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1. 发明授权

US08476246B2 Combination of a chemotherapeutic agent and an inhibitor of the TGF-beta system 有权
标题翻译：化疗药物与TGF-β系统抑制剂的组合
公开(公告)号：US08476246B2
公开(公告)日：2013-07-02
申请号：US13059623
申请日：2010-07-30
申请人： Karl-Hermann Schlingensiepen , Frank Jaschinski , Tanja Rothammer-Hampl , Anneliese Schneider
发明人： Karl-Hermann Schlingensiepen , Frank Jaschinski , Tanja Rothammer-Hampl , Anneliese Schneider
IPC分类号： A01N43/04 , C12N15/63 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1136 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2320/31 , A61K2300/00
摘要： Pharmaceutical composition comprising a chemotherapeutic agent and a TGF-beta antisense oligonucleotide, wherein the antisense oligonucleotide reduces the sensitivity and IC50, respectively, of the cytotoxicity of the chemotherapeutic agent. Preferably, the antisense oligonucleotide is a TGF-beta 1, 2, and/or 3 antisense oligonucleotide and the chemotherapeutic agent is preferably gemcitabine, 5-fluorouracil, temozolomide, dacarbacine, docetaxel, cisplatin, oxaliplatin, tamoxifen, or irinotecan.
摘要翻译：包含化学治疗剂和TGF-β反义寡核苷酸的药物组合物，其中所述反义寡核苷酸分别降低了化学治疗剂的细胞毒性的敏感性和IC50。优选地，反义寡核苷酸是TGF-β1,2和/或3反义寡核苷酸，并且化学治疗剂优选是吉西他滨，5-氟尿嘧啶，替莫唑胺，达卡氏素，多西他赛，顺铂，奥沙利铂，他莫昔芬或伊立替康。

2. 发明申请

US20110137289A1 PORTABLE EQUIPMENT FOR ADMINISTRATION OF FLUIDS INTO TISSUES AND TUMORS BY CONVECTION ENHANCED DELIVERY TECHNIQUE 有权
标题翻译：便携式设备通过对流增强交付技术将流体输送到组织和肿瘤中
公开(公告)号：US20110137289A1
公开(公告)日：2011-06-09
申请号：US13027037
申请日：2011-02-14
申请人： Mechthild Kunst
发明人： Mechthild Kunst
IPC分类号： A61M5/142 , A61M5/00
CPC分类号： A61M5/14244 , A61M39/0208 , A61M39/04 , A61M2005/1581 , A61M2039/0211 , A61M2205/32 , A61M2210/0693
摘要： The present invention is directed to a device for a portable convection enhanced delivery system that allows administering liquids to specific locations within the body, especially tissues and tumors also allowing outsubject treatment. The application system comprises a portable extracorporal pump with a fluid reservoir that is connected via an infusion system to an infusion catheter placeable to any tissue or tumor the fluid should be administered to by high flow microperfusion. The system enables administration of fluids of any kind by convection enhanced delivery also in out-patient treatment. The system can be used for delivering various drugs, proteins, protein toxins, antibodies for treatment or imaging, proteins in enzyme replacement therapy, growth factors and viruses or oligonucleotides in gene therapy etc. The application methods as well as the surgical method to implant this device are enclosed to this invention.
摘要翻译：本发明涉及一种用于便携式对流增强递送系统的装置，其允许将液体施用于身体内的特定位置，特别是组织和肿瘤，还允许外部治疗。应用系统包括具有流体储存器的便携式体外泵，其经由输注系统连接到可置于任何组织或肿瘤的输注导管，流体应通过高流量微灌注施用。该系统能够通过门诊治疗中的对流增强输送来管理任何种类的流体。该系统可用于递送各种药物，蛋白质，蛋白质毒素，用于治疗或成像的抗体，酶替代疗法中的蛋白质，基因治疗中的生长因子和病毒或寡核苷酸等。应用方法以及植入该方法的手术方法装置被封装到本发明。

3. 发明授权

US07910563B2 Antisense oligonucleotide to inhibit melanoma inhibitory activity, MIA 失效
标题翻译：反义寡核苷酸抑制黑素瘤抑制活性，MIA
公开(公告)号：US07910563B2
公开(公告)日：2011-03-22
申请号：US10567879
申请日：2004-08-11
申请人： Karl-Hermann Schlingensiepen , Reimar Schlingensiepen
发明人： Karl-Hermann Schlingensiepen , Reimar Schlingensiepen
IPC分类号： C07H21/00 , C07H21/02 , C12N15/11 , A61K48/00
CPC分类号： C12N15/1135 , A61K38/00 , C12N15/113 , C12N2310/311 , C12N2310/312 , C12N2310/3125 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3513 , C12N2310/3515
摘要： An antisense oligonucleotide selected from the group of the sequence 5′-TTG CAT AAA CCC AAG GAG-3′ (SEQ ID NO: 1) and modifications thereof a fragment having at least 8 nucleotides of the sequence 5′-TTG CAT AAA CCC AAG GAG-3′ (SEQ ID NO: 1) and modifications thereof.
摘要翻译：选自序列5'-TTG CAT AAA CCC AAG GAG-3'（SEQ ID NO：1）的反义寡核苷酸及其修饰具有序列5'-TTG CAT AAA CCC AAG的至少8个核苷酸的片段 GAG-3'（SEQ ID NO：1）及其修饰。

4. 发明申请

US20100273705A1 Method for inhibiting "Melanoma Inhibitory Activity" MIA 有权
标题翻译：抑制“黑素瘤抑制活性”的方法MIA
公开(公告)号：US20100273705A1
公开(公告)日：2010-10-28
申请号：US12289153
申请日：2008-10-21
申请人： Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
发明人： Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
IPC分类号： A61K38/10 , C07K7/08 , C07K7/06 , A61K38/08 , A61P35/00
CPC分类号： C07K16/2842 , A61K38/00 , C07K7/06 , C07K7/08 , C07K16/3053
摘要： The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA).
摘要翻译：本发明涉及抑制“黑素瘤抑制活性”（MIA）活性的肽，抗体和抗体片段。

5. 发明授权

US08936910B2 Method for selective oligonucleotide modification 有权
标题翻译：选择性寡核苷酸修饰方法
公开(公告)号：US08936910B2
公开(公告)日：2015-01-20
申请号：US13703260
申请日：2011-06-10
申请人： Andreas Mitsch , Karl-Hermann Schlingensiepen , Bernd Betzler , Frank Jaschinski , Anneliese Schneider
发明人： Andreas Mitsch , Karl-Hermann Schlingensiepen , Bernd Betzler , Frank Jaschinski , Anneliese Schneider
IPC分类号： C12Q1/68 , C12N15/11 , C07H21/02
CPC分类号： C12N15/10 , A61K31/713 , A61K45/06 , A61K47/64 , C12N15/111 , C12N15/113 , C12N15/1136 , C12N2310/3513 , C12N2310/3515 , C12N2320/51
摘要： Method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5′-end or the 3′-end of the oligonucleotide via native ligation forming a native ligation site, with the proviso that the polymer and/or the compound is not a protein or peptide, if only the 5′-end of the oligonucleotide is modified by binding of the polymer or compound via native ligation. The invention is further directed to a modified oligonucleotide obtainable by the inventive method as well as the use of such modified oligonucleotide for the preparation of a medicament for preventing and/or treating a tumor, formation of metastasis, an immune disease or disorder, a cardiovascular disease or disorder, and/or a viral disease or disorder.
摘要翻译：制备修饰寡核苷酸的方法，其中至少一种聚合物，优选聚环氧烷，和/或化合物通过天然连接形成天然连接位点与寡核苷酸的5'端或3'末端共价结合，条件是聚合物和/或化合物不是蛋白质或肽，如果仅通过经由天然连接的聚合物或化合物的结合来修饰寡核苷酸的5'末端。本发明还涉及通过本发明方法获得的修饰的寡核苷酸以及这种修饰的寡核苷酸在制备用于预防和/或治疗肿瘤，形成转移，免疫疾病或病症的药物中的用途，心血管疾病或病症，和/或病毒性疾病或病症。

6. 外观设计

USD709183S1 Pump for pharmaceutical and cosmetic products 有权
标题翻译：泵用于制药和化妆品
公开(公告)号：USD709183S1
公开(公告)日：2014-07-15
申请号：US29433324
申请日：2012-09-28
申请人： Antisense Pharma GmbH
设计人： Till Kemlein

7. 发明申请

US20120027873A1 COMBINATION OF A CHEMOTHERAPEUTIC AGENT AND AN INHIBITOR OF THE TGF-BETA SYSTEM 有权
标题翻译：化学治疗剂与TGF-beta系统的抑制剂的组合
公开(公告)号：US20120027873A1
公开(公告)日：2012-02-02
申请号：US13059623
申请日：2010-07-30
申请人： Karl-Hermann Schlingensiepen , Frank Jaschinski , Tanja Rothammer-Hampl , Anneliese Schneider
发明人： Karl-Hermann Schlingensiepen , Frank Jaschinski , Tanja Rothammer-Hampl , Anneliese Schneider
IPC分类号： A61K31/7088 , A61P35/00 , A61K33/24
CPC分类号： C12N15/1136 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2320/31 , A61K2300/00
摘要： Pharmaceutical composition comprising a chemotherapeutic agent and a TGF-beta antisense oligonucleotide, wherein the antisense oligonucleotide reduces the sensitivity and IC50, respectively, of the cytotoxicity of the chemotherapeutic agent. Preferably, the antisense oligonucleotide is a TGF-beta 1, 2, and/or 3 antisense oligonucleotide and the chemotherapeutic agent is preferably gemcitabine, 5-fluorouracil, temozolomide, dacarbacine, docetaxel, cisplatin, oxaliplatin, tamoxifen, or irinotecan.
摘要翻译：包含化学治疗剂和TGF-β反义寡核苷酸的药物组合物，其中所述反义寡核苷酸分别降低了化学治疗剂的细胞毒性的敏感性和IC50。优选地，反义寡核苷酸是TGF-β1,2和/或3反义寡核苷酸，并且化学治疗剂优选是吉西他滨，5-氟尿嘧啶，替莫唑胺，达卡氏素，多西他赛，顺铂，奥沙利铂，他莫昔芬或伊立替康。

8. 发明授权

US08822425B2 Dosage of oligonucleotides suitable for the treatment of tumors 有权
标题翻译：适用于治疗肿瘤的寡核苷酸的剂量
公开(公告)号：US08822425B2
公开(公告)日：2014-09-02
申请号：US12453487
申请日：2009-05-12
申请人： Karl-Hermann Schlingensiepen , Hubert Heinrichs , Susanne Schmaus
发明人： Karl-Hermann Schlingensiepen , Hubert Heinrichs , Susanne Schmaus
IPC分类号： C12N15/11 , C07H21/04
CPC分类号： C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： A method for preventing and/or treating a tumor, the method comprising: intravenously administering an antisense oligonucleotide in an amount of between about 400 to about 800 mg/m2/treatment cycle, the antisense oligonucleotide comprises 8 to 30 nucleotide building blocks, which hybridizes with mRNA of TGF-beta-2, -1 and/or -3 for the preparation of a pharmaceutical composition.
摘要翻译：一种用于预防和/或治疗肿瘤的方法，所述方法包括：以约400至约800mg / m 2 /处理周期的量静脉内施用反义寡核苷酸，所述反义寡核苷酸包含8至30个核苷酸结构单元，其与与TGF-β-2，-1和/或-3的mRNA用于制备药物组合物。

9. 发明授权

US08177775B2 Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique 有权
标题翻译：便携式设备，用于通过对流增强输送技术将液体输送到组织和肿瘤中
公开(公告)号：US08177775B2
公开(公告)日：2012-05-15
申请号：US13027037
申请日：2011-02-14
申请人： Mechthild Kunst
发明人： Mechthild Kunst
IPC分类号： A61M31/00 , A61M37/00 , A61K9/22
CPC分类号： A61M5/14244 , A61M39/0208 , A61M39/04 , A61M2005/1581 , A61M2039/0211 , A61M2205/32 , A61M2210/0693
摘要： The present invention is directed to a device for a portable convection enhanced delivery system that allows administering liquids to specific locations within the body, especially tissues and tumors also allowing outsubject treatment. The application system comprises a portable extracorporal pump with a fluid reservoir that is connected via an infusion system to an infusion catheter placeable to any tissue or tumor the fluid should be administered to by high flow microperfusion. The system enables administration of fluids of any kind by convection enhanced delivery also in out-patient treatment. The system can be used for delivering various drugs, proteins, protein toxins, antibodies for treatment or imaging, proteins in enzyme replacement therapy, growth factors and viruses or oligonucleotides in gene therapy etc. The application methods as well as the surgical method to implant this device are enclosed to this invention.
摘要翻译：本发明涉及一种用于便携式对流增强递送系统的装置，其允许将液体施用于身体内的特定位置，特别是组织和肿瘤，还允许外部治疗。应用系统包括具有流体储存器的便携式体外泵，其经由输注系统连接到可置于任何组织或肿瘤的输注导管，流体应通过高流量微灌注施用。该系统能够通过门诊治疗中的对流增强输送来管理任何种类的流体。该系统可用于递送各种药物，蛋白质，蛋白质毒素，用于治疗或成像的抗体，酶替代疗法中的蛋白质，基因治疗中的生长因子和病毒或寡核苷酸等。应用方法以及植入该方法的手术方法装置被封装到本发明。

10. 发明授权

US08148493B2 Method for inhibiting “melanoma inhibitory activity” MIA 有权
标题翻译：抑制“黑素瘤抑制活性”的方法MIA
公开(公告)号：US08148493B2
公开(公告)日：2012-04-03
申请号：US12289153
申请日：2008-10-21
申请人： Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
发明人： Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
IPC分类号： A61K38/04
CPC分类号： C07K16/2842 , A61K38/00 , C07K7/06 , C07K7/08 , C07K16/3053
摘要： The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA).
摘要翻译：本发明涉及抑制“黑素瘤抑制活性”（MIA）活性的肽，抗体和抗体片段。

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