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1. 发明授权

US10221333B2 Ice release coatings 有权
公开(公告)号：US10221333B2
公开(公告)日：2019-03-05
申请号：US15025888
申请日：2014-09-30
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： Kenneth J. Wynne , Wei Zhang
IPC分类号： B32B27/40 , C08G77/54 , C09D183/14 , C09D171/02 , C08G77/388 , C08G65/336 , C08L71/02 , C08L75/04 , C08K5/5465 , C09K3/18
摘要： A compound is provided, having the formula (I), wherein Rs is a soft block polymer; wherein each T is independently a urethane or urea linkage; see formulae (A) and (B); wherein each RD is independently —CH3, —CH2CH3, —CH2CH2CH3, or —CH2CH2CH2CH3; wherein each R′D is independently —CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, or —ORD; and wherein each p is independently 1, 2, or 3. Compositions containing the compound, and methods of making and using the compound are provided.

2. 发明授权

US10117436B2 Antimicrobial polymeric compositions 有权
公开(公告)号：US10117436B2
公开(公告)日：2018-11-06
申请号：US15080567
申请日：2016-03-24
申请人： Virginia Commonwealth University
发明人： Kenneth J. Wynne , Souvik Chakrabarty , Wei Zhang , Asima Chakravorty , Olufemi O. Oyesanya
IPC分类号： A01N55/00 , C08G65/22 , C08G18/50 , C08G65/336 , C07F7/18 , C08G18/48 , C08G18/61 , C08G18/66 , C08G18/71 , C08G18/75 , C09D175/04 , C08G65/18
摘要： A compound having the formula: wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect are described.

3. 发明授权

US09808523B2 Methods for treatment of brain injury utilizing biologics 有权
公开(公告)号：US09808523B2
公开(公告)日：2017-11-07
申请号：US14536611
申请日：2014-11-08
申请人： TACT IP LLC
发明人： Edward Lewis Tobinick
IPC分类号： A61K39/395 , C07K14/715 , C07K16/24 , A61K9/00 , A61K38/17 , A61K39/00
CPC分类号： A61K39/3955 , A61K9/0085 , A61K38/1793 , A61K2039/505 , C07K14/7151 , C07K16/241 , C07K2319/30
摘要： A method of using biologics to treat chronic brain injury or spasticity due to stroke, trauma and other causes. Preferred embodiments include perispinal, parenteral, transepidermal or intranasal use of TNF antagonists. The TNF antagonists include TNF receptor fusion proteins, TNF monoclonal antibodies (mAbs), humanized TNF mAbs, fully human TNF mAbs, chimeric TNF mAbs, domain TNF antibodies, mAB fragments, anti-TNF nanobodies, dominant negative TNF constructs and TNF inhibitory single chain antibody fragments. One of the preferred embodiments of this invention is the perispinal administration of etanercept for treatment of mammals following stroke. The use of Trendelenburg positioning, catheters, pumps, or depot formulations are included.

4. 发明授权

US09802665B2 Cruise saddle 有权
公开(公告)号：US09802665B2
公开(公告)日：2017-10-31
申请号：US14382373
申请日：2013-03-05
申请人： Tampa Bay Recreation, LLC
发明人： Steven G. Toll
IPC分类号： B62J1/00 , B62J1/08 , B62J1/18
CPC分类号： B62J1/007 , B62J1/08 , B62J1/18
摘要： A split-nose touring bicycle seat for touring, comprising: a rigid plastic base provided with attachment points for mounting the seat to a bicycle frame; a total length of the seat of about 230-265 mm; a total width of about 270-310 mm; a split nose section formed by two elongated protrusions of substantially constant width extending forward from a medial section to a front surface; said elongated protrusions angle inwardly, a cushioned pubis bone support surface with a substantially flat side profile, and a drooped nose section forward thereof and substantially vertical outer sides.

5. 发明授权

US09745734B2 Weir grate 有权
公开(公告)号：US09745734B2
公开(公告)日：2017-08-29
申请号：US14565743
申请日：2014-12-10
申请人： William Francis Swanston
发明人： William Francis Swanston
IPC分类号： E03F5/04 , E03C1/22 , E03F5/06 , B21D31/00 , B21D28/24
CPC分类号： E03F5/06 , B21D28/24 , B21D31/00 , E03C1/22 , E03C2201/00 , E03F5/0407 , E03F5/0408 , Y10T29/49826
摘要： A weir grate (10, 100) comprises a base tray (12, 112) having an outlet (14, 114), and an infill tray (16, 116) positionable in the base tray. The base tray comprises a plurality of discretely positioned posts (22, 122) projecting upwardly therefrom in use. The infill tray comprises a plurality of correspondingly positioned locators (40, 140) projecting downwardly therefrom in use. Each locator is arranged for engaged with a respective post when the infill tray is positioned in the base tray.

6. 发明授权

US09713434B2 Microwave contactless heart rate sensor 有权
公开(公告)号：US09713434B2
公开(公告)日：2017-07-25
申请号：US14377845
申请日：2013-02-07
申请人： SENSIFREE LTD.
发明人： Ilan Saul Barak
IPC分类号： A61B5/05 , A61B5/024 , A61B5/00 , A61B5/026 , G01S13/58 , G01S13/88
CPC分类号： A61B5/0507 , A61B5/02444 , A61B5/026 , A61B5/681 , G01S13/583 , G01S13/88
摘要： A heart-rate sensor for detecting artery blood-flow volume per unit length change in a human or animal subject, which comprises an antenna for sensing the instantaneous volume of blood in the artery of the subject, to be measured; a RADAR unit for transmitting microwave signals into a subject's body part or limb representing tissue targets. The output of the RADAR unit includes a superposition of signals each of which corresponding to a different tissue target with amplitudes that relate to the target's reflection strength; a sampling circuitry for converting reflected signals to digital; a window function circuitry for suppressing unwanted spectral sidebands originating from the subsequent processor operating on time truncated data; an FFT processor following the window function circuitry, for splitting the superposition according to its relative frequency into a multiplicity of bins, each of which with an amplitude that represents the reflection magnitude of a target at a specific distance from the antenna; a signal processor for filtering out the effect of the sensor movement with respect to the subject body part, or the movement of the body part, and for generating a signal, the amplitude of which is proportional to the artery varying dilatation representing the heart-rate; a heart-rate estimator for measuring the frequency of the artery dilatation variations and for canceling the interference of the amplitude of any signal that does not originate from the artery; a battery for powering the sensor.

7. 发明授权

US09523033B2 Method for large scale synthesis of optically stimulated luminescence grade polycrystalline ceramic material 有权
标题翻译：用于大规模合成光学激发的发光级多晶陶瓷材料的方法
公开(公告)号：US09523033B2
公开(公告)日：2016-12-20
申请号：US13925809
申请日：2013-06-24
申请人： THE SECRETARY, DEPARTMENT OF ATOMIC ENERGY
发明人： Kunal Purnachandra Muthe , Mukund Shrinivas Kulkarni , Anuj Soni , Ajay Singh , Narender Singh Rawat , Devesh Ramdhar Mishra , Ratna Pradeep , Shovit Bhattacharya , Deva Nand Sharma , Shiv Kumar Gupta
IPC分类号： C09K11/65 , C04B35/01 , C04B35/44 , C04B35/653
CPC分类号： C09K11/655 , C04B35/013 , C04B35/44 , C04B35/653 , C04B2235/3225 , C04B2235/422 , C04B2235/604 , C04B2235/6562 , C04B2235/6565 , C04B2235/6581 , C04B2235/764
摘要： A method for the synthesis of OSL grade polycrystalline mass of ceramic materials with dopant C involving source ceramic material preferably in its readily available powder form comprising the steps of melting of the said ceramic material in graphite environment including a graphite crucible/container in vacuum; and obtaining there from polycrystalline aggregate by rapid solidification of said melt to thereby provide said polycrystalline mass of ceramic materials with dopant C of optically stimulated luminescence grade. The said powder form of the ceramic material is compacted and formed into pellets before subjecting to melting.
摘要翻译：一种用于合成具有掺杂剂C的陶瓷材料的OSL级多晶体质量的方法，其中所述掺杂剂C优选以其易于获得的粉末形式包括源陶瓷材料，包括在真空中包括石墨坩埚/容器的石墨环境中熔化所述陶瓷材料的步骤; 并通过所述熔体的快速固化从多晶聚集体获得，从而向所述陶瓷材料的多晶质体提供具有光学激发等级的掺杂剂C. 所述粉末形式的陶瓷材料在熔化之前被压实并形成颗粒。

8. 发明授权

US09078917B2 Extract of Phaleria macrocarpa as an antineoplastic, anti-inflammatory and antiangiogenic agent 有权
标题翻译： Phaleria macrocarpa的提取物作为抗肿瘤，抗炎和抗血管生成剂
公开(公告)号：US09078917B2
公开(公告)日：2015-07-14
申请号：US12997171
申请日：2009-06-08
申请人： Raymond R. Tjandrawinata , Asep Aripin , Poppy Firzani Arifin , Dina Rahmi
发明人： Raymond R. Tjandrawinata , Asep Aripin , Poppy Firzani Arifin , Dina Rahmi
IPC分类号： A61K36/00 , A61K36/83
CPC分类号： A61K36/83
摘要： A pharmaceutical dosage form comprising an extract of Phaleria macrocarpa which has antineoplastic, anti-inflammatory, and antiangiogenic activity. Its use as an antineoplastic agent is to inhibit tumour growth. Its use as an anti-inflammatory agent is to relieve inflammation and pain, and also as an antipyretic. Another use is as an antiangiogenic agent to inhibit the growth of new blood vessels to prevent cancer metastasis.
摘要翻译：一种药物剂型，其包含具有抗肿瘤，抗炎和抗血管生成活性的大戟提取物。其用作抗肿瘤药物是抑制肿瘤生长。其作为抗炎剂的用途是缓解炎症和疼痛，并且作为解热药。另一个用途是作为一种抗血管生成剂来抑制新血管的生长以预防癌症转移。

9. 发明授权

US09070151B2 Systems, methods and devices for trusted transactions 有权
标题翻译：受信任事务的系统，方法和设备
公开(公告)号：US09070151B2
公开(公告)日：2015-06-30
申请号：US13797744
申请日：2013-03-12
申请人： Scott A. Moskowitz
发明人： Scott A. Moskowitz
IPC分类号： G06Q30/06 , G06F21/10 , G06Q20/08 , G06Q20/38 , G06Q20/40 , H04L29/06 , H04L9/32
CPC分类号： G06Q20/40 , G06F1/266 , G06F7/582 , G06F7/588 , G06F21/10 , G06F21/12 , G06F2221/0711 , G06F2221/0737 , G06Q20/085 , G06Q20/382 , G06Q20/38215 , G06Q20/3823 , G06Q20/3829 , G06Q20/401 , G06Q30/06 , G06Q30/0609 , G06Q2220/00 , H04L9/0618 , H04L9/0643 , H04L9/14 , H04L9/30 , H04L9/3228 , H04L9/3231 , H04L9/3247 , H04L9/3297 , H04L63/0428 , H04L63/08 , H04L63/12 , H04L2209/42 , H04L2209/56 , H04L2209/603 , H04L2209/608 , H04L2463/101 , H04L2463/102
摘要： The invention discloses a system for enhancing trust in transactions, most particularly in remote transactions between a plurality of transactional parties, for instance a seller and buyer(s) of goods and/or services over a public computer network such as the internet. Trust is disclosed to be a multivalent commodity, in that the trust that is to be enhanced relates to information about the subject matter of the transactions (e.g., the suitability of the goods and services sold), the bona fides of the supplier of the goods and services, the appropriateness of a pricing structure for a particular transaction or series of transactions, a quantum of additional transactional value that may be imparted to the transactional relationship, security of information exchange.
摘要翻译：本发明公开了一种用于增强交易信任的系统，特别是在多个交易方之间的远程交易中，例如通过诸如互联网的公共计算机网络的货物和/或服务的卖方和/或服务者之间的远程交易。信托披露为多价商品，因为要加强的信托涉及交易主题的信息（例如，出售的商品和服务的适用性），商品供应商的善意和服务，特定交易或一系列交易的定价结构的适当性，可能被赋予交易关系的附加交易价值的量子，信息交换的安全性。

10. 发明授权

US09061061B2 Method of treating dysglycemia and glucose excursions 有权
标题翻译：治疗血糖异常和葡萄糖偏离的方法
公开(公告)号：US09061061B2
公开(公告)日：2015-06-23
申请号：US12744301
申请日：2009-08-24
申请人： Alexander MacGregor
发明人： Alexander MacGregor
IPC分类号： A61K31/155 , A61K45/06 , A61K9/20
CPC分类号： A61K45/06 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K31/155
摘要： The present application relates to pharmaceutical compositions for reducing glucose excursions in a normal subject or a subject having an insulin-related disorder or dysglycemia. The pharmaceutical composition contains one or more active agent-containing layers, which each contain a dry blended mixture including a therapeutically effective amount of a polar ionizable insulin-sensitizing oral hypoglycemic agent or a pharmaceutically acceptable salt thereof, and an amphipathic compound in monomelic form consisting of an amphipathic ionic compound in monomelic form. Each dry blended mixture contains a sufficient amount of the amphipathic ionic compound such that upon contact with an aqueous fluid, the amphipathic ionic compound forms a reverse micelle comprising the polar ionizable insulin-sensitizing oral hypoglycemic agent. The present invention also relates to a use of a modified release pharmaceutical composition comprising a therapeutically effective amount of an insulin-sensitizing oral hypoglycemic agent for sensitizing pre-prandial (basal) insulin levels and/or reducing postprandial glucose excursions in a normal patient or a patient having an insulin-related disorder.
摘要翻译：本申请涉及用于降低正常受试者或具有胰岛素相关障碍或血糖异常的受试者的葡萄糖偏离的药物组合物。药物组合物含有一种或多种含活性剂的层，其各自含有干混混合物，其包含治疗有效量的极性可电离的胰岛素敏化口服降血糖剂或其药学上可接受的盐，以及单体形式的两亲性化合物，包括的两亲性离子化合物。每个干混混合物含有足量的两亲离子化合物，使得在与水性液体接触时，两亲性离子化合物形成包含极性可电离的胰岛素敏化口服降血糖剂的反胶束。本发明还涉及包含治疗有效量的胰岛素敏化口服降血糖剂用于对餐前（基础）胰岛素水平进行敏化和/或减少正常患者的餐后葡萄糖偏离的改良释放药物组合物的用途，或患有胰岛素相关疾病的患者。

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