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1. 发明授权

US11071982B2 Fluid holding and dispensing micro-feature 有权
公开(公告)号：US11071982B2
公开(公告)日：2021-07-27
申请号：US15755676
申请日：2016-08-29
申请人： ATIVA MEDICAL CORPORATION
发明人： Phillip Henning , Elizabeth Palaima , Pamela Wong , Daniel R. McPeak , Ka Man Lee , Eric R. Peltola
IPC分类号： G01N1/40 , G01N33/80 , B01L3/00 , C12Q1/24 , G01N15/06 , G01N15/04 , G01N15/00 , G01N15/14
摘要： Apparatus, system and method for dispensing a particle-laden fluid from a fluid holding and dispensing micro-feature and/or multiple lysing channel structures. In some implementations, the apparatus includes: a chamber having one or more surfaces that define a volume to receive fluid containing particulate matter, a soluble surface coating on a portion of the one or more surfaces of the chamber, and an outlet port to dispense at least a portion of the fluid from the chamber. In some implementations, the particle-laden fluid may be whole blood, and the soluble surface coating may include reagents and/or dyes that are diffused into the whole blood received within the chamber to generate signals to visualize various cellular components. In some implementations, the apparatus may also include a second soluble surface coating on portions of surfaces of the multiple lysing channel structures.

2. 发明授权

US09366606B1 Fluid processing micro-feature devices and methods 有权
标题翻译：流体加工微特征装置和方法
公开(公告)号：US09366606B1
公开(公告)日：2016-06-14
申请号：US14837697
申请日：2015-08-27
申请人： Ativa Medical Corporation
发明人： Daniel R. McPeak , Ka Man Lee
IPC分类号： G01N1/38 , G01N33/50 , B01L3/00 , B01F13/00
CPC分类号： G01N1/38 , B01F13/0062 , B01F13/0093 , B01L3/5027 , B01L3/502776 , B01L2200/0647 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487
摘要： The present description provides, in some embodiments, an apparatus for mixing a fluid in a circuit having an inlet channel defining a flow path for a fluid including particulate matter, a first reagent channel in fluid communication with the inlet channel and defining a first reagent flow path for a first reagent, the inlet channel and first reagent channel configured to shear the fluid entering the first reagent channel from the inlet channel at a first junction, a shearing channel in fluid communication with the inlet channel and first reagent channel at the first junction, and a diffusion channel in fluid communication with the shearing channel at a second junction, the sheared fluid collectable into the diffusion channel such that the fluid is compressed at least in part by the first reagent to have a thickness close to a diameter of the particulate matter in the fluid.
摘要翻译：在一些实施例中，本说明书提供了一种用于在具有限定用于包括颗粒物质的流体的流动路径的入口通道的回路中混合流体的装置，与入口通道流体连通并限定第一试剂流的第一试剂通道第一试剂的通路，入口通道和第一试剂通道，其构造成在第一接合处从入口通道剪切进入第一试剂通道的流体，与入口通道流体连通的剪切通道和第一接合处的第一试剂通道以及在第二连接处与剪切通道流体连通的扩散通道，所述剪切流体可收集到扩散通道中，使得流体至少部分地被第一试剂压缩以具有接近颗粒直径的厚度在流体中的物质。

3. 发明授权

US10612070B2 Fluid holding and dispensing micro-feature 有权
公开(公告)号：US10612070B2
公开(公告)日：2020-04-07
申请号：US15397349
申请日：2017-01-03
申请人： Ativa Medical Corporation
发明人： Daniel R. McPeak , Ka Man Lee , Eric R. Peltola
IPC分类号： C12Q1/24 , G01N33/80 , G01N1/40 , B01L3/00
CPC分类号： C12Q1/24 , B01L3/502707 , B01L3/502753 , G01N1/4077 , G01N33/80 , B01L2200/0652 , B01L2200/10 , B01L2300/0816 , B01L2300/0858 , B01L2300/0864 , B01L2300/16 , B01L2400/0457
摘要： Apparatus, system and method for dispensing a particle-laden fluid from a fluid holding and dispensing micro-feature. In some implementations, the apparatus includes: a chamber having one or more surfaces that define a volume to receive fluid containing particulate matter, and an outlet port to dispense at least a portion of the fluid from the chamber. The outlet port may have a normal vector that, when the apparatus is positioned to dispense the fluid, is substantially perpendicular to gravity. The apparatus may be used to measure a number of individual particles from the fluid that flow through the outlet port over a period of them, measure a total volume of the fluid dispensed through the outlet port over the period of time, and calculate a concentration of the particulate matter within the chamber. In some implementations, the particle-laden fluid may be whole blood.

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