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1. 发明授权

US10188505B2 Materials and methods for improved bone tendon bone transplantation 有权
公开(公告)号：US10188505B2
公开(公告)日：2019-01-29
申请号：US15458603
申请日：2017-03-14
申请人： RTI Surgical, Inc.
发明人： Kevin C. Carter , Michael Esch , Paul LaRochelle , James Gross
IPC分类号： A61F2/08 , A61B17/16 , A61F2/28 , A61F2/46
摘要： Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of harvesting grafts that has improved efficiency and increases the quantity of extracted tissue and minimizes time required by surgeon for implantation.

2. 发明授权

US09763787B2 Assembled implant 有权
公开(公告)号：US09763787B2
公开(公告)日：2017-09-19
申请号：US12690074
申请日：2010-01-19
申请人： John R. Bianchi , C. Randal Mills , P. J. Gorham , Michael Esch , Kevin C. Carter , Pat Coleman , Kevin Ross , Harry W. Rambo , Darren G. Jones , Dayna Buskirk
发明人： John R. Bianchi , C. Randal Mills , P. J. Gorham , Michael Esch , Kevin C. Carter , Pat Coleman , Kevin Ross , Harry W. Rambo , Darren G. Jones , Dayna Buskirk
IPC分类号： A61F2/28 , A61L2/00 , A61L2/025 , A61F2/08 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.

3. 发明申请

US20140193798A1 CYCLIC IMPLANT PERFUSION, CLEANING AND PASSIVATION PROCESS AND IMPLANT PRODUCED THEREBY 有权
标题翻译：循环植入灌注，清洁和钝化过程及植物生长
公开(公告)号：US20140193798A1
公开(公告)日：2014-07-10
申请号：US14203925
申请日：2014-03-11
申请人： RTI Surgical, Inc.
发明人： C. Randal Mills , John F. Wironen , Sean Hanstke
IPC分类号： A01N1/02
CPC分类号： A01N1/0289 , A61L2/0088 , A61L2/025
摘要： This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
摘要翻译：本发明是一种用于灌注多孔植入物的新方法，其实现期望因子的有效相互渗透和植入物的孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少植入抗原性。

4. 发明申请

US20210137993A1 OSTEOINDUCTIVE PUTTIES AND METHODS OF MAKING AND USING SUCH PUTTIES 有权
公开(公告)号：US20210137993A1
公开(公告)日：2021-05-13
申请号：US17149465
申请日：2021-01-14
申请人： RTI Surgical, Inc.
发明人： Jordan Katz
IPC分类号： A61K35/32 , A61L27/24
摘要： The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing.

5. 发明授权

US09707082B2 Assembled cartilage repair graft 有权
公开(公告)号：US09707082B2
公开(公告)日：2017-07-18
申请号：US14246930
申请日：2014-04-07
申请人： RTI Surgical, Inc.
发明人： Predrag Bursac , Lauren M. Brown , Eric J. Schmitt , Guy B. Grover
IPC分类号： A61F2/30 , A61F2/28 , A61B17/86
CPC分类号： A61F2/30771 , A61B17/86 , A61F2/28 , A61F2/30756 , A61F2002/30057 , A61F2002/30075 , A61F2002/30138 , A61F2002/302 , A61F2002/30224 , A61F2002/30233 , A61F2002/30299 , A61F2002/30332 , A61F2002/30337 , A61F2002/30485 , A61F2002/30751 , A61F2002/30766 , A61F2002/30772 , A61F2002/30878 , A61F2002/30883 , A61F2002/30929 , A61F2220/0025 , A61F2220/0033 , A61F2230/0017 , A61F2230/0065 , A61F2230/0069 , A61F2230/0093
摘要： Bifunctional and assembled implants are provided for osteochondral implantation.

6. 发明授权

US09370608B2 Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith 有权
公开(公告)号：US09370608B2
公开(公告)日：2016-06-21
申请号：US14568339
申请日：2014-12-12
申请人： PIONEER SURGICAL TECHNOLOGY
发明人： Francis Vincent Lamberti , Ronald Stewart Hill , Adam MacMillan , Edward Ahn , Brian Schlossberg , Stephen Capistron , William H. Lloyd
IPC分类号： A61F2/28 , A61L27/46 , A61K9/00 , A61L27/54 , A61L27/58 , C08L89/00 , A61L27/48 , A61L27/22 , A61L27/40 , A61L27/56
CPC分类号： A61L27/46 , A61K9/0024 , A61L27/22 , A61L27/40 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2400/06 , A61L2430/02 , C08L89/00 , C08L5/02
摘要： The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with a second polymer and further comprise particles of a porous, osteoconductive material dispersed in the continuous matrix. The composition can be provided in a dehydrated form. The disclosure further provides methods of preparing the composition in a clinically useful form, methods of using the composition in regenerating bone, and kits including the composition.

7. 发明申请

US20140257516A1 Connective-Tissue-Based or Dermal-Tissue-Based Grafts/Implants 有权
标题翻译：基于连接组织或基于皮肤的组织移植物/植入物
公开(公告)号：US20140257516A1
公开(公告)日：2014-09-11
申请号：US14284918
申请日：2014-05-22
申请人： RTI Surgical, Inc.
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
IPC分类号： A61F2/08 , A61F2/10
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
摘要翻译：本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。本发明的组合物和/或组织移植物或植入物可以与接种的细胞，组织生长因子和/或趋化性配偶组合以吸引所需细胞。

8. 发明授权

US10918670B2 Osteoinductive putties and methods of making and using such putties 有权
公开(公告)号：US10918670B2
公开(公告)日：2021-02-16
申请号：US15617234
申请日：2017-06-08
申请人： RTI Surgical, Inc.
发明人： Jordan Katz
IPC分类号： A61K35/32 , A61L27/24
摘要： The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing.

9. 发明授权

US10271859B2 Undercutting system for use in conjunction with sacroiliac fusion 有权
公开(公告)号：US10271859B2
公开(公告)日：2019-04-30
申请号：US15865592
申请日：2018-01-09
申请人： RTI Surgical, Inc.
发明人： Robert Assell , Jeremy Carr , Eugene Dickhudt , Thomas Berg , Brian Beaubien
IPC分类号： A61B17/16
摘要： A method of preparing a region between adjacent bones for fusion. A first aperture is formed that extends through one of the bones. An undercutting system is inserted into the first aperture. The undercutting system includes an insertion apparatus and a cutting assembly. A first path is cut between the adjacent bones by extending or retracting the cutting assembly with respect to the insertion apparatus.

10. 发明授权

US09700584B2 Osteoinductive putties and methods of making and using such putties 有权
公开(公告)号：US09700584B2
公开(公告)日：2017-07-11
申请号：US12341917
申请日：2008-12-22
申请人： Jordan Michael Katz
发明人： Jordan Michael Katz
IPC分类号： A61K35/52 , A61K35/32 , A61L27/24
CPC分类号： A61K35/32 , A61L27/24 , A61L2430/02
摘要： The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing.

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