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1. 发明申请

US20080274131A1 Molecular antigen arrary 审中-公开
标题翻译：分子抗原可以是arrary
公开(公告)号：US20080274131A1
公开(公告)日：2008-11-06
申请号：US12010107
申请日：2008-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

2. 发明申请

US20110070267A1 PACKAGED VIRUS-LIKE PARTICLES FOR USE AS ADJUVANTS: METHOD OF PREPARATION AND USE 审中-公开
标题翻译：用作ADJUVANTS的包装的病毒颗粒：制备和使用方法
公开(公告)号：US20110070267A1
公开(公告)日：2011-03-24
申请号：US12790708
申请日：2010-05-28
申请人： Martin F. Bachmann , Wolfgang A. Renner
发明人： Martin F. Bachmann , Wolfgang A. Renner
IPC分类号： A61K39/35 , A61K39/36 , A61P37/04 , A61P37/08
CPC分类号： C12N7/00 , A61K39/0011 , A61K39/35 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/55516 , A61K2039/55561 , A61K2039/55588 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C12N2730/10122 , C12N2730/10123 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded and packaged, respectively, with DNA oligonucleotides rich in non-methylated C and G (CpGs). If such CpG-VLPs are mixed with antigens, the immunogenicity of these antigens are dramatically enhanced. In addition, the T cell responses against the antigens are especially directed to the Th1 type. Surprisingly, no covalent linkage of the antigen to the VLP is required; it is sufficient to simply mix the VLPs with the adjuvants for co-administration. In addition, it was found that VLPs did not enhance immune responses unless they were loaded and packaged, respectively, with CpGs. Antigens mixed with CpG-packaged VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译：本发明涉及可以分别用富含非甲基化C和G（CpG）的DNA寡核苷酸装载和包装病毒样颗粒（VLPs）的发现。如果这种CpG-VLP与抗原混合，则这些抗原的免疫原性显着增强。此外，针对抗原的T细胞应答特别针对Th1型。令人惊讶的是，不需要抗原与VLP的共价连接; 简单地将VLP与用于共同给药的佐剂混合就足够了。此外，发现VLP除了分别用CpG装载和包装外，还没有增强免疫应答。因此，与CpG包装的VLP混合的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

3. 发明授权

US07264810B2 Molecular antigen array 有权
标题翻译：分子抗原阵列
公开(公告)号：US07264810B2
公开(公告)日：2007-09-04
申请号：US10050902
申请日：2002-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
IPC分类号： A61K39/385 , A61K9/00 , A61K39/00 , A61K47/30
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

4. 发明授权

US07229624B2 Ordered molecular presentation of antigens, method of preparation and use 失效
标题翻译：有序分子表达的抗原，制备和使用方法
公开(公告)号：US07229624B2
公开(公告)日：2007-06-12
申请号：US10733582
申请日：2003-12-12
申请人： Wolfgang A. Renner , Frank Hennecke , Lars Nieba , Martin Bachmann
发明人： Wolfgang A. Renner , Frank Hennecke , Lars Nieba , Martin Bachmann
IPC分类号： A61K39/385
CPC分类号： A61K39/00 , A61K2039/5256 , A61K2039/5258
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a virus, virus-like particle, viral capsid particle, phage or recombinant form thereof coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions. In one specific embodiment, a versatile new technology based on a cassette-type system (AlphaVaccine Technology) allows production of antigen coated viral particles. Other specific embodiments allow the production of antigen coated hepatitis B virus-like particles or antigen coated Measles virus-like particles.
摘要翻译：本发明提供用于产生有序和重复抗原或抗原决定簇的组合物和方法。本发明的组合物可用于生产用于预防感染性疾病，过敏症的治疗和癌症治疗的疫苗。作为特定相互作用的结果，本发明的各种实施方案提供以高度有序和重复的方式包被任何所需抗原的病毒，病毒样颗粒，病毒衣壳颗粒，噬菌体或重组形式。在一个具体实施方案中，基于盒式系统（AlphaVaccine Technology）的多功能新技术允许产生抗原包被的病毒颗粒。其他具体实施方案允许产生抗原包被的乙型肝炎病毒样颗粒或抗原包被的麻疹病毒样颗粒。

5. 发明授权

US06576443B2 Replicon based activation of endogenous genes 失效
公开(公告)号：US06576443B2
公开(公告)日：2003-06-10
申请号：US09733042
申请日：2000-12-11
申请人： Frank Hennecke , Wolfgang A. Renner
发明人： Frank Hennecke , Wolfgang A. Renner
IPC分类号： C12Q168
CPC分类号： C12N15/85 , A01K2217/05 , A61K48/00 , C07K14/505 , C12N15/86 , C12N15/907 , C12N2770/36143 , C12N2800/30 , C12N2830/008 , C12N2830/42 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to methods for the modification of genomes of eukaryotic cells to alter the expression of endogenous genes. The invention also relates to recombinant eukaryotic host cells and polypeptides produced by the practice of the disclosed methods. The invention further relates to vector systems useful for modifying the genomes of eukaryotic cells to alter the expression of endogenous genes.

6. 发明授权

US06524792B1 Expression cloning processes for the discovery, characterization and isolation of genes encoding polypeptides with a predetermined property 失效
标题翻译：用于发现，表征和分离编码具有预定特性的多肽的基因的表达克隆方法
公开(公告)号：US06524792B1
公开(公告)日：2003-02-25
申请号：US09193707
申请日：1998-11-17
申请人： Wolfgang A. Renner , Georg H. Orberger , Daniel Koller , James E. Bailey
发明人： Wolfgang A. Renner , Georg H. Orberger , Daniel Koller , James E. Bailey
IPC分类号： C12Q168
CPC分类号： C12N15/1086 , C12Q1/6897 , Y10S435/911 , Y10S435/912
摘要： The present invention is directed to a method for detection, characterization and isolation of nucleic acids encoding proteins of a desired property, such as a particular cellular localization. The invention further provides for rapid expression of such proteins or glycoproteins in mammalian cells and for facilitated purification of the novel secreted proteins or glycoproteins. Further, the invention provides for radioactive labelling of the novel proteins or glycoproteins, for rapid identification of sites of binding including animals and for rapid production of infective viral vectors for use in gene transfer.
摘要翻译：本发明涉及用于检测，表征和分离编码具有所需性质（例如特定细胞定位）的蛋白质的核酸的方法。本发明进一步提供了这些蛋白质或糖蛋白在哺乳动物细胞中的快速表达，并促进新分泌的蛋白质或糖蛋白的纯化。此外，本发明提供新型蛋白质或糖蛋白的放射性标记，用于快速鉴定包括动物在内的结合位点，并快速产生用于基因转移的感染性病毒载体。

7. 发明授权

US06197502B1 Expression cloning processes for the discovery characterization, and isolation of genes encoding polypeptides with a predetermined property 失效
标题翻译：用于发现表征的表达克隆过程，以及分离编码具有预定特性的多肽的基因
公开(公告)号：US06197502B1
公开(公告)日：2001-03-06
申请号：US08972218
申请日：1997-11-17
申请人： Wolfgang A. Renner , Georg H. Orberger , Daniel Koller , James E. Bailey
发明人： Wolfgang A. Renner , Georg H. Orberger , Daniel Koller , James E. Bailey
IPC分类号： C12Q168
CPC分类号： C12N15/1086 , C12Q1/6897 , Y10S435/911 , Y10S435/912
摘要： The present invention is directed to a method for detection, characterization and isolation of nucleic acids encoding proteins of a desired property, such as a particular cellular localization. The invention further provides for rapid expression of such proteins or glycoproteins in mammalian cells and for facilitated purification of the novel secreted proteins or glycoproteins. Further, the invention provides for radioactive labelling of the novel proteins or glycoproteins, for rapid identification of sites of binding including animals and for rapid production of infective viral vectors for use in gene transfer.
摘要翻译：本发明涉及用于检测，表征和分离编码具有所需性质（例如特定细胞定位）的蛋白质的核酸的方法。本发明进一步提供了这些蛋白质或糖蛋白在哺乳动物细胞中的快速表达，并促进新分泌的蛋白质或糖蛋白的纯化。此外，本发明提供新型蛋白质或糖蛋白的放射性标记，用于快速鉴定包括动物在内的结合位点，并快速产生用于基因转移的感染性病毒载体。

8. 发明授权

US08574564B2 Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity 失效
标题翻译：免疫刺激核酸包装颗粒治疗超敏反应
公开(公告)号：US08574564B2
公开(公告)日：2013-11-05
申请号：US12576086
申请日：2009-10-08
申请人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
IPC分类号： A01N63/00 , A61K48/00
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译：本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。

9. 发明申请

US20120258130A1 VACCINATION REGIMEN FOR B-CELL VACCINES 审中-公开
标题翻译： B细胞疫苗的疫苗接种
公开(公告)号：US20120258130A1
公开(公告)日：2012-10-11
申请号：US13292579
申请日：2011-11-09
申请人： Patrik Maurer , Thomas Pfister , Martin F. Bachmann , Philipp Müller , Wolfgang A. Renner
发明人： Patrik Maurer , Thomas Pfister , Martin F. Bachmann , Philipp Müller , Wolfgang A. Renner
IPC分类号： A61K39/385 , A61P25/34 , A61P25/30
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/55505
摘要： This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto.
摘要翻译：本发明涉及疫苗接种和治疗或预防疾病领域。特别地，本发明涉及通过在接种疫苗的受试者中诱导半抗原特异性抗体应答来治疗或预防疾病。本发明还提供了通过在受试者中诱导半抗原特异性抗体来预防或治疗疾病的方法，所述方法包括向所述受试者施用包含RNA噬菌体的病毒样颗粒和至少一种与其连接的半抗原的组合物。

10. 发明授权

US06964769B2 Molecular antigen array 失效
标题翻译：分子抗原阵列
公开(公告)号：US06964769B2
公开(公告)日：2005-11-15
申请号：US09848616
申请日：2001-05-04
申请人： Peter Sebbel , Nicolas Dunant , Martin Bachmann , Alain Tissot , Franziska Lechner , Wolfgang A. Renner , Frank Hennecke , Lars Nieba
发明人： Peter Sebbel , Nicolas Dunant , Martin Bachmann , Alain Tissot , Franziska Lechner , Wolfgang A. Renner , Frank Hennecke , Lars Nieba
IPC分类号： A61K38/00 , A61K39/385 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/245 , C12N15/30 , C12N15/31 , C12N15/33 , C12N15/51 , A61K39/29 , A61K39/295 , C07K14/02 , C07K17/00
CPC分类号： A61K39/385 , A61K38/00 , A61K2039/57 , A61K2039/6068 , A61K2039/625 , C07K14/245 , C07K2319/00 , Y10S530/807
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a core particle that is coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions.
摘要翻译：本发明提供用于产生有序和重复抗原或抗原决定簇的组合物和方法。本发明的组合物可用于生产用于预防感染性疾病，过敏症的治疗和癌症治疗的疫苗。作为特定相互作用的结果，本发明的各种实施方案提供以高度有序和重复的方式涂覆任何所需抗原的核心颗粒。

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