类号： A61M60/148 , A61M60/258 , A61M60/40 , A61M60/50 , A61M60/894 , F04B35/04 , A61M60/562 , A61M60/892
摘要： A pulsatile blood pump including a chamber having an upstream portion, a downstream portion, and a wall coupling the upstream portion to the downstream portion, the upstream portion defining an inlet sized to fit within a ventricle of a heart, the downstream portion defining an outlet, and the wall defining a bore; a piston disposed within the bore of the wall, the piston including a first side in continuous fluid communication with the ventricle of the heart when the inlet is within the ventricle of the heart and defining a travel path within the bore including an upstream direction toward the inlet and a downstream direction toward the outlet; and a valve coupled to the piston and defining a one-way fluid flow path within the chamber through the first side of the piston in the downstream direction.

5. 发明申请

US20220062617A1 DRY DISCONNECT/BUBBLE FREE COUPLING FOR BLOOD TRANSFER 有权
公开(公告)号：US20220062617A1
公开(公告)日：2022-03-03
申请号：US17500032
申请日：2021-10-13
申请人： HeartWare, Inc.
发明人： Stanley P. Mack , Charles R. Shambaugh
IPC分类号： A61M39/26 , A61M1/36 , F16L37/244 , F16L37/36
摘要： A dry disconnect device including a first portion defining an outlet and an outlet portion of a fluid pathway and a female valve disposed within the first portion having an extended position, including the female valve being configured to seal the outlet portion, and a retracted position. A second portion defining an inlet and an inlet portion of the fluid pathway is lockingly engageable with the first portion. A male valve is disposed within the second portion including a male valve transition member configured to translate the male valve from an extended position to a retracted position including the male valve being configured to seal the inlet portion. The extended position of the male valve causes the female valve to transition from the extended position to the retracted position and causes the outlet portion and the inlet portion of the fluid pathway to be in fluid communication with each other.

6. 发明授权

US11154701B2 Heart rate determination based on VAD current waveform 有权
公开(公告)号：US11154701B2
公开(公告)日：2021-10-26
申请号：US16534615
申请日：2019-08-07
申请人： HeartWare, Inc.
发明人： Carlos Reyes , Fernando Casas , Justin Wolman
IPC分类号： A61B5/02 , A61M60/148 , A61B5/024 , A61M60/50 , A61B5/029 , A61M60/40 , A61B5/00
摘要： The present disclosure provides for methods and systems for determining heart rate of a patient. Based on motor current signals of a ventricular assist device (VAD), each of first, second and third events in the measured current signal may be detected, the first event being indicative of a rise or fall in the current signal, the second event being indicative of a rise or fall in the current signal in the opposite direction as the first event, and the third event being indicative of a rise or fall in the current signal in the same direction as the first event. A timer counter may be initiated upon detection of the first event, and an elapsed time may be measured upon detection of the third event. Heart rate may be determined based on the elapsed time of the timer counter.

7. 发明申请

US20210052219A1 PUMP HOMEOSTASIS INDICATOR (PHI) 有权
公开(公告)号：US20210052219A1
公开(公告)日：2021-02-25
申请号：US17089924
申请日：2020-11-05
申请人： HeartWare, Inc.
发明人： Neil VOSKOBOYNIKOV , Veronica RAMOS
IPC分类号： A61B5/00 , A61M1/10 , A61B5/02 , A61B5/024
摘要： A method determining adverse events from operation of an implantable blood pump including calculating a moving average convergence divergence (MACD) based on power consumed by the implantable blood pump to maintain a constant rotational speed of an impeller of the implantable blood pump. An alert is generated when the calculated MACD diverges from a predetermined MACD threshold and a predetermined MACD zero-crossing time threshold.

8. 发明授权

US10881768B2 Drive line infection prevention using a flexible artificial skin ultra violet (UV) light emitter 有权
公开(公告)号：US10881768B2
公开(公告)日：2021-01-05
申请号：US16131340
申请日：2018-09-14
申请人： HeartWare, Inc.
发明人： Fernando Casas
IPC分类号： A61M1/10 , A61M1/12 , A61L2/10 , A61L2/00 , A61L2/26 , A61N5/06 , A61M39/02 , A61M39/16
摘要： A driveline for an implantable blood pump including a percutaneous outer tube configured to connect with the blood pump when the blood pump is implanted within a body of a patient and an external controller outside of the body of the patient and at least one ultra-violet light emitter coupled to the outer tube.

9. 发明授权

US10881767B2 Cannula tip for use with a VAD 有权
公开(公告)号：US10881767B2
公开(公告)日：2021-01-05
申请号：US16129231
申请日：2018-09-12
申请人： HeartWare, Inc.
发明人： Heinrich Schima , Martin Stoiber , Georg Wieselthaler , Zeno Deckert
IPC分类号： A61M1/10 , A61M25/00 , A61M1/36 , A61M1/12
摘要： The present invention includes various embodiments of methods of circulating blood in a mammalian circulatory system, and various blood circulation assemblies adapted to perform such circulation. In one embodiment of the present invention, a blood circulation assembly includes a blood circulation device having an inlet and a discharge; a first cannula including a proximal portion in communication with the inlet, the proximal portion having a wall extending around a first longitudinal axis and having outer and inner faces, said inner face defining a bore, and a distal portion including an outer face tapering distally toward said axis and at least two openings extending from said outer face and merging with one another to form a hollow space within said distal portion, said hollow space communicating with said bore of said proximal portion; and a second cannula including a proximal portion in communication with the discharge, the proximal portion having a wall extending around a first longitudinal axis and having outer and inner faces, said inner face defining a bore, and a distal portion including an outer face tapering distally toward said axis and at least two openings extending from said outer face and merging with one another to form a hollow space within said distal portion, said hollow space communicating with said bore of said proximal portion.

10. 发明授权

US10806839B2 Physiologically responsive VAD for cardiac events 有权
公开(公告)号：US10806839B2
公开(公告)日：2020-10-20
申请号：US15708998
申请日：2017-09-19
申请人： HeartWare, Inc.
发明人： Barry M. Yomtov , Fernando Casas
IPC分类号： A61M1/10 , A61M1/12
摘要： A ventricular assist system including an implantable rotary pump, a pump drive circuit for supplying power to the pump, and a signal processing circuit receiving one or more electrophysiological signals and one or more physiological signals of the subject. The signal processing circuit is operable to receive inputs from the one or more electrophysiological sensors and the physiological sensor, and determine the presence or absence of a non-normal sinus cardiac rhythm condition based on the input from the electrophysiological sensors. In the presence of a non-normal sinus rhythm, the circuit operates the pump in a modified mode of operation. In the absence of a non-normal sinus rhythm, the circuit operates the pump in a normal mode of operation. In either case, the circuit controls the power to the pump and/or speed of the pump based on the input from the physiological sensor and the mode of operation.

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