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1. 发明授权

US11344008B1 Production of human DNaseI in erythrocytes of transgenic non-human mammal using erythroid-specific promoter 有权
公开(公告)号：US11344008B1
公开(公告)日：2022-05-31
申请号：US16295155
申请日：2019-03-07
申请人： Hai Xing Chen , Hong Yang Wang , Zhongtian Qi
发明人： Hai Xing Chen , Hong Yang Wang , Zhongtian Qi
IPC分类号： A01K67/027 , C12N9/22 , C12N15/85
摘要： A method of producing a non-erythroid protein in erythrocytes of a transgenic animal using an erythroid-specific promoter includes synthesizing an erythroid-specific globin gene promoter and globin gene locus control region and cloning the promoter and the globin gene locus control region and a gene encoding a non-erythroid protein into a vector to obtain a transgene; introducing the transgene in pronuclear embryos collected from a mammalian animal in vitro; transplanting the pronuclear embryos containing the transgene into oviduct of a female recipient of the mammalian animal to obtain a transgenic animal which then expresses the non-erythroid protein in progenitor cells of erythrocytes; and collecting blood from the transgenic animal and isolating the non-erythroid protein from the erythrocytes. Further disclosed are a transgenic animal expressing a non-erythroid protein in progenitor cells of erythrocytes and an isolated erythrocyte of a non-human transgenic animal containing a human non-erythroid protein encoded by a transgene.

2. 发明授权

US11207366B2 Traditional Chinese medicine composition comprising dried tangerine peels and dark tea for treating diabetes and preparation method thereof 有权
公开(公告)号：US11207366B2
公开(公告)日：2021-12-28
申请号：US16317621
申请日：2017-11-10
申请人： Guosheng Chang , Fengcan Jiang
发明人： Guosheng Chang , Fengcan Jiang
IPC分类号： A61K36/752 , A61K36/82 , A61P3/10 , A23F3/14 , A23L19/00 , A23F3/08
摘要： A traditional Chinese medicine composition for treating diabetes and a preparation method thereof, the composition comprises dried tangerine peels and dark tea. The preparation method utilizes Pu'er tea to shuffle placement with the dried tangerine peels to preserve the dried tangerine peels, mixes different kinds of dried tangerine peels of different aging years, adds the mixed dried tangerine peels with pile-fermented black tea, presses the mixed black tea into tea bricks, and secondarily-ferments the tea bricks, then ages the secondary fermented tea bricks for two years.

3. 发明授权

US11051821B2 Surgical string applicator for anastomosis surgery 有权
公开(公告)号：US11051821B2
公开(公告)日：2021-07-06
申请号：US16373432
申请日：2019-04-02
申请人： Unique Surgical Innovations LLC
发明人： Francisco Sergio Pinheiro Regadas
IPC分类号： A61B17/12 , A61B17/04 , A61B17/11 , A61B17/115 , A61B17/132 , B65B13/02 , A61B17/00
摘要： A surgical string applicator for anastomosis surgery is provided. The surgical string applicator includes an elongate shaft; a string applying assembly including a pair of opposing jaws connected to the elongate shaft, each jaw having an opening at its distal end, one or more surgical strings housed in the jaws in a form of an open loop with one end of the surgical string at the distal end of one jaw and an opposing end of the surgical string at the distal end of the other jaw, and a string fastening mechanism adapted to engage and fasten the surgical string around a tubular organ; and a handle portion including control mechanisms adapted to open and close at least one of the jaws and to actuate the string fastening mechanism. Further provided is an intra-lumenal position guide to be used together with the surgical string applicator.

4. 发明授权

US08741596B2 Smart packaging for detecting microorganisms 有权
标题翻译：用于检测微生物的智能包装
公开(公告)号：US08741596B2
公开(公告)日：2014-06-03
申请号：US13319048
申请日：2010-04-21
申请人： M. C. Cristina Nerín De La Puerta , Laura Gutierrez Bartolome , Cristina Sanchez Jarabo
发明人： M. C. Cristina Nerín De La Puerta , Laura Gutierrez Bartolome , Cristina Sanchez Jarabo
IPC分类号： C12Q1/04 , B65D79/02 , A61B19/00 , A61B19/02 , B65D71/00
CPC分类号： C12Q1/04
摘要： The present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the growth of microorganisms in different types of products to be detected visually without having to be in direct contact with the microorganism or with the medium containing same.
摘要翻译：本发明涉及新颖的智能包装，其使用包含浸渍有香草醛溶液的部分极性吸附固体基质的新型材料设计，其允许不同类型产品中的微生物的生长被目视检测而不必直接接触与微生物或含有相同的培养基。

5. 发明授权

US08590465B2 Liquid-cooled grill plate comprising wear plates and stepped grill made of such grill plates 失效
标题翻译：包含耐磨板和由这种格栅制成的阶梯式格栅的液冷格栅板
公开(公告)号：US08590465B2
公开(公告)日：2013-11-26
申请号：US12673537
申请日：2008-08-11
申请人： Michael Sandeman , Thomas Stiefel
发明人： Michael Sandeman , Thomas Stiefel
IPC分类号： F23H7/08 , F23H3/02
CPC分类号： F23H3/02 , F23G5/002 , F23G2200/00 , F23G2203/101 , F23H1/02 , F23H7/08 , F23H17/02 , F23H17/12 , F23H2700/002 , F23H2900/03021 , F23H2900/17002
摘要： The liquid-cooled grill plate has a carrier and drive design (15), having a separate cooling body (K) that can be placed into said carrier and drive design (15) and permeated by the liquid and having wear plates mounted onto said cooling body (K). The cooling body (K) is a welded design formed by square tube sections (20-26) and profiled sections (27), said design forming continuous elongated recesses (28-30) extending across the entire extension with the exception of the square tube sections (23-26) bridging said recesses (28-30). The carrier design is a ribbed configuration made of planar steel parts that are welded together and the drive unit (15) encloses a hydraulic cylinder-piston unit, which is accommodated in the inside of a square tube (18), said tube being guided displaceably in a tunnel-like breakthrough on said ribbed configuration. Between the wear plates and the cooling body (K) a highly heat-conductive soft silicone film (31) is clamped, which ensures good heat transfer. In this way, it is ensured that during operation the wear plates always remain in the non-critical temperature range in that they are cooled by the cooling body (K) disposed beneath, which heats up to about 50° C. Said grill plate is much easier and inexpensive to produce because the welding work is considerably reduced and less complex as a result of the use of a separate cooling body (K).
摘要翻译：液冷格栅板具有载体和驱动设计（15），其具有可以放置在所述载体和驱动设计（15）中并且被液体渗透并具有安装在所述冷却器上的耐磨板的单独的冷却体（K）身体（K）。冷却体（K）是由方管部分（20-26）和成形部分（27）形成的焊接设计，所述设计形成延伸穿过整个延伸部的连续细长凹槽（28-30），但方管桥接所述凹部（28-30）的部分（23-26）。载体设计是由平面钢部件制成的肋状结构，其被焊接在一起，并且驱动单元（15）包围容纳在方管（18）内部的液压缸 - 活塞单元，所述管被可移动地引导在所述肋状构造上的隧道状突破中。在耐磨板和冷却体（K）之间，夹持高导热软硅胶膜（31），确保良好的热传递。以这种方式，确保在操作期间，耐磨板总是保持在非临界温度范围，因为它们被设置在下面的冷却体（K）冷却，加热至高达约50℃。所述格栅板是由于使用单独的冷却体（K），焊接作业大大降低并且复杂度较低，所以制造成本更加容易和便宜。

6. 发明授权

US08511465B2 Closure for the metered addition of a component 失效
标题翻译：关闭以计量添加组件
公开(公告)号：US08511465B2
公开(公告)日：2013-08-20
申请号：US12747232
申请日：2008-12-10
申请人： Fritz Seelhofer
发明人： Fritz Seelhofer
IPC分类号： B65D25/08
CPC分类号： B65D51/2821
摘要： The closure includes a rotary dispenser cap (1), and is used for metering of a component in the content of a so-equipped mixing vessel (17) before use. It contains a separately filled folding container (3) which is held on its lower side by resilient spacer elements (7) over stationary piercing teeth (8) and which is pusable downword by means of rotating the rotary dispenser cap (1) which will screw down the press ring (2) and press the container (3) over the piercing teeth (8). The folding container (3) is thereby torn open. By further screwing down of the pressing ring (2), the folding container (3) is being squeezed and pressed out, so that its contents are mixed in the underlying container (17).
摘要翻译：所述封闭件包括旋转式分配器盖（1），并且用于在使用前装备如此装备的混合容器（17）的内容物中的组分的计量。它包含一个单独填充的折叠容器（3），其通过在静止刺穿齿（8）上方的弹性间隔元件（7）保持在其下侧，并且通过旋转旋转分配器盖（1）可以下降，这将旋转沿着压环（2）下压并将容器（3）压在穿孔齿（8）上。折叠容器（3）被撕开。通过进一步拧紧压环（2），折叠容器（3）被挤压并压出，使得其内容物在下面的容器（17）中混合。

7. 外观设计

USD685113S1 Insulated roof panel with flat roof tile style skin layer 有权
标题翻译：绝缘屋顶板采用平屋顶瓦面风格皮层
公开(公告)号：USD685113S1
公开(公告)日：2013-06-25
申请号：US29420706
申请日：2012-05-11
申请人： Jose L Henriquez
设计人： Jose L Henriquez

8. 发明授权

US08083918B2 Process and device for the producing and recycling of nanoemulsions as well as for the surface treatment of parts by means of the same 有权
标题翻译：用于生产和回收纳米乳剂的方法和装置以及通过其进行部件的表面处理
公开(公告)号：US08083918B2
公开(公告)日：2011-12-27
申请号：US11891478
申请日：2007-08-11
申请人： Edgar Schmidlin
发明人： Edgar Schmidlin
IPC分类号： B01F11/00 , B05D1/00
CPC分类号： C11D17/0021
摘要： The invention relates to a device comprising a tubular circuit provided with at least one pump (9), a vacuum chamber (1) for processing the surfaces of parts placed therein, an actuation device (10), high voltage electrodes and a high frequency coil comprising a separate generator provided with a frequency converter for producing an electric field. The inventive device also comprises a transversal resonator for producing an aerosol and injection nozzles for spraying said aerosol into the vacuum chamber (1). The emulsion crosses the actuation device (10) in which electric and electromagnetic fields of 1-10000 volts, whose superimposed frequencies ranging from 10 Hz to 1 GHz are produced by a high-voltage electrode and the high frequency electromagnetic coil with the aid of the generator. By superimpose in the fields, a potential Zeta variation generates the transformation of a microemulsion into a nanoemulsion for processing part surfaces.
摘要翻译：本发明涉及一种装置，其包括设置有至少一个泵（9）的管状电路，用于处理放置在其中的部件的表面的真空室（1），致动装置（10），高压电极和高频线圈包括设置有用于产生电场的变频器的单独的发电机。本发明的装置还包括用于产生用于将所述气溶胶喷射到真空室（1）中的气溶胶和喷嘴的横向谐振器。乳化剂穿过致动装置（10），其中通过高压电极和高频电磁线圈借助于高压电极和高频电磁线圈产生1-10000伏的电场和电磁场，其叠加频率范围为10Hz至1GHz 发电机。通过在场中叠加，潜在的Zeta变化产生微乳液转变为用于处理部分表面的纳米乳液。

9. 发明授权

US07609369B2 Methods of detection of iron deficiency and hemochromatosis 有权
标题翻译：检测铁缺乏症和血色素沉着症的方法
公开(公告)号：US07609369B2
公开(公告)日：2009-10-27
申请号：US11524682
申请日：2006-09-21
申请人： Ramon Simon-Lopez
发明人： Ramon Simon-Lopez
IPC分类号： G01N33/48 , G01N33/49 , G01N33/72
CPC分类号： G01N33/90 , G01N15/12 , G01N33/721 , G01N2015/0069 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1062 , G01N2015/1093 , Y10T436/11
摘要： New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The parameters include a RBC size factor, RSf1 defined by the formula of (MCV×MRV)1/2, or RSf2 defined by the formula of (MCV×MRV)/100, a volume-hemoglobin factor (VHf) defined by the formula of (MCV×Hgb)/100, and a volume-hemoglobin/distribution factor (VHDWf) defined by the formula of (MCV×Hgb)/(RDW×10). Further disclosed are the methods of using these parameters for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency. Also disclosed is a method of using RSf for detection of hemochromatosis.
摘要翻译：已经公开了用于检测绝对铁缺乏，潜在铁缺乏，功能性铁缺乏或潜在功能性铁缺乏症的新的诊断参数或指标。参数包括RBC大小因子，由式（MCVxMRV）1/2定义的RSf1或由式（MCVxMRV）/ 100定义的RSf2，由式（MCVxHgb）定义的体积血红蛋白因子（VHf） / 100，和由（MCVxHgb）/（RDW×10）式定义的体积 - 血红蛋白/分布因子（VHDWf）。还公开了使用这些参数来检测绝对铁缺乏，潜铁缺乏，功能性铁缺乏或潜在功能缺铁的方法。还公开了使用RSf检测血色素沉着症的方法。

10. 发明授权

US07586589B2 Methods of determination of responsiveness to erythropoietin treatment 有权
标题翻译：测定对促红细胞生成素治疗反应的方法
公开(公告)号：US07586589B2
公开(公告)日：2009-09-08
申请号：US11524635
申请日：2006-09-21
申请人： Ramon Simon-Lopez
发明人： Ramon Simon-Lopez
IPC分类号： G01N33/49 , G01N33/48
CPC分类号： G01N33/80 , G01N33/721 , G01N2800/52
摘要： Methods for determining the responsiveness of a patient to recombinant human erythropoietin therapy are disclosed. In one approach, the method includes obtaining a volume-Hgb factor (VHf) defined as a product function of MCV and Hgb from a patient's blood sample; comparing VHf to a predetermined criterion; and reporting indication of responder if VHf meets the predetermined criterion. The method further includes using a RBC size-hemoglobin factor (RSHf) defined as a product function of MCV, MRV and Hgb, or using a function of VHf and RDW for determining the responsiveness. In another approach, the method includes using a RBC size factor (RSf) defined as a product function of MCV and MRV, in combination with transferrin saturation (TSAT) for determining the responsiveness to the erythropoietin therapy.
摘要翻译：公开了确定患者对重组人促红细胞生成素治疗的反应性的方法。在一种方法中，该方法包括获得定义为来自患者血液样品的MCV和Hgb的乘积函数的体积-Hgb因子（VHf）; 将VHf与预定标准进行比较; 并且如果VHf满足预定标准，则报告响应者的指示。该方法还包括使用定义为MCV，MRV和Hgb的乘积函数的RBC大小 - 血红蛋白因子（RSHf），或使用VHf和RDW的函数来确定反应性。在另一种方法中，该方法包括使用定义为MCV和MRV的产物功能的RBC大小因子（RSf），结合转铁蛋白饱和度（TSAT）来确定对红细胞生成素治疗的反应性。

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