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1. 发明授权

US11452796B2 Cellular bone grafts, and methods of manufacture and use 有权
公开(公告)号：US11452796B2
公开(公告)日：2022-09-27
申请号：US16625457
申请日：2018-06-29
申请人： AlloSource
发明人： Reginald Stilwell , Ramasamy Sakthivel , William Maslanik
IPC分类号： A61L27/00 , A61L27/36 , A61L27/22 , A61L27/38
摘要： The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

2. 发明申请

US20210353422A1 CARTILAGE MOSAIC COMPOSITIONS AND METHODS 有权
公开(公告)号：US20210353422A1
公开(公告)日：2021-11-18
申请号：US17388388
申请日：2021-07-29
申请人： AlloSource
发明人： Carolyn Barrett Rorick , Yaling Shi
IPC分类号： A61F2/30 , A61L27/36
摘要： Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.

3. 发明授权

US10730122B2 Osseous-sanding accessory system 有权
公开(公告)号：US10730122B2
公开(公告)日：2020-08-04
申请号：US15838879
申请日：2017-12-12
申请人： Allosource
发明人： Denis M. Meade , Shane Graham
IPC分类号： B24B45/00 , B23D45/00 , B24B27/06 , B24B23/02 , B24B19/00 , B23D55/00 , A61F2/46 , A61B17/14 , B23D45/06
摘要： There are disclosed systems and methods for safely and effectively removing the articular cartilage and cortical bone layers from an articular surface of a human cadaveric femoral head. One embodiment includes an osseous-sanding accessory system installed upon a conventional band saw having a motor and a cabinet that houses a pulley coupled with a primary drive shaft rotated by the motor. The accessory system may include a threaded drive shaft coupled with the primary drive shaft, a grinding disk having an abrasive surface and affixed about a distal end of the threaded drive shaft, and a removable accessory table mounted to the band saw below the grinding disk. When the motor rotates the primary drive shaft, and thus the threaded drive shaft, the grinding disk rotates relative to the accessory table and abrades osseous tissues introduced to the abrasive surface of the grinding disk. Other embodiments are also disclosed.

4. 发明授权

US10661312B2 High-pressure water debridement system 有权
公开(公告)号：US10661312B2
公开(公告)日：2020-05-26
申请号：US15815075
申请日：2017-11-16
申请人： Allosource
发明人： Denis M. Meade , Shane Graham , Kyle von Kaenel
IPC分类号： B08B3/02 , A61F2/46 , A61B90/70 , A61L2/00
摘要： There is disclosed a system and methods for debriding soft tissue from bone using a high-pressure water debridement system. One embodiment includes a cylindrical sleeve bounded by endcaps and having a drainage port positioned for effluent drainage. A central shaft is configured to receive a bone segment and is disposed along a longitudinal center of the sleeve and rotatively coupled between the endcaps. At least one high-pressure water nozzle is disposed on each side of the sleeve, each of which is positioned to impact the bone segment with a high-pressure water stream. A rotational actuator is configured to rotate the central shaft and the bone segment relative to the sleeve and the water nozzles such that when the high-pressure water nozzles are operational, the high-pressure water streams debride the bone segment. Other embodiments are also disclosed.

5. 发明授权

US10449062B2 Sterile water dispersion system for allograft preparation and processing 有权
公开(公告)号：US10449062B2
公开(公告)日：2019-10-22
申请号：US15259376
申请日：2016-09-08
申请人： Allsource
发明人： Donald Von Kaenel , Daniel R. Hanten, II
IPC分类号： A61F2/46
摘要： There is disclosed a system and method for dispersing sterile water from a circulating high-purity water system to a processing field containing allograft tissue. One embodiment includes a fluid inlet that is fluidly coupled with and configured to receive sterile water from the water system. The dispersion system also includes at least first and second fluid outlets that are selectively operable to deliver respective first and second fluid streams into different areas of the processing field. At least one of the first and second fluid outlets may be associated with a regulator valve configured to provide an adjustable flowrate to conserve water pulled from the circulating water system to meet the needs of the application taking place within the processing field. Other embodiments are also disclosed.

6. 发明授权

US10052046B2 Trochlea-angle measurement template 有权
公开(公告)号：US10052046B2
公开(公告)日：2018-08-21
申请号：US14944457
申请日：2015-11-18
申请人： ALLOSOURCE
发明人： Brittany Nickolas , Christopher Mast , Todd Huft , Meghan Gabriel
IPC分类号： A61B5/00 , A61B5/107 , A61F2/46 , A61B90/00 , A61F2/38
CPC分类号： A61B5/1071 , A61B2090/067 , A61F2/3877 , A61F2/4657 , A61F2002/4668
摘要： The disclosure provides apparatus and methods of use pertaining to a measurement template for use in allograft preparation and processing. Specifically, the template may be used to measure the trochlea angle of the trochlea groove of the distal human femur. The measurement template may be formed of a flat metal plate having first and second ends, each forming a different angle designed to fit against the trochlea groove and provide an indication of the angle of the groove in relation to the angles formed by the template. The trochlea angle of the allograft may then be documented, allowing for proper matching between allograft tissue and transplant recipient physiology. The measurement template may be adapted for a variety of configurations depending on desired and/or common allograft requirements. Other embodiments are also disclosed.

7. 发明授权

US09829302B2 System and method for measuring a non-bone tendon 有权
公开(公告)号：US09829302B2
公开(公告)日：2017-11-28
申请号：US14940549
申请日：2015-11-13
申请人： ALLOSOURCE
发明人： Tyler A. Reinke
IPC分类号： A61B5/107 , G01B5/08 , A61B19/00 , A61B5/00
CPC分类号： G01B5/08 , A61B5/107 , A61B5/4523 , A61B19/46 , A61B90/06 , A61B2019/461 , A61B2090/061
摘要： There is disclosed a system and method for measuring the diameter or thickness of a tendon. In an embodiment, the device includes an adjustable tube having a variably sized cross-sectional diameter in a direction perpendicular to an axis extending between the first end and the second end, the adjustable tube being positionable from an open configuration in which the variably sized cross-sectional diameter is larger than a diameter of a tendon so as to allow loading of the tendon, to a closed configuration in which the variably sized cross-sectional diameter approximates the diameter of the tendon so as to allow measurement of the tendon. The device includes a measurement gradient in operable configuration with the adjustable tube so as to allow measurement of the tendon in the closed configuration. Other embodiments are also disclosed.

8. 发明授权

US09814803B2 Allografts combined with tissue derived stem cells for bone healing 有权
公开(公告)号：US09814803B2
公开(公告)日：2017-11-14
申请号：US14880563
申请日：2015-10-12
申请人： AlloSource
发明人： Yaling Shi
IPC分类号： A61K35/38 , A61L27/38 , A61L27/36 , A61L27/54 , C12N5/0775 , A01N1/02 , A61K35/12
CPC分类号： A61L27/3834 , A01N1/021 , A61K35/12 , A61K35/38 , A61L27/3608 , A61L27/3847 , A61L27/3895 , A61L27/54 , A61L2300/406 , A61L2430/02 , C12N5/0662 , C12N5/0667 , C12N2509/00 , C12N2533/18 , C12N2533/90
摘要： There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose tissue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.

9. 发明授权

US09603710B2 Methods of manufacturing perforated osteochondral allograft compositions 有权
公开(公告)号：US09603710B2
公开(公告)日：2017-03-28
申请号：US14858386
申请日：2015-09-18
申请人： AlloSource
发明人： Yaling Shi , Carolyn Barrett
IPC分类号： A61F2/28 , A61F2/30 , A61L27/36 , A61L27/38 , A61L27/56
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/3094 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30784 , A61F2002/30827 , A61F2002/3096 , A61F2002/3097 , A61L27/3612 , A61L27/3804 , A61L27/56 , A61L2430/24
摘要： Osteochondral graft composition that include a cartilage component and a bone component, and which include one or more perforations in the bone component and/or the cartilage component, are provided. Methods of manufacturing and using such osteochondral graft compositions are also provided.

10. 发明授权

US09267870B2 Constant force compression tool 有权
标题翻译：恒力压缩工具
公开(公告)号：US09267870B2
公开(公告)日：2016-02-23
申请号：US13746929
申请日：2013-01-22
申请人： Allosource
发明人： Raymond J. Klein
IPC分类号： G01N3/08 , G01F19/00
CPC分类号： G01N3/08 , G01F19/00 , G01F19/007
摘要： There is disclosed a constant force compression tool for measuring a compressible material. In an embodiment, the tool includes a handle having a passageway receiving a plunger. The tool includes a biasing member in communication with the plunger and the handle. The tool includes a retaining element in communication with the plunger and the handle. There is disclosed a system for measuring a compressible material with a measurement tube and a constant force compression tool. There is disclosed a method of measuring a compressible material. In an embodiment, the method includes selecting a measurement tube. The method includes placing a compressible material into the measurement tube. The method includes pressing a plunger against the compressible material. The method includes monitoring an indicator to determine a full volume of compressible material between the end of the plunger and the conical tube. Other embodiments are also disclosed.
摘要翻译：公开了一种用于测量可压缩材料的恒力压缩工具。在一个实施例中，该工具包括具有接收柱塞的通道的把手。该工具包括与柱塞和手柄连通的偏置构件。该工具包括与柱塞和手柄连通的保持元件。公开了一种用测量管和恒力压缩工具测量可压缩材料的系统。公开了一种测量可压缩材料的方法。在一个实施例中，该方法包括选择测量管。该方法包括将可压缩材料放入测量管中。该方法包括将柱塞压靠在可压缩材料上。该方法包括监测指示器以确定柱塞端部和锥形管之间的可压缩材料的全部体积。还公开了其他实施例。

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