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1. 发明授权

US11052082B2 Combination of opioids and anticancer drugs for cancer treatment 有权
公开(公告)号：US11052082B2
公开(公告)日：2021-07-06
申请号：US16000467
申请日：2018-06-05
申请人： UNIVERSITÄT ULM
发明人： Claudia Friesen , Erich Miltner
IPC分类号： A61K31/137 , A61K31/485 , A61K31/704 , A61K45/06 , A61K31/4468 , A61K31/7048 , A61K31/7076 , A61K33/24 , G01N33/50 , A61K31/445
摘要： The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.

2. 发明申请

US20160206699A1 USE OF INTERLEUKIN 10 MRNA TRANSFECTED MACROPHAGES IN ANTI-INFLAMMATORY THERAPIES 审中-公开
公开(公告)号：US20160206699A1
公开(公告)日：2016-07-21
申请号：US15071163
申请日：2016-03-15
申请人： Ruprecht-Karls-Universität Heidelberg , Universität Ulm
发明人： Ziya KAYA , Hugo KATUS , Oliver ZIMMERMANN , Wolfgang ROTTBAUER , Jan TORZEWSKI
IPC分类号： A61K38/20 , C12N5/0786 , A61K45/06
CPC分类号： C07K14/5428 , A61K35/15 , A61K38/2066 , A61K45/06 , C12N5/0645 , C12N2510/00
摘要： The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.

3. 发明申请

US20150265594A1 COMBINATION OF OPIOIDS AND ANTICANCER DRUGS FOR CANCER TREATMENT 审中-公开
标题翻译：用于癌症治疗的OPIOIDS和抗癌药物的组合
公开(公告)号：US20150265594A1
公开(公告)日：2015-09-24
申请号：US14434138
申请日：2013-10-08
申请人： UNIVERSITÄT ULM
发明人： Claudia Friesen , Erich Miltner
IPC分类号： A61K31/485 , A61K31/445 , G01N33/50 , A61K45/06
CPC分类号： A61K31/485 , A61K31/137 , A61K31/445 , A61K31/4468 , A61K31/704 , A61K31/7048 , A61K31/7076 , A61K33/24 , A61K45/06 , G01N33/5011 , G01N33/5014 , G01N2500/04 , A61K2300/00
摘要： The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.
摘要翻译：本发明涉及基于阿片受体激动剂和抗癌化合物的组合治疗癌症患者的新策略。

4. 发明申请

US20220214331A1 APPARATUS AND METHOD FOR DETECTING A SPATIAL ELONGATION OF AT LEAST ONE ADHERENT BIOLOGICAL CELL 有权
公开(公告)号：US20220214331A1
公开(公告)日：2022-07-07
申请号：US17270014
申请日：2019-08-20
申请人： UNIVERSITÄT ULM
发明人： Tobias NECKERNUSS , Daniel GEIGER , Othmar MARTI
IPC分类号： G01N33/50 , G01N15/14 , G02B21/06
摘要： An apparatus for detecting a spatial elongation of at least one adherent biological cell is provided. The apparatus contains at least one biological cell, which is adhered to a substrate, a laser for irradiating the at least one biological cell for a spatial elongation of the cell in a direction parallel to the irradiation direction and a detector for detecting the spatial elongation of the cell in the direction parallel to the radiation direction. Further, a corresponding method for spatial elongation of an adherent biological cell is provided and the uses of the apparatus and of the method proposed. Using the apparatus and method, it is possible to ascertain, from parts of adherent cells to entire groups of adherent cells, the mechanical properties in the natural, adherent state of the cell(s) in spatially selective, temporally selective and contactless fashion.

5. 发明授权

US08835573B2 Biodegradable composite system and the use thereof 有权
标题翻译：可生物降解复合体系及其用途
公开(公告)号：US08835573B2
公开(公告)日：2014-09-16
申请号：US12745224
申请日：2008-11-28
申请人： Hartmut Seliger , Hans Häberlein
发明人： Hartmut Seliger , Hans Häberlein
IPC分类号： C08F283/04 , C08K11/00 , C08L89/00 , C08L97/02 , C08G18/73 , C08L67/04 , C08L75/06 , C08G18/42 , C08L3/00 , C08L1/08
CPC分类号： C08G18/4283 , C08G18/73 , C08G2230/00 , C08G2261/126 , C08L1/08 , C08L3/00 , C08L67/04 , C08L75/06 , C08L97/02 , C08L2205/16 , C08L2666/20 , C08L75/04 , C08L2666/02 , C08L2666/26
摘要： The invention relates to a composite system comprising at least one biodegradable blend, containing at least one biodegradable block copolyester urethane (PEU) and also at least one polyhydroxyalkanoate (PHA), possibly a filler comprising a polysaccharide and/or derivatives thereof and also possibly further biocompatible additives. Composite systems of this type are used for producing molded articles, molded parts or extrudates. Furthermore, the invention relates to possibilities for using the composite system.
摘要翻译：本发明涉及包含至少一种包含至少一种可生物降解的嵌段共聚酯氨基甲酸酯（PEU）和至少一种聚羟基链烷酸酯（PHA）的可生物降解的共混物的复合体系，可能是包含多糖和/或其衍生物的填料，并且还可能进一步生物相容性添加剂。这种类型的复合系统用于生产模塑制品，模制件或挤出物。此外，本发明涉及使用复合系统的可能性。

6. 发明申请

US20140255988A1 MONOMERIC VARIANTS OF THE TETRAMERIC eqFP611 审中-公开
标题翻译：四元组的单体变量eqFP611
公开(公告)号：US20140255988A1
公开(公告)日：2014-09-11
申请号：US14164903
申请日：2014-01-27
申请人： Universität Ulm
发明人： Jörg Wiedenmann , Simone Kredel , Franz Oswald , Gerd Ulrich Nienhaus
IPC分类号： C07K14/435 , G01N33/58
CPC分类号： C07K14/43504 , C07K14/43595 , G01N33/582
摘要： DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA comprising a nucleotide sequence selected from the group consisting of SEQ ID No. 2, SEQ ID No. 4 and SEQ ID No. 6.
摘要翻译：编码红色荧光蛋白eqFP611的单体变体的DNA，其包含选自SEQ ID No.1，SEQ ID No.3和SEQ ID No.5的氨基酸序列。包含选自下组的核苷酸序列的DNA： SEQ ID No.2，SEQ ID No.4和SEQ ID No.6。

7. 发明申请

US20120243509A1 METHOD FOR COMMUNICATING INFORMATION 审中-公开
标题翻译：传播信息的方法
公开(公告)号：US20120243509A1
公开(公告)日：2012-09-27
申请号：US13511590
申请日：2010-11-15
申请人： Petar Popovski , Zoran Utkovski
发明人： Petar Popovski , Zoran Utkovski
IPC分类号： H04W8/22 , H04W36/00 , H04W16/02 , H04W72/04
CPC分类号： H04W28/04 , H04L1/004 , H04W84/12
摘要： The invention relates to a method for communicating intended information between a sender and at least one receiver in a communication system. The method comprises providing a plurality of elements to be sent from the sender to the receiver, the plurality of elements being in a first order; sending to the receiver the elements in a second order, the second order representing the intended information; receiving the plurality of elements; determining whether an order in which the elements have been received is different from the first order; if the order in which the elements have been received is different from the first order, determining an information based on the order in which the elements have been received; and if the order in which the elements have been received is the second order, the information determined is the intended information.
摘要翻译：本发明涉及一种用于在通信系统中的发送者和至少一个接收者之间传送预期信息的方法。该方法包括提供要从发送器发送到接收器的多个元件，多个元件处于第一顺序; 以二级向接收方发送元素，第二级表示预期信息; 接收所述多个元件; 确定已经接收到元素的顺序是否不同于第一顺序; 如果已经接收到元素的顺序与第一顺序不同，则基于已经接收到元素的顺序来确定信息; 并且如果已经接收到元素的顺序是第二顺序，则确定的信息是预期信息。

8. 发明申请

US20220348615A1 PRODUCTION OF BACTERIOCINS 有权
公开(公告)号：US20220348615A1
公开(公告)日：2022-11-03
申请号：US17724712
申请日：2022-04-20
申请人： Norwegian University of Science and Technology (NTNU) , UNIVERSITÄT ULM , NORWEGIAN UNIVERSITY OF LIFE SCIENCES , DANMARKS TEKNISKE UNIVERSITET , UNIVERSITÄT DES SAARLANDES
发明人： Gerd Michael SEIBOLD , Christoph WITTMANN , Dzung DIEP , Nadav BAR , Christian U. REIDEL , Dominik WEIXLER , Oliver GOLDBECK
IPC分类号： C07K14/34
摘要： The present invention relates to the production of bacteriocins, and in particular the production of bacteriocins of class I or II by recombinant expression in coryneform bacteria as the bacterial cell host. Also provided are modified coryneform bacteria for use as production hosts for production of bacteriocins.

9. 发明申请

US20210325293A1 METHOD AND DEVICE FOR ANALYSING CELLS 有权
公开(公告)号：US20210325293A1
公开(公告)日：2021-10-21
申请号：US16479689
申请日：2018-01-26
申请人： UNIVERSITÄT ULM
发明人： Daniel GEIGER , Tobias NECKERNUSS , Othmar MARTI
IPC分类号： G01N15/14 , G06T7/00 , G06T7/269 , G01N1/40
摘要： Disclosed is a method for analysing cells, in which cells are separated and the individual cells pass via a measurement region of a unit for spatially resolved radiation intensity measurement, wherein, for at least one of the separated cells, when passing via the measurement region, a time sequence of spatial intensity patterns of an electromagnetic radiation emitted from and/or influenced by the cell is created, the optical flow of a respective two of the spatial intensity patterns is calculated for at least one portion of the sequence of intensity patterns using a computer unit, and an evaluation of the calculated optical flows occurs. Also disclosed is a device for analysing cells, comprising a device for separating cells, a unit for spatially resolved radiation intensity measurement, and a computer unit for calculating the optical flow of a respective two of the created intensity patterns, and for evaluating the calculated optical flows.

10. 发明授权

US10384230B2 Method for producing a substrate structured by nanowires, produced substrate, and use of the substrate 有权
公开(公告)号：US10384230B2
公开(公告)日：2019-08-20
申请号：US15537545
申请日：2015-12-14
申请人： UNIVERSITÄT ULM
发明人： Steffen Strehle , Daniel Markus Rosskopf , Andreas Magnus Probst
IPC分类号： B05D1/28 , H05K3/12 , B81C1/00 , H05K1/03 , H05K1/09 , B82B3/00 , H05K3/10
摘要： The invention relates to a method for producing a substrate structured by nanowires, characterized in that no lubricant and no lithographic resist mask is used in the method, and only by moving a donor substrate having nanowires relative to a substrate and by locally tribological properties on the surface of the substrate, a specified number of nanowires is deposited selectively at locally defined points of the substrate. The invention further relates to a substrate that can be produced using the method according to the invention, and which selectively contains a specified number of nanowires on a surface at locally defined points. The invention further relates to the use of the substrate according to the invention in microelectronics, microsystems technology, and/or micro-sensor systems.

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