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1. 发明申请

US20210338386A1 DENTAL PROSTHESIS SYSTEM, FOR THE USE WITH AT LEAST TWO DENTAL IMPLANTS 有权
公开(公告)号：US20210338386A1
公开(公告)日：2021-11-04
申请号：US17272140
申请日：2019-08-27
申请人： UNIVERSIDADE DO PORTO
发明人： Jose Joaquim ROCHA FERREIRA
IPC分类号： A61C8/00
摘要： A dental prosthesis system, for the use with at least two dental implants, wherein the dental prosthesis is divided in a first prosthetic part and a second prosthetic part, jointed by a prosthetic screw, and wherein the first prosthetic part is connected to the dental implants through at least two connectors, and such dental prosthesis has an engaging and guidance system, including two female elements, disposed on the top of the first prosthetic part, and two corresponding male elements, disposed on the bottom of the second prosthetic part, whereby the connection between the two female elements and the two male elements is releasable. The problems solved in the prior art are related to a bending moment derived from masticatory forces. The solution comprises installing a mechanical weakness in the prosthesis to protect the bone tissue.

2. 发明申请

US20210315866A1 (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS 有权
公开(公告)号：US20210315866A1
公开(公告)日：2021-10-14
申请号：US17254048
申请日：2019-05-02
申请人： UNIVERSIDADE DE COIMBRA , UNIVERSIDADE DO PORTO
发明人： Lucilia Helena ATAIDE SARAIVA , Joana Oliveira GAMA SOARES , Teresa Margarida VASCONCELOS DIAS DE PINHO E MELO , Helena Isabel NQGUEIRA RAMOS ROCHA
IPC分类号： A61K31/429 , C07D513/04 , A61K45/06 , A61P35/00
摘要： The present application relates to compounds of formula I, which are (3S)- and (3R)-6,7-bis(Hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. The present application also relates to pharmaceutical compositions having the compounds and the use of these compounds in the treatment of conditions influenced by wild-type or mutant p53 forms. More specifically, these compounds represent a completely new chemical family of p53-activating agents and show a higher selectivity towards the p53-pathway compared to the reactivators of p53 currently under clinical trials. For some cancer types these compounds revealed to be more potent than the reactivators of p53 currently under clinical trials. In addition to these advantages, the presently disclosed compounds are not genotoxic and have no apparent undesirable toxic side effects.

3. 发明授权

US11066652B2 Vaccine for immunocompromised hosts 有权
公开(公告)号：US11066652B2
公开(公告)日：2021-07-20
申请号：US15313327
申请日：2015-06-12
申请人： UNIVERSIDADE DO PORTO—REITORIA
发明人： Paula Maria Das Neves Ferreira Da Silva , Pedro Jorge Fonseca Madureira
IPC分类号： C12N9/02 , A01K67/027 , A61K39/108 , A61K39/085 , A61K39/09 , A61K39/095 , A61K39/104 , C07K16/40 , A61K39/00
摘要： The invention provides peptides derived from a ubiquitous protein, and nucleic acids encoding such peptides. The invention extends to various uses of these peptides and nucleic acids, for example, as antigens for use in vaccines per se and in the generation of antibodies for use in therapeutic drugs for the prevention, amelioration or treatment of infections caused by sepsis-inducing bacteria. The invention particularly benefits immunocompromised hosts such as neonates, babies, children, women of fertile age, pregnant women, foetuses, the elderly and diabetics.

4. 发明申请

US20210172955A1 ANTIGEN BIOMARKER OF MICROSATELLITE INSTABILITY 有权
公开(公告)号：US20210172955A1
公开(公告)日：2021-06-10
申请号：US17052243
申请日：2019-05-03
申请人： Instituto de Patologia e Imunologia da Universidade do Porto (IPATIMUP)
发明人： Celso ALBUQUERQUE REIS , Stefan MEREITER , Ana Maria RODRIGUES LEITE DE MAGALHÄES , Karol POLOM , Franco ROVIELLO
IPC分类号： G01N33/574 , C07K16/28
摘要： The present invention refers to the use of antibodies against the Thomsen-Friedenreich (TF) as reagents for in vitro diagnostics of Microsatellite Instability (MSI).
Another aspect of this invention refers to a method for the in vitro diagnostics of MSI comprising the said composition employing the anti-TF antigen antibodies and measuring the expression of the TF antigen in a tissue sample.
The present invention further refers to a kit comprising the above mentioned compositions for detecting MSI by conducting the present invention's method.
The use, composition, methods and kit may be advantageously applied to significantly facilitate the identification of MSI in the clinical setting through a single marker-based sensitive and specific detection of MSI in patients with cancers of gastric, colorectal and other tissues for diagnostics, prognostics or prediction of response to treatment.

5. 发明申请

US20210093722A1 CYANOBACTERIUM EXTRACELLULAR POLYMER, COMPOSITIONS AND USES THEREOF 有权
公开(公告)号：US20210093722A1
公开(公告)日：2021-04-01
申请号：US17019991
申请日：2020-09-14
申请人： INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR - IBMC , UNIVERSIDADE DO PORTO
发明人： Rita GIL VASCONCELOS MOTA , Paula TAMAGNINI , Luis Miguel GALES PEREIRA PINTO , José Pedro SANTOS LEITE , Sara Isabel MACEDO BERNARDES PEREIRA
IPC分类号： A61K47/36 , A61K8/73 , A61Q19/08 , A61K9/00 , A61Q19/00 , A61K9/08 , A61P17/02 , A61K8/04 , A61K8/64 , A61K9/06 , A61K45/06
摘要： The polysaccharide released from the unicellular cyanobacterium Cyanothece sp. CCY 0110 exhibits low cytotoxicity and proves to be suitable for the delivery of macromolecules. The cyanobacterium extracellular polymer disclosed in the present subject-matter, namely a polysaccharide and more in particular an heteropolysaccharide, assembles with proteins into a new phase with gel-like behaviour and the release kinetics can be modulated (i.e., delayed) by adding divalent cations and/or also exhibits physical and chemical properties typical of a bioemulsifier or a bioflocculant.

6. 发明授权

US09692604B2 Probabilistic key distribution in vehicular networks with infrastructure support 有权
公开(公告)号：US09692604B2
公开(公告)日：2017-06-27
申请号：US15051817
申请日：2016-02-24
申请人： UNIVERSIDADE DO PORTO
发明人： Joäo Francisco Cordeiro De Oliveira Barros , Joäo Paulo Patriarca De Almeida , Mate Boban , Saurabh Shintre
IPC分类号： H04L29/06 , H04L9/32 , H04L9/08 , H04W12/04 , H04L9/14 , H04L9/30 , H04L29/08 , H04L9/00 , H04W12/06 , H04W4/04 , H04W84/18
CPC分类号： H04L9/3263 , H04L9/006 , H04L9/083 , H04L9/0838 , H04L9/0844 , H04L9/14 , H04L9/30 , H04L9/3265 , H04L63/06 , H04L63/061 , H04L63/062 , H04L63/065 , H04L63/068 , H04L63/0869 , H04L67/12 , H04L2209/24 , H04L2209/80 , H04L2209/84 , H04W4/046 , H04W12/04 , H04W12/06 , H04W84/18
摘要： Method and system of key distribution by trusted nodes for a vehicular ad hoc network, the nodes of said network having at least one pair of public-private keys and the corresponding certificates, issued by a CA, said method comprising each vehicle node, on entering said network region, requesting a set of keys from an RSU node that is within range and within that region, said RSU node sending said vehicle node a set of private keys, selected from a pool of private keys, and a list with the key identifiers of the private keys shared by said vehicle node and the other vehicle nodes that have most recently contacted said RSU for a predetermined period of time; such that two nodes are able to establish a secure connection without further interaction by deriving a shared secret which is a cryptographic hash function of the keys shared by said two nodes.

7. 发明申请

US20090308376A1 SMART DEVICE FOR ABSORBING SOLAR ENERGY AND CONTROLING SUNLIGHT ADMISSION 有权
标题翻译：用于吸收太阳能和控制阳光照射的智能装置
公开(公告)号：US20090308376A1
公开(公告)日：2009-12-17
申请号：US12520026
申请日：2007-12-18
申请人： José Roberto Tinoco Cavalheiro , Mário Alexandre Sousa Tavares Da Fonseca
发明人： José Roberto Tinoco Cavalheiro , Mário Alexandre Sousa Tavares Da Fonseca
IPC分类号： F24J2/40
CPC分类号： E06B3/6722 , E06B9/24 , E06B2009/2411 , F24S10/50 , F24S20/63 , F24S50/80 , Y02B10/20 , Y02B10/22 , Y02E10/44
摘要： The present invention provides a process for absorbing solar energy and, simultaneously having a continuous control of the light admission making it possible to install the device in external openings of buildings and equipment, such as windows, shutters or skylights. The system comprises two frames which support plates of transparent material, between which it is possible to introduce a colourful solution coming from an external reservoir. Both frames are interconnected through a flexible membrane which allows the plates to be pushed against each other, making the window transparent, or pushed away interposing the colourful solution, which will make the window uniform and gradually translucent or opaque. The said liquid comes from a reservoir and the access to the gap between the plates through is obtained by means of a channel that separates the two frames, allowing the liquid to flow evenly into the whole surface, thus being a homogenous and adjustable darkening obtainable. The inflow or outflow of the liquid between the plates is ruled by the vacuum level inside the reservoir containing the colourful solution. When the window is opaque or partially transparent, the solar energy heats the liquid which is then forced to flow by a circulating pump, passing through a heat exchanger which allows the energy absorption.
摘要翻译：本发明提供了一种吸收太阳能的方法，同时具有连续的光入射控制，使得可将该装置安装在诸如窗户，百叶窗或天窗的建筑物和设备的外部开口中。该系统包括支撑透明材料板的两个框架，两个框架可以引入来自外部储存器的五颜六色的溶液。两个框架通过柔性膜互连，这允许板被彼此推压，使得窗户透明，或推开多彩的溶液，这将使窗户均匀并且逐渐半透明或不透明。所述液体来自储存器，并且通过分隔两个框架的通道获得对通孔之间的间隙的访问，允许液体均匀地流入整个表面，因此是可获得的均匀且可调节的变暗。液体在板之间的流入或流出由包含彩色溶液的储存器内部的真空度决定。当窗户不透明或部分透明时，太阳能加热液体，然后液体被循环泵强制流过，通过允许能量吸收的热交换器。

8. 发明申请

US20090081796A1 METHOD FOR THE DETERMINATION OF PHOSPHOLIPIDS IN AMNIOTIC FLUID SAMPLES 审中-公开
标题翻译：用于确定生物流体样品中磷脂的方法
公开(公告)号：US20090081796A1
公开(公告)日：2009-03-26
申请号：US12159768
申请日：2007-07-31
申请人： Maria Irene De Oliveira Monteiro Jesus Rebelo , Belmiro Dos Santos Patricio
发明人： Maria Irene De Oliveira Monteiro Jesus Rebelo , Belmiro Dos Santos Patricio
IPC分类号： G01N30/94
CPC分类号： G01N30/94 , G01N2030/945
摘要： The present invention refers to a fast method for the determination of phospholipids in amniotic fluid samples by HPTLC (high performance thin layer chromatography). This innovative method presents high sensitivity, reproducibility and resolution. It has also the advantage of being of easy laboratorial interpretation, allowing the elimination of false results due to the contamination of the sample with blood or meconium.
摘要翻译：本发明涉及通过HPTLC（高效薄层色谱法）测定羊水样品中磷脂的快速方法。这种创新的方法具有高灵敏度，重复性和分辨率。它还具有易于实验解释的优点，允许消除由于样品与血液或胎粪的污染导致的错误结果。

9. 发明申请

US20230140634A1 MULTI-CONVOLUTIONAL TWO-DIMENSIONAL ATTENTION UNIT FOR ANALYSIS OF A MULTIVARIABLE TIME SERIES THREE-DIMENSIONAL INPUT DATA 有权
公开(公告)号：US20230140634A1
公开(公告)日：2023-05-04
申请号：US18010501
申请日：2020-11-27
申请人： UNIVERSIDADE DO PORTO
发明人： Rui Jorge PEREIRA GONÇALVES , Fernando Manuel FERREIRA LOBO PEREIRA , Vítor Miguel DE SOUSA RIBEIRO
IPC分类号： G06N3/02
摘要： It is therefore an object of the present invention a multi-convolutional two-dimensional (2D) attention unit to be applied in performing MTS three-dimensional (3D) data analysis, of input data (1) with cyclic properties, using an RRN architecture. This unit is able to constructs one independent attention vector a per variable of the MTS using 2D convolutional operations to capture the importance of a time-step inside surrounding segments and time-steps area. For that purpose, the two-dimensional attention unit is comprised by a splitting block (2), a attention block (3), a concatenation block (4) and a scaling block (5).

10. 发明申请

US20230081205A1 PROCESS FOR SEPARATING THE COMPONENTS OF HARDENED CONCRETE WASTE FOR PRODUCING RECYCLED CEMENT 有权
公开(公告)号：US20230081205A1
公开(公告)日：2023-03-16
申请号：US17801829
申请日：2021-02-23
申请人： INSTITUTO SUPERIOR TÉCNICO , INSTITUTO POLITÉCNICO DE SETÚBAL , UNIVERSIDADE DO PORTO
发明人： José Alexandre de Brito Aleixo BOGAS , Manuel Francisco Costa PEREIRA , Ana Mafalda Saldanha GUEDES , Ana Chambel CARRIÇO , Susana HU , Rui Jorge Coelho de SOUSA
IPC分类号： C04B7/24 , B03C1/18 , B03C1/00 , B03C1/30
摘要： The present invention lies within the field of construction materials and concerns a process for separating the constituents of hardened concrete, with the aim of extracting the cementitious fraction to be used in the production of thermoactivated recycled cement, involving the essential steps of: (a) crushing the concrete waste; (b) screening the crushed material to separate material smaller than about 1 mm; (c) fragmenting material larger than 1 mm; (d) screening material smaller than 1 mm into various granulometric fractions; (e) high intensity magnetic separation of the material; (f) grinding of the cementitious fraction resulting from the magnetic separation in the previous step to a size that allows its efficient thermoactivation; and (g) obtaining a thermoactivated recycled cement.

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