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1. 发明授权

US11617796B2 Conjugate of minoxidil and peptide 有权
公开(公告)号：US11617796B2
公开(公告)日：2023-04-04
申请号：US16326618
申请日：2017-08-04
申请人： CAREGEN CO., LTD.
发明人： Yong Ji Chung , Eun Mi Kim
IPC分类号： A61K47/64 , A61Q7/00 , C07K7/08 , A61K31/506 , C07K7/06 , A61K47/50 , C07K19/00 , A61K8/49 , A61P17/14 , A61K8/64 , A61K9/00 , A61K31/513 , A61K38/17
摘要： The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which Minoxidil and a peptide are chemically connected, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the compound. The compound having a structure in which Minoxidil and a peptide are chemically connected according to the present invention has not only excellent physiological activity such as hair loss reduction, hair growth promotion or cell growth promotion, but also excellent stability in water, and can therefore be useful as a composition for preventing hair loss and promoting hair growth.

2. 发明授权

US11518785B2 Peptide showing melanogenesis promoting activity and use thereof 有权
公开(公告)号：US11518785B2
公开(公告)日：2022-12-06
申请号：US17104663
申请日：2020-11-25
申请人： CAREGEN CO., LTD.
发明人： Yong Ji Chung , Eun Mi Kim , Eung-Ji Lee
IPC分类号： A61K38/10 , A61K38/08 , A61K38/00 , A61K8/64 , A61P17/00 , C07K7/06 , C07K7/08 , A61Q19/00 , A61Q19/04
摘要： The present invention provides a peptide exhibiting melanogenesis promoting activity. A peptide according to the present invention increases the activity and expression of tyrosinase and the expression of factors involved in melanogenesis, thereby exhibiting an outstanding effect on melanogenesis. The peptide of the present invention can be used for the prevention, alleviation, and treatment of hypomelanosis. The outstanding activity and stability stated above allow the peptide of the present invention to be very favorably applied to medicines, quasi-medicines, and cosmetics.

3. 发明授权

US11351266B2 Conjugate of isotretinoin and peptide 有权
公开(公告)号：US11351266B2
公开(公告)日：2022-06-07
申请号：US16612125
申请日：2018-05-11
申请人： CAREGEN CO., LTD.
发明人： Yong Ji Chung , Eun Mi Kim
IPC分类号： A61K47/64 , A61K38/10 , A61K8/64 , A61K31/19 , A61Q17/00 , A61Q19/00 , C07K7/08 , C07K19/00
摘要： A compound comprising a structure in which isotretinoin is linked to a peptide via a covalent bond and an antibiotic, anti-inflammatory, or anti-oxidative pharmaceutical or cosmetic composition comprising the same. A compound having a structure in which isotretinoin is linked to a peptide via a covalent bond according to the present invention exhibits excellent physiological activity such as antibiotic, anti-inflammatory, or anti-oxidative actions, as well as having outstanding properties, such as solubility in water, etc., and thus can find useful applications in various fields including medicines, cosmetics, etc.

4. 发明授权

US11104704B2 Peptide having cytoprotective effect against environmental pollutant and use thereof 有权
公开(公告)号：US11104704B2
公开(公告)日：2021-08-31
申请号：US16497056
申请日：2018-02-14
申请人： CAREGEN CO., LTD.
发明人： Yong Ji Chung , Eun Mi Kim , Eung-ji Lee
IPC分类号： C07K7/06 , A61K38/08 , A61K38/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , A23L33/18 , A61K8/64
摘要： Provided are a peptide with a cytoprotective effect against environmental pollutants and a use thereof. The peptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, or 3 directly binds to 2,3,7,8-tetrachlorodibenzo-p-dioxin (hereinafter, referred to as TCDD), known as being the most toxic among the class of dioxins, to prevent dermal penetration and the activation mechanism of AhR by TCDD and polycyclic aromatic hydrocarbons contained in fine dust. Such a direct cytoprotective effect against environmental pollutants is distinguished from preexisting methods that are configured to indirectly block opportunities to contact these materials or to reduce toxicity through barrier reinforcement.

5. 发明授权

US11072636B2 Peptide for inhibiting angiogenesis and use thereof 有权
公开(公告)号：US11072636B2
公开(公告)日：2021-07-27
申请号：US16649327
申请日：2018-03-14
申请人： CAREGEN CO., LTD.
发明人： Yong Ji Chung , Eun Mi Kim , Eung Ji Lee
IPC分类号： A61K38/08 , A61K38/10 , A61K38/00 , C07K7/06 , C07K7/08 , C07K7/00 , A23L33/18
摘要： Peptide having an angiogenesis inhibitory activity and a use of the peptide, related to the treatment or prevention of excessive angiogenesis-related diseases. Particularly, a novel peptide that binds, in competition with vascular endothelial growth factors (VEGF), to VEGF receptors and can significantly inhibit the proliferation, migration and differentiation of vascular endothelial cells, thereby being effectively usable as an active ingredient of a composition or a health functional food for preventing or treating diseases, such as macular degeneration, a tumor, arthritis or psoriasis, caused by excessive angiogenesis.

6. 发明申请

US20210079041A1 PEPTIDE SHOWING MELANOGENESIS PROMOTING ACTIVITY AND USE THEREOF 有权
公开(公告)号：US20210079041A1
公开(公告)日：2021-03-18
申请号：US17104663
申请日：2020-11-25
申请人： CAREGEN CO., LTD.
发明人： Yong Ji CHUNG , Eun Mi KIM , Eung-Ji LEE
IPC分类号： C07K7/06 , A61K8/64 , A61Q19/00
摘要： The present invention provides a peptide exhibiting melanogenesis promoting activity. A peptide according to the present invention increases the activity and expression of tyrosinase and the expression of factors involved in melanogenesis, thereby exhibiting an outstanding effect on melanogenesis. The peptide of the present invention can be used for the prevention, alleviation, and treatment of hypomelanosis. The outstanding activity and stability stated above allow the peptide of the present invention to be very favorably applied to medicines, quasi-medicines, and cosmetics.

7. 发明授权

US10738081B2 Peptide with anti-obesity and anti-diabetes activity and use thereof 有权
公开(公告)号：US10738081B2
公开(公告)日：2020-08-11
申请号：US16359675
申请日：2019-03-20
申请人： CAREGEN CO., LTD.
发明人： Yong Ji Chung , Eun Mi Kim
IPC分类号： A61K38/08 , C07K7/06 , A61P3/06 , A61P3/00 , A61P3/10 , A61K38/22 , A61K38/30 , A61P3/04 , A61K38/00
摘要： A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of PPARγ, ACC, and aP2, which are adipogenic markers, increase the expression of pHSL, AMPK-α1, CGI-58, and ATGL, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values. The peptide and the peptide complex of the present invention, which have excellent activity and safety, can be advantageously applied to drugs and quasi-drugs.

8. 发明申请

US20200246473A1 CONJUGATE OF ISOTRETINOIN AND PEPTIDE 审中-公开
公开(公告)号：US20200246473A1
公开(公告)日：2020-08-06
申请号：US16612125
申请日：2018-05-11
申请人： CAREGEN CO., LTD.
发明人： Yong Ji CHUNG , Eun Mi KIM
IPC分类号： A61K47/64 , A61K8/64 , A61Q17/00
摘要： The present invention relates to a compound having a structure in which isotretinoin is linked to a peptide via a covalent bond and an antibiotic, anti-inflammatory, or anti-oxidative pharmaceutical or cosmetic composition comprising the same. A compound having a structure in which isotretinoin is linked to a peptide via a covalent bond according to the present invention exhibits excellent physiological activity such as antibiotic, anti-inflammatory, or anti-oxidative actions, as well as having outstanding properties, such as solubility in water, etc., and thus can find useful applications in various fields including medicines, cosmetics, etc.

9. 发明授权

US10238710B2 Peptide having anti-inflammatory, osteogenic and hair growth promoting activities, and use of same 有权
公开(公告)号：US10238710B2
公开(公告)日：2019-03-26
申请号：US15307943
申请日：2014-11-21
申请人： CAREGEN CO., LTD.
发明人： Yong Ji Chung , Eun Mi Kim , Eung Ji Lee , Kyoung Mi Cho , A Reum Han
IPC分类号： A61K38/08 , C07K7/06 , A61K8/64 , A61Q7/00
摘要： Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. A peptide formed from the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, according to the present invention, consequently shows an anti-inflammatory activity by inhibiting an inflammatory cytokine expression and proliferation of inflammatory cells, and consequently promotes osteogenic differentiation by increasing phosphorylation of PI3K, Smad1, Smad5 and Smad8, which contribute to osteogenesis, and by increasing ALP, OPG and BSP expressions. And a peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, consequently shows efficacy for preventing hair loss and promoting hair growth by promoting proliferation of hair follicle cells and human umbilical vein endothelial cells, increasing phosphorylation of EPK, increasing expressions of PI3K, β-catenin, IGF-1, KGF and Wnt3a which are proteins that contribute to hair growth, and reducing an expression of DKK-1 which is a hairless gene.

10. 发明授权

US08691195B2 Peptide having activity of transforming growth factor and production method therefor 有权
标题翻译：具有转化生长因子活性的肽及其制备方法
公开(公告)号：US08691195B2
公开(公告)日：2014-04-08
申请号：US13264290
申请日：2009-04-14
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
IPC分类号： A61K8/64 , C07K7/08
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/02 , A61Q19/08 , C07K14/495
摘要： The present invention relates to a transforming growth factor-beta (TGF-β)-mimicking peptide containing a particular amino acid sequence and a composition for preventing or treating TGF-β-effective disorders or conditions using the same. The peptide of the present invention may be much higher stability than natural-occurring TGF-β and improve drawbacks caused by high molecular weight of natural-occurring TGF-β. The peptide of this invention can be advantageously applied to treatment or improvement of TGF-β-effective disorders or conditions and have excellent efficacies on skin whitening and wrinkle improvement.
摘要翻译：本发明涉及含有特定氨基酸序列的转化生长因子-β（TGF-β）模拟肽和用于预防或治疗TGF-β1有效性障碍或使用其的病症的组合物。本发明的肽可能比天然存在的TGF- 并改善由高分子量天然存在的TGF-β受体引起的缺陷。本发明的肽可有利地应用于治疗或改善TGF-βB活性障碍或病症，并且具有优异的皮肤美白和皱纹改善的功效。

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