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1. 发明授权

US11428919B2 Objective changing and focusing apparatus for microscopes, and microscope having such objective changing and focusing apparatus 有权
公开(公告)号：US11428919B2
公开(公告)日：2022-08-30
申请号：US16764075
申请日：2018-11-09
申请人： 3DHISTECH KFT.
发明人： Bela Molnar , Viktor Sebestyen Varga , Janos Tibor Devenyi
IPC分类号： G02B21/24 , G02B7/02 , G02B7/14 , G02B21/02 , G02B27/64 , G02B21/00
摘要： The object of the invention relates to an objective changing and focussing apparatus (10) for microscopes (100) containing a plurality of objectives (12), and having an optical axis Z, the essence of which is that it contains—a first rail system (16a) having a first guide rail (17a) fixed to the microscope (100) and a first moving member (18a) guided by the first guide rail (17a), wherein the first rail system (16a) is arranged along an axis X perpendicular to the optical axis Z, —a first drive unit (20a) in drive connection with the first rail system (16a), —a plurality of objective interface elements (24), adapted for being connected to the objectives (12), arranged next to one another along the X axis and fixed to the first moving member (18a) movably along the Z axis, —a second rail system (16b) having a second guide rail (17b) fixed to the microscope (100) and a second moving member (18b) guided by the second guide rail (17b), wherein the second rail system (16b) is arranged parallel to the optical axis Z, and defines a starting position along the X axis, and—a second drive unit (20b) having a second drive connection with the second rail system (16b), and the second moving member (18b) is provided with a lifting element (26) providing a releasable connection with an objective interface (24) located in the starting position. The object of the invention also relates to a microscope containing such an objective changing and focusing apparatus (10).

2. 发明申请

US20090022419A1 Method for realistic stitching image blocks of an electronically recorded multipart image 有权
标题翻译：电子记录多部分图像的逼真拼接图像块的方法
公开(公告)号：US20090022419A1
公开(公告)日：2009-01-22
申请号：US11826752
申请日：2007-07-18
申请人： Bela Molnar , Viktor Sebestyen Varga , Attila Tagscherer , Gabor Csendes
发明人： Bela Molnar , Viktor Sebestyen Varga , Attila Tagscherer , Gabor Csendes
IPC分类号： G06T5/20
CPC分类号： G06T5/20 , G06T3/40 , G06T7/30
摘要： A method for realistic stitching and showing image blocks of an electronically recorded multipart image wherein relative positional offset values of the image blocks recorded with overlap are determined in a co-ordinate system in directions x and y and stored in matrix format, and the image blocks to be presented are stitched together on the basis of the stored values the method comprising: subdividing the overlaps of the individual image blocks into smaller regions with fixed relative positions; picking up at least one region most useful for the determination of the stitching; determining the offset goodness value based on the similarity of pattern of the image blocks; stitching the blocks of the image so that first the two image blocks characterised by the best offset goodness values are stitched together and the two image blocks characterised by the worst offset goodness values are stitched together last, whereas only the co-ordinates of the images figuring in a table are modified in the course of the stitching process; and distributing the errors produced by the stitching process over several image blocks.
摘要翻译：一种用于逼真拼接并示出电子记录的多部分图像的图像块的方法，其中在坐标系统中以x和y的方向确定以重叠记录的图像块的相对位置偏移值并以矩阵格式存储，并且图像块基于所存储的值将要呈现的方法包括：将各个图像块的重叠细分成具有固定相对位置的较小区域; 拾起至少一个区域最有用的确定缝合的区域; 基于图像块的图案的相似度来确定偏移良品值; 缝合图像的块，使得首先将由最佳偏移良品值表征的两个图像块缝合在一起，并且将最差偏移良品值表征的两个图像块最后拼接在一起，而仅图像的坐标在缝纫过程中修改了表格; 并且通过多个图像块分布由拼接处理产生的错误。

3. 发明授权

US10649195B2 Confocal slide-digitizing apparatus 有权
公开(公告)号：US10649195B2
公开(公告)日：2020-05-12
申请号：US15756370
申请日：2016-08-31
申请人： 3DHISTECH KFT.
发明人： Viktor Sebestyén Varga , Béla Molnár , Gergely Kovách , Dániel Luczi
IPC分类号： G02B21/36 , G02B21/26 , G02B21/00 , G02B21/33 , G02B21/24 , H04N5/225
摘要： A confocal slide-digitizing apparatus (100) includes a slide handling unit (20) and an imaging unit (10), wherein the slide handling unit (20) has a slide supplier unit (90). The imaging unit (10) has a light source (40) to illuminate the sample to be digitized at the imaging position through an objective (18) arranged in a light path that enables confocal imaging of at least a region of the sample and an image recording unit to receive light with information on at least an illuminated region of the sample through the objective (18) and generate a digital image of a section of a given thickness of said illuminated region. Moreover, said slide handling unit (20) and said imaging unit (10) are joined mechanically together in a tiltable manner relative to one another, thereby correcting the light path of said confocal imaging.

4. 发明申请

US20080123913A1 Method and Computer Program Product For the Storage Ensuring Fast Retrieval and Efficient Transfer of Interrelated High-Volume 3D Information 审中-公开
标题翻译：用于存储的方法和计算机程序产品确保快速检索和高效传输相关的大容量3D信息
公开(公告)号：US20080123913A1
公开(公告)日：2008-05-29
申请号：US11662976
申请日：2005-01-27
申请人： Tibor Virag , Attila Laszlo , Bela Molnar , Attila Tagscherer , Viktor Sebestyen Varga
发明人： Tibor Virag , Attila Laszlo , Bela Molnar , Attila Tagscherer , Viktor Sebestyen Varga
IPC分类号： G06K9/00
CPC分类号： H04N19/60 , G06F16/51 , G06F19/321 , H04N19/63 , H04N19/70
摘要： A method for the storage ensuring fast retrieval and efficient transfer of interrelated, high volume, mainly 3D, information, whereby the input information is assigned to two files, so that image data information required for histological reconstruction is stored in one file and information regarding predetermined parameters of the image data is stored in the other file, whereas in the course of the storing of the received information, associated information regarding the hierarchical relationship of individual image data is also stored in a further file. A computer program product for the storage ensuring fast retrieval and efficient transfer of interrelated, high-volume, mainly 3D, information, contains a computer-readable storage medium including a computer-readable programme code, further a software tool to store associated information regarding the hierarchical relationship of individual image data, while storing input information.
摘要翻译：一种用于存储的方法，其确保快速检索和有效传输相关的大量，主要是3D信息，由此将输入信息分配给两个文件，使得组织学重建所需的图像数据信息被存储在一个文件中并且关于预定的信息图像数据的参数存储在另一个文件中，而在存储接收到的信息的过程中，关于各个图像数据的分层关系的关联信息也被存储在另外的文件中。用于存储的计算机程序产品确保快速检索和有效传输相关的，大容量的主要3D信息，包含计算机可读存储介质，其包括计算机可读程序代码，还有一个软件工具，用于存储关于同时存储输入信息的单独图像数据的分层关系。

5. 发明授权

US11287631B2 Device for moving a microscope stage and microscope comprising such a device 有权
公开(公告)号：US11287631B2
公开(公告)日：2022-03-29
申请号：US16619266
申请日：2018-06-22
申请人： 3DHistech Kft.
发明人： David Istvan Szocs , Janos Tibor Devenyi , Viktor Sebestyen Varga , Bela Molnar
IPC分类号： G02B21/26
摘要： A microscope stage is movably mounted to a base and is movable relative to the base by two separate drive units on separate rail systems situated at an angle relative to one another. The drive units are mechanically isolated from one another and one of the drive units uses a belt drive.

6. 发明授权

US07663078B2 Focusing method for the high-speed digitalisation of microscope slides and slide displacing device, focusing optics, and optical rangefinder 失效
标题翻译：用于显微镜幻灯片和滑动位移装置，聚焦光学元件和光学测距仪的高速数字化的聚焦方法
公开(公告)号：US07663078B2
公开(公告)日：2010-02-16
申请号：US11661677
申请日：2005-01-27
申请人： Tibor Virág , Attila László , Béla Molnár , Attila Tagscherer , Viktor Sebestyén Varga
发明人： Tibor Virág , Attila László , Béla Molnár , Attila Tagscherer , Viktor Sebestyén Varga
IPC分类号： G02B7/04 , G01N21/86 , G01C3/08 , G01B9/00
CPC分类号： G02B21/245 , G02B21/242 , G02B21/26 , G02B21/34
摘要： A focusing method is provided for the high speed digitalization of microscope slides using an imaging device, wherein the slide is divided into fields of view according to the imaging device and focusing is performed. During rough focusing, several images are captured within the focus range using large focus steps. On the basis of this set of images the position of the best contrast is determined. Fine focusing is performed by adjusting the focus according to the focus distance already determined for another field of view and by focusing with fine steps. A slide displacing device is provided, which enables the displacement of a slide parallel to the optical axis. The slide displacing device includes slide holding elements affixed to one side of a supporting member having two parallel sides, which are connected by stiffening elements defining at least two parallel planes.
摘要翻译：提供了一种使用成像装置对显微镜幻灯片进行高速数字化的聚焦方法，其中根据成像装置将幻灯片划分成视野并进行聚焦。在粗调聚焦期间，使用大的对焦步骤在对焦范围内捕获多个图像。在这组图像的基础上，确定最佳对比度的位置。通过根据已经为另一视场确定的对焦距离并通过精细对准进行对焦来调整对焦来执行精细对焦。提供了一种滑动位移装置，其使平行于光轴的滑块位移。滑动位移装置包括固定在具有两个平行侧面的支撑构件的一侧上的滑动保持元件，其通过限定至少两个平行平面的加强元件连接。

7. 发明授权

US09625478B2 Automated integrated slide-processing system 有权
公开(公告)号：US09625478B2
公开(公告)日：2017-04-18
申请号：US14771380
申请日：2014-02-28
申请人： 3DHISTECH KFT.
发明人： Márton Hegedüs , Béla Molnár , Tibor Virág
IPC分类号： A61B10/00 , G01N35/00 , G01N1/31 , G01N35/10 , G01N35/04
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00584 , G01N35/1002 , G01N35/1011 , G01N2035/00089 , G01N2035/00138 , G01N2035/00168 , G01N2035/00356 , G01N2035/0463
摘要： The present invention relates to an integrated automated slide processing system, especially to stain, to cover and to digitize one or more microscope slides (49) in one turn. Said system comprises, as a single apparatus, at least one incubation drawer, an incubation drawer carrier (1), a manipulation tray (2), a manipulation arm (3), a reagent changing unit (4), a washing and rinsing unit, a drop removal unit, a staining/pipetting unit (13), a coverslipping unit (14), a preview image recording unit (15), a digitizing unit (16) and a control computer (18) electrically connected with and providing control over said units, wherein each of the one or more unstained and un-covered microscope slides with sample to be stained, covered and digitized is arranged in an incubation drawer having sidewalls defining a vertically constrained slide receiving space, and wherein the above listed units form a treating path along which said microscope slide (49) is converted into a stained, covered and, at least partially, digitized microscope slide when simultaneously guided over said treating path upon and in harmony with respective control signals provided by the control computer (18) to the respective units.

8. 发明授权

US08443960B2 System for handling slides 有权
标题翻译：处理幻灯片的系统
公开(公告)号：US08443960B2
公开(公告)日：2013-05-21
申请号：US12663537
申请日：2008-06-06
申请人： Tibor Virág , Béla Molnár , Ferenc Szipöcs , Ottó Németh , Attila Biletzky , Viktor Sebestyén Varga , Attila László
发明人： Tibor Virág , Béla Molnár , Ferenc Szipöcs , Ottó Németh , Attila Biletzky , Viktor Sebestyén Varga , Attila László
IPC分类号： B65G37/00
CPC分类号： G02B21/34 , G01N2035/00138 , G01N2035/00376
摘要： A system for handling slides having a tray moving on a carriage with seats for the slides and with a tray moving mechanism, a slide loading arm, and a slide holding frame having a slide loading arm driving motor. There are outstretched Maltese crosses on the lower side of the tray of the slide feeder and a crank is arranged in the carriage, opposite to and parallel with the crosses. The slide loading arm is arranged movably and tiltably above and a supporting plate is arranged movably and tiltably below the slide holder. The slide holding frame has a lifting means for tilting the slide loading arm and the supporting plate. The lifting means is actuated by a controller arranged on the disk of the crank.
摘要翻译：一种用于处理滑块的系统，其具有在具有用于滑块的座的托架上移动的托盘，并具有托盘移动机构，滑动装载臂和具有滑动装载臂驱动马达的滑动保持框架。在滑动进料器的托盘的下侧有伸出的马耳他十字架，并且在滑架中布置有与十字架相对并平行的曲柄。滑动装载臂在上方可移动地倾斜地布置，并且支撑板被可移动地和倾斜地布置在载玻片保持器下方。滑动保持框架具有用于使滑动装载臂和支撑板倾斜的提升装置。提升装置由布置在曲柄盘上的控制器致动。

9. 发明授权

US08203575B2 Method and system for accessing a slide from a remote workstation 有权
标题翻译：从远程工作站访问幻灯片的方法和系统
公开(公告)号：US08203575B2
公开(公告)日：2012-06-19
申请号：US12042050
申请日：2008-03-04
申请人： Béla Molnár , Viktor Sebestyén Varga , Attila Tagscherer
发明人： Béla Molnár , Viktor Sebestyén Varga , Attila Tagscherer
IPC分类号： G09G5/00 , G06K9/00
CPC分类号： G06F17/30265 , G06F19/00 , G06F19/321 , G16H10/40
摘要： The invention relates to a method for accessing a slide from a plurality of digitized microscope slides from a remote workstation, wherein the plurality of digitized microscope slides are accessible via a plurality of data station units (DSU), the method comprising: providing a central management station unit (CMSU) connected to a communication network for storing slide information of the plurality of digitized microscope slides, allowing the workstation to connect to the CMSU via the communication network; providing at least a part of the slide information of the plurality of digitized microscope slides to the workstation; allowing the workstation to select a digitized microscope slide based on the provided slide information; and allowing for a direct connection over the communication network between the remote workstation and a DSU enabling access to the selected digitized microscope slide. The invention further relates to a system and a CMSU for carrying out the method.
摘要翻译：本发明涉及一种用于从远程工作站的多个数字化显微镜载玻片上进入幻灯片的方法，其中所述多个数字化显微镜幻灯片可通过多个数据站单元（DSU）访问，所述方法包括：提供中央管理站单元（CMSU），连接到通信网络，用于存储多个数字化显微镜幻灯片的幻灯片信息，允许工作站经由通信网络连接到CMSU; 将多个数字化显微镜幻灯片的幻灯片信息的至少一部分提供给工作站; 允许工作站根据所提供的幻灯片信息选择数字化的显微镜幻灯片; 并且允许通过远程工作站和DSU之间的通信网络的直接连接，使得能够访问所选择的数字化显微镜幻灯片。本发明还涉及一种用于执行该方法的系统和CMSU。

10. 发明授权

US08041147B2 Method for realistic stitching image blocks of an electronically recorded multipart image 有权
标题翻译：电子记录多部分图像的逼真拼接图像块的方法
公开(公告)号：US08041147B2
公开(公告)日：2011-10-18
申请号：US11826752
申请日：2007-07-18
申请人： Bela Molnar , Viktor Sebestyen Varga , Attila Tagscherer , Gabor Csendes
发明人： Bela Molnar , Viktor Sebestyen Varga , Attila Tagscherer , Gabor Csendes
IPC分类号： G06K9/36
CPC分类号： G06T5/20 , G06T3/40 , G06T7/30
摘要： A method for realistic stitching and showing image blocks of an electronically recorded multipart image wherein relative positional offset values of the image blocks recorded with overlap are determined in a co-ordinate system in directions x and y and stored in matrix format, and the image blocks to be presented are stitched together on the basis of the stored values the method comprising: subdividing the overlaps of the individual image blocks into smaller regions with fixed relative positions; picking up at least one region most useful for the determination of the stitching; determining the offset goodness value based on the similarity of pattern of the image blocks; stitching the blocks of the image so that first the two image blocks characterized by the best offset goodness values are stitched together and the two image blocks characterized by the worst offset goodness values are stitched together last, whereas only the co-ordinates of the images figuring in a table are modified in the course of the stitching process; and distributing the errors produced by the stitching process over several image blocks.
摘要翻译：一种用于逼真拼接并示出电子记录的多部分图像的图像块的方法，其中在坐标系统中以x和y的方向确定以重叠记录的图像块的相对位置偏移值并以矩阵格式存储，并且图像块基于所存储的值将要呈现的方法包括：将各个图像块的重叠细分成具有固定相对位置的较小区域; 拾起至少一个区域最有用的确定缝合的区域; 基于图像块的图案的相似度来确定偏移良品值; 缝合图像的块，使得首先将由最佳偏移良品值表征的两个图像块缝合在一起，并且将最差偏移良品值表征的两个图像块最后拼接在一起，而仅图像的坐标在缝纫过程中修改了表格; 并且通过多个图像块分布由拼接处理产生的错误。

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