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    • 5. 发明授权
    • Method of treatment using cysteine mutants of beta interferon
    • 使用β干扰素半胱氨酸突变体的治疗方法
    • US08859497B2
    • 2014-10-14
    • US13886427
    • 2013-05-03
    • Bolder BioTechnology Inc.
    • George N. Cox
    • A61K38/21C07K14/00C07K14/535A61K47/48C07K14/565A61K38/00
    • C07K14/565A61K38/00A61K47/48215A61K47/60C07K14/535
    • The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
    • 生长激素超基因家族包含大于20个结构相关的细胞因子和生长因子。 提供了一种用于产生这些蛋白质的位点特异性,生物活性缀合物的通用方法。 该方法包括将半胱氨酸残基添加到蛋白质的非必需区域中,或者使用定点突变将蛋白质中的非必需氨基酸取代半胱氨酸残基,然后将半胱氨酸反应性聚合物或其它类型的半胱氨酸反应性部分共价偶联到 通过添加的半胱氨酸残基的蛋白质。 本文公开了用于添加半胱氨酸残基或将半胱氨酸取代引入蛋白质的优选位点,以及由此产生的蛋白质和蛋白质衍生物。 还公开了使用本发明的半胱氨酸变体的治疗方法。
    • 6. 发明申请
    • DERIVATIVES OF GROWTH HORMONE AND RELATED PROTEINS, AND METHODS OF USE THEREOF
    • 生长激素和相关蛋白的衍生物及其使用方法
    • US20110172151A1
    • 2011-07-14
    • US12886876
    • 2010-09-21
    • George N. Cox, IIIDaniel H. Doherty
    • George N. Cox, IIIDaniel H. Doherty
    • A61K38/22C07K14/535A61P37/02
    • A61K38/193A61K47/60C07K14/475C07K14/505C07K14/52C07K14/535C07K14/5431C07K14/61
    • The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
    • 生长激素超基因家族包含大于20个结构相关的细胞因子和生长因子。 提供了一种用于产生这些蛋白质的位点特异性,生物活性缀合物的通用方法。 该方法包括将半胱氨酸残基添加到蛋白质的非必需区域中,或者使用定点突变将蛋白质中的非必需氨基酸取代半胱氨酸残基,然后将半胱氨酸反应性聚合物或其它类型的半胱氨酸反应性部分共价偶联到 通过添加的半胱氨酸残基的蛋白质。 本文公开了用于添加半胱氨酸残基或将半胱氨酸取代引入蛋白质的优选位点,以及由此产生的蛋白质和蛋白质衍生物。 还公开了使用本发明的半胱氨酸变体的治疗方法。