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1. 发明申请

US20210348137A1 Microorganisms and Methods for the Fermentation of Cannabinoids 有权
公开(公告)号：US20210348137A1
公开(公告)日：2021-11-11
申请号：US16753983
申请日：2018-10-04
申请人： Intrexon Corporation
发明人： Bela Krisztian Szamecz , Szilvia Varszegi , Attila Nemeth , Lorand Szabo , Abhunav Kumar
IPC分类号： C12N9/10 , C12P7/42 , A61K31/352 , C12N15/81 , C12P17/06
摘要： Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenic acid (CBCA), Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC). Enzymes useful for the synthesis of CBGA and cannabinoids, include but are not limited to acyl activating enzyme (AAE1), polyketide synthase (PKS), olivetolic acid cyclase (OAC), prenyltransferase (PT), THCA synthase (THCAS), CBDA synthase (CBDAS), CBCA synthase (CBCAS), HMG-Co reductase (HMG1), and/or farnesyl pyrophosphate synthetase (ERG20). The microorganisms can also have one or more genes disrupted, such as gene that that controls beta oxidation of long chain fatty acids.

2. 发明授权

US11034940B2 Expression of novel cell tags 有权
公开(公告)号：US11034940B2
公开(公告)日：2021-06-15
申请号：US16001759
申请日：2018-06-06
申请人： Intrexon Corporation
发明人： Rutul Shah , Peter Emtage , Ramya Yarlagadda
IPC分类号： C12N9/12 , A61K39/395 , C07K14/705 , A61K35/17 , C07K14/71 , C07K16/28 , C07K14/725 , A61P35/00 , C07K14/54 , C07K16/32 , A61K39/00
摘要： Disclosed herein are polynucleotides encoding cell tags for use in immunotherapeutic applications, and systems comprising polynucleotide cell tags for regulating the activity of a cell. The compositions, methods and systems described herein provide tools for regulating activity of genetically engineered cells in a subject.

3. 发明授权

US10570158B2 Boron-containing diacylhydrazine compounds 有权
公开(公告)号：US10570158B2
公开(公告)日：2020-02-25
申请号：US15915415
申请日：2018-03-08
申请人： Intrexon Corporation
发明人： Ray A. James , Sheela K. Chellappan , Robert E. Hormann
IPC分类号： A61K31/69 , C07F5/02 , C07D263/06 , A01N37/28 , A01N55/08 , A61K45/06
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

4. 发明授权

US10131916B2 Regulatory element for heterologous protein production in the fruiting body of filamentous fungi 有权
公开(公告)号：US10131916B2
公开(公告)日：2018-11-20
申请号：US14851819
申请日：2015-09-11
申请人： Intrexon Corporation
发明人： Zhixin Shi , Jack Q. Wilkinson , Donald S. Walters , C. Peter Romaine
IPC分类号： C12N15/63 , C12N15/80
摘要： The present invention provides compositions and methods for regulating expression of nucleotide sequences in fungi. Compositions are novel nucleotide sequences for a tissue preferred promoter isolated from the Agaricus bisporus lectin gene. The sequences drive expression preferentially to fruit body tissue. A method for expressing a nucleotide sequence in fungi using the regulatory sequences disclosed herein is provided. The method comprises transforming a fungal cell to comprise a nucleotide sequence operably linked to one or more of the regulatory sequences of the present invention and regenerating a stably transformed fungus from the transformed cell.

5. 发明授权

US09724430B2 Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof 有权
公开(公告)号：US09724430B2
公开(公告)日：2017-08-08
申请号：US14864265
申请日：2015-09-24
申请人： Intrexon Corporation
发明人： Bethany Lynn Merenick , Robert P. Beech , Thomas D. Reed , Anna P. Tretiakova , Richard E. Peterson
IPC分类号： C07H21/04 , C12N15/00 , C12N15/63 , A61K48/00 , A61K31/7088 , C12N15/85 , A01K67/00 , A61K35/12
CPC分类号： A61K48/0066 , A61K31/7088 , A61K35/12 , C12N15/635 , C12N15/85 , C12N2510/02 , C12N2830/002 , C12N2830/15
摘要： The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.

6. 发明授权

US09675642B2 Engineered dendritic cells and uses for the treatment of cancer 有权
公开(公告)号：US09675642B2
公开(公告)日：2017-06-13
申请号：US13737316
申请日：2013-01-09
申请人： Intrexon Corporation , University Of Pittsburgh—Of The Commonwealth System Of Higher Education
发明人： J. Mark Braughler , Prasanna Kumar , Walter J Storkus , Hideho Okada
IPC分类号： A61K48/00 , C07H21/04 , A61K35/15 , A61K31/00 , A61K31/166 , A61K31/4245 , A61K45/06 , C07K14/54 , C12N5/0784 , G01N33/68 , A01K67/00 , A61K38/00
CPC分类号： A61K35/15 , A61K31/00 , A61K31/166 , A61K31/4245 , A61K38/00 , A61K45/06 , C07K14/5434 , C07K2319/715 , C12N5/0639 , C12N2501/23 , C12N2501/24 , C12N2510/00 , C12N2710/10343 , C12N2830/002 , C12N2840/203 , G01N33/6866 , G01N2333/57 , G01N2800/52 , A61K2300/00
摘要： This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL-12) under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals including human.

7. 发明授权

US09617317B2 Endoplasmic reticulum localization signals 有权
公开(公告)号：US09617317B2
公开(公告)日：2017-04-11
申请号：US14850990
申请日：2015-09-11
申请人： Intrexon Corporation
发明人： Thomas D. Reed
IPC分类号： C07K14/47 , A01K67/027 , C12N15/62 , C12N15/85 , C07K2/00
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K2/00 , C07K2319/04 , C12N15/625 , C12N15/8509
摘要： The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form. The localization signals are utilized as research tools or are linked to therapeutics. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to the endoplasmic reticulum of eukaryotic cells. The polypeptides of the invention optionally include linkage to reporters, epitopes and/or other experimental or therapeutic molecules. The invention also encompasses polynucleotides encoding the localization signals and vectors comprising these polynucleotides.

8. 发明申请

US20160257964A1 Novel Substitution Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System 审中-公开
公开(公告)号：US20160257964A1
公开(公告)日：2016-09-08
申请号：US15069057
申请日：2016-03-14
申请人： Intrexon Corporation
发明人： Subba Reddy PALLI , Mohan Basavaraju Kumar , Dean Ervin Cress , Ted Tsutomu Fujimoto
IPC分类号： C12N15/63 , C12N7/00 , C12N15/86
CPC分类号： C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

9. 发明授权

US09402919B2 Vectors conditionally expressing protein 有权
标题翻译：有条件表达蛋白质的载体
公开(公告)号：US09402919B2
公开(公告)日：2016-08-02
申请号：US14001943
申请日：2012-03-02
申请人： Jeremiah F. Roeth , Charles C. Reed , Brandon Cuthbertson , Sunil Chada , William E. Fogler , Fayaz Khazi
发明人： Jeremiah F. Roeth , Charles C. Reed , Brandon Cuthbertson , Sunil Chada , William E. Fogler , Fayaz Khazi
IPC分类号： A61K48/00 , C12N15/86 , C07K14/505 , C07K14/54 , C07K14/56 , C07K14/565 , C07K14/705 , C07K14/47 , C12N15/85
CPC分类号： A61K48/0025 , A61K38/1816 , A61K38/208 , A61K38/212 , A61K48/0066 , A61K48/0075 , C07K14/4713 , C07K14/505 , C07K14/5428 , C07K14/5434 , C07K14/56 , C07K14/565 , C07K14/70567 , C07K2319/70 , C07K2319/715 , C07K2319/81 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2750/14143 , C12N2830/002 , C12N2830/75 , C12N2830/85 , C12N2840/203
摘要： This invention relates to the field of therapeutics. Disclosed are methods of conditionally expressing erythropoietin under the control of an ecdysone receptor-based gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. The methods of the invention cause an in vivo increase in the expression of erythropoietin and an increase in the hematocrit or volume percentage of red blood cells in blood after administration of the ligand.
摘要翻译：本发明涉及治疗领域。公开了在活化配体的存在下在基于蜕皮激素受体的基因表达调节系统的控制下有条件地表达促红细胞生成素的方法和用于动物中的治疗目的的方法。本发明的方法导致体内增加促红细胞生成素的表达，并且在给予配体后血液中红血细胞的血细胞比容或体积百分数增加。

10. 发明授权

US09371517B2 Modified forms of Pseudomonas exotoxin A 有权
标题翻译：假单胞菌外毒素A的修饰形式
公开(公告)号：US09371517B2
公开(公告)日：2016-06-21
申请号：US14561707
申请日：2014-12-05
申请人： Intrexon Corporation
发明人： Timothy David Jones , Francis Joseph Carr
IPC分类号： C12N9/10 , C07K16/28 , C07K14/21 , A61K39/00 , A61K39/02 , A61K38/00
CPC分类号： C12N9/1077 , A61K38/00 , A61K39/00 , A61K39/02 , C07K14/21 , C07K16/2803 , C07K2317/622 , C12Y204/02036
摘要： Pseudomonas exotoxin A or “PE” is a 66 kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as antibodies, to generate therapeutically useful cytotoxin conjugates that selectively target cells of a desired phenotype (such as tumor cells). In the present invention, peptides spanning the sequence of an approximately 38kD form of Pseudomonas exotoxin A protein were analyzed for the presence of immunogenic CD4+ T cell epitopes. Six immunogenic T cell epitopes were identified. Residues were identified within each epitope for introduction of targeted amino acid substitutions to reduce or prevent immunogenic T-cell responses in PE molecules which may be administered to a heterologous host.
摘要翻译：假单胞菌外毒素A或“PE”是由铜绿假单胞菌分泌的66kD，高效的细胞毒性蛋白质。已经将各种形式的PE偶联到其它蛋白质，例如抗体，以产生选择性靶向所需表型细胞（例如肿瘤细胞）的治疗上有用的细胞毒素缀合物。在本发明中，分析跨越约38kD形式的假单胞菌外毒素A蛋白的序列的免疫原性CD4 + T细胞表位的存在。鉴定了6种免疫原性T细胞表位。在每个表位内鉴定出残基，用于引入靶向氨基酸取代，以减少或预防可能施用于异源宿主的PE分子中的免疫原性T细胞应答。

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