专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06793927B1 Construction of Pasteurella haemolytica vaccines 有权
标题翻译：建立溶血性巴氏杆菌疫苗
公开(公告)号：US06793927B1
公开(公告)日：2004-09-21
申请号：US09210747
申请日：1998-12-15
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39102
CPC分类号： C12N9/1092 , A61K39/102 , C12N9/1007 , C12N9/22 , C12N15/102 , C12N15/74
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.
摘要翻译： DNA的甲基化可能是将DNA引入溶血杆菌中的关键步骤。为此目的已经分离并分子克隆了甲基转移酶。使用甲基转移酶已经允许构建定义的，减毒的突变体，用作疫苗以保护牛。

2. 发明授权

US06573093B2 Temperature sensitive plasmids of P. haemolytica 有权
标题翻译：溶血白僵菌的温度敏感质粒
公开(公告)号：US06573093B2
公开(公告)日：2003-06-03
申请号：US09981897
申请日：2001-10-19
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： C12N1500
CPC分类号： C12N15/01 , A61K39/00 , A61K39/102 , C07K14/285 , C12N15/74 , C12R1/01
摘要： Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.
摘要翻译：当用作反刍动物疫苗（例如牛，绵羊和山羊）时，溶血性乳杆菌的突变体具有良好的安全性和有效性，可能患有肺炎巴氏杆菌病。它们可以通过各种途径进行管理。特别优选的是在动物饲料中的用途。突变体不回复，不含有外来DNA，也没有引入抗生素抗性基因。

3. 发明授权

US06331303B1 LKTA deletion mutant of P. haemolytica 有权
标题翻译：溶血白僵菌的LKTA缺失突变体
公开(公告)号：US06331303B1
公开(公告)日：2001-12-18
申请号：US09160340
申请日：1998-09-25
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39102
CPC分类号： C12N15/01 , A61K39/00 , A61K39/102 , C07K14/285 , C12N15/74 , C12R1/01
摘要： Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.
摘要翻译：当用作反刍动物疫苗（例如牛，绵羊和山羊）时，溶血性乳杆菌的突变体具有良好的安全性和有效性，可能患有肺炎巴氏杆菌病。它们可以通过各种途径进行管理。特别优选的是在动物饲料中的用途。突变体不回复，不含有外来DNA，也没有引入抗生素抗性基因。

4. 发明授权

US5824525A Construction of Pasteurella haemolytica vaccines 失效
公开(公告)号：US5824525A
公开(公告)日：1998-10-20
申请号：US643301
申请日：1996-05-08
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/10 , C12N15/54 , C12N15/55 , C12N15/74
CPC分类号： C12N9/1092 , A61K39/102 , C07K14/285 , C12N15/102 , C12N15/74 , C12N9/1007 , C12N9/22
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.

5. 发明授权

US07351416B2 Vaccines comprising acapsular P. multocida hyaE deletion mutants 有权
标题翻译：疫苗包括acapular多杀巴氏杆菌hyaE缺失突变体
公开(公告)号：US07351416B2
公开(公告)日：2008-04-01
申请号：US10882666
申请日：2004-07-02
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285
摘要： Acapsular hyaE deletion mutants of P. multocida can be administered to mammals, particularly ungulates, or birds to provide protective immunity against wild-type P. multocida, e.g., to prevent or reduce the severity of hemorrhagic septicemia or pneumonia in mammals, particularly livestock, ungulates, and companion animals, or fowl cholera in birds, particularly poultry.
摘要翻译：可以将哺乳动物，特别是有蹄类动物或鸟类给予多发性耻骨瘤多肽的突变体，以提供针对野生型多杀巴斯德氏体的保护性免疫，例如预防或降低哺乳动物，特别是家畜中出血性败血病或肺炎的严重性，有蹄类动物，伴侣动物，或鸟类禽鸟，特别是家禽。

6. 发明授权

US5733780A Construction of Pasteurella haemolytica vaccines 失效
标题翻译：建立溶血性巴氏杆菌疫苗
公开(公告)号：US5733780A
公开(公告)日：1998-03-31
申请号：US643298
申请日：1996-05-08
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/10 , C12N15/54 , C12N15/55 , C12N15/74 , C12N15/00
CPC分类号： C12N9/1092 , A61K39/102 , C07K14/285 , C12N15/102 , C12N15/74 , C12N9/1007 , C12N9/22
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.
摘要翻译： DNA的甲基化可能是将DNA引入溶血杆菌中的关键步骤。为此目的已经分离并分子克隆了甲基转移酶。使用甲基转移酶已经允许构建定义的，减毒的突变体，用作疫苗以保护牛。

7. 发明授权

US5693777A DNA encoding pasteurella haemolytica PhaI restriction endonuclease and methyltransterase 失效
标题翻译：编码溶血苏打乳杆菌PhaI限制性内切核酸酶和甲基淀粉酶的DNA
公开(公告)号：US5693777A
公开(公告)日：1997-12-02
申请号：US643297
申请日：1996-05-08
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/10 , C12N15/54 , C12N15/55 , C12N15/74 , C07H21/04 , C12N9/16
CPC分类号： C12N9/1092 , A61K39/102 , C07K14/285 , C12N15/102 , C12N15/74 , C12N9/1007 , C12N9/22
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.
摘要翻译： DNA的甲基化可能是将DNA引入溶血杆菌中的关键步骤。为此目的已经分离并分子克隆了甲基转移酶。使用甲基转移酶已经允许构建定义的，减毒的突变体，用作疫苗以保护牛。

8. 发明授权

US5683900A Pasteurella haemolytica PhaI restriction endonuclcape and methyltranstesase 失效
标题翻译：巴氏杀菌杆菌PhaI限制性内切酶和甲基淀粉酶
公开(公告)号：US5683900A
公开(公告)日：1997-11-04
申请号：US643300
申请日：1996-05-08
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/10 , C12N15/54 , C12N15/55 , C12N15/74 , C12N9/16
CPC分类号： C12N9/1092 , A61K39/102 , C07K14/285 , C12N15/102 , C12N15/74 , C12N9/1007 , C12N9/22
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.
摘要翻译： DNA的甲基化可能是将DNA引入溶血杆菌中的关键步骤。为此目的已经分离并分子克隆了甲基转移酶。使用甲基转移酶已经允许构建定义的，减毒的突变体，用作疫苗以保护牛。

9. 发明授权

US5587305A Pasteurella haemolytica transformants 失效
标题翻译：溶血性巴斯德氏菌转化株
公开(公告)号：US5587305A
公开(公告)日：1996-12-24
申请号：US162392
申请日：1993-12-06
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/10 , C12N15/54 , C12N15/55 , C12N15/74 , C12N15/09 , C12N15/63
CPC分类号： C12N9/1092 , A61K39/102 , C07K14/285 , C12N15/102 , C12N15/74 , C12N9/1007 , C12N9/22
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.
摘要翻译： DNA的甲基化可能是将DNA引入溶血杆菌中的关键步骤。为此目的已经分离并分子克隆了甲基转移酶。使用甲基转移酶已经允许构建定义的，减毒的突变体，用作疫苗以保护牛。

10. 发明授权

US4016640A Method of fabricating and installing the grip of a hand-held implement 失效
标题翻译：制造和安装手持式工具的把手的方法
公开(公告)号：US4016640A
公开(公告)日：1977-04-12
申请号：US608348
申请日：1975-08-27
申请人： Robert E. Briggs
发明人： Robert E. Briggs
IPC分类号： A63B53/14 , A63B59/00 , A63B59/06 , B23P11/02 , B25G1/00 , B25G1/10 , B25G3/34 , B29C63/22
CPC分类号： B25G1/10 , A63B60/06 , A63B60/08 , A63B60/10 , B23P11/022 , B29C63/22 , A63B2208/12 , Y10T29/4987 , Y10T29/53657
摘要： A grip for the handle of a hand-held implement that, in as-produced form, is comprised of a thin walled tubular member open at one end and a boot integral with the tubular member that closes its other end. The grip's average internal girth along its longitudinal axis, as produced, is substantially less than the average external girth of the implement's handle portion to be covered by the grip along that handle portion's longitudinal axis. The grip, which may have a novel exterior gripping surface, is produced by dipping a male mandrel into an elastomeric latex and, thereafter, curing the latex skin formed on the mandrel prior to stripping of the grip from the mandrel. The grip is installed on an implement's handle by creating a pressure differential between the interior and exterior of the grip, thereby causing the grip to stretch radially outward from its longitudinal axis. This stretching step allows the implement's handle to be inserted through the grip's open end until the handle's free end bottoms out in the grip's boot. Subsequently, the pressure differential is released, thereby causing the grip to stretch into a tight friction fit with the handle. The grip's boot may thereafter be removed by slicing off, if desired.
摘要翻译：用于手持工具的手柄的手柄，其以制造形式由一个在一端开口的薄壁管状构件和与封闭其另一端的管状构件一体的靴子组成。沿着其纵向轴线的手柄的平均内部周长，如所产生的，大大小于沿着手柄部分的纵向轴线被把手覆盖的器具的把手部分的平均外围。可以具有新颖的外部抓持表面的把手通过将阳性芯棒浸入弹性体胶乳中，然后在从心轴剥离手柄之前固化形成在心轴上的乳胶皮肤来生产。把手通过在把手的内部和外部之间产生压力差而安装在工具的把手上，从而使把手从其纵向轴线径向向外伸展。该拉伸步骤允许工具的手柄通过手柄的开口端插入，直到手柄的自由端在手柄的靴子内部伸出。随后，释放压力差，从而使把手伸展成与手柄的紧密摩擦配合。如果需要，可以通过切片将手柄的靴子除去。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式