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1. 发明授权

US11466076B2 Binding domain or antibody specific to a human serum albumin (HSA) 有权
公开(公告)号：US11466076B2
公开(公告)日：2022-10-11
申请号：US16098085
申请日：2017-04-28
申请人： UCB BIOPHARMA SPRL
发明人： Ralph Adams , Sam Philip Heywood
IPC分类号： C07K16/00 , C07K16/18 , C07K14/76 , C07K14/765 , C07K16/06 , A61K39/395 , A61K39/00 , C07K16/46
摘要： The present disclosure relates to a method of modulating the half-life of a binding domain specific to a serum carrier protein by mutating the sequence and a modulated binding domain specific to a serum carrier protein.

2. 发明授权

US11324896B2 Cap for an injector 有权
公开(公告)号：US11324896B2
公开(公告)日：2022-05-10
申请号：US16608400
申请日：2018-04-25
申请人： UCB Biopharma SPRL
发明人： Barry Alan Knight , Marko Plevnik , Norihiko Inoue , Jamie Buckley , Lisa Hornsey
IPC分类号： A61M5/32
摘要： Provided is a cap for an injector comprising a syringe with a needle cover. The cap comprises a cap body defining an inner and outer cap body; provided to the inner cap body, a grip for gripping the needle cover of said syringe; provided to the outer cap body, an opposing pair of recessed portions, wherein each recessed portion defines a recess base, and wherein each recessed portion is bounded by a peripheral lip; and provided to the recess base of each recessed portion, an over-coating. The cap body comprises a generally rigid material and each over-coating comprises a more flexible material. Each peripheral lip defines banks that extend beyond the over-coating of the recess base.

3. 发明授权

US11059911B2 Sequence symmetric modified IgG4 bispecific antibodies 有权
公开(公告)号：US11059911B2
公开(公告)日：2021-07-13
申请号：US16242378
申请日：2019-01-08
申请人： UCB Biopharma SPRL
发明人： David Paul Humphreys , Shirley Jane Peters
IPC分类号： C07K16/46 , C07K16/00
摘要： The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain:
the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and
optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

4. 发明申请

US20200377578A1 NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXINS TCDA AND TCDB OF CLOSTRIDIUM DIFFICILE 审中-公开
公开(公告)号：US20200377578A1
公开(公告)日：2020-12-03
申请号：US16919576
申请日：2020-07-02
申请人： UCB Biopharma SPRL
发明人： David Paul Humphreys , Daniel John Lightwood , Kerry Louise Tyson , David Edward Ormonde Knight , Karine Jeannine Madeleine Hervé , Joanne Elizabeth Compson , Matthew Jon Timothy Page , Andrew Charles Payne , Nicola Louise Fisher , Brendon MacKenzie , Matthew Cox
IPC分类号： C07K16/12 , A61K39/40 , A61K45/06 , G01N33/569 , G01N33/573 , G01N33/68
摘要： This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.

5. 发明授权

US10730952B2 Molecules with specificity for CD45 and CD79 有权
公开(公告)号：US10730952B2
公开(公告)日：2020-08-04
申请号：US15326499
申请日：2015-07-16
申请人： UCB BIOPHARMA SPRL
发明人： Helene Margaret Finney , Stephen Edward Rapecki , Michael John Wright , Kerry Louise Tyson
IPC分类号： A61K39/00 , C07K16/28 , C07K16/18 , C07K16/46
摘要： The present disclosure relates to a multispecific molecule comprising a binding domain specific to the antigen CD45 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising same and use of each in treatment, for example treatment of autoimmune disease.

6. 发明授权

US10479824B2 Single chain FC polypeptides 有权
公开(公告)号：US10479824B2
公开(公告)日：2019-11-19
申请号：US12374213
申请日：2007-07-24
申请人： Alastair David Griffiths Lawson , Paul Edward Stephens
发明人： Alastair David Griffiths Lawson , Paul Edward Stephens
IPC分类号： C07K16/00
摘要： The present invention relates to single chain polypeptides comprising one or more immunoglobulin Fc domains. In particular the present invention relates to single-chain Fc polypeptides in which at least one functional Fc domain is formed within the polypeptide chain.

7. 发明授权

US10464932B2 Iminothiadiazinane dioxide derivatives as plasmepsin V inhibitors 有权
公开(公告)号：US10464932B2
公开(公告)日：2019-11-05
申请号：US16076387
申请日：2017-02-22
申请人： UCB Biopharma SPRL
发明人： Teresa De Haro Garcia , Martin Alexander Lowe , Malcolm Maccoss , Richard David Taylor , Zhaoning Zhu
IPC分类号： C07D417/10 , C07D417/14 , A61P33/06
摘要： A series of 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted in the 5-position by a phenyl moiety NH which in turn is meta-substituted by an optionally substituted fused bicyclic heteroaromatic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

8. 发明授权

US10457748B2 Single linker FabFv antibodies and methods of producing same 有权
公开(公告)号：US10457748B2
公开(公告)日：2019-10-29
申请号：US14654240
申请日：2013-12-20
申请人： UCB Biopharma SPRL
发明人： Emma Dave , Sam Philip Heywood , David Paul Humphreys
IPC分类号： C07K16/18 , C07K16/46 , C07K16/28
摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III): V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

9. 发明授权

US10344081B2 Tau-binding antibodies 有权
公开(公告)号：US10344081B2
公开(公告)日：2019-07-09
申请号：US15742070
申请日：2016-07-05
申请人： UCB BIOPHARMA SPRL
发明人： Kerry Louise Tyson , Terence Seward Baker , Georges Mairet-Coello , Patrick Downey , Jean-Philippe Courade , David Edward Ormonde Knight
IPC分类号： C07K16/18 , G01N33/68 , A61K39/00 , C07K14/47 , A61P25/28
摘要： The present invention relates to Tau-binding antibodies and binding fragments thereof.

10. 发明授权

US10322093B2 Method for producing a transdermal therapeutic system which contains a D2 agonist 有权
公开(公告)号：US10322093B2
公开(公告)日：2019-06-18
申请号：US10936620
申请日：2004-09-07
申请人： Walter Mueller , James V. Peck
发明人： Walter Mueller , James V. Peck
IPC分类号： A61K9/70 , A61K31/381
摘要： A substantially solvent-free matrix layer containing (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol is produced by adding an active substance to an adhesive solution, coating the resultant active substance-containing adhesive solution onto a suitable sheet, and removing the solvents in a drying process to give said substantially solvent-free matrix layer.

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