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1. 发明申请

US20230140143A1 Behavior Modification Feedback For Improving Diabetes Management 有权
公开(公告)号：US20230140143A1
公开(公告)日：2023-05-04
申请号：US17974290
申请日：2022-10-26
申请人： Dexcom, Inc.
发明人： Giada Acciaroli , Margaret A. Crawford , Mark Derdzinski , Lauren H. Jepson , Sarah Kate Pickus , Robert J. Dowd , Apurv U. Kamath
IPC分类号： G16H40/63 , G16H20/00
摘要： Glucose measurements are received and features for corresponding time periods over a time window are generated, the features being values indicating whether the user has been engaging in beneficial diabetes management behaviors. Using the aggregated features patterns indicating that beneficial diabetes management behaviors are not being engaged in are identified. Potential behavior modification feedback is generated by including in the potential behavior modification feedback at least one behavior modification feedback, for each of the identified patterns, that a user could take to engage in beneficial diabetes management behavior. At least one of the potential behavior modification feedback is selected and displayed or otherwise presented to the user.

2. 发明申请

US20230139158A1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS 有权
公开(公告)号：US20230139158A1
公开(公告)日：2023-05-04
申请号：US18089351
申请日：2022-12-27
申请人： DexCom, Inc.
发明人： Jiong Zou , Robert J. Boock , Andrew Trinin Dennis , Ted Tang Lee , Jeff T. Suri , David Sze , Mark A. Tapsak , Huashi Zhang , Shanger Wang
IPC分类号： G01N27/327 , C12N11/089 , C12N11/093 , C12N11/08 , C08L39/06 , C08L69/00 , C08L75/04 , C12Q1/00 , A61B5/00 , A61B5/145 , A61B5/1486 , G01N33/66 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , A61B5/1473
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

3. 发明申请

US20230136127A1 ANALYTE SENSOR 有权
公开(公告)号：US20230136127A1
公开(公告)日：2023-05-04
申请号：US18148950
申请日：2022-12-30
申请人： Dexcom, Inc.
发明人： Peter C. Simpson , James H. Brauker , Mark C. Brister , Paul Goode , Apurv U. Kamath , Aarthi Mahalingam , Jack Pryor , Matthew D. Wightlin , Victor Ha , Steve Masterson , Melissa A. Nicholas , John E. Nolting , James R. Petisce , Sean T. Saint , Vance E. Swanson , Kum Ming Woo
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/00 , A61B5/05 , A61B5/15 , A61B5/1473 , A61B5/1495 , A61B17/34
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

4. 发明申请

US20230133195A1 GLUCOSE MONITORING OVER PHASES AND CORRESPONDING PHASED INFORMATION DISPLAY 有权
公开(公告)号：US20230133195A1
公开(公告)日：2023-05-04
申请号：US17900372
申请日：2022-08-31
申请人： DexCom, Inc.
发明人： Alexander Michael Diener , Stacey Lynne Fischer , Harry Shaw Strothers , Chad M. Patterson , Justin Yuen , Apurv U. Kamath , Andrew Merrill Terry , Margaret A. Crawford , Mark Derdzinski , Sarah Kate Pickus , Lauren H. Jepson , Adam G. Noar , Douglas S. Kanter , Sonya Sokolash
IPC分类号： A61B5/145 , A61B5/00
摘要： Glucose monitoring over phases and corresponding phased information display is described. A multi-phase glucose monitoring program that includes at least a first phase and a second phase is initiated. First glucose data of a user is obtained during the first phase of the multi-phase glucose monitoring program. The output of the first glucose data in a glucose monitoring user interface is prevented during the first phase of the multi-phase glucose monitoring program. Second glucose data of the user is then obtained during a second phase of the multi-phase glucose monitoring program. The second glucose data is output, in real-time, in the glucose monitoring user interface during the second phase of the multi-phase glucose monitoring program.

5. 发明申请

US20230133145A1 WIRELESS SETUP AND SECURITY OF A CONTINUOUS ANALYTE SENSOR SYSTEM DEPLOYED IN HEALTHCARE INFRASTRUCTURE 有权
公开(公告)号：US20230133145A1
公开(公告)日：2023-05-04
申请号：US18048818
申请日：2022-10-21
申请人： Dexcom, Inc.
发明人： Aniel ALVAREZ , Jorge R. BARRERAS , Reinier SANCHEZ BAO , Barry Nicholas SOLOMON , Victor VILLAVERDE GARCIA
IPC分类号： H04W12/069 , A61B5/00 , H04W12/03
摘要： Techniques and protocols for facilitating wired or wireless secure communications between a sensor system and one or more other devices deployed in healthcare facilities are disclosed. In certain embodiments, the techniques and protocols include secure device pairing techniques and protocols for achieving heightened security, for example, recommended in healthcare facilities. In certain embodiments, a method comprises executing, at an application layer of a sensor system, a password authenticated key exchange (PAKE) protocol with a display device to derive an authentication key; executing, at the sensor system, an authenticated pairing protocol with the display device; after the authenticating is successful, establishing an encrypted connection between the sensor system and the display device; and transmitting, from the sensor system to the display device, analyte data indicative of measured analyte levels via the encrypted connection.

6. 发明授权

US11638543B2 Analyte sensor electrode arrangements 有权
公开(公告)号：US11638543B2
公开(公告)日：2023-05-02
申请号：US16929906
申请日：2020-07-15
申请人： DexCom, Inc.
发明人： Sebastian Bohm , Wenjie Lan , Thomas Robert Porter , Daiting Rong , Jason Halac
IPC分类号： A61B5/1468 , A61B5/145 , C09D133/08
摘要： Various examples are directed to a glucose sensor comprising a working electrode to support an oxidation reaction and a reference electrode to support a redox reaction. The reference electrode may comprise silver and silver chloride. The Glucose sensor may also comprise an anti-mineralization agent positioned at the reference electrode to reduce formation of calcium carbonate at the reference electrode.

7. 发明申请

US20230129902A1 Disease Prediction Using Analyte Measurement Features and Machine Learning 有权
公开(公告)号：US20230129902A1
公开(公告)日：2023-04-27
申请号：US17971238
申请日：2022-10-21
申请人： Dexcom, Inc.
发明人： Jee Hye Park , Spencer Troy Frank , David A. Price , Kazanna C. Hames , Charles R. Stroyeck , Joseph J. Baker , Arunachalam Panch Santhanam , Peter C. Simpson , Abdulrahman Jbaily , Justin Yi-Kai Lee , Qi An
IPC分类号： G16H50/30 , G06N20/00
摘要： Disease prediction using analyte measurements and machine learning is described. In one or more implementations, a combination of features of analyte measurements may be selected from a plurality of features of the analyte measurements based on a robustness metric and a performance metric of the combination, and a machine learning model may be trained to predict a health condition classification using the combination. The performance metric may be associated with an accuracy of predicting the health condition classification, and the robustness metric may be associated with an insensitivity to analyte sensor manufacturing variabilities on the accuracy. Once trained, the machine learning model predicts the health condition classification for a user based on analyte measurements of the user collected by a wearable analyte monitoring device. The combination of features may be extracted from the analyte measurements of the user and input into the machine learning model to predict the classification.

8. 发明授权

US11633156B2 Retrospective retrofitting method to generate a continuous glucose concentration profile by exploiting continuous glucose monitoring sensor data and blood glucose measurements 有权
公开(公告)号：US11633156B2
公开(公告)日：2023-04-25
申请号：US16373454
申请日：2019-04-02
申请人： DexCom, Inc.
发明人： Claudio Cobelli , Simone Del Favero , Andrea Facchinetti , Giovanni Sparacino
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1495 , G16H50/30 , G16H50/20
摘要： Continuous Glucose Monitoring (CGM) devices provide glucose concentration measurements in the subcutaneous tissue with limited accuracy and precision. Therefore, CGM readings cannot be incorporated in a straightforward manner in outcome metrics of clinical trials e.g. aimed to assess new glycaemic-regulation therapies. To define those outcome metrics, frequent Blood Glucose (BG) reference measurements are still needed, with consequent relevant difficulties in outpatient settings. Here we propose a “retrofitting” algorithm that produces a quasi continuous time BG profile by simultaneously exploiting the high accuracy of available BG references (possibly very sparsely collected) and the high temporal resolution of CGM data (usually noisy and affected by significant bias). The inputs of the algorithm are: a CGM time series; some reference BG measurements; a model of blood to interstitial glucose kinetics; and a model of the deterioration in time of sensor accuracy, together with (if available) a priori information (e.g. probabilistic distribution) on the parameters of the model. The algorithm first checks for the presence of possible artifacts or outliers on both CGM datastream and BG references, and then rescales the CGM time series by exploiting a retrospective calibration approach based on a regularized deconvolution method subject to the constraint of returning a profile laying within the confidence interval of the reference BG measurements. As output, the retrofitting algorithm produces an improved “retrofitted” quasi-continuous glucose concentration signal that is better (in terms of both accuracy and precision) than the CGM trace originally measured by the sensor. In clinical trials, the so-obtained retrofitted traces can be used to calculate solid outcome measures, avoiding the need of increasing the data collection burden at the patient level.

9. 发明申请

US20230089907A1 SYSTEM AND METHOD FOR COMMUNICATION OF ANALYTE DATA 有权
公开(公告)号：US20230089907A1
公开(公告)日：2023-03-23
申请号：US18051862
申请日：2022-11-01
申请人： Dexcom, Inc.
发明人： Aditya MANDAPAKA , Douglas William BURNETTE , Hari HAMPAPURAM , Francis William PASCUAL , James Stephen AMIDEI , Darin Edward CHUM DEW , Apurv Ullas KAMATH , Nathanael PAUL , William A. PENDER , Michael A. PLOOF
IPC分类号： H04W76/10 , H04Q9/00 , A61B5/00 , H04B17/318 , H04B17/391
摘要： Systems, devices, and methods are disclosed for wireless communication of analyte data. In this regard, in embodiments, a mobile includes a transceiver configured to transmit and receive wireless signals. The mobile device includes circuitry operatively coupled to the transceiver. The mobile device also includes a non-transitory computer-readable medium operatively coupled to the circuitry and storing instructions that, when executed, cause the mobile device to perform a number of operations. One such operation is to obtain a derivative of a first signal received via a first link. Another such operation is to obtain a derivative of a second signal received via a second link; and. Yet another such operation is to generate a selection for connection to an analyte sensor system, based on a comparison of the derivative of the first signal and the derivative of the second signal.

10. 发明申请

US20230074617A1 CONTINUOUS ANALYTE MONITOR DATA RECORDING DEVICE OPERABLE IN A BLINDED MODE 有权
公开(公告)号：US20230074617A1
公开(公告)日：2023-03-09
申请号：US18050365
申请日：2022-10-27
申请人： Dexcom, Inc.
发明人： Jorge VALDES , David PRICE , Leif N. BOWMAN , Kristin Koenekamp COTE
IPC分类号： A61B5/00 , A61B5/15 , A61B5/151 , A61B5/155 , A61B5/157 , G16H40/67 , A61B5/145 , A61B5/1486
摘要： A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor. Instead, data received from the continuous analyte sensor is used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement. In another embodiment, the device provides for toggling between two modes, with one mode that allows for display of glucose concentration values associated with the continuous glucose sensor and a second mode that prevents the display of glucose concentration values associated with the continuous glucose sensor.

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