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1. 发明授权

US11235055B2 Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides 有权
公开(公告)号：US11235055B2
公开(公告)日：2022-02-01
申请号：US16023871
申请日：2018-06-29
申请人： Los Alamos National Security, LLC , Oxford University Innovation Limited
发明人： Bette T. M. Korber , Tomas Hanke , Andrew McMichael
IPC分类号： A61K39/21 , A61K39/12 , C07K14/16 , C07K14/005
摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.

2. 发明授权

US10946090B2 Consensus/ancestral immunogens 有权
公开(公告)号：US10946090B2
公开(公告)日：2021-03-16
申请号：US15813992
申请日：2017-11-15
申请人： Duke University , The University of Alabama at Birmingham Research Foundation , Los Alamos National Security, LLC
发明人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise L. Monti , Ying Ying Li , Julie Decker , Hua-Xin Liao
IPC分类号： A61K39/21 , C07K14/005 , C07K16/42 , A61K39/12 , A61K39/00
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

3. 发明授权

US10887682B1 Resonance-enhanced compact nonlinear acoustic source of low frequency collimated beam for imaging applications in highly attenuating media 有权
公开(公告)号：US10887682B1
公开(公告)日：2021-01-05
申请号：US15902939
申请日：2018-02-22
申请人： Los Alamos National Security, LLC
发明人： Cristian Pantea , Dipen N. Sinha
IPC分类号： H04R1/28 , H04R3/04
摘要： Acoustic signal sources include acoustic resonators that include acoustic nonlinear materials. Acoustic signals at higher frequencies are mixed in the nonlinear materials to produce a lower frequency acoustic signal. Resonance provides increased efficiency in producing acoustic signals at difference frequencies corresponding to resonance frequencies. Higher frequency acoustic signals used in nonlinear mixing are preferably at frequencies corresponding to resonance frequencies as well.

4. 发明授权

US10883901B1 High efficiency environmental sampling with rapidly cured peelable coatings 有权
公开(公告)号：US10883901B1
公开(公告)日：2021-01-05
申请号：US15785295
申请日：2017-10-16
申请人： Los Alamos National Security, LLC
发明人： Vladimir Henzl , Rollin Lakis , Sylvia Ann Junghans
IPC分类号： G01N1/02 , C08F2/48 , B01J20/291 , G01N21/76 , B01J20/32 , C08L33/08 , B01J20/286
摘要： A rapidly curable liquid gel for collecting an analyte from a sampling surface includes a polymer precursor mixture including a monomer and/or an oligomer; and an additive to enhance extraction of the analyte from the sampling surface. A kit for collecting an analyte from a sampling surface may include the rapidly curable liquid gel and a portable device for rapidly curing the gel. The rapidly curable liquid gel is cured to thereby form a peelable sampling film, and the sampling film is removed from the sampling surface, thereby collecting the analyte. In one embodiment, the rapidly curable liquid gel is UV-curable, the polymer precursor mixture further includes a photoinitiator compound, and the portable device includes a UV light source configured to emit UV light of a wavelength range absorbed by the photoinitiator compound.

5. 发明授权

US10590398B2 Productivity and bioproduct formation in phototropin knock/out mutants in microalgae 有权
公开(公告)号：US10590398B2
公开(公告)日：2020-03-17
申请号：US15831178
申请日：2017-12-04
申请人： NMC, INC. , LOS ALAMOS NATIONAL SECURITY, LLC
发明人： Sangeeta Negi , Richard Thomas Sayre , Shawn Robert Starkenburg
IPC分类号： C12N9/12 , C12P19/04 , C12P23/00 , C12N1/12 , C12P7/64 , C07K14/405 , C12N9/02 , C12N9/22 , C12N15/01 , C12N15/11
摘要： Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 μmol photons m−2 s−1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.

6. 发明授权

US10352907B2 High-temperature, high pressure acoustic resonance cell 有权
公开(公告)号：US10352907B2
公开(公告)日：2019-07-16
申请号：US15039365
申请日：2014-11-26
申请人： Triad National Security, LLC
发明人： Blake T. Sturtevant , Cristian Pantea , Dipen N. Sinha
IPC分类号： G01N29/22 , G01N29/036
摘要： A compact, rugged and portable measurement cell design for the determination of sound speed in fluids at temperatures up to 250° C. and pressures up to 3,000 psi is described. Swept Frequency Acoustic Interferometry measurement for liquid sound speed determinations in liquids up to 250° C. is of both fundamental interest, as in the case of basic equations of state, and applied interest, such as for characterizing geothermal or petroleum down hole environments. Representative sound speeds for water, as a function of temperature and pressure, are in agreement with an internationally accepted standard for the sound speed of water.

7. 发明申请

US20180278641A1 USING NEW EDGES FOR ANOMALY DETECTION IN COMPUTER NETWORKS 审中-公开
公开(公告)号：US20180278641A1
公开(公告)日：2018-09-27
申请号：US16002870
申请日：2018-06-07
申请人： Los Alamos National Security, LLC
发明人： Joshua Charles Neil
IPC分类号： H04L29/06 , G06N7/00
摘要： Creation of new edges in a network may be used as an indication of a potential attack on the network. Historical data of a frequency with which nodes in a network create and receive new edges may be analyzed. Baseline models of behavior among the edges in the network may be established based on the analysis of the historical data. A new edge that deviates from a respective baseline model by more than a predetermined threshold during a time window may be detected. The new edge may be flagged as potentially anomalous when the deviation from the respective baseline model is detected. Probabilities for both new and existing edges may be obtained for all edges in a path or other subgraph. The probabilities may then be combined to obtain a score for the path or other subgraph. A threshold may be obtained by calculating an empirical distribution of the scores under historical conditions.

8. 发明授权

US10076567B2 MPER-liposome conjugates and uses thereof 有权
公开(公告)号：US10076567B2
公开(公告)日：2018-09-18
申请号：US15024600
申请日：2014-09-29
申请人： Duke University , Los Alamos National Security, LLC
发明人： Barton F. Haynes , Bette T. Korber , S. Munir Alam
IPC分类号： A61K39/21 , A61K38/16 , A61K38/21 , A61K9/127 , A61K9/00 , A61K39/12 , A61K47/48 , C07K14/005 , A61K39/39 , C12N7/00 , A61K39/00
CPC分类号： A61K39/21 , A61K9/0019 , A61K9/127 , A61K38/162 , A61K38/212 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K2039/545 , A61K2039/55555 , A61K2039/55572 , A61K2039/575 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , A61K2300/00
摘要： The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.

9. 发明授权

US10015183B1 Using new edges for anomaly detection in computer networks 有权
公开(公告)号：US10015183B1
公开(公告)日：2018-07-03
申请号：US15637475
申请日：2017-06-29
申请人： Los Alamos National Security, LLC
发明人： Joshua Charles Neil
IPC分类号： H04L29/06 , G06N7/00
CPC分类号： H04L63/1425 , G06F21/577 , G06N5/02 , G06N5/022 , G06N5/045 , G06N7/005 , H04L1/002 , H04L63/1408 , H04L63/1416 , H04L63/1433 , H04L2463/144
摘要： Creation of new edges in a network may be used as an indication of a potential attack on the network. Historical data of a frequency with which nodes in a network create and receive new edges may be analyzed. Baseline models of behavior among the edges in the network may be established based on the analysis of the historical data. A new edge that deviates from a respective baseline model by more than a predetermined threshold during a time window may be detected. The new edge may be flagged as potentially anomalous when the deviation from the respective baseline model is detected. Probabilities for both new and existing edges may be obtained for all edges in a path or other subgraph. The probabilities may then be combined to obtain a score for the path or other subgraph. A threshold may be obtained by calculating an empirical distribution of the scores under historical conditions.

10. 发明申请

US20180109544A1 PATH SCANNING FOR THE DETECTION OF ANOMALOUS SUBGRAPHS AND USE OF DNS REQUESTS AND HOST AGENTS FOR ANOMALY/CHANGE DETECTION AND NETWORK SITUATIONAL AWARENESS 审中-公开
公开(公告)号：US20180109544A1
公开(公告)日：2018-04-19
申请号：US15809297
申请日：2017-11-10
申请人： Los Alamos National Security, LLC
发明人： Joshua Charles Neil , Michael Edward Fisk , Alexander William Brugh , Curtis Lee Hash, Jr. , Curtis Byron Storlie , Benjamin Uphoff , Alexander Kent
IPC分类号： H04L29/06 , G06N7/00
CPC分类号： H04L63/1425 , G06F21/577 , G06N5/02 , G06N7/005 , H04L1/002 , H04L63/1408 , H04L63/1416 , H04L63/1433 , H04L2463/144
摘要： A system, apparatus, computer-readable medium, and computer-implemented method are provided for detecting anomalous behavior in a network. Historical parameters of the network are determined in order to determine normal activity levels. A plurality of paths in the network are enumerated as part of a graph representing the network, where each computing system in the network may be a node in the graph and the sequence of connections between two computing systems may be a directed edge in the graph. A statistical model is applied to the plurality of paths in the graph on a sliding window basis to detect anomalous behavior. Data collected by a Unified Host Collection Agent (“UHCA”) may also be used to detect anomalous behavior.

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