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1. 发明授权

US11497762B2 MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation 有权
公开(公告)号：US11497762B2
公开(公告)日：2022-11-15
申请号：US16760396
申请日：2018-11-02
申请人： INTERNA TECHNOLOGIES B.V.
发明人： Eljo Y. Van Battum , Vamshi R. Vangoor , Alwin A. H. A. Derijck , Roeland Quirinus Jozef Schaapveld , R. Jeroen Pasterkamp
IPC分类号： A61K31/713 , C12N15/113 , C12Q1/68
摘要： The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a neuronal deficiency or a disease and condition associated with neuronal deficiency.

2. 发明授权

US11263675B2 Buyer and seller information application and method 有权
公开(公告)号：US11263675B2
公开(公告)日：2022-03-01
申请号：US16583338
申请日：2019-09-26
申请人： Drive Automation LLC
发明人： Adam Geake
IPC分类号： G06Q30/00 , G06Q30/06 , G06Q10/10
摘要： A method of a buyer and a seller information network sharing service is provided. The method includes providing information from a seller of at least one product to a potential buyer. The buyer is able to request a meeting to inspect the product, either a car, home, or consumer product. The seller upon accepting a meeting request, has an application on a mobile device that will access real-time location data for display on the seller mobile device to provide an estimated time of arrival of the buyer, to the seller location.

3. 发明授权

US11242406B2 Methods for the treatment of a cancer or fibrotic disorder associated with MENA or MENA(INV) by administering a map kinase inhibitor 有权
公开(公告)号：US11242406B2
公开(公告)日：2022-02-08
申请号：US16312988
申请日：2017-07-07
申请人： METASTAT, INC.
发明人： Douglas A. Hamilton , Anna L. Blois
IPC分类号： C07K16/40 , A61P35/00 , A61P35/02 , A61K9/00 , C07K7/00 , C07K16/28 , A61K39/395 , A61K31/337 , A61P9/00 , A61K31/5377 , A61K31/7105 , G01N33/50 , A61K31/167 , A61K31/166
摘要： Phosphorylation and dephosphorylation of MENA and MENA isoforms regulates the metastatic activity of cancer cells. Administration of a MENA kinase inhibitor results in significant reduction in the development of cancer metastasis in established and developing tumors. Administration of a MENA kinase inhibitor in conjunction with a tyrosine kinase inhibitor enhances efficacy of tyrosine kinase inhibitor therapy. Administration of a MENA kinase inhibitor in conjunction with anti-microtubule agent results in significant reduction in chemotherapy-induced tumor cell dissemination and enhances efficacy of anti-microtubule therapy.

4. 外观设计

USD839656S1 Pan 有权
公开(公告)号：USD839656S1
公开(公告)日：2019-02-05
申请号：US29565082
申请日：2016-05-18
申请人： Handi -Foil Corporation
设计人： Raj Patel
摘要： FIG. 1 is a front side perspective view of a first embodiment of a pan, showing my new design;
FIG. 2 is a left side view thereof,
FIG. 3 is a right side view thereof;
FIG. 4 is a front view thereof;
FIG. 5 is a rear side view thereof;
FIG. 6 is a top plan view thereof;
FIG. 7 is a bottom plan view thereof;
FIG. 8 is a bottom perspective view thereof;
FIG. 9 is a front side perspective view of a second embodiment of the pan, showing my new design;
FIG. 10 is a left side view thereof,
FIG. 11 is a right side view thereof;
FIG. 12 is a front view thereof;
FIG. 13 is a rear side view thereof;
FIG. 14 is a top plan view thereof;
FIG. 15 is a bottom plan view thereof; and,
FIG. 16 is a bottom perspective view thereof.
The evenly broken lines represent parts of the article that form no part of the claim. The dot-dash lines represent the boundaries of the claim and form no part thereof.

5. 外观设计

USD801110S1 Set of nested lids for pans 有权
公开(公告)号：USD801110S1
公开(公告)日：2017-10-31
申请号：US29598097
申请日：2017-03-23
申请人： HFA, INC.
设计人： Brad Sarnoff , Raj Patel

6. 外观设计

USD797561S1 Bottle 有权
公开(公告)号：USD797561S1
公开(公告)日：2017-09-19
申请号：US29563826
申请日：2016-05-09
申请人： Berlin Packaging, LLC
设计人： Jonathan Eziquiel-Shriro

7. 发明授权

US08813426B2 Duct access door 有权
标题翻译：管道通道门
公开(公告)号：US08813426B2
公开(公告)日：2014-08-26
申请号：US14095227
申请日：2013-12-03
申请人： Omni Containment Systems, LLC
发明人： Kevin R. Chwala
IPC分类号： E05C21/02
CPC分类号： F24F13/029 , E05B17/06 , E05B35/008 , E05B63/143 , E05B65/006 , E05C3/042 , E05C21/00 , E06B3/04 , E06B5/00 , F16B31/00 , F16L45/00 , F23J13/08 , F24F13/0254 , F24F13/0263 , F24F13/20
摘要： An access panel for an opening in a duct is provided. The access panel includes an exterior and an interior. The access panel further includes a section positioned on the interior and having a profile substantially corresponding to the opening in the duct. A plurality of fasteners is positioned about the section. Each fastener has a clip configured to move to a position defined to extend away from the profile of the section on the interior. When the access panel is positioned with the section on the interior against the opening in the duct and the fasteners are moved to the locking position the clips rotate to extend over the profile and secure a portion of the duct adjacent to the opening against the interior of the access panel.
摘要翻译：提供了一种用于管道中的开口的检修面板。检修面板包括外部和内部。检修面板还包括位于内部并具有基本对应于管道中的开口的轮廓的部分。多个紧固件围绕该部分定位。每个紧固件具有被构造成移动到限定为远离内部的部分的轮廓延伸的位置的夹子。当检查面板被定位成使得内部上的部分抵靠管道中的开口并且紧固件移动到锁定位置时，夹子旋转以在轮廓上延伸，并将管道的一部分邻近开口固定在内部检修面板。

8. 发明授权

US11766489B2 Adeno-associated virus variant capsids and use for inhibiting angiogenesis 有权
公开(公告)号：US11766489B2
公开(公告)日：2023-09-26
申请号：US16765758
申请日：2018-11-26
申请人： 4D MOLECULAR THERAPEUTICS INC.
发明人： David H. Kirn , Melissa Kotterman , David Schaffer , Paul Szymanski , Peter Francis
IPC分类号： C07K14/005 , C07K16/22 , A61K48/00 , A61K9/00 , C12N7/00
CPC分类号： A61K48/005 , A61K9/0048 , A61K48/0008 , A61K48/0075 , C07K14/005 , C07K16/22 , C12N7/00 , C12N2750/14122 , C12N2750/14143
摘要： Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina for the treatment of retinal disorders and diseases.

9. 发明授权

US11524081B2 Codon optimized REP1 genes and uses thereof 有权
公开(公告)号：US11524081B2
公开(公告)日：2022-12-13
申请号：US17740045
申请日：2022-05-09
申请人： 4D MOLECULAR THERAPEUTICS INC.
发明人： David H. Kirn , Melissa A. Kotterman , Peter Francis
IPC分类号： A61K48/00 , C12N9/10 , C12N15/86 , A61P27/02
摘要： The present disclosure provides codon optimized nucleotide sequences encoding human REP1, vectors, and host cells comprising codon optimized REP1 sequences, and methods of treating retinal disorders such as choroideremia comprising administering to the subject a codon optimized sequence encoding human REP1.

10. 发明授权

US11186950B2 Efficient methods and compositions for recovery of products from organic acid pretreatment of plant materials 有权
公开(公告)号：US11186950B2
公开(公告)日：2021-11-30
申请号：US17058595
申请日：2018-05-28
申请人： Pierson Capital Environmental (Beijing) Limited
发明人： Feng Ling
IPC分类号： B01D1/26 , D21C11/00 , B01D1/00 , B01D3/14 , B01D3/38 , B04B11/02 , B04B11/08 , C05F5/00 , C07G1/00 , C08B1/08 , C08L5/14 , C12F3/10 , D21C9/00
摘要： Provided are compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.

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