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1. 发明授权

US10300038B2 Combination comprising N-acetyl-L-cysteine and its use 有权
公开(公告)号：US10300038B2
公开(公告)日：2019-05-28
申请号：US15791290
申请日：2017-10-23
申请人： IASOMAI AB
发明人： Tiziana Parasassi , Graziella Costa , Ewa Krasnowska , Eugenia Pittaluga
IPC分类号： A61K31/198 , A61K45/06 , A61K31/28 , A61K31/4045 , A61K31/573 , A61K8/44 , A61K8/58 , A61Q19/08 , A61K8/23 , A61L29/08 , A61K8/49 , A61K8/63
摘要： A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.

2. 发明申请

US20120238627A1 N-ACETYL-L-CYSTEINE FOR THE TREATMENT OF ENDOMETRIOSIS 有权
标题翻译：用于治疗子宫内膜异位症的N-乙酰-L- CYSTEINE
公开(公告)号：US20120238627A1
公开(公告)日：2012-09-20
申请号：US13428984
申请日：2012-03-23
申请人： Tiziana Parasassi , Maria Grazia Porpora
发明人： Tiziana Parasassi , Maria Grazia Porpora
IPC分类号： A61K31/195 , A61P25/00 , A61P15/00 , C07C321/14
CPC分类号： A61K31/198
摘要： The invention relates to a new prescription of NAC in the treatment of endometriosis and of indications associated with endometriosis, in a human or mammalian animal patient. In addition an effective dose regimen of NAC in the treatment of endometriosis is proposed. In one embodiment of the present invention the prescribed treatment regimen may be used e.g. in order to control the frequency and the intensity of pain symptoms (dysmenorrhea, dyspareunia and acyclic chronic pelvic pain), to reduce the size of endometriotic lesions eventually up to their disappearance, to reduce recurrences after surgery and/or to improve fertility. Side effects of this treatment are virtually absent and, in particular, this treatment does not hinder pregnancy.
摘要翻译：本发明涉及NAC在人或哺乳动物患者中治疗子宫内膜异位症和与子宫内膜异位症有关的适应症的新处方。另外提出了NAC治疗子宫内膜异位症的有效剂量方案。在本发明的一个实施方案中，可以使用规定的治疗方案。为了控制疼痛症状的频率和强度（痛经，性交痛和非循环性慢性盆腔疼痛），最终减少子宫内膜异位病变的大小消失，减少手术后复发和/或改善生育能力。这种治疗的副作用几乎不存在，特别是这种治疗不妨碍怀孕。

3. 发明公开

US20230226009A1 NEW COMBINATION COMPRISING N-ACETYL-L-CYSTEINE AND ITS USE 审中-公开
公开(公告)号：US20230226009A1
公开(公告)日：2023-07-20
申请号：US17940958
申请日：2022-09-08
申请人： IASOMAI AB
发明人： Tiziana Parasassi , Graziella Costa , Ewa Krasnowska , Eugenia Pittaluga , Thomas Lundeberg
IPC分类号： A61K31/28 , A61K31/198 , A61K31/573 , A61K8/44 , A61K8/58 , A61Q19/08 , A61K8/23 , A61K8/49 , A61K8/63 , A61K31/4045 , A61K45/06 , A61L29/08
CPC分类号： A61K31/28 , A61K31/198 , A61K31/573 , A61K8/447 , A61K8/58 , A61Q19/08 , A61K8/23 , A61K8/4913 , A61K8/63 , A61K31/4045 , A61K45/06 , A61L29/08 , Y02A50/30
摘要： A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.

4. 发明授权

US09795582B2 Combination comprising N-acetyl-L-cysteine and its use 有权
公开(公告)号：US09795582B2
公开(公告)日：2017-10-24
申请号：US14042282
申请日：2013-09-30
申请人： IASOMAI AB
发明人： Tiziana Parasassi , Graziella Costa , Ewa Krasnowska , Eugenia Pittaluga
IPC分类号： A61K31/198 , A61K45/06 , A61K31/28 , A61K31/4045 , A61K31/573 , A61K8/44 , A61K8/58 , A61Q19/08 , A61K8/23 , A61L29/08 , A61K8/49 , A61K8/63
CPC分类号： A61K31/28 , A61K8/23 , A61K8/447 , A61K8/4913 , A61K8/58 , A61K8/63 , A61K31/198 , A61K31/4045 , A61K31/573 , A61K45/06 , A61L29/08 , A61Q19/08 , Y02A50/473 , A61K2300/00
摘要： A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.

5. 发明授权

US11207287B2 Combination comprising N-acetyl-L-cysteine and its use 有权
公开(公告)号：US11207287B2
公开(公告)日：2021-12-28
申请号：US16401621
申请日：2019-05-02
申请人： IASOMAI AB
发明人： Tiziana Parasassi , Graziella Costa , Ewa Krasnowska , Eugenia Pittaluga
IPC分类号： A61K31/28 , A61K8/23 , A61K31/4045 , A61K45/06 , A61K31/198 , A61K31/573 , A61K8/44 , A61K8/58 , A61Q19/08 , A61K8/49 , A61K8/63 , A61L29/08
摘要： A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.

6. 发明授权

US09585854B2 N-acetyl-L-cysteine for use in in vitro fertilization 有权
标题翻译： N-乙酰基-L-半胱氨酸用于体外受精
公开(公告)号：US09585854B2
公开(公告)日：2017-03-07
申请号：US14441104
申请日：2013-11-06
申请人： IASOMAI AB
发明人： Thomas Lundeberg , Tiziana Parasassi , Eugenia Pittaluga , Roberto Brunelli
IPC分类号： A61K31/198 , A61K31/4045
CPC分类号： A61K31/198 , A61K31/4045 , A61K2300/00
摘要： The invention relates to a new use of NAC in IVF, in a human or mammalian animal patient. In addition an effective dose regimen of NAC in IVF is proposed.
摘要翻译：本发明涉及NAC在人类或哺乳动物患者体内IVF中的新用途。此外，提出了一种有效的NAC在IVF中的剂量方案。

7. 发明申请

US20220110907A1 COMBINATION COMPRISING N-ACETYL-L-CYSTEINE AND ITS USE 有权
公开(公告)号：US20220110907A1
公开(公告)日：2022-04-14
申请号：US17560902
申请日：2021-12-23
申请人： IASOMAI AB
发明人： Tiziana Parasassi , Graziella Costa , Ewa Krasnowska , Eugenia Pittaluga
IPC分类号： A61K31/28 , A61K8/23 , A61Q19/08 , A61L29/08 , A61K45/06 , A61K31/573 , A61K8/44 , A61K8/49 , A61K8/58 , A61K8/63 , A61K31/198 , A61K31/4045
摘要： A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.

8. 发明申请

US20150283103A1 N-ACETYL-L-CYSTEINE FOR USE IN IN VITRO FERTILIZATION 有权
标题翻译：用于体外培养的N-乙酰基-L- CYSTEINE
公开(公告)号：US20150283103A1
公开(公告)日：2015-10-08
申请号：US14441104
申请日：2013-11-06
申请人： IASOMAI AB
发明人： Thomas Lundeberg , Tiziana Parasassi , Eugenia Pittaluga , Roberto Brunelli
IPC分类号： A61K31/198
CPC分类号： A61K31/198 , A61K31/4045 , A61K2300/00
摘要： The invention relates to a new use of NAC in IVF, in a human or mammalian animal patient. In addition an effective dose regimen of NAC in IVF is proposed.
摘要翻译：本发明涉及NAC在人类或哺乳动物患者体内IVF中的新用途。此外，提出了一种有效的NAC在IVF中的剂量方案。

9. 发明申请

US20140030307A1 NEW COMBINATION COMPRISING N-ACETYL-L-CYSTEINE AND ITS USE 有权
标题翻译：包含N-乙酰-L-青霉素的新组合及其用途
公开(公告)号：US20140030307A1
公开(公告)日：2014-01-30
申请号：US14042282
申请日：2013-09-30
申请人： IASOMAI AB
发明人： Tiziana Parasassi , Graziella Costa , Ewa Krasnowska , Eugenia Pittaluga
IPC分类号： A61K31/4045 , A61K31/28 , A61K45/06 , A61K31/198 , A61L29/08
CPC分类号： A61K31/28 , A61K8/23 , A61K8/447 , A61K8/4913 , A61K8/58 , A61K8/63 , A61K31/198 , A61K31/4045 , A61K31/573 , A61K45/06 , A61L29/08 , A61Q19/08 , Y02A50/473 , A61K2300/00
摘要： A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.
摘要翻译：描述了N-乙酰基-L-半胱氨酸，硒代甲硫氨酸形式的硒和褪黑激素的组合以及可用于治疗各种疾病和病症的包含这种组合的医药产品或药物组合物。 N-乙酰基-L-半胱氨酸，硒代甲硫氨酸形式的硒和褪黑素的组合也可用于皮肤的美容治疗和作为抗菌剂。

10. 发明授权

US08637573B2 N-acetyl-L-cysteine for the treatment of endometriosis 有权
标题翻译： N-乙酰-L-半胱氨酸用于治疗子宫内膜异位症
公开(公告)号：US08637573B2
公开(公告)日：2014-01-28
申请号：US13428984
申请日：2012-03-23
申请人： Tiziana Parasassi , Maria Grazia Porpora
发明人： Tiziana Parasassi , Maria Grazia Porpora
IPC分类号： A61K31/195 , C07C321/00
CPC分类号： A61K31/198
摘要： The invention relates to a new prescription of NAC in the treatment of endometriosis and of indications associated with endometriosis, in a human or mammalian animal patient. In addition an effective dose regimen of NAC in the treatment of endometriosis is proposed. In one embodiment of the present invention the prescribed treatment regimen may be used e.g. in order to control the frequency and the intensity of pain symptoms (dysmenorrhea, dyspareunia and acyclic chronic pelvic pain), to reduce the size of endometriotic lesions eventually up to their disappearance, to reduce recurrences after surgery and/or to improve fertility. Side effects of this treatment are virtually absent and, in particular, this treatment does not hinder pregnancy.
摘要翻译：本发明涉及NAC在人或哺乳动物患者中治疗子宫内膜异位症和与子宫内膜异位症有关的适应症的新处方。另外提出了NAC治疗子宫内膜异位症的有效剂量方案。在本发明的一个实施方案中，可以使用规定的治疗方案。为了控制疼痛症状的频率和强度（痛经，性交痛和非循环性慢性盆腔疼痛），最终减少子宫内膜异位病变的大小消失，减少手术后复发和/或改善生育能力。这种治疗的副作用几乎不存在，特别是这种治疗不妨碍怀孕。

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