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1. 发明授权

US11344329B2 Vascular graft securement apparatuses and related kits and methods 有权
公开(公告)号：US11344329B2
公开(公告)日：2022-05-31
申请号：US15739082
申请日：2016-06-24
申请人： SCOTT & WHITE HEALTHCARE
发明人： Jack Leigh Eidson, III
IPC分类号： A61B17/34 , A61B17/11 , A61F2/06 , A61B17/00 , A61B17/064 , A61B17/22
摘要： Some of the present apparatuses include a flexible vascular graft defining a lumen and a hub having a distal end configured to penetrate a blood vessel, a proximal end, and a wall extending between the distal end and the proximal end that defines an interior passageway. In some apparatuses, the vascular graft is non-removably coupled to the hub, and the lumen of the vascular graft is in communication with the interior passageway of the hub. Some apparatuses include one or more helical protrusions fixed in relation to the wall and configured to secure the hub relative to the blood vessel, each of the one or more helical protrusions extending away from the interior passageway. In some apparatuses, the wall has an outer surface defining an annular recess that extends around the wall, the recess configured to receive at least a portion of a wall of the blood vessel.

2. 发明申请

US20210353365A1 Ultrasound Locatable Surgical Guidewire System and Method 有权
公开(公告)号：US20210353365A1
公开(公告)日：2021-11-18
申请号：US17323070
申请日：2021-05-18
申请人： Baylor University , Scott & White Healthcare
发明人： Linda J. OLAFSEN , Keith E. SCHUBERT , Jeffrey S. OLAFSEN , Samantha DAYAWANSA , Jason H. HUANG
IPC分类号： A61B34/20 , A61B8/08
摘要： The present disclosure provides a system and method for using widely available ultrasound imaging to overcome the limitations of imaging guidewires and other small objects that may be subwavelength in size relative to an ultrasound wavelength. The system and method can reduce the use of X-rays and exposure to the dangerous effects of radiation and avoids the expense of MRI technology. The subwavelength object, such as a guidewire, can be detected using several methods and associated systems described herein, including the object changing positions at a frequency that creates a brighter ultrasound image of the object as the object progresses across a scanned region of the ultrasound detector. In some embodiments, the movement of the small object causes a different speckle signature than the object itself would otherwise generate. Analysis of changes in speckle patterns due to progressive movement of an object can yield a detectable object.

3. 发明授权

US09877692B2 Method and system of measuring anatomical features in subcutaneous images to assess risk of injury 有权
公开(公告)号：US09877692B2
公开(公告)日：2018-01-30
申请号：US14729602
申请日：2015-06-03
申请人： BAYLOR UNIVERSITY , SCOTT & WHITE HEALTHCARE
发明人： Brian A. Garner , Christopher Chaput , Jacob Hoffman
IPC分类号： G06K9/00 , A61B6/00 , A61B6/03 , G06T7/00 , G06T7/60 , A61B5/107
CPC分类号： A61B6/5217 , A61B5/1075 , A61B6/032 , A61B6/50 , G06T7/0012 , G06T7/60 , G06T2207/10081 , G06T2207/30012
摘要： The present disclosure provides a method and system using software and associated equipment to automatically identify two or more preselected anatomical features by examining pixels within images, such as computerized tomography (CT) scanned images, determining appropriate measurements between such identified features based on dimensions and scaling available within the image file, comparing these measurements to normative data, and providing output of the results to a user, such as medical personnel. In at least one embodiment, the system can measure an interval between a first anatomical feature and a second anatomical feature that may be useful for medical analysis.

4. 发明授权

US09745381B2 Bispecific scFv immunofusion (BIf) 有权
公开(公告)号：US09745381B2
公开(公告)日：2017-08-29
申请号：US14402009
申请日：2013-05-18
申请人： Scott & White Healthcare
发明人： Jen-Sing Liu , Shu-Ru Kuo
IPC分类号： C07K16/28 , C07K16/30
CPC分类号： C07K16/30 , C07K16/2809 , C07K16/2866 , C07K16/2896 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/92
摘要： Certain embodiments are directed to a bispecific immunoglobulin that is capable of binding cell surface molecules on a target cell, such as cancer cells, and cell surface molecules on immune effector cell, such as cytotoxic T lymphocytes, resulting in the targeted killing of target cells. In certain aspects a Bif is a polypeptide comprising a first target binding domain that specifically binds a cancer cell, a second effector binding domain that specifically binds an immunologic effector, and an immunoglobulin constant region linker operatively coupling the first and second binding domain.

5. 发明授权

US09220922B2 Clearance check devices, systems, and methods 有权
标题翻译：清关检查设备，系统和方法
公开(公告)号：US09220922B2
公开(公告)日：2015-12-29
申请号：US14559717
申请日：2014-12-03
申请人： Scott & White Healthcare
发明人： Andrew Morrow , Brian Massingill
IPC分类号： A61N5/01 , A61N5/10 , A61B6/08 , A61B6/10 , A61B6/04
CPC分类号： A61N5/1049 , A61B6/0492 , A61B6/08 , A61B6/102
摘要： Clearance check devices, systems, and methods that can be used to indicate whether a proposed treatment plan will cause a collision between a patient/couch and a medical device, such as a linac, are described herein. Some devices and/or systems include an adjustable clearance member to account for the rotation of the medical device and a rotatable frame segment to account for the rotation of the patient or couch. Others include a frame segment that has an inner surface defining an arc that has a radius that is substantially equal to or less than an orbital radius of a centermost portion of a medical equipment component. Still others are disclosed.
摘要翻译：这里描述了可用于指示所提出的治疗计划是否会导致患者/沙发和医疗设备（例如直线加速器）之间的碰撞的间隙检查装置，系统和方法。一些装置和/或系统包括可调节的间隙构件以解决医疗装置的旋转和可旋转的框架部分，以解决患者或沙发的旋转。其他包括框架段，其具有限定弧的内表面，该内表面具有基本上等于或小于医疗设备部件的中心部分的轨道半径的半径。还有一些被披露。

6. 发明授权

US09078621B2 Method and system of measuring anatomical features in subcutaneous images to assess risk of injury 有权
标题翻译：测量皮下图像解剖特征的方法和系统，以评估损伤风险
公开(公告)号：US09078621B2
公开(公告)日：2015-07-14
申请号：US14074980
申请日：2013-11-08
申请人： BAYLOR UNIVERSITY , SCOTT & WHITE HEALTHCARE
发明人： Brian A. Garner , Christopher Chaput , Jacob Hoffman
IPC分类号： G06T7/00 , A61B5/00 , G06T7/60
CPC分类号： A61B6/5217 , A61B5/4504 , A61B6/032 , A61B6/505 , G06T7/0012 , G06T7/0014 , G06T7/60 , G06T2207/10081 , G06T2207/30012
摘要： The present disclosure provides a method and system using software and associated equipment to automatically identify two or more preselected anatomical features by examining pixels within images such as computerized tomography (CT) scanned images, determining appropriate measurements between such identified features based on dimensions and scaling available within the image file, comparing these measurements to normative data, and providing output of the results to a user, such as medical personnel. In at least one embodiment, system can measure the basion-dens interval (BDI), which has been shown to be an effective indicator of ligament injury within the occipito-cervical complex (“OCC”) that may not present with other symptoms, is not revealed with standard CT imaging, and is of mortal danger to the patient if untreated. The system can automate interpreting CT scanned images and alert medical personnel about the risk of OCC ligament damage.
摘要翻译：本公开提供了一种使用软件和相关联的设备的方法和系统，通过检查诸如计算机断层摄影（CT）扫描图像的图像内的像素来自动识别两个或更多个预先选择的解剖特征，基于尺寸和可用尺度来确定在所识别的特征之间的适当测量在图像文件内，将这些测量与规范数据进行比较，并将结果的输出提供给诸如医务人员的用户。在至少一个实施例中，系统可以测量已经显示为可能不存在于其他症状的枕骨 - 颈部复合体（“OCC”）内的韧带损伤的有效指标的基底间隔（BDI）不能用标准的CT成像显示，如果未经治疗则对患者造成致命的危险。该系统可以自动解释CT扫描图像，并向医务人员报告OCC韧带损伤的风险。

7. 发明申请

US20140133726A1 METHOD AND SYSTEM OF MEASURING ANATOMICAL FEATURES IN SUBCUTANEOUS IMAGES TO ASSESS RISK OF INJURY 有权
标题翻译：测量不规则图像中的解剖特征以评估伤害风险的方法和系统
公开(公告)号：US20140133726A1
公开(公告)日：2014-05-15
申请号：US14074980
申请日：2013-11-08
申请人： SCOTT & WHITE HEALTHCARE , BAYLOR UNIVERSITY
发明人： Brian A. GARNER , Christopher CHAPUT , Jacob HOFFMAN
IPC分类号： A61B5/00 , G06T7/00
CPC分类号： A61B6/5217 , A61B5/4504 , A61B6/032 , A61B6/505 , G06T7/0012 , G06T7/0014 , G06T7/60 , G06T2207/10081 , G06T2207/30012
摘要： The present disclosure provides a method and system using software and associated equipment to automatically identify two or more preselected anatomical features by examining pixels within images such as computerized tomography (CT) scanned images, determining appropriate measurements between such identified features based on dimensions and scaling available within the image file, comparing these measurements to normative data, and providing output of the results to a user, such as medical personnel. In at least one embodiment, system can measure the basion-dens interval (BDI), which has been shown to be an effective indicator of ligament injury within the occipito-cervical complex (“OCC”) that may not present with other symptoms, is not revealed with standard CT imaging, and is of mortal danger to the patient if untreated. The system can automate interpreting CT scanned images and alert medical personnel about the risk of OCC ligament damage.
摘要翻译：本公开提供了一种使用软件和相关联的设备的方法和系统，通过检查诸如计算机断层摄影（CT）扫描图像的图像内的像素来自动识别两个或更多个预先选择的解剖特征，基于尺寸和可用尺度来确定在所识别的特征之间的适当测量在图像文件内，将这些测量与规范数据进行比较，并将结果的输出提供给诸如医务人员的用户。在至少一个实施例中，系统可以测量已经显示为可能不存在于其他症状的枕骨 - 颈部复合体（“OCC”）内的韧带损伤的有效指标的基底间隔（BDI）不能用标准的CT成像显示，如果未经治疗则对患者造成致命的危险。该系统可以自动解释CT扫描图像，并向医务人员报告OCC韧带损伤的风险。

8. 发明申请

US20140079680A1 MELATONIN-BASED TREATMENT AND DIAGNOSIS OF BILE DUCT DISEASE 有权
标题翻译：基于MELATONIN的治疗和诊断BILE DUCT疾病
公开(公告)号：US20140079680A1
公开(公告)日：2014-03-20
申请号：US14009276
申请日：2012-04-02
申请人： Gianfranco Alpini , Sharon DeMorrow , Shannon Glaser
发明人： Gianfranco Alpini , Sharon DeMorrow , Shannon Glaser
IPC分类号： A61K38/43 , A61K31/4045 , A61K31/713
CPC分类号： A61K38/43 , A61K31/4045 , A61K31/713 , A61K38/45 , A61K48/00 , A61K48/005 , C12N15/1137 , C12N2310/11 , C12N2310/141 , C12N2310/3233 , C12N2320/11 , C12Y201/01004 , C12Y203/01087 , G01N33/57488
摘要： Methods and composition for a melatonin signaling modulator-based diagnosis and therapy are described. For example, in certain aspects methods for administering an anti-tumor therapy using a melatonin signaling modulator are described. Furthermore, the invention provides compositions and methods for detecting biliary tract disease such as cholangiocarcinoma.
摘要翻译：描述了基于褪黑素信号调节剂的诊断和治疗的方法和组合。例如，在某些方面，描述了使用褪黑素信号调节剂施用抗肿瘤治疗的方法。此外，本发明提供了检测胆管癌如胆管癌等的组合物和方法。

9. 发明授权

US08634134B2 Microscope slide separation devices and methods 失效
标题翻译：显微镜滑块分离装置及方法
公开(公告)号：US08634134B2
公开(公告)日：2014-01-21
申请号：US13090226
申请日：2011-04-19
申请人： Amin A. Mohammad , Nita Searcy , Alvin Michael Spiekerman
发明人： Amin A. Mohammad , Nita Searcy , Alvin Michael Spiekerman
IPC分类号： G02B21/26
CPC分类号： G02B21/34
摘要： A microscope slide separation device and method of storing microscope slides are disclosed. In specific embodiments, the microscope slide separation device can be placed a folded position that forms a cavity between at least first and second members configured to receive a microscope slide to which both a sample and a slip cover have been coupled. In particular embodiments, the first member may have at least one side configured not to stick to cover slip mounting media.
摘要翻译：公开了一种显微镜载玻片分离装置和存储显微镜幻灯片的方法。在具体实施例中，显微镜载玻片分离装置可以被放置在折叠位置，该折叠位置在至少第一和第二构件之间形成空腔，所述至少第一和第二构件被构造成接收样品和滑盖两者已经联接到的显微镜载玻片。在具体实施例中，第一构件可以具有至少一个侧面，其构造成不粘附到盖滑动安装介质。

10. 发明申请

US20110319372A1 METHOD OF DIAGNOSING AND THERAPEUTICALLY TREATING A PATIENT FOR A TRAUMATIC BRAIN INJURY 失效
标题翻译：诊断和治疗TRAUMATIC脑损伤的患者的方法
公开(公告)号：US20110319372A1
公开(公告)日：2011-12-29
申请号：US13160735
申请日：2011-06-15
申请人： JULES B. PUSCHETT , LEE SHAPIRO
发明人： JULES B. PUSCHETT , LEE SHAPIRO
IPC分类号： A61K31/58 , A61P25/00 , G01N33/566
CPC分类号： G01N33/53 , A61K31/585 , G01N33/743 , G01N2800/28 , G01N2800/40
摘要： Known or suspected traumatic brain injuries may be treated therapeutically by administering a therapeutically effective dose of resibufogenin. A preferred method for determining if a patient has a traumatic brain injury includes obtaining a body specimen from the patient, determining the concentration of marinobufagenin in the body specimen, comparing the concentration of marinobufagenin to the concentration in such body specimens in normal patients, and if the marinobufagenin concentration is substantially above the concentration of a normal patient, concluding traumatic brain injury exists. In a preferred embodiment, a substantial elevation is deemed to be an increase of about 30 percent above the marinobufagenin concentration of a normal patient. The body specimen may be blood, urine, or cerebrospinal fluid. If a substantial elevation is deemed to exist, the magnitude of the departure from the concentration of a normal patient may be employed in determining the timing and nature of treatment provided to the patient. The method may be repeated at predetermined intervals to monitor changes in the marinobufagenin with time.
摘要翻译：可以通过施用治疗有效剂量的抗纤维蛋白原治疗来治疗已知或怀疑的创伤性脑损伤。用于确定患者是否具有创伤性脑损伤的优选方法包括从患者获得身体标本，确定身体标本中海马素原基因的浓度，将正常患者中的马氏原虫基因的浓度与这些身体标本中的浓度进行比较，以及如果造血干细胞因子浓度明显高于正常患者的浓度，结论存在创伤性脑损伤。在优选的实施方案中，认为实质高程比普通患者的海因素原基因浓度高出约30％。身体标本可能是血液，尿液或脑脊液。如果认为存在实质性高程，则在确定提供给患者的治疗的时间和性质时可以采用偏离正常患者浓度的大小。可以以预定的间隔重复该方法以随时间监测马铃薯白蛋白原的变化。

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