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1. 发明申请

US20230126007A1 NANOPARTICLES ENCAPSULATING SOLUBLE BIOLOGICS, THERAPEUTICS, AND IMAGING AGENTS 有权
公开(公告)号：US20230126007A1
公开(公告)日：2023-04-27
申请号：US18083458
申请日：2022-12-16
申请人： The Trustees of Princeton University
发明人： Robert F. PAGELS , Robert K. PRUD'HOMME
IPC分类号： A61K9/51 , A61K31/00 , A61K31/405 , A61K31/7036 , A61K38/06 , A61K38/14 , A61K38/47 , C09B67/02
摘要： An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.

2. 发明申请

US20230118593A1 MICROLENS AMPLITUDE MASKS FOR FLYING PIXEL REMOVAL IN TIME-OF-FLIGHT IMAGING 有权
公开(公告)号：US20230118593A1
公开(公告)日：2023-04-20
申请号：US17915536
申请日：2022-03-17
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： Ilya Chugunov , Seung-Hwan Baek , Qiang` Fu , Wolfgang Heidrich , Felix Heide
IPC分类号： G06T7/50 , G01S17/894 , G01S7/481 , G01S7/4912
摘要： The microlens amplitude masks for flying pixel removal in time-of-flight imaging includes systems, devices, methods, and instructions for image depth determination, including receiving an image, adding noise to the image, determining a set of correlation images, each correlation image having a varying phase offset, for each pixel of the image, generating a masked pixel by applying a mask array, and for each masked pixel, determining the depth of the masked pixel to generate a depth map for the image on a per pixel basis.

3. 发明授权

US11618798B2 Quasicrystalline structures and uses thereof 有权
公开(公告)号：US11618798B2
公开(公告)日：2023-04-04
申请号：US17064955
申请日：2020-10-07
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Paul Joseph Steinhardt , Paul Michael Chaikin , Weining Man
IPC分类号： H01L33/00 , B82Y20/00 , B82Y30/00 , C08F220/56 , G02B6/122 , C08F222/38 , C08G65/22 , C08G59/24 , B33Y80/00
摘要： This invention relates generally to the field of quasicrystalline strictures. In preferred embodiments, the stopgap structure is more spherically symmetric than periodic structures facilitating the formation of stopgaps in nearly all directions because of higher rotational symmetries. More particularly, the invention relates to the use of quasicrystalline structures for optical, mechanical, electrical and magnetic purposes. In some embodiments, the invention relates to manipulating, controlling, modulating and directing waves including electromagnetic, sound, spin, and surface waves, for pre-selected range of wavelengths propagating in multiple directions.

4. 发明申请

US20230100536A1 INTERCELLULAR AND INTRACELLULAR PROXIMITY-BASED LABELING COMPOSITIONS AND SYSTEMS 有权
公开(公告)号：US20230100536A1
公开(公告)日：2023-03-30
申请号：US17802823
申请日：2021-02-26
申请人： The Trustees of Princeton University
发明人： Aaron Trowbridge , Ciaran Seath , David W.C. MacMillan
IPC分类号： C07D213/22 , C07D213/56 , C07D213/79 , C07D401/14 , C07F15/00 , C09K11/06
摘要： In one aspect, transition metal complexes are described herein having composition and electronic structure for generating reactive labeling intermediates having lifetimes and diffusion radii advantageous for proximity-based labeling of various biomolecular species, including proteins, in intracellular and intercellular environments.

5. 发明授权

US11583844B2 Tri-(adamantyl)phosphines and applications thereof 有权
公开(公告)号：US11583844B2
公开(公告)日：2023-02-21
申请号：US17167606
申请日：2021-02-04
申请人： The Trustees of Princeton University
发明人： Brad P Carrow , Liye Chen
IPC分类号： B01J31/24 , C07F9/50 , C07B37/04 , B01J31/22 , C07F15/00 , C07F1/00 , C07F3/00
摘要： In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.

6. 发明申请

US20230028572A1 HIGH-THROUGHPUT MONODISPERSE AEROSOLS OF MICRO-SHELL PARTICLES 有权
公开(公告)号：US20230028572A1
公开(公告)日：2023-01-26
申请号：US17778135
申请日：2020-11-19
申请人： The Trustees of Princeton University
发明人： Maksym MEZHERICHER , Howard A. STONE
IPC分类号： B05B17/04 , B65D83/28
摘要： Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle. The generated aerosol particles are extremely light-weight (few micrograms) and have very small wall thickness (couple of microns), which enables precise delivery of materials and rapid evaporation of solvent in their liquid walls. The process production rate is easily scalable. In terms of possible applications, liquid used for aerosol generation can be enriched with suspended or dissolved materials, for instance by a medical drug for direct delivery into a patient's airways, or by organic/inorganic solvent which solidifies during drying enabling formation of soft or rigid spherical shells out of particles with liquid shells. The blowing gas can have suspended micron/nano particles in it and these particles will be encapsulated by liquid walls of formed micro-shells, which can potentially solidify during their motion, and thus produced aerosols can be used as transport agents for material delivery. Formation of fine monodisperse liquid or solid foams is possible by collecting liquid micro-shells from the generated aerosol on a surface or in a vessel, while the liquid walls of particles of adhere to each other and then can solidify due to solvent evaporation, freezing or polymerization.

7. 发明申请

US20220400375A1 SYSTEM AND METHOD FOR PHONE PRIVACY 有权
公开(公告)号：US20220400375A1
公开(公告)日：2022-12-15
申请号：US17419895
申请日：2021-03-02
申请人： The Trustees of Princeton University
发明人： Paul Schmitt
IPC分类号： H04W12/02 , H04W12/06 , H04W12/63 , H04W12/72 , H04W12/40
摘要： According to various embodiments, a cellular architecture for enhanced privacy regarding identity and location of a computing device is disclosed. The architecture includes a next generation core (NGC). The NGC includes an authentication server function (AUSF) configured to determine whether the computing device contains a valid subscriber identity module (SIM) card, and a user plane function (UPF) configured to allow a computing device to connect to the Internet. The architecture further includes a gateway connected to the UPF, the gateway configured to authenticate the computing device while hiding the identity of the computing device by verifying authentication tokens that represent units of access.

8. 发明授权

US11481495B2 Anomalous behavior detection in processor based systems 有权
公开(公告)号：US11481495B2
公开(公告)日：2022-10-25
申请号：US16410675
申请日：2019-05-13
申请人： SRI International , The Trustees of Princeton University
发明人： Sek M. Chai , Zecheng He , Aswin Nadamuni Raghavan , Ruby B. Lee
IPC分类号： G06F21/56 , G06N7/00 , H04L9/40 , G06F11/34
摘要： A method, apparatus and system for anomaly detection in a processor based system includes training a deep learning sequence prediction model using observed baseline behavioral sequences of at least one processor behavior of the processor based system, predicting baseline behavioral sequences from the observed baseline behavioral sequences using the sequence prediction model, determining a baseline reconstruction error distribution profile using the baseline behavioral sequences and the predicted baseline behavioral sequences, predicting test behavioral sequences from observed, test behavioral sequences using the sequence prediction model, determining a testing reconstruction error distribution profile using the observed test behavioral sequences and the predicted test behavioral sequences, and comparing the baseline reconstruction error distribution profile to the testing reconstruction error distribution profile to determine if an anomaly exists in a processor behavior of the processor based system.

9. 发明申请

US20220319636A1 VARIATION POLYGENIC INDEX/SCORE 有权
公开(公告)号：US20220319636A1
公开(公告)日：2022-10-06
申请号：US17696069
申请日：2022-03-16
申请人： The Trustees of Princeton University
发明人： Dalton Conley
IPC分类号： G16B20/40 , G16B20/20 , G16B40/00 , G16B50/00 , G16B30/00
摘要： Disclosed is a method for calculating genetic score based on genotypic information that predicts plasticity in a phenotype. More particularly, disclosed is an algorithm to calculate a particular type of genetic score based on basic genotypic information that is provided by commercially available technologies ranging from “SNP-chips” to whole genome sequencing. Polygenic scores— attempts to summarize the genetic propensity for or risk of a given phenotype (i.e., disease or trait)—have been around for more than a decade. They aim to predict the level of a trait—i.e., how tall or short someone may be or what their blood pressure or BMI might be. The Variation Polygenic Score (“vPGS”) disclosed herein is different. Its purpose is not to predict whether someone who scores higher or lower on the vPGS will be, for instance, heavier or lighter or have a higher or lower IQ. Rather, it is formulated to predict variation. The disclosed vPGS does not predict the mean level but rather the dispersion around that mean. It likely also predicts individual changes in a phenotype over the lifecourse (e.g., whether an individual tends to fluctuate greatly in weight). The disclosed approach is very suited for gene-environment interaction studies: that is, it is a good measure of the genetic propensity to be influenced by the environment for or intervention on a particular trait, disease or other phenotype.

10. 发明申请

US20220291119A1 ACTIVE STABILIZATION OF PARASITIC FRINGES IN OPTICAL SPECTROMETERS 有权
公开(公告)号：US20220291119A1
公开(公告)日：2022-09-15
申请号：US17689579
申请日：2022-03-08
申请人： The Trustees of Princeton University
发明人： Chu C. Teng , Gerard Wysocki
IPC分类号： G01N21/31
摘要： Disclosed are a system and method for active stabilization of parasitic fringes in optical spectrometers, wherein the spectrometer obtains the transmission spectrum, and a signal processor extracts the etalon drift from the spectral signatures of parasitic fringes. The disclosed approach improves spectrometer accuracy, minimizes drift, and increases time between calibrations.

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