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    • 3. 发明授权
    • Gene therapy using TGF-β
    • 使用TGF-β的基因治疗
    • US07338655B1
    • 2008-03-04
    • US09707900
    • 2000-11-08
    • Moon Jong NohKyoung Ae KangKwan Hee Lee
    • Moon Jong NohKyoung Ae KangKwan Hee Lee
    • A01N65/00A01N63/00A01N43/04A61K31/70A61K48/00
    • A61K48/00A61K31/70A61K38/1841
    • The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-β cDNA expression vectors into fibroblasts (NIH 3T3-TGF-β1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.
    • 本发明涉及使用属于转化生长因子-β(TGF-β)超家族的成员的骨科疾病的细胞介导的基因治疗治疗。 证实了TGF-β基因治疗作为退行性关节炎的新治疗方法。 将TGF-βcDNA表达载体转染到成纤维细胞(NIH 3T3-TGF-β1)后,将细胞注射到兔子跟腱和膝关节中,人工制造软骨缺损。 进行Intratendinous注射以确定体内表达的最佳浓度。 进行部分缺陷软骨模型,以模拟膝关节退行性关节炎。 用细胞介导的基因治疗程序处理的部分软骨缺损被新形成的透明软骨覆盖,表明细胞存活并刺激了该区域的基质形成。 完全剥落的软骨区域被纤维胶原覆盖。
    • 7. 发明授权
    • Gene therapy using TGF-&bgr;
    • 使用TGF-β的基因治疗
    • US06797703B1
    • 2004-09-28
    • US09702718
    • 2000-11-01
    • Moon Jong NohKyoung Ae KangKwan Hee Lee
    • Moon Jong NohKyoung Ae KangKwan Hee Lee
    • A61K3500
    • A61K38/1841A61K35/12A61K48/00C07K14/495
    • The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factory-&bgr; (TGF-&bgr;) superfamily. TGF-&bgr; gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-&bgr; cDNA expression vectors into fibroblasts (NIH 3T3-TGF-&bgr;1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.
    • 本发明涉及使用属于转化生长工厂-β(TGF-β)超家族的成员的骨科疾病的细胞介导的基因治疗治疗。 证实了TGF-β基因治疗作为退行性关节炎的新治疗方法。 将TGF-βcDNA表达载体转染到成纤维细胞(NIH 3T3-TGF-β1)后,将细胞注射到兔子跟腱和膝关节中,人工制造软骨缺损。 进行Intratendinous注射以确定体内表达的最佳浓度。 进行部分缺陷软骨模型,以模拟膝关节退行性关节炎。 用细胞介导的基因治疗程序处理的部分软骨缺损被新形成的透明软骨覆盖,表明细胞存活并刺激了该区域的基质形成。 完全剥落的软骨区域被纤维胶原覆盖。
    • 8. 发明授权
    • Recording/playing device and method for processing broadcast signal
    • 用于处理广播信号的记录/播放装置和方法
    • US08190004B2
    • 2012-05-29
    • US12355283
    • 2009-01-16
    • Kwan Hee LeeWoo Hyun Paik
    • Kwan Hee LeeWoo Hyun Paik
    • H04N5/93H04N5/765
    • H04N21/4408H04N5/775H04N5/781H04N5/85H04N5/907H04N9/7921H04N9/8205H04N21/4135H04N21/4325H04N21/43622
    • A recording/playing device and a method for processing a broadcast signal are disclosed. The device includes an external storage device, and a broadcast receiver. The external storage device includes at least one storage medium. And, the broadcast receiver includes a broadcast processor, an interface unit, and a record/play controlling unit. The broadcast processor receives a broadcast signal of a specific channel and demodulates and decodes the received broadcast signal. The interface unit is capable of being connected to the storage medium of the external storage device. And, the record/play controlling unit activates a record/play mode, when a connection with the storage medium of the external storage device is detected through the interface unit, and stores the demodulated broadcast signal in the storage medium of the external storage device through the interface unit, or reads and plays (or plays-back) the broadcast signal from the storage medium of the external storage device.
    • 公开了一种用于处理广播信号的记录/播放装置和方法。 该设备包括外部存储设备和广播接收机。 外部存储装置包括至少一个存储介质。 并且,广播接收机包括广播处理器,接口单元和记录/播放控制单元。 广播处理器接收特定信道的广播信号,并对所接收的广播信号进行解调和解码。 接口单元能够连接到外部存储设备的存储介质。 并且,当通过接口单元检测到与外部存储装置的存储介质的连接时,记录/播放控制单元激活记录/播放模式,并且将解调的广播信号存储在外部存储装置的存储介质中,通过 接口单元,或从外部存储设备的存储介质读取和播放(或重放)广播信号。