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1. 发明授权

US11605452B2 Radiotherapy treatment plan optimization using machine learning 有权
公开(公告)号：US11605452B2
公开(公告)日：2023-03-14
申请号：US16512972
申请日：2019-07-16
申请人： Elekta AB (publ)
发明人： Jonas Anders Adler , Jens Olof Sjölund
IPC分类号： G16H20/40 , G06N3/08
摘要： Techniques for solving a radiotherapy treatment plan optimization problem are provided. The techniques include receiving a radiotherapy treatment plan optimization problem; processing the radiotherapy treatment plan optimization problem with a machine learning model to estimate one or more optimization variables of the radiotherapy treatment plan optimization problem, wherein the machine learning model is trained to establish a relationship between the one or more optimization variables and parameters of a plurality of training radiotherapy treatment plan optimization problems; and generating a solution to the radiotherapy treatment plan optimization problem based on the estimated one or more optimization variables of the radiotherapy treatment plan optimization problem.

2. 发明授权

US11097128B2 Radiotherapy treatment plans using differentiable dose functions 有权
公开(公告)号：US11097128B2
公开(公告)日：2021-08-24
申请号：US16512938
申请日：2019-07-16
申请人： Elekta AB (publ)
发明人： Jens Olof Sjölund
IPC分类号： A61N5/10
摘要： Techniques for generating a radiotherapy treatment plan parameter are provided. The techniques include receiving radiotherapy treatment plan information; processing the radiotherapy treatment plan information to estimate one or more radiotherapy treatment plan parameters based on a process that depends on the output of a subprocess that estimates a derivative of a dose calculation; and generating a radiotherapy treatment plan using the estimated one or more radiotherapy treatment plan parameters.

3. 发明授权

US11033756B2 Portal imaging during radiotherapy 有权
公开(公告)号：US11033756B2
公开(公告)日：2021-06-15
申请号：US14851527
申请日：2015-09-11
申请人： ELEKTA AB (PUBL)
发明人： John Allen , Colin Winfield
IPC分类号： A61N5/10 , A61B6/03
摘要： A radiotherapy apparatus comprises a source for producing a beam of ionising radiation along an axis, the beam covering a maximum aperture of the source, a collimator for collimating the beam to produce a collimated beam covering a sub-part of the maximum aperture, a patient support positioned in the path of the beam, a rotatable gantry, on which the source is mounted, for rotating the source around the patient support thereby to deliver the beam from a range of directions, an imaging device located opposite the source and with the patient support between the source and the imaging device, and mounted on the gantry via a drive member allowing translational motion of the imaging device in at least one direction perpendicular to the axis, and a control unit adapted to control the drive member to move the imaging device within the maximum aperture and maintain coincidence between the imaging device and the sub-part of the maximum aperture. Accordingly, the EPID can be moved during the treatment in order to maintain the collimated field of the radiation beam within the bounds of the EPID. This ensures that the image is valid and prevents damage to the EPID as a result of exposure of more sensitive (or less shielded) parts to the beam.

4. 发明申请

US20210158929A1 PARAMETER SEARCH IN RADIOTHERAPY TREATMENT PLAN OPTIMIZATION 有权
公开(公告)号：US20210158929A1
公开(公告)日：2021-05-27
申请号：US17248670
申请日：2021-02-02
申请人： Elekta AB (publ)
发明人： Jens Olof Sjolund
IPC分类号： G16H20/40 , G16H50/70 , G16H50/20 , G16H30/40 , G16H50/50 , G06N3/08 , A61N5/10
摘要： Techniques for generating a radiotherapy treatment plan are provided. The techniques include receiving a radiotherapy optimization problem, the radiotherapy problem comprising a plurality of parameters; processing the radiotherapy optimization problem to instantiate a first set of candidate parameters; converting the first set of candidate parameters into an adapted representation; defining an adapted radiotherapy optimization problem as a function of the adapted representation such that a given solution to the adapted optimization problem estimates a solution to the radiotherapy optimization problem; processing the adapted radiotherapy optimization problem to estimate a function of the solution to the adapted radiotherapy optimization problem; and processing the estimated function of the solution to the adapted optimization problem to generate a deliverable radiotherapy treatment plan.

5. 发明授权

US10946215B2 Radiotherapy planning systems 有权
公开(公告)号：US10946215B2
公开(公告)日：2021-03-16
申请号：US15780782
申请日：2016-12-02
申请人： Elekta AB (publ)
发明人： Jens Sjolund
IPC分类号： A61N5/10
摘要： Embodiments of the present disclosure are directed to treatment planning systems for a radiotherapy apparatus. In one implementation, a treatment planning system may include a computational processor configured to apply a set of instructions to an input data set. The input data set may include a three-dimensional dose distribution for delivery by the radiotherapy apparatus to a volume to be irradiated, a three-dimensional volume image characterizing tissue types within the volume to be irradiated, and a set of apparatus parameters which characterize the radiotherapy apparatus. The set of instructions may include a computational process configured to output a treatment plan for delivery of the dose distribution by the radiotherapy apparatus, by optimising a function representing a time-dependent response of the tissue types to an applied radiation.

6. 发明申请

US20210020297A1 RADIOTHERAPY TREATMENT PLAN OPTIMIZATION USING MACHINE LEARNING 有权
公开(公告)号：US20210020297A1
公开(公告)日：2021-01-21
申请号：US16512972
申请日：2019-07-16
申请人： Elekta AB (publ)
发明人： Jonas Anders Adler , Jens Olof Sjölund
IPC分类号： G16H20/40 , G06N3/08
摘要： Techniques for solving a radiotherapy treatment plan optimization problem are provided. The techniques include receiving a radiotherapy treatment plan optimization problem; processing the radiotherapy treatment plan optimization problem with a machine learning model to estimate one or more optimization variables of the radiotherapy treatment plan optimization problem, wherein the machine learning model is trained to establish a relationship between the one or more optimization variables and parameters of a plurality of training radiotherapy treatment plan optimization problems; and generating a solution to the radiotherapy treatment plan optimization problem based on the estimated one or more optimization variables of the radiotherapy treatment plan optimization problem.

7. 发明授权

US10773102B2 Radiotherapy and imaging apparatus 有权
公开(公告)号：US10773102B2
公开(公告)日：2020-09-15
申请号：US15624433
申请日：2017-06-15
申请人： Elekta AB (publ)
发明人： John Allen , Duncan Neil Bourne , Kevin Brown
IPC分类号： A61N5/10
摘要： Radiotherapy apparatus comprises a source of radiation mounted on a chassis, the chassis being rotatable about a rotation axis and the source being adapted to emit a beam of radiation along a beam axis that intersects with the rotation axis; a patient support, moveable along a translation axis; a set of magnetic coils located on either side of the beam, for establishing a magnetic field at the point of intersection, spaced from that point along a first direction; the translation axis, the rotation axis, and the first direction being substantially parallel; and further comprising a multi-leaf collimator fixed in its orientation with respect to the source of radiation, the multi-leaf collimator comprising a plurality of elongate leaves disposed with their longitudinal directions substantially aligned with the first direction and movable in that direction between a withdrawn position in which the leaf lies outside the beam.

8. 发明授权

US10391336B2 Image guided radiotherapy with adjusted angular range of source 有权
公开(公告)号：US10391336B2
公开(公告)日：2019-08-27
申请号：US15117695
申请日：2015-02-04
申请人： Elekta AB (publ)
发明人： Per Carlsson
IPC分类号： A61N5/10
摘要： An apparatus comprises a radiotherapy delivery apparatus having a radiation source for emitting a beam of radiation and wherein the source is rotatable around an axis intersecting the beam through a range of at least x degrees, an imaging device, and a control unit controlling the source and imaging device. The apparatus further comprises a treatment planning computer receiving a first image of a patient, and parameters defining the operations of the radiotherapy delivery apparatus. Parameters include an available range of rotation for the source, x-e, where e>0. The treatment planning computer generates a treatment plan for the patient based on the received image and parameters. The control unit determines a patient position using the imaging device, determines a rotation r of the patient around the axis relative to the first image, and compensates for the rotation by offsetting the source by a rotation, r, when r

9. 发明授权

US09737732B2 Machine vision system 有权
公开(公告)号：US09737732B2
公开(公告)日：2017-08-22
申请号：US15337501
申请日：2016-10-28
申请人： Elekta AB (publ)
发明人： Shakil Ahmed Awan , Adrian Maxwell Smith
IPC分类号： G01K1/04 , A61N5/10 , G21K1/04 , G06T7/00 , H04N5/225 , A61B90/00
CPC分类号： A61N5/1049 , A61B2090/3941 , A61N5/1042 , A61N5/1045 , A61N5/1048 , A61N2005/1059 , G06T7/0012 , G06T2207/10064 , G06T2207/30204 , G21K1/04 , G21K1/046 , H04N5/2256
摘要： A fluorescing marker is used in order to mark (for example) a leaf of a multi-leaf collimator and/or the reference points within the field of view. The markers are illuminated with light tuned to cause the markers to fluoresce at a wavelength different to that of the illuminating light. The fluorescence is then detected by a camera. This method allows the image to be captured by the camera with increased contrast. Accordingly, the present invention provides a multi-leaf collimator for a radiotherapeutic apparatus, comprising at least one leaf having a fluorescent marker. The fluorescent marker will usually emit light of a wavelength longer than the incident light, allowing suitable filters to be provided in order to distinguish the light emitted by the markers. A suitable material for use in the fluorescent markers is ruby. The present invention also provides a radiotherapeutic apparatus comprising a multi-leaf collimator as defined above, and a camera arranged to view the fluorescent markers. A source of illumination for the fluorescent markers is ideally monochromatic, or nearly so. The camera can have a filter arranged to substantially prevent light of the wavelength emitted by the source of illumination from entering the camera, thereby improving the contrast of the image. The radiotherapeutic apparatus can also comprise a source of illumination that is optically co-located with a radiation source, to allow the radiation field that will be emitted to be checked visually by an operator. The co-located source is preferably substantially monochromatic, emitting substantially no light at the wavelength of the fluorescent markers. A filter can then be placed over an output of the radiotherapeutic apparatus, for blocking light of the wavelength of the fluorescent markers and thereby enhancing the contrast of the image that is taken of the fluorescent markers.

10. 发明授权

US09526917B2 Image-guided radiotherapy 有权
标题翻译：图像引导放射治疗
公开(公告)号：US09526917B2
公开(公告)日：2016-12-27
申请号：US14266622
申请日：2014-04-30
申请人： Elekta AB (Publ)
发明人： Per Carlsson
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61B6/032 , A61N5/1049 , A61N5/107 , A61N5/1081 , A61N2005/1061
摘要： A radiotherapy apparatus comprises a rotatable gantry, supporting a source of therapeutic radiation and a source of diagnostic radiation. The two sources may be rotationally spaced apart around a rotation axis of the gantry, with at least one collimator associated with the source of therapeutic radiation and arranged to limit the cross-sectional area of a beam produced by that source. A control means may be arranged to conduct a treatment fraction using the apparatus by causing the apparatus to acquire images of a patient using the source of diagnostic radiation, retain those images at least temporarily, select a retained image acquired when the source of diagnostic radiation was at a rotational position corresponding to the instantaneous rotational position of the source of therapeutic radiation, and control the beam relative to the patient using information derived from the selected image.
摘要翻译：放射治疗装置包括可旋转机架，支撑治疗辐射源和诊断辐射源。两个源可以围绕台架的旋转轴线旋转间隔开，其中至少一个准直器与治疗辐射源相关联并且被布置成限制由该源产生的梁的横截面面积。控制装置可以被布置成通过使装置使用诊断辐射源获取患者的图像，使用该装置进行治疗分数，至少暂时保留那些图像，选择当诊断辐射源为在对应于治疗辐射源的瞬时旋转位置的旋转位置处，并且使用从所选择的图像导出的信息来控制相对于患者的束。

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