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1. 发明授权

US10982206B2 Electroporation-induced electrosensitization 有权
公开(公告)号：US10982206B2
公开(公告)日：2021-04-20
申请号：US15972856
申请日：2018-05-07
申请人： OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
发明人： Olga Pakhomova , Andrei G. Pakhomov
IPC分类号： C12N13/00 , A61N1/32
摘要： Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.

2. 发明授权

US10029093B2 Treatment of biological tissues using subnanosecond electric pulses 有权
公开(公告)号：US10029093B2
公开(公告)日：2018-07-24
申请号：US15151149
申请日：2016-05-10
申请人： OLD DOMINION RESEARCH FOUNDATION
发明人： Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
IPC分类号： A61N1/00 , A61B5/00 , A61N1/36 , A61N1/40
摘要： A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.

3. 发明申请

US20180110978A1 SYNERGISTIC REGULATED CELL DEATH INDUCTION WITH HSP90 INHIBITORS AND NANOSECOND PULSED ELECTRIC FIELDS 审中-公开
公开(公告)号：US20180110978A1
公开(公告)日：2018-04-26
申请号：US15559324
申请日：2016-03-18
申请人： Old Dominion University Research Foundation
发明人： Stephen J. BEEBE , John D. CATRAVAS
IPC分类号： A61N1/36 , A61K31/395 , A61K45/06 , A61P35/00
CPC分类号： A61N1/36002 , A61K31/395 , A61K45/06 , A61N1/0412 , A61N1/327 , A61N1/36014 , A61P35/00
摘要： Methods for treating tumors employing HSp90 inhibitors in combination with nanosecond pulsed electric fields (nsPEFs) are disclosed. The methods are directed to induce regulated cell death (RCD) in tumor cells and tissues. Further, Hsp90 inhibitors in combination with nsPEF are used at low non-toxic concentrations, thereby reducing the side-effects associated with these drugs. Additionally, nsPEFs are employed at lower electric fields and/or with fewer number of pulses than when nsPEFs are employed alone. Further, the mechanisms by which nsPEFs and Hsp90 inhibitors act upon cancer cells are different, thereby combining these treatments results in a synergistic effect.

4. 发明申请

US20170165003A1 SYSTEM AND METHODS OF TREATMENT USING ELECTROMAGNETIC ILLUMINATION 审中-公开
公开(公告)号：US20170165003A1
公开(公告)日：2017-06-15
申请号：US15169154
申请日：2016-05-31
申请人： Karl H. Schoenbach , Shu Xiao
发明人： Karl H. Schoenbach , Shu Xiao
IPC分类号： A61B18/18 , A61N7/02
CPC分类号： A61B18/18 , A61B18/1815 , A61N7/02
摘要： A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.

5. 发明申请

US20170095664A1 TREATMENT OF BIOLOGICAL TISSUES USING SUBNANOSECOND ELECTRIC PULSES 审中-公开
公开(公告)号：US20170095664A1
公开(公告)日：2017-04-06
申请号：US15151149
申请日：2016-05-10
申请人： Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
发明人： Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
IPC分类号： A61N1/36 , A61N1/40
CPC分类号： A61N1/36014 , A61N1/40 , A61N2/006 , A61N5/02
摘要： A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.

6. 发明授权

US09168373B2 Nanosecond pulsed electric fields cause melanomas to self-destruct 有权
标题翻译：纳秒脉冲电场会导致黑素瘤自我毁灭
公开(公告)号：US09168373B2
公开(公告)日：2015-10-27
申请号：US12280280
申请日：2007-02-26
申请人： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
发明人： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
IPC分类号： A61B18/14 , A61N1/32
CPC分类号： A61N1/205 , A61N1/327
摘要： Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
摘要翻译：提供了通过施加纳秒脉冲电场（“nsPEF”）治疗实体皮肤肿瘤的新的无药物治疗方法。在本发明的一个实施方案中，细胞是黑素瘤细胞，并且所应用的nsPEFs渗透到肿瘤细胞的内部并使肿瘤细胞核迅速收缩并且肿瘤血流停止。这种新技术提供了高度定位的肿瘤细胞靶向，对上覆皮肤仅起微量的作用。

7. 发明申请

US20140331993A1 GREEN PROCESS TO HYDROLYZE CARBOHYDRATES FROM TOBACCO BIOMASS USING SUBCRITICAL WATER 有权
标题翻译：使用亚细菌水从烟草生物质中水解碳酸氢盐的绿色过程
公开(公告)号：US20140331993A1
公开(公告)日：2014-11-13
申请号：US14270839
申请日：2014-05-06
申请人： OLD DOMINION UNIVERSITY RESEARCH FOUNDATION , TYTON BIOSCIENCES
发明人： Sandeep KUMAR , Jose Luis Garcia MOSCOSO , Iulian BOBE , Peter MAJERANOWSKI
IPC分类号： C13K1/02 , C07D401/04
CPC分类号： C13K1/04 , A24B7/00 , A24B15/24 , A24B15/243 , C07D401/04 , C08H8/00 , C11B1/10 , C13K1/02
摘要： Processes for recovering sugars and nicotine from a tobacco biomass include feeding a biomass of tobacco plants and subcritical water to a reactor, hydrolyzing the biomass of tobacco plants with the subcritical water at a temperature between about 150° C. and 305° C. and recovering a liquid product and a solid product from the reactor, wherein the liquid product contains water-soluble sugars and nicotine.
摘要翻译：从烟草生物质回收糖和尼古丁的方法包括将烟草植物和亚临界水的生物质进料到反应器中，在约150℃至305℃的温度下用亚临界水水解烟草植物的生物量并回收液体产物和来自反应器的固体产物，其中液体产物含有水溶性糖和尼古丁。

8. 发明授权

US08450370B2 Production of glycerol-related products from a high temperature reaction 有权
标题翻译：从高温反应生产甘油相关产品
公开(公告)号：US08450370B2
公开(公告)日：2013-05-28
申请号：US13204884
申请日：2011-08-08
申请人： Patrick G. Hatcher , Zhanfei Liu , Elodie Salmon
发明人： Patrick G. Hatcher , Zhanfei Liu , Elodie Salmon
IPC分类号： A61K31/20
CPC分类号： C10L1/026 , C10G2300/1014 , C10G2300/4081 , C11C3/003 , Y02E50/13 , Y02P20/582 , Y02P30/20
摘要： Disclosed are processes for producing glycerol related products. One process comprises introducing a biomass and an alkylation reagent to a substantially oxygen free environment, hydrolyzing at a temperature at or above 200° C. one or more lipid glycerides in the biomass, methylating one or more fatty acids in the biomass with methyl groups from the alkylation reagent, wherein the hydrolyzing and methylating occur contemporaneously and separating resulting biodiesel and methylated glycerol-related products from a residue of the biomass by condensation.
摘要翻译：公开了生产甘油相关产品的方法。一种方法包括将生物质和烷基化试剂引入基本上不含氧的环境中，在等温或高于200℃的温度下水解生物质中的一种或多种脂质甘油酯，将生物质中的一种或多种脂肪酸甲基化，烷基化试剂，其中水解和甲基化同时发生，并通过冷凝从生物质的残余物分离所得生物柴油和甲基化甘油相关产物。

9. 发明申请

US20120154397A1 METHOD AND SYSTEM FOR GENERATING MESH FROM IMAGES 审中-公开
标题翻译：用于从图像生成网格的方法和系统
公开(公告)号：US20120154397A1
公开(公告)日：2012-06-21
申请号：US13311335
申请日：2011-12-05
申请人： Andrey Chernikov , Nikos Chrisochoides
发明人： Andrey Chernikov , Nikos Chrisochoides
IPC分类号： G06T17/20
CPC分类号： G06T17/205
摘要： A method for generating mesh from an image. The method includes inputting an image; setting a quality bound and a fidelity bound for a mesh to be generated; generating an initial mesh for the image with a maximum fidelity and a very high quality; generating a refined mesh by coarsening the initial mesh while maintaining the quality bound and the fidelity bound. The refined mesh includes a smaller number of elements than that of the initial mesh.
摘要翻译：一种从图像生成网格的方法。该方法包括输入图像; 为要生成的网格设置质量界限和保真度界限; 以最大的保真度和非常高的质量为图像生成初始网格; 通过粗化初始网格同时保持质量界限和保真度界限来生成精细网格。细化网格包含比初始网格元素少的元素。

10. 发明申请

US20120109263A1 Medical Instrument for Delivery of High Voltage Pulses and Method of Delivering the Same 有权
标题翻译：用于交付高压脉冲的医疗仪器及其传送方法
公开(公告)号：US20120109263A1
公开(公告)日：2012-05-03
申请号：US13264729
申请日：2010-04-14
申请人： Juergen F. Kolb , Karl H. Schoenbach , Stephen P. Beebe
发明人： Juergen F. Kolb , Karl H. Schoenbach , Stephen P. Beebe
IPC分类号： A61N1/32
CPC分类号： A61N1/325 , A61N1/0502 , A61N1/306 , A61N1/327
摘要： An instrument 10 for delivering a high voltage pulse to tissue is disclosed. The instrument 10 can include an outer support member 12 with a liquid reservoir 14 that has a liquid-contacting interior surface 16, an opening 18 at a distal end 20 of the outer support member 12, and a ground electrode 22 extending in a longitudinal direction and having a lower surface 23 proximate the opening 18. The instrument 10 can also include a working electrode 26 extending longitudinally from the liquid-contacting interior surface 16 with a needle-shaped distal portion 28 proximate the distal end 20; and an inlet port 31 and an outlet port 34 in liquid communication with the liquid reservoir 14. The working electrode 26 can be electrically isolated from the ground electrode 22 by an insulating portion 30 of the outer support member 12, and a direct path can exist through the liquid reservoir 14 between the ground electrode 22 and the working electrode 26.
摘要翻译：公开了一种用于将高电压脉冲传送到组织的器械10。仪器10可以包括具有液体储存器14的外部支撑构件12，该储存器14具有液体接触内表面16，在外部支撑构件12的远端20处的开口18和沿纵向方向延伸的接地电极22 并且具有靠近开口18的下表面23.仪器10还可以包括从液体接触内表面16纵向延伸的工作电极26，其具有靠近远端20的针状远端部分28; 以及与液体储存器14液体连通的入口31和出口34.工作电极26可以通过外部支撑构件12的绝缘部分30与接地电极22电隔离，并且可以存在直接路径通过接地电极22和工作电极26之间的液体贮存器14。

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