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1. 发明申请

US20210123066A1 METHODS OF REGENERATION AND TRANSFORMATION OF STEVIA PLANT AND TRANSGENIC STEVIA PLANTS HAVING ENHANCED STEVIOL GLYCOSIDES CONTENT 有权
公开(公告)号：US20210123066A1
公开(公告)日：2021-04-29
申请号：US16963133
申请日：2019-01-17
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED
发明人： In-Cheol JANG , Jun-shi ZHENG , Mi Jung KIM
IPC分类号： C12N15/82 , A01H4/00
摘要： The present invention relates to a method for Agrobacterium-mediated transformation and regeneration of Stevia plants. In particular, the method involves co-culturing leaf explants with Agrobacterium in a medium comprising acetosyringone and 2,4-dichlorophenoxyacetic acid in the dark, callus induction and shoot regeneration in a medium comprising 6-benzylaminopurine, 3-indoleacetic acid, a selective agent and an Agrobacterium eradicant in the dark, and root regeneration in a medium comprising 3-indoleacetic acid in a light/dark cycle. The present invention also relates to the overexpression of SrDXS1 and SrKAH in transgenic plants, resulting in the enhancement of steviol glycosides in the transgenic plants. The present invention further relates to the overexpression SrUGT76G1 in transgenic plants, resulting in higher Rebaudioside A (Reb A) to stevioside ratios in the transgenic plants.

2. 发明授权

US10266837B2 Terpene synthases from ylang ylang (Cananga odorata var. fruticosa) 有权
公开(公告)号：US10266837B2
公开(公告)日：2019-04-23
申请号：US15519595
申请日：2015-10-19
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED
发明人： In-cheol Jang , Mi Jung Kim
IPC分类号： C12N9/18 , C12N15/82 , C12N9/88 , C12P7/04 , C12P5/00
摘要： The present invention relates to the field of plant molecular biology. More particularly, the present invention relates to the isolation of nucleic acids encoding terpene synthases (TPSs), including a novel, multifunctional TPS identified herein as CoTPS2.

3. 发明申请

US20190062799A1 DETECTION OF BETA-HEMOLYTIC PATHOGENS 审中-公开
公开(公告)号：US20190062799A1
公开(公告)日：2019-02-28
申请号：US16079270
申请日：2017-02-23
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED
发明人： Rongji SUM , Muthukaruppan SWAMINATHAN , Ian CHEONG
IPC分类号： C12Q1/04 , C12Q1/14 , C12Q1/10
摘要： The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.

4. 发明授权

US09650647B2 Molecular interaction between XA10 and AVRXA10 有权
公开(公告)号：US09650647B2
公开(公告)日：2017-05-16
申请号：US13820860
申请日：2010-09-06
申请人： Zhong Chao Yin , Ke Yu Gu , Dong Sheng Tian
发明人： Zhong Chao Yin , Ke Yu Gu , Dong Sheng Tian
IPC分类号： C12N15/29 , C12N15/82 , C07K14/415
CPC分类号： C12N15/8281 , C07K14/415 , C12N15/8239
摘要： The present invention provides nucleic acids and methods for conferring resistance to bacterial disease in plants. The present invention also provides promoters and promoter sequences useful for controlling expression in transgenic plants.

5. 发明授权

US09574205B2 Microsomal ω6 oleate desaturases 有权
标题翻译：微粒体ω6油酸去饱和酶
公开(公告)号：US09574205B2
公开(公告)日：2017-02-21
申请号：US14118767
申请日：2011-09-28
申请人： Jian Ye , Jing Qu , Hui Zhu Mao
发明人： Jian Ye , Jing Qu , Hui Zhu Mao
IPC分类号： C12N15/82 , C12N5/14 , C12N9/02 , C12P7/64
CPC分类号： C12N15/8247 , C12N5/14 , C12N9/001 , C12N9/0083 , C12N15/8218 , C12P7/64 , C12Y103/01035 , Y02P20/52
摘要： The present invention relates to the field of plant molecular biology, more particularly Jatropha microsomal co6 oleate desaturases. The present invention also relates to Jatropha plants or plants of other oil crops having seeds with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention relates to Jatropha plants or plants of other oil crops where the plants exhibit elevated levels of oleic acid.
摘要翻译：本发明涉及植物分子生物学领域，尤其涉及麻风树微粒体co6油酸酯去饱和酶。本发明还涉及麻风树植物或其他油料作物的植物，其具有改变比例的单饱和多不饱和脂肪的种子。特别地，本发明涉及麻风树植物或其他油料作物的植物，其中植物表现出高水平的油酸。

6. 发明申请

US20150101373A1 NITROGEN-FIXING BACTERIAL INOCULANT FOR IMPROVEMENT OF CROP PRODUCTIVITY AND REDUCTION OF NITROUS OXIDE EMISSION 有权
标题翻译：用于改善作物生产力和减少氧化氮排放的氮固定物质
公开(公告)号：US20150101373A1
公开(公告)日：2015-04-16
申请号：US14386673
申请日：2013-03-20
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED
发明人： Madhaiyan Munusamy , Lianghui Ji
IPC分类号： C05F11/08 , C05D9/02 , A01N63/00 , C12N1/20 , C12R1/01
CPC分类号： C05F11/08 , A01N63/00 , C05D9/02 , C12N1/20 , C12N9/0095 , C12N9/0097 , C12R1/01 , C12Y118/06001 , C12Y119/06001 , Y02P60/218
摘要： The present invention relates to methods of reducing chemical fertilizer usage and greenhouse gas nitrous oxide emission and to methods of improving plant growth rate and seed productivity in agriculture through the application of a novel artificially manufactured formula containing a nitrogen-fixing bacterium that efficiently colonizes non-legume plants in aerial parts and the root system. The bacteria inocula and methods are particularly suitable for plants in the genera Jatropha, Sorghum, Gossypium, Elaeis, Ricinus, Oryza and Manihot.
摘要翻译：本发明涉及减少化肥使用和温室气体一氧化二氮排放的方法，以及通过应用含有固氮细菌的新型人工制剂，有效地定植非化学肥料的方法，提高农业中植物生长速率和种子生产力的方法，豆类植物在地上部分和根系。细菌接种物和方法特别适用于麻风树属，高粱属，棉子属，ae属，蓖麻属，Oryza和Manihot属的植物。

7. 发明授权

US08852928B2 LexA-based chemical-inducible gene expression system for use in transgenic animals 有权
标题翻译：基于LexA的化学诱导型基因表达系统用于转基因动物
公开(公告)号：US08852928B2
公开(公告)日：2014-10-07
申请号：US12663323
申请日：2008-07-02
申请人： Alexander Emelyanov , Sergey Parinov , Nam-Hai Chua
发明人： Alexander Emelyanov , Sergey Parinov , Nam-Hai Chua
IPC分类号： C12N15/00 , C07H21/02 , C07H21/04 , C12N15/85 , A01K67/027 , A01K67/00
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2217/203 , A01K2227/40 , A01K2267/03 , A01K2267/0393 , C07K2319/71 , C07K2319/715 , C07K2319/80 , C12N15/8509 , C12N2800/40 , C12N2830/002
摘要： The present invention relates generally to chemical-inducible system and to methods of use in transgenic animals. More specifically, the present invention relates to a chimeric transcription factor that binds to a ligand and functions in ligand-dependent manner to induce expression of genes of interest under the control of a synthetic operator-promoter sequence. The expression of genes of interest can be tightly controlled by adding or removing the ligand.
摘要翻译：本发明一般涉及化学诱导系统和转基因动物中使用的方法。更具体地，本发明涉及结合配体并以配体依赖性方式起作用以在合成的操作者 - 启动子序列的控制下诱导感兴趣的基因表达的嵌合转录因子。感兴趣的基因的表达可以通过添加或除去配体来严格控制。

8. 发明授权

US08574581B2 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof 有权
标题翻译：血液凝集素和流感病毒H5亚型或N1亚型的神经氨酸酶特异性单克隆抗体及其用途
公开(公告)号：US08574581B2
公开(公告)日：2013-11-05
申请号：US13610021
申请日：2012-09-11
申请人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
IPC分类号： A61K39/42 , C07K16/10 , C07K17/00 , C12Q1/70
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
摘要翻译：提供了与禽流感病毒（AIV）N1亚型的H5亚型或神经氨酸酶糖蛋白的包膜糖蛋白特异性结合的单克隆抗体和相关结合蛋白。单克隆抗体和相关结合蛋白可用于检测A5的H5和N1亚型，包括H5N1亚型，并为危险病毒感染的诊断，监测和治疗提供手段。

9. 发明申请

US20130225515A1 METHOD FOR ISOLATING SMALL MOLECULES WITH IMPORTANT BIOLOGICAL ACTIVITY USING YEAST 审中-公开
标题翻译：使用YEAST分离具有重要生物活性的小分子的方法
公开(公告)号：US20130225515A1
公开(公告)日：2013-08-29
申请号：US13762925
申请日：2013-02-08
申请人： Temasek Life Sciences Laboratory Limited
发明人： Rajesh Narhari PATKAR , Naweed Isaak NAQVI
IPC分类号： A61K31/7048
CPC分类号： A61K31/7048 , C07K1/16 , C07K14/37
摘要： Methods of isolating biologically active molecules from an organism, for example from a fungus, are described. The methods involve isolating an active molecule which possesses a specific biological activity on, in or against wild-type yeast cells, but not on, in or against yeast cells that express a given ABC transporter from a given organism, including but not limited to Magnaporthe species such as Magnaporthe grisea. In preferred embodiments, the biological activity is antifungal activity. In most preferred embodiments, the antifungal activity is against a human pathogen, including but not limited to Candida albicans. The biologically active molecules can be formulated as pharmaceutical compositions and used to treat fungal infections in a subject, including a human subject.
摘要翻译：描述了从生物体（例如真菌）分离生物活性分子的方法。所述方法包括分离在野生型酵母细胞中或对抗野生型酵母细胞但不包括表达来自给定生物体的给定ABC转运蛋白的酵母细胞中或之上具有特定生物活性的活性分子，包括但不限于Magnaporthe 物种如Magnaporthe grisea。在优选的实施方案中，生物活性是抗真菌活性。在最优选的实施方案中，抗真菌活性是针对人类病原体，包括但不限于白色念珠菌。生物活性分子可以配制成药物组合物并用于治疗受试者（包括人类受试者）中的真菌感染。

10. 发明申请

US20120270259A1 FISH CANCER MODEL 失效
标题翻译：鱼类模型
公开(公告)号：US20120270259A1
公开(公告)日：2012-10-25
申请号：US13533117
申请日：2012-06-26
申请人： Sergey PARINOV , Alexander EMELYANOV
发明人： Sergey PARINOV , Alexander EMELYANOV
IPC分类号： C12Q1/02 , C12N5/071
CPC分类号： C07K14/82 , A01K67/0275 , A01K2217/05 , A01K2227/40 , A01K2267/0331 , A01K2267/0393 , C07K5/101 , C07K14/461 , C07K2319/60 , C12N15/8509 , C12N2830/008 , G01N33/5011
摘要： The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening for drugs or agents that modulate oncogene-mediated neoplastic or hyperplasic transformation, or that modulate sensitivity to chemotherapy or radiation therapy Immortal tumor cells lines, methods of making immortal tumor cells lines and methods of their use are also provided.
摘要翻译：本发明涉及其基因组整合有可操作地连接到启动子的致癌核酸的鱼。还提供了制作鱼的方法及其使用方法。鱼可以有利地用于筛选调节癌基因介导的肿瘤或超基因转化或调节对化学疗法或放射治疗的敏感性的药物或试剂的方法。永生肿瘤细胞系，制备不死的肿瘤细胞系的方法及其使用方法也提供。

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