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1. 发明申请

US20110103657A1 METHODS OF OBTAINING GEOMETRY FROM IMAGES 有权
标题翻译：从图像中获取几何的方法
公开(公告)号：US20110103657A1
公开(公告)日：2011-05-05
申请号：US12811537
申请日：2009-01-02
申请人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
发明人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/107 , A61B5/489 , A61B6/504 , A61B6/508 , A61B2576/02 , G06K9/4609 , G06K9/4638 , G06K9/6215 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/74 , G06T15/08 , G06T2207/10028 , G06T2207/10072 , G06T2207/10116 , G06T2207/20004 , G06T2207/30101 , G06T2207/30172 , G06T2211/404
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.
摘要翻译：在一个方面，提供一种使用适于响应于至少一个特征的匹配滤波器来检测至少一个血管的至少一个图像中的至少与血管相关联的特征的方法。所述方法包括对所述至少一个图像中的选定体素应用比例检测滤波器以确定每个所选择的体素处的匹配滤波器的比例，确定每个所选择的体素处的匹配滤波器的取向，其中确定取向通过使用在每个所选择的体素中确定的比例来辅助，在每个所选择的体素处以每个所选择的体素应用匹配滤波器，并且在每个所选择的体素处确定取向以在每个所选择的体素处获得滤波器响应，以及分析每个所选择的体素处的过滤器响应，以确定相应的体素是否对应于所述至少一个特征。

2. 发明申请

US20100159497A1 Binned Micro-Vessel Density Methods and Apparatus 有权
标题翻译： Binned微血管密度方法和装置
公开(公告)号：US20100159497A1
公开(公告)日：2010-06-24
申请号：US12308908
申请日：2007-06-28
申请人： Benjamin Kimia , Raul A. Brauner , John Heymach , Jesse Funaro
发明人： Benjamin Kimia , Raul A. Brauner , John Heymach , Jesse Funaro
IPC分类号： C12Q1/02
CPC分类号： G06T7/0012 , G06T7/44 , G06T7/62 , G06T2207/10116 , G06T2207/30024 , G06T2207/30101
摘要： In one aspect, a method of obtaining micro-vessel density (MVD) measurements from an image of biological vasculature containing a plurality of vessels is provided. The method comprises acts of analyzing a region of interest of the image for each of a plurality of bins, each of the plurality of bins associated with a predetermined range of vessel sizes, the act of analyzing the region of interest including determining which of the plurality of bins that portions of any vessel subject matter identified in the region of interest belong based on a size associated with the respective portions of the vessel subject matter, and associating each portion of the vessel subject matter with the corresponding one of the plurality of bins to which the portion belongs, and computing at least one measurement for each of the plurality of bins, the at least one measurement related to the MVD of the portions of vessel subject matter associated with the respective bin.
摘要翻译：一方面，提供从包含多个血管的生物脉管系统的图像获得微血管密度（MVD）测量的方法。该方法包括针对多个箱中的每个箱分析图像的感兴趣区域的动作，多个箱中的每一个与预定范围的容器尺寸相关联，分析感兴趣区域的动作包括确定多个箱中的哪一个在所述感兴趣区域中识别的任何船舶标的物的部分基于与所述船舶主题的各个部分相关联的尺寸，并且将所述船舶主体的每个部分与所述多个箱中的相应的一个箱相关联到该部分属于该部分，并且计算多个箱体中的每个箱体的至少一个测量值，所述至少一个测量值与与相应箱体相关联的血管主体的部分的MVD相关。

3. 发明授权

US09721341B2 Methods of obtaining geometry from images 有权
公开(公告)号：US09721341B2
公开(公告)日：2017-08-01
申请号：US15043345
申请日：2016-02-12
申请人： Bio-Tree Systems, Inc.
发明人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
IPC分类号： G06K9/00 , G06T7/00 , G06K9/62 , G06T7/20 , G06T15/08 , G06T7/73 , A61B5/055 , G06T7/60 , A61B6/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/107 , A61B5/489 , A61B6/504 , A61B6/508 , A61B2576/02 , G06K9/4609 , G06K9/4638 , G06K9/6215 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/74 , G06T15/08 , G06T2207/10028 , G06T2207/10072 , G06T2207/10116 , G06T2207/20004 , G06T2207/30101 , G06T2207/30172 , G06T2211/404
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.

4. 发明申请

US20170024882A1 METHODS OF OBTAINING GEOMETRY FROM IMAGES 审中-公开
标题翻译：从图像中获取几何的方法
公开(公告)号：US20170024882A1
公开(公告)日：2017-01-26
申请号：US15043345
申请日：2016-02-12
申请人： Bio-Tree Systems, Inc.
发明人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
IPC分类号： G06T7/00 , A61B6/00 , A61B5/055 , G06K9/62 , G06T7/60
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/107 , A61B5/489 , A61B6/504 , A61B6/508 , A61B2576/02 , G06K9/4609 , G06K9/4638 , G06K9/6215 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/74 , G06T15/08 , G06T2207/10028 , G06T2207/10072 , G06T2207/10116 , G06T2207/20004 , G06T2207/30101 , G06T2207/30172 , G06T2211/404
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.
摘要翻译：在一个方面，提供一种使用适于响应于至少一个特征的匹配滤波器来检测至少一个血管的至少一个图像中的至少与血管相关联的特征的方法。所述方法包括对所述至少一个图像中的选定体素应用比例检测滤波器以确定每个所选择的体素处的匹配滤波器的比例，确定每个所选择的体素处的匹配滤波器的取向，其中确定取向通过使用在每个所选择的体素中确定的比例来辅助，在每个所选择的体素处以每个所选择的体素应用匹配滤波器，并且在每个所选择的体素处确定取向以在每个所选择的体素处获得滤波器响应，以及分析每个所选择的体素处的过滤器响应，以确定相应的体素是否对应于所述至少一个特征。

5. 发明申请

US20160239956A1 METHODS AND SYSTEM FOR LINKING GEOMETRY OBTAINED FROM IMAGES 审中-公开
标题翻译：用于连接从图像获取的几何的方法和系统
公开(公告)号：US20160239956A1
公开(公告)日：2016-08-18
申请号：US14853940
申请日：2015-09-14
申请人： Bio-Tree Systems, Inc.
发明人： Kongbin Kang , Yanchun Wu , Raul A. Brauner
IPC分类号： G06T7/00 , G06T17/00 , G06K9/62 , A61B6/00 , A61B6/03
CPC分类号： G06T7/0012 , A61B6/032 , A61B6/504 , A61B6/5247 , G06K9/6202 , G06K9/6212 , G06K9/6214 , G06T7/11 , G06T7/12 , G06T7/181 , G06T7/187 , G06T7/70 , G06T17/005 , G06T2207/10081 , G06T2207/30101
摘要： Techniques for linking geometry extracted from one or more medical images, the geometry including a plurality of geometric objects each having parameter values including at least one value for location and at least one value for direction/orientation, the plurality of geometric objects comprising a target geometric object and at least two candidate geometric objects, the techniques include: (A) comparing parameter values of the target geometric object with parameter values of the at least two candidate geometric objects, (B) selecting one of the at least two candidate geometric objects to link to the target geometric object based, at least in part, on the comparison; and (C) linking the target geometric object with the selected candidate geometric object.
摘要翻译：用于链接从一个或多个医学图像提取的几何的技术，所述几何包括多个几何对象，每个几何对象具有包括用于位置的至少一个值和至少一个用于方向/取向的值的参数值，所述多个几何对象包括目标几何所述技术包括：（A）将所述目标几何对象的参数值与所述至少两个候选几何对象的参数值进行比较，（B）选择所述至少两个候选几何对象中的一个至少两个候选几何对象至少部分地基于比较来链接到目标几何对象; 和（C）将目标几何对象与所选择的候选几何对象相链接。

6. 发明授权

US08761466B2 Methods of obtaining geometry from images 有权
标题翻译：从图像获取几何的方法
公开(公告)号：US08761466B2
公开(公告)日：2014-06-24
申请号：US12811537
申请日：2009-01-02
申请人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
发明人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/107 , A61B5/489 , A61B6/504 , A61B6/508 , A61B2576/02 , G06K9/4609 , G06K9/4638 , G06K9/6215 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/74 , G06T15/08 , G06T2207/10028 , G06T2207/10072 , G06T2207/10116 , G06T2207/20004 , G06T2207/30101 , G06T2207/30172 , G06T2211/404
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.
摘要翻译：在一个方面，提供一种使用适于响应于至少一个特征的匹配滤波器来检测至少一个血管的至少一个图像中的至少与血管相关联的特征的方法。所述方法包括对所述至少一个图像中的选定体素应用比例检测滤波器以确定每个所选择的体素处的匹配滤波器的比例，确定每个所选择的体素处的匹配滤波器的取向，其中确定取向通过使用在每个所选择的体素中确定的比例来辅助，在每个所选择的体素处以每个所选择的体素应用匹配滤波器，并且在每个所选择的体素处确定取向以在每个所选择的体素处获得滤波器响应，以及分析每个所选择的体素处的过滤器响应，以确定相应的体素是否对应于所述至少一个特征。

7. 发明授权

US10366792B2 System and method for detecting retina disease 有权
公开(公告)号：US10366792B2
公开(公告)日：2019-07-30
申请号：US15581315
申请日：2017-04-28
申请人： Bio-Tree Systems, Inc.
发明人： Raul A. Brauner , Kongbin Kang , Yanchun Wu
IPC分类号： G06K9/00 , G16H50/20 , G06T7/00 , G06F19/00 , G16H50/50
摘要： A system and method for diagnosing retina disease is disclosed. The method comprises capturing a plurality of images of the vascular network within the retina, such as through the use of optical coherence tomography (OCT). This plurality of images are then processed to determine the location and diameter of each vessel in the three-dimensional vascular network in the retina. The vascular network is then divided into a plurality of equal unit volumes. The vessel density, vascular volume density and other metrics can then be determined for each unit volume. This information can then be used to identify retina disease. The information can be parsed and presented in a variety of ways.

8. 发明申请

US20090328239A1 BLOOD VESSEL IMAGING AND USES THEREFOR 审中-公开
标题翻译：血管成像及其使用
公开(公告)号：US20090328239A1
公开(公告)日：2009-12-31
申请号：US12363283
申请日：2009-01-30
申请人： Raul A. Brauner , John Heymach , George Naumov , Kongbin Kang
发明人： Raul A. Brauner , John Heymach , George Naumov , Kongbin Kang
IPC分类号： A61K49/00 , G01N33/00 , C12Q1/00 , A61P43/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/508
摘要： Methods are disclosed for analyzing representations of one or more structures in the body of a subject (e.g., a human subject or other animal subject) to glean information about the health of the subject or to evaluate the subject's response to a therapy or other condition. Aspects of the invention relate to obtaining structural information from casts (e.g., vascular casts from animal models) and using the information as a reference for evaluating structures in the body of a subject. Methods are disclosed for diagnosing, staging, grading, and monitoring diseases. Methods also are disclosed for targeting treatments, monitoring the effectiveness of therapies, and/or screening or validating therapies based analyzing structures (e.g., vascular structures) in a subject and comparing them to reference structures observed in casts obtained from models (e.g., animal models) of related diseases or conditions.
摘要翻译：公开了用于分析受试者（例如，人类受试者或其他动物受试者）体内的一种或多种结构的表现以收集关于受试者健康的信息或评估受试者对治疗或其他状况的反应的方法。本发明的方面涉及从铸件（例如，来自动物模型的血管形态）获得结构信息，并且使用该信息作为评估受试者体内的结构的参考。公开了用于诊断，分期，分级和监测疾病的方法。公开了用于靶向治疗，监测疗法的有效性和/或筛选或验证基于对象的分析结构（例如，血管结构）的治疗方法并将其与从模型（例如动物模型）获得的模型中观察到的参考结构进行比较的方法）相关疾病或病症。

9. 发明申请

US20220020144A1 METHODS OF OBTAINING 3D RETINAL BLOOD VESSEL GEOMETRY FROM OPTICAL COHERENT TOMOGRAPHY IMAGES AND METHODS OF ANALYZING SAME 有权
公开(公告)号：US20220020144A1
公开(公告)日：2022-01-20
申请号：US17182971
申请日：2021-02-23
申请人： BIO-TREE SYSTEMS, INC.
发明人： Kongbin KANG , Yanchun WU , Raul A. BRAUNER
IPC分类号： G06T7/00
摘要： Embodiments relate to extracting blood vessel geometry from one or more optical coherent tomography (OCT) images for use in analyzing biological structures for diagnostic and therapeutic applications for diseases that can be detected by vascular changes in the retina. An OCT image refers generally to one or more images of any dimension obtained using any one or combination of OCT techniques. Some embodiments include a method of identifying a region of interest of a retina from a plurality of retinal blood vessels in at least one optical coherence tomography (OCT) image of at least a portion of the retina. Some embodiments include a method of distinguishing between a plurality of retinal layers from vessel morphology information of retinal blood vessels in at least one optical coherence tomography (OCT) image of at least a portion of the retina.

10. 发明授权

US10235756B2 Vascular analysis methods and apparatus 有权
公开(公告)号：US10235756B2
公开(公告)日：2019-03-19
申请号：US14692342
申请日：2015-04-21
申请人： Bio-Tree Systems, Inc.
发明人： Raul A. Brauner , Kongbin Kang , Yanchun Wu , Joao Cruz
IPC分类号： A61B6/00 , G06T7/00 , G06T7/11 , G06T7/13 , G06T7/149 , G06T7/155
摘要： According to some aspects, a method of identifying a boundary of a portion of a vasculature is provided, the vasculature comprising a geometric representation of a plurality of vessels. The method comprises logically dividing the geometric representation into a plurality of regions, determining at least one feature within each of the plurality of regions, and defining the boundary of the portion of the vasculature based, at least in part, on the at least one feature determined within each of the plurality of regions, wherein the boundary forms a volume defining a separation between inside and outside of the portion of the vasculature. According to some aspects, a method of performing vascular analysis using a geometric representation of a plurality of vessels of the vasculature is provided. The method comprises computing a boundary of a portion of the vasculature based on the geometric representation, logically dividing the geometric representation within the boundary into a plurality of regions, and analyzing at least one feature for each of the plurality of regions within the boundary.

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