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1. 发明授权

US07834140B2 Polypeptide fragment of constitutive coactivator of PPARgamma 失效
标题翻译： PPARgamma的组成共激活因子的多肽片段
公开(公告)号：US07834140B2
公开(公告)日：2010-11-16
申请号：US11870736
申请日：2007-10-11
申请人： Dechun Li
发明人： Dechun Li
IPC分类号： A61K38/00 , A01N37/18
CPC分类号： C07K14/4705 , C07K16/18 , C12N15/113 , C12N2310/14 , G01N33/5041 , G01N2333/70567
摘要： This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which regulate transcription factor PPARγ. and enhance or inhibit the transcription of genes responsible for directing cell differentiation towards a pathway of adipogenesis. More specifically, disclosed herein is a novel polypeptide coactivator of PPARγ, and fragments thereof, which possess coactivator or corepressor activity. Also related are nucleotide sequences which express these polypeptides. Also disclosed is an interfering RNA that may be used to inhibit adipogenesis.
摘要翻译：本发明一般涉及利用核受体调节细胞中脂肪生成的组合物和方法。具体地，本发明涉及调节转录因子PPARγ的组合物。并且增强或抑制负责将细胞分化导向脂肪形成途径的基因的转录。更具体地，本文公开了具有共激活剂或共抑制因子活性的PPARγ的新型多肽共活化剂及其片段。还涉及表达这些多肽的核苷酸序列。还公开了可用于抑制脂肪形成的干扰RNA。

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