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1. 发明授权

US11364377B2 Instrument for facilitating transseptal delivery of cardiac therapeutic devices 有权
公开(公告)号：US11364377B2
公开(公告)日：2022-06-21
申请号：US16578379
申请日：2019-09-22
申请人： Synecor LLC
发明人： Richard S Stack , William L Athas , Kevin Johnson , Emer M Feerick , Matthew Moran , Damian Muldoon , Liam Ruddy
IPC分类号： A61M60/857 , A61B17/34 , A61F2/24 , A61M25/09 , A61M60/135 , A61M60/148 , A61M25/10 , A61B17/00
摘要： An instrument for facilitating transseptal delivery of a cardiac therapeutic device is positionable in a left ventricle. The instrument includes an elongate shaft having a tubular lumen, the shaft having a proximal portion and a distal portion actively steerable between a generally straight position and a curved position. An external pull wire and an internal pull wire are each actuatable to move the distal portion to the curved position. The external pull wire extends internally through the proximal portion of the shaft and longitudinally along the exterior of the distal portion of the shaft, while the internal pull wire extends internally through the proximal portion of the shaft adjacent to the external pull wire, and extends internally through the distal portion of the shaft.

2. 发明授权

US11000637B2 Systems and methods for transseptal delivery of percutaneous ventricular assist devices and other non-guidewire based transvascular therapeutic devices 有权
公开(公告)号：US11000637B2
公开(公告)日：2021-05-11
申请号：US16578373
申请日：2019-09-22
申请人： Synecor LLC
发明人： Richard S Stack , William L Athas , Kevin Johnson , Emer M Feerick , Matthew Moran , Damian Muldoon , Liam Ruddy , William Cannon , Rory O'Brien
IPC分类号： A61M1/12 , A61M25/09 , A61M1/10 , A61B17/34 , A61F2/24 , A61M25/10 , A61B17/00
摘要： A system and method used to deliver a percutaneous ventricular assist device (pVAD) or other cardiac therapeutic device to a site within the heart, such as a site at the aortic valve. A flexible device is percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The venous-side end of the flexible device is withdrawn out the venous vasculature superior to the heart, and a pVAD is secured to the flexible device. The pVAD is pushed in a distal direction while the arterial-side end of the flexible device is pulled in the proximal direction to advance the pVAD to the target site. A left ventricle redirector aids in orienting the pVAD and preventing migration of the flexible member towards delicate structures of the heart during advancement of the pVAD.

3. 发明申请

US20210085851A1 DEVICES FOR USE IN EXTRACTING PERCUTANEOUS VENTRICULAR ASSIST DEVICES 有权
公开(公告)号：US20210085851A1
公开(公告)日：2021-03-25
申请号：US16579779
申请日：2019-09-23
申请人： Synecor LLC
发明人： Richard S Stack , William L Athas , Kevin Johnson , Salvatore Castro
IPC分类号： A61M1/12
摘要： A system and method for extracting a pVAD device that is implanted with a distal portion in an aorta of the heart and a drive line extending across an inter-atrial septum and out of the body via a superior vessel of the venous vasculature, include a first device that is introduced into a femoral artery and through the descending aorta used to engage a distal part of the pVAD device in the aorta of a patient using an instrument. A second, cutter, device is introduced into the venous vasculature superior to heart, advanced to a position adjacent the inter-atrial septum, and used to cut the pVAD drive line adjacent to the inter-atrial septum. After cutting, a first portion of the pVAD is withdrawn from the body via the venous vasculature, and a second portion is withdrawn from the body via the femoral artery.

4. 发明申请

US20210085848A1 PERCUTANEOUS SHEATHS FOR USE WITH PERCUTANEOUS VENTRICULAR ASSIST DEVICES 有权
公开(公告)号：US20210085848A1
公开(公告)日：2021-03-25
申请号：US16579781
申请日：2019-09-23
申请人： Synecor LLC
发明人： Richard S. Stack , William L. Athas , Kevin Johnson
IPC分类号： A61M1/12 , A61M1/10
摘要： Percutaneous access sheaths used to provide access to the vasculature and heart for the introduction of percutaneous ventricular assist devices (pVADs), and to remain in place for the duration of pVAD use. The sheaths include actively closeable seals engageable to seal against the drive lines of the pVADs to minimize blood loss during pVAD use.

5. 发明申请

US20140148883A1 Intravascular Electrode System and Method 有权
标题翻译：血管内电极系统及方法
公开(公告)号：US20140148883A1
公开(公告)日：2014-05-29
申请号：US13869024
申请日：2013-04-23
申请人： Synecor LLC
发明人： Richard S. Stack , Michael S. Williams , Daniel W. Fifer , Richard A. Glenn , Geoffrey A. Orth , Lynn Elliott , Colleen Stack
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/36114 , A61N1/36117 , A61N2007/0043
摘要： An intravascular electrode system includes an expandable anchor and a flexible substrate which carries at least one electrode. The anchor is positioned in a blood vessel and expanded to an expanded position to bias the electrode in contact with the vessel wall. The flexible substrate may be longitudinally withdrawn from its position between the anchor and the vessel wall without removing the anchor from the blood vessel. A second flexible substrate may be longitudinally inserted into position between the anchor and vessel wall as replacement for the first substrate.
摘要翻译：血管内电极系统包括可扩张锚和携带至少一个电极的柔性基底。锚固件定位在血管中并且膨胀到扩张位置以偏压与血管壁接触的电极。柔性基底可以从其位于锚固体和血管壁之间的位置纵向取出，而不需要将锚固体从血管中移除。第二柔性基底可以纵向地插入到锚固体和血管壁之间的位置，作为第一基底的替代。

6. 发明申请

US20140052208A1 Neuromodulation Systems and Methods for Treating Acute Heart Failure Syndromes 有权
标题翻译：神经调节系统和治疗急性心力衰竭综合征的方法
公开(公告)号：US20140052208A1
公开(公告)日：2014-02-20
申请号：US14064544
申请日：2013-10-28
申请人： Synecor LLC
发明人： Terrance J Ransbury , William E Sanders , Richard S Stack , Colleen Stack
IPC分类号： A61N1/362 , A61N1/05
CPC分类号： A61N1/3621 , A61B5/01 , A61B5/0215 , A61B5/024 , A61M25/0074 , A61M25/0125 , A61M25/0147 , A61M25/04 , A61M2025/0175 , A61N1/056 , A61N1/057 , A61N1/36114 , A61N1/3627
摘要： A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.
摘要翻译：用于治疗急性心力衰竭综合征的神经调节系统包括具有适于定位在诸如上腔静脉的第一血管内的副交感神经治疗元件的第一导管和适于用第二不同血液定位的第二导管交感神经治疗元件血管如肺动脉。导管包括其中一个导管可滑动地布置在另一个导管上的系统。该系统还可以可滑动地设置在第三细长元件（例如可定位在肺动脉内的Swan-Ganz导管）之间，使得Swan-Ganz可用于监测神经调节治疗期间的血压和心输出量等参数。副交感神经治疗元件被激励以将神经调节治疗递送到副交感神经纤维例如迷走神经，而交感神经治疗元件通电以将神经调节治疗递送至交感神经纤维如交感神经纤维。对于急性心力衰竭综合征的治疗，神经调节治疗可用于降低心率并增加心脏内向性。

7. 发明授权

US08372325B2 Highly convertible endolumenal prostheses and methods of manufacture 失效
公开(公告)号：US08372325B2
公开(公告)日：2013-02-12
申请号：US12148895
申请日：2008-04-22
申请人： Michael S. Williams , Robert S. Langer , Yadong Wang
发明人： Michael S. Williams , Robert S. Langer , Yadong Wang
IPC分类号： B29C41/02 , C08G63/16
CPC分类号： A61F2/06 , A61L31/04 , A61L31/041 , A61L31/14 , A61L2400/16
摘要： Endolumenal prostheses that readily and extensively convert from a delivery configuration to a deployed configuration are disclosed. Endolumenal prostheses may be fabricated from one or more shape memory polymers, a high modulus elastomer, a polymer that is both elastomeric and exhibits shape memory behavior, a hydrogel, or some combination thereof. Polymers used to fabricate the prostheses are selectively synthesized to exhibit desired characteristics such as crystallinity, strain fixity rate, strain recovery rate, elasticity, tensile strength, mechanical strength, cross-linking density, extent physical cross-linking, extent of covalent cross-linking, extent of interpenetrating networks, rate of erosion, heat of fusion, crystallization temperature, and acidity during erosion. The endolumenal prostheses convert to the deployed configuration following delivery to a treatment site, upon exposure to an initiator either present within the body naturally or introduced into the body.

8. 发明授权

US07919162B2 Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same 有权
标题翻译：具有选择性改性结晶度的聚合材料的管腔内假体及其制备方法
公开(公告)号：US07919162B2
公开(公告)日：2011-04-05
申请号：US11146455
申请日：2005-06-07
申请人： Joseph M. DeSimone , Michael S. Williams
发明人： Joseph M. DeSimone , Michael S. Williams
IPC分类号： B29D22/00 , A61F2/06
CPC分类号： A61F2/07 , A61L27/44 , A61L27/54 , A61L27/58 , A61L31/04 , A61L31/14 , A61L2300/20 , Y10T428/1352 , Y10T428/139
摘要： Methods of manufacturing polymeric intraluminal prostheses include annealing the polymeric material to selectively modify the crystallinity thereof. Annealing may be utilized to selectively modify various properties of the polymeric material of an intraluminal prosthesis, including: selectively increasing the modulus of the polymeric material; selectively increasing the hoop strength of the intraluminal prosthesis; selectively modifying the elution rate (increase or decrease) of a pharmacological agent subsequently disposed on or within the annealed polymeric material; selectively increasing/decreasing stress in the intraluminal prosthesis; and selectively modifying the polymeric material such that it erodes at a different rate.
摘要翻译：制造聚合物腔内假体的方法包括退火聚合物材料以选择性地改变其结晶度。可以使用退火来选择性地修改管腔内假体的聚合材料的各种性质，包括：选择性地增加聚合材料的模量; 选择性地增加腔内假体的环箍强度; 选择性地改变随后设置在退火的聚合材料上或其内的药剂的洗脱速率（增加或减少）; 在腔内假体中选择性增加/减少应力; 并且选择性地改性聚合材料，使得其以不同的速率腐蚀。

9. 发明授权

US07617007B2 Method and apparatus for retaining medical implants within body vessels 有权
标题翻译：保留体内血管植入物的方法和装置
公开(公告)号：US07617007B2
公开(公告)日：2009-11-10
申请号：US10977060
申请日：2004-10-29
申请人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Kevin Holbrook
发明人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Kevin Holbrook
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.
摘要翻译：本申请描述了用于将医疗装置锚定在脉管系统内的保持装置。该装置可以包括联接到血管内医疗装置并且成比例地用于在容器内接收的可扩张构件。可膨胀构件的至少一部分可扩张以径向接合容器壁并由此将医疗装置保持在容器内。该系统适用于各种血管内装置，包括但不限于ICD，起搏器和血管内药物递送系统。

10. 发明申请

US20080281405A1 Highly convertible endolumenal prostheses and methods of manufacture 失效
公开(公告)号：US20080281405A1
公开(公告)日：2008-11-13
申请号：US12148895
申请日：2008-04-22
申请人： Michael S. Williams , Robert S. Langer , Yadong Wang
发明人： Michael S. Williams , Robert S. Langer , Yadong Wang
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61L31/04 , A61L31/041 , A61L31/14 , A61L2400/16
摘要： Endolumenal prostheses that readily and extensively convert from a delivery configuration to a deployed configuration are disclosed. Endolumenal prostheses may be fabricated from one or more shape memory polymers, a high modulus elastomer, a polymer that is both elastomeric and exhibits shape memory behavior, a hydrogel, or some combination thereof. Polymers used to fabricate the prostheses are selectively synthesized to exhibit desired characteristics such as crystallinity, strain fixity rate, strain recovery rate, elasticity, tensile strength, mechanical strength, cross-linking density, extent physical cross-linking, extent of covalent cross-linking, extent of interpenetrating networks, rate of erosion, heat of fusion, crystallization temperature, and acidity during erosion. The endolumenal prostheses convert to the deployed configuration following delivery to a treatment site, upon exposure to an initiator either present within the body naturally or introduced into the body.

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