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1. 发明授权

US11565251B2 Microfluidic chip as a model for blood-tissue barriers 有权
公开(公告)号：US11565251B2
公开(公告)日：2023-01-31
申请号：US16786335
申请日：2020-02-10
申请人： WEST VIRGINIA UNIVERSITY
发明人： Paul Lockman
IPC分类号： B01L3/00 , C12M3/06
摘要： A microfluidic device is useful for modelling drug transmission across the vasculature and vascular barriers. The device includes a frame, a fluid-permeable lumen configured to carry a fluid through the frame in a first direction, a first chamber surrounding the lumen, and a second chamber surrounding the first fluid-permeable chamber. At least one surface of the first chamber is configured for deposition of a first population of endothelial cells. An outer surface of the second chamber is configured for deposition a second population of cells. The second chamber is configured to carry a fluid through the frame in a second direction. The fluid-permeable lumen is configured to allow the fluid to permeate through a wall of the lumen into the first chamber, and the first chamber and the second chamber are in fluid communication with each other.

2. 发明授权

US11564765B2 Medical assembly comprising a medical article and a package containing said article 有权
公开(公告)号：US11564765B2
公开(公告)日：2023-01-31
申请号：US17519991
申请日：2021-11-05
申请人： DEPUY SYNTHES PRODUCTS, INC.
发明人： Olivier Richart , Gregoire Larche , Jean-Pierre Podgorski
IPC分类号： B65D81/32 , A61B50/30 , A61F2/00 , B65D77/04 , A61B17/86 , A61B50/00
摘要： A medical package containing a medical article, including: a support element comprising a hollow support tube and a support cap, wherein the support element includes a first chamber configured to enclose the medical article and wherein the support cap includes a support structure configured to hold the medical article captive; a stopper configured to be coupled to the hollow support tube in such a way that the support element has a grip part that protrudes from the stopper, the grip part of the support element configured to be held by a hand of a person; a hollow protective cover configured to be coupled to the stopper in such a way as to delimit, in cooperation with the stopper, a second chamber inside which there extends the grip part of the support element, the hollow protective cover configured to be separated from the stopper, wherein when the hollow protective cover is coupled to the stopper, a part of the stopper protrudes from the hollow protective cover, and is configured to form a grip end of the stopper that is configured to be held by a hand of a person, when the hollow protective cover is separated from the stopper, wherein a part of the support element is configured to be engaged by force inside the stopper, and when the hollow protective cover is separated from the stopper, the support element remains coupled to the stopper while the support element is also separable from the stopper when a person holds the grip part of the support element and pulls the support element so as to separate it from the stopper.

3. 发明授权

US11504344B2 Nutritional compositions of non-psychotropic cannabinoids and xanthines 有权
公开(公告)号：US11504344B2
公开(公告)日：2022-11-22
申请号：US16541770
申请日：2019-08-15
申请人： John H. Owoc
发明人： John H. Owoc
IPC分类号： A61K31/352 , A61K31/05 , A61K9/00 , A61K31/522 , A61K31/4375 , A61P25/28 , A61K9/14
摘要： This invention discloses a nutritional composition of matter that effectively provide a nootropic effect beyond the effects simple obtain by cannabinoids alone. Effectively reduce anxiety due to ingestion of xanthines containing oral products. Similarly reduce the side effects associated with the exogenous ingestion of yohimbine and its derivatives.

4. 发明授权

US11376294B2 Mangiferin-containing compositions for improving sports performance 有权
公开(公告)号：US11376294B2
公开(公告)日：2022-07-05
申请号：US16365015
申请日：2019-03-26
申请人： Polifenoles Naturales, S.L.
发明人： Miguel Jimenez del Rio , Julia C. Wiebe , Laura Lopez-Rios , Tanausu Vega-Morales , Ruben Perez-Machin , Alvaro Sanchez-Rodriquez , Carlos J. Mateos , Nigel Peter Gericke
IPC分类号： A61K36/22 , A61K36/48 , A61K36/51 , A61K36/38 , A61K36/725 , A61K31/522 , A61K36/69 , A61K31/352 , A61K31/7048 , A61P25/00 , A61K36/8905 , A61K45/06 , A61K36/37 , A61K9/48 , A61K9/68 , A61K9/00 , A61K9/46
摘要： A method for enhancing at least one of alertness, attention, concentration and memory in a person in need thereof, comprising co-administering an effective amount of mangiferin, norathyriol, or an extract comprising mangiferin or norathyriol; and caffeine to the person. The components may be co-administered in a single composition, or administered in separate compositions. The mangiferin and/or norathyriol exhibit synergistic effects on brain wave activity when co-administered with caffeine.

5. 发明授权

US11272968B2 Slotted periprosthetic plate for variable angle holes 有权
公开(公告)号：US11272968B2
公开(公告)日：2022-03-15
申请号：US16150747
申请日：2018-10-03
申请人： DePuy Synthes Products, Inc.
发明人： David W. Bogle
IPC分类号： A61B17/80 , A61B17/74 , A61B17/72
摘要： A bone plate comprises a body including an elongated opening extending therethrough, the opening being open at a distal end of the body and including a distal portion and a proximal portion, the distal portion having a width smaller than a width of the proximal portion, the width being a dimension between two longitudinal sides of the opening extending parallel to a longitudinal axis of the body, the body further including an insert including a head portion and a base portion, the base portion being shaped to be slidably mounted within the proximal portion of the opening, a diameter of the base portion being larger than a width of the distal portion of the opening such that the base portion is prevented from exiting the opening through the distal portion thereof, the insert further including a central fixation element receiving hole configured to receive a bone fixation element therethrough.

6. 发明授权

US11040963B2 Piperazine derivatives for influenza virus inhibitions 有权
公开(公告)号：US11040963B2
公开(公告)日：2021-06-22
申请号：US16483283
申请日：2018-02-01
申请人： JANSSEN VACCINES & PREVISION B.V.
发明人： Maria Van Dongen , Jaroslaw Juraszek , Griet Wim Bert Schepens , Charles Edward Lawson , Brian Shook , Maria Tim Hugo Jonckers , Abdellah Tahri , Bernard Pierre Jean-Marie Raboisson , Nestor CHristophe Francis Robert Buyck
IPC分类号： C07D413/10 , A61P31/16 , C07D401/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D487/08 , C07D498/04 , C07D263/57 , C07D413/12 , C07D277/66 , C07D417/12 , C07D295/108 , C07D307/79 , C07D235/18
摘要： The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.

7. 发明授权

US10890722B2 Fiber optic connector 有权
公开(公告)号：US10890722B2
公开(公告)日：2021-01-12
申请号：US16539718
申请日：2019-08-13
申请人： Steve Cheng
发明人： Steve Cheng
IPC分类号： G02B6/38 , G02B6/44
摘要： A method of providing fiber optic connectivity including gripping a rotatable coupler of a fiber optic connector at a grip portion thereof, inserting the rotatable coupler into a bulkhead adapter in a straight direction, turning the rotatable coupler in a clockwise or counterclockwise direction to increase a tension of the spring while pushing the rotatable coupler forward, and releasing the rotatable coupler such that the rotatable coupler rotates in a counter clockwise direction and locks the fiber optic connector into the bulkhead adapter.

8. 发明授权

US10760283B2 Deck system and components 有权
公开(公告)号：US10760283B2
公开(公告)日：2020-09-01
申请号：US14704466
申请日：2015-05-05
申请人： ADMIRAL COMPOSITE TECHNOLOGIES, INC.
发明人： Vincent F. Carrubba
IPC分类号： E04F15/02 , E04B1/68 , E04F15/10 , E04F13/08 , F24D13/02
摘要： A decking system is made up of a variety of decking boards and other components are disclosed. In some aspects, the decking boards are connectable to each other so that adjacent boards will provide a water barrier and a drainage channel. Some versions of the boards may have a hollow region to accept the provision of heating elements or other accessory structures. A connector piece is disclosed in various embodiments span the gap between the butt ends of the boards to provide a water barrier at the butt ends of the boards. A gutter and downspout system is disclosed, as well as structures for protecting the ends or sides of the deck structure.

9. 发明授权

US10717061B1 Fluidized bed reactor system allowing particle sampling during an ongoing reaction 有权
公开(公告)号：US10717061B1
公开(公告)日：2020-07-21
申请号：US16453571
申请日：2019-06-26
申请人： X ENERGY, LLC
发明人： Howard Taery Kim
IPC分类号： B01J8/18 , B01J8/00
摘要： A fluidized gas reactor includes a system for preventing a fluidizing gas comprising a reactant from premature reaction. The fluidized gas reactor includes a reaction chamber including a particle bed; a gas distribution plate having a plurality of openings therethrough, wherein each opening opens into the reaction chamber; and a plurality of vertical fluidizing gas inlet tubes, each of the fluidizing gas inlet tubes being in fluid communication with one of the openings in the gas distribution plate. Each fluidizing gas inlet tube is configured to receive a fluidizing gas and transport the fluidizing gas to the reaction chamber. A fluidizing gas source provides a stream of the fluidizing gas to the fluidizing gas inlet tubes. A coolant system prevents the fluidizing gas from undergoing reaction before entering the reaction chamber. The coolant system has a fluid inlet; a coolant flow path in fluid communication with the fluid inlet, the coolant flow path being configured to cool each fluidizing gas inlet tube; and a fluid outlet in fluid communication with the coolant flow path. Each fluidizing gas inlet tube may include a particle outlet and a valve system, where the valve system allows the fluidizing gas flow to the fluidizing gas inlet tubes to be stopped; and allows recovery of particles from the particle bed while the fluidizing gas flow is stopped.

10. 发明授权

US10708354B2 Communication system and its method and communication apparatus and its method 有权
公开(公告)号：US10708354B2
公开(公告)日：2020-07-07
申请号：US16361921
申请日：2019-03-22
申请人： DATA SCAPE LTD.
发明人： Akihiro Morohashi
IPC分类号： G06F15/16 , H04L29/08 , H04N21/262 , G06F16/40 , G06F16/60 , G06F16/68 , G11B27/031 , G11B27/034 , G11B27/10 , G11B27/11 , G11B27/34 , G11B27/36 , H04L29/06 , G06F3/0482 , G06F3/0484 , H04N21/472 , G06Q30/06
摘要： A communication apparatus configured to transmit data to an apparatus, the communication apparatus including: a storage medium configured to store management information of data to be transferred to the apparatus; a communicator configured to communicate data with the apparatus; a detector configured to detect whether the communication apparatus and the apparatus are connected; an editor configured to select certain data to be transferred and to edit the management information based on the selection without regard to the connection of the communication apparatus and the apparatus; and a controller configured to control transfer of the selected data stored in the communication apparatus to the apparatus via the communicator based on the management information edited by the editor when the detector detects that the communication apparatus and the apparatus are connected, wherein the controller is configured to compare the management information edited by the editor with management information of data stored in the apparatus, determine the size of the selected data in the communication apparatus, and transmit data in the communication apparatus based on result of the comparison and the determination.

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