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1. 发明申请

US20090053754A1 Assay for Low Molecular Weight Heparin 有权
标题翻译：测定低分子量肝素
公开(公告)号：US20090053754A1
公开(公告)日：2009-02-26
申请号：US12103456
申请日：2008-04-15
申请人： Ted C. K. Lee , Amanda B. McBride , Frank M. LaDuca
发明人： Ted C. K. Lee , Amanda B. McBride , Frank M. LaDuca
IPC分类号： C12Q1/02
CPC分类号： C12Q1/56 , G01N33/86 , G01N2405/04
摘要： A prothrombin time reagent for determination of low molecular weight heparin in fresh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster is used in formulating the reagent. The recombinant animal tissue factor includes rabbit brain. The synthetic phospholipids of the mixture include palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylserine (POPS), and a phosphatidylalcohol. The phosphatidyl alcohol includes dioleoylphosphatidylethanol, dioleoylphosphatidylmethanol, dioleoylphosphatidylpropanol, dioleoylphosphatidylbutanol, and dioleoylphosphatidylinositol. The sensitivity adjuster included in the formulation buffer is γ-Cyclodextrin. The formulated reagent is air-dried and remains stable for at least 3 weeks at 37° C.
摘要翻译：提供了一种用于测定新鲜全血和抗凝血剂处理血液中低分子量肝素的凝血酶原时间试剂。试剂由重组动物组织因子和合成磷脂的混合物组成，该混合物包含磷脂酰醇。在配制试剂时使用包含灵敏度调节剂的制剂缓冲液。重组动物组织因子包括兔脑。该混合物的合成磷脂包括棕榈酰胆碱磷脂酰胆碱（POPC），棕榈酰叶酰磷脂酰丝氨酸（POPS）和磷脂酰醇。磷脂酰胆固醇包括二油酰磷脂酰乙醇，二油酰磷脂酰基甲醇，二油酰磷脂酰丙醇，二油酰磷脂酰丁醇和二油酰磷脂酰肌醇。制剂缓冲液中的灵敏度调节剂是γ-环糊精。将配制的试剂空气干燥，并在37℃下保持稳定至少3周。

2. 发明授权

US5836360A Volume controlled receptacle 失效
标题翻译：音量控制插座
公开(公告)号：US5836360A
公开(公告)日：1998-11-17
申请号：US823973
申请日：1997-03-25
申请人： Michael Gavin , James A. Mawhirt
发明人： Michael Gavin , James A. Mawhirt
IPC分类号： B01L3/00 , G01F19/00 , B65B1/04 , B65B3/04
CPC分类号： B01L3/508 , G01F19/00 , B01L2200/12 , B01L2400/0406
摘要： A volume-control receptacle has a reservoir with a bottom. The reservoir is adapted for receiving a fluid. The receptacle has a plurality of capillaries opening on the reservoir at a specific height above the bottom; the capillaries draw off the excess fluid from the receptacle, thereby leaving a specific amount of fluid in the reservoir. In a preferred embodiment, the volume-control receptacle is adapted for use with a disposable cuvette. The reservoir of the receptacle has a drain at the bottom connected to the cuvette for delivering the fluid to a testing instrument or other final application point. The volume-control receptacle has a lip projecting upward from a promontory of the receptacle. A rib extends downward from the lip to the bottom of the reservoir for guiding the fluid into the reservoir.
摘要翻译：容积控制容器具有底部的容器。容器适于接收流体。容器具有在底部上方的特定高度处在储存器上开口的多个毛细管; 毛细管从容器中排出多余的液体，从而在容器中留下特定量的流体。在优选实施例中，音量控制插座适于与一次性比色皿一起使用。容器的储存器在底部具有连接到反应杯的排水口，用于将流体输送到测试仪器或其他最终施加点。音量控制插座具有从插座的岬向上突出的唇部。肋条从储存器的唇缘向底部延伸到底部，以将流体引导到储存器中。

3. 发明授权

US5782852A Plastic incision blade 失效
标题翻译：塑料切口刀片
公开(公告)号：US5782852A
公开(公告)日：1998-07-21
申请号：US934212
申请日：1997-09-19
申请人： Donald Foggia , Anthony F. Kuklo, Jr. , James A. Mawhirt , Gerald Feldman
发明人： Donald Foggia , Anthony F. Kuklo, Jr. , James A. Mawhirt , Gerald Feldman
IPC分类号： A61B5/15 , A61B19/00 , A61D17/32
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150427 , A61B5/150916 , A61B5/15113 , A61B5/15117 , A61B2090/0814
摘要： An apparatus for implementing a skin incision has an incision blade having at least three facets and at least one sharpened apex. Each of the facets narrows down to one of the apexes. A housing having an exterior surface adapted to be placed flush against the skin and an elongated slot located on the exterior of the surface housing the incision blade. A blade pivoting mechanism located in the housing guides the incision blade through the slot. The blade pivoting mechanism has a first end and second end wherein the first end is pivotally coupled to the housing and the second end supports the incision blade. An actuatable depressing mechanism, located within the housing means, engages and holds the blade pivoting mechanism in a set position, preventing the pivotal movement of the blade pivoting mechanism within the housing. When the depressing mechanism is actuated, the blade pivoting mechanism disengages and transverses the sloped surface, displacing the second end of the blade pivoting mechanism toward the elongated slot, such that the multiple facets of the incision blade emerge from the elongated slot and incise the skin.
摘要翻译：用于实施皮肤切口的装置具有至少具有三个小面和至少一个锐化顶点的切割刀片。每个方面都缩小到其中一个顶点。具有适于与皮肤相对放置的外表面的壳体和位于容纳切割刀片的表面的外部上的细长槽。位于壳体中的刀片枢转机构通过狭槽引导切口刀片。刀片枢转机构具有第一端和第二端，其中第一端枢转地联接到壳体，并且第二端支撑切口刀片。位于壳体装置内的致动按压机构将刀片枢转机构接合并保持在设定位置，防止刀片枢转机构在壳体内的枢转运动。当按压机构被致动时，刀片枢转机构脱离并横向倾斜的表面，使刀片枢转机构的第二端朝向细长槽移动，使得切口刀片的多个面从细长的槽中出来并切开皮肤。

4. 发明授权

US5772677A Incision device capable of automatic assembly and a method of assembly 失效
公开(公告)号：US5772677A
公开(公告)日：1998-06-30
申请号：US718774
申请日：1996-09-24
申请人： James A. Mawhirt , Anthony F. Kuklo, Jr. , Christopher R. Vander Wal , Peter J. Sklenar
发明人： James A. Mawhirt , Anthony F. Kuklo, Jr. , Christopher R. Vander Wal , Peter J. Sklenar
IPC分类号： A61B17/32 , A61B17/14
CPC分类号： A61B17/32093
摘要： An apparatus for implementing a skin incision has a torsion spring and a method of assembling the apparatus. The apparatus has a housing having a pair of housing sections, each of the housing section having a base and a plurality of walls. The housing defines an inner space and an exterior. A pivot arm is pivotally mounted to a base of a housing section. The pivot arm is guided between a first position and a second position by a follower in a cam carried by the housing. A torsion spring carried by a spring post is coupled to the arm to exert a spring force on the arm in the first position. The housing has an indentation with a raised level and a lower groove on the base for receiving a portion of the spring post. The opening through the base extends from the lower groove. The spring post has a cylindrical base portion adapted to be received by the indentation in the base and a detent portion. The detent portion has a circular segment detent portion and a turn element accessible from the exterior of the housing. The circular segment detent portion is adapted to engage the raised level of the indentation in the install position and be retained in the lower groove in the loaded position. A trigger mechanism is received in the housing and acts with the pivot arm when activated whereby the arm moves from the first position to the second position due to the spring energy.

5. 发明授权

US5591403A Portable prothrombin time test apparatus and associated method of performing a prothrombin time test 失效
标题翻译：便携式凝血酶原时间检测装置及其相关方法进行凝血酶原时间检测
公开(公告)号：US5591403A
公开(公告)日：1997-01-07
申请号：US617296
申请日：1996-03-18
申请人： Michael Gavin , Catherine M. Cimini , Ming Huang , Anthony Kuklo, Jr. , James A. Mawhirt , Eduardo Marcelino , Albert Simone
发明人： Michael Gavin , Catherine M. Cimini , Ming Huang , Anthony Kuklo, Jr. , James A. Mawhirt , Eduardo Marcelino , Albert Simone
IPC分类号： G01N33/49 , G01N33/86 , G01N37/00
CPC分类号： G01N33/4905 , G01N33/86 , Y10T436/10
摘要： A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.
摘要翻译：一种用于对患者血液进行凝血测试的便携式装置。首先使用刺血针从患者抽血。然后将血液供应到放置在测试装置内的一次性比色皿。血液被吸入比色皿内的多个管道。每个管道含有由血液再水合的干燥或冻干的活化剂。每个导管中的血液然后往复运动跨越限制区域，直到发生预定的凝结程度。由于在多个管道中监测凝固时间，因此可以确定给定样品的凝固时间。在至少一个导管中存在归一化控制剂。归一化控制剂抵抗血液样品中存在的抗凝血剂的任何作用，从而允许血液样品具有大致正常的凝血特性。与未处理的血液同时测试归一化的血液，以提供参考值，可以判断测试系统的功能和样品的质量。

6. 发明授权

US5055099A Apparatus and method for utilizing autotransfusion systems and related equipment 失效
标题翻译：使用自动补偿系统和相关设备的装置和方法
公开(公告)号：US5055099A
公开(公告)日：1991-10-08
申请号：US340773
申请日：1989-04-20
申请人： Michael D. Mintz
发明人： Michael D. Mintz
IPC分类号： A61M1/02
CPC分类号： A61M1/02
摘要： There is disclosed an autotransfusion system which essentially is contained in a unitary housing section which enables a practitioner to utilize the system in a rapid and efficient manner. The housing section has integrally associated therewith a blood reservoir, which is a major component of an autotransfusion system. The housing has secured thereto a set of instructions which are adapted to be mounted on the arm of an IV pole and which, when positioned on the arm of the IV pole, specifies vertical distances necessary to perform autotransfusion during a blood collection or blood distribution mode. The housing section, as containing the reservoir, with the package and instruction component, is used as a yardstick to establish specified distances in order to control pressure as afforded by gravity. The entire unit lends itself to the rapid installation of an autotransfusion system while providing visual instructions which are integrally associated therewith to provide users with operational guidance that is thereby readily available during an operative procedure. The housing further permits pre-assembly and sterilization of the various components of an autotransfusion system.

7. 发明授权

US08323475B2 Apparatus and method for analytical determinations using amperometric techniques 有权
标题翻译：使用电流分析技术进行分析测定的仪器和方法
公开(公告)号：US08323475B2
公开(公告)日：2012-12-04
申请号：US10394674
申请日：2003-03-20
申请人： Scott Everett Blomberg , James Donald Kurkowski , Kee Van Sin
发明人： Scott Everett Blomberg , James Donald Kurkowski , Kee Van Sin
IPC分类号： G01N27/327 , G01N27/403
CPC分类号： G01N27/404 , G01N27/3271 , G01N33/4925
摘要： A system for operating at least first and second amperometric sensors includes a cartridge and a control device. The cartridge includes a first amperometric sensor and a second amperometric sensor. The first amperometric sensor is in fluid flow communication with a liquid sample inlet and includes a first electrode. The second amperometric sensor is in fluid flow communication with a liquid sample and includes a second electrode. The control device sets the first and second electrodes to about the same potential such that the first and second amperometric sensors can be operated simultaneously.
摘要翻译：用于操作至少第一和第二电流传感器的系统包括盒和控制装置。盒包括第一电流传感器和第二电流传感器。第一电流传感器与液体样品入口流体流动连通并且包括第一电极。第二电流传感器与液体样品流体流动连通并且包括第二电极。控制装置将第一和第二电极设置成大约相同的电位，使得第一和第二电流传感器可以同时操作。

8. 发明授权

US07906299B2 Assay for low molecular weight heparin 有权
标题翻译：测定低分子量肝素
公开(公告)号：US07906299B2
公开(公告)日：2011-03-15
申请号：US12103456
申请日：2008-04-15
申请人： Ted C. K. Lee , Amanda B. McBride , Frank M. LaDuca
发明人： Ted C. K. Lee , Amanda B. McBride , Frank M. LaDuca
IPC分类号： C12Q1/56
CPC分类号： C12Q1/56 , G01N33/86 , G01N2405/04
摘要： A prothrombin time reagent for determination of low molecular weight heparin in fresh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster is used in formulating the reagent. The recombinant animal tissue factor includes rabbit brain. The synthetic phospholipids of the mixture include palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylserine (POPS), and a phosphatidylalcohol. The phosphatidyl alcohol includes dioleoylphosphatidylethanol, dioleoylphosphatidylmethanol, dioleoylphosphatidylpropanol, dioleoylphosphatidylbutanol, and dioleoylphosphatidylinositol. The sensitivity adjuster included in the formulation buffer is γ-Cyclodextrin. The formulated reagent is air-dried and remains stable for at least 3 weeks at 37° C.
摘要翻译：提供了一种用于测定新鲜全血和抗凝血剂处理血液中低分子量肝素的凝血酶原时间试剂。试剂由重组动物组织因子和合成磷脂的混合物组成，该混合物包含磷脂酰醇。在配制试剂时使用包含灵敏度调节剂的制剂缓冲液。重组动物组织因子包括兔脑。该混合物的合成磷脂包括棕榈酰胆碱磷脂酰胆碱（POPC），棕榈酰叶酰磷脂酰丝氨酸（POPS）和磷脂酰醇。磷脂酰胆固醇包括二油酰磷脂酰乙醇，二油酰磷脂酰基甲醇，二油酰磷脂酰丙醇，二油酰磷脂酰丁醇和二油酰磷脂酰肌醇。制剂缓冲液中的灵敏度调节剂是γ-环糊精。将配制的试剂空气干燥，并在37℃下保持稳定至少3周。

9. 发明授权

US07358337B2 Assay for low molecular weight heparin 有权
标题翻译：测定低分子量肝素
公开(公告)号：US07358337B2
公开(公告)日：2008-04-15
申请号：US10222345
申请日：2002-08-16
申请人： Ted C. K. Lee , Amanda B. McBride , Frank M. LaDuca
发明人： Ted C. K. Lee , Amanda B. McBride , Frank M. LaDuca
IPC分类号： A61K35/14
CPC分类号： C12Q1/56 , G01N33/86 , G01N2405/04
摘要： A prothrombin time reagent for determination of low molecular weight heparin in frsh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster is used in formulating the reagent. The recombinant animal tissue factor includes rabbit brain. The synthetic phospholipids of the mixture include palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylserine (POPS), and a phosphatidylalcohol. The phosphatidyl alcohol includes dioleoylphosphatidylethanol, dioleoylphosphatidylmethanol, dioleoylphosphatidylpropanol, dioleoylphosphatidylbutanol, and dioleoylphosphatidylinositol. The sensitivity adjuster included in the formulation buffer is γ-Cyclodextrin. The formulated reagent is air-dried and remains stable for at least 3 weeks at 37° C.
摘要翻译：提供了一种凝血酶原时间试剂，用于测定全血和抗凝血剂处理的血液中的低分子肝素。试剂由重组动物组织因子和合成磷脂的混合物组成，该混合物包含磷脂酰醇。在配制试剂时使用包含灵敏度调节剂的制剂缓冲液。重组动物组织因子包括兔脑。该混合物的合成磷脂包括棕榈酰胆碱磷脂酰胆碱（POPC），棕榈酰叶酰磷脂酰丝氨酸（POPS）和磷脂酰醇。磷脂酰胆固醇包括二油酰磷脂酰乙醇，二油酰磷脂酰基甲醇，二油酰磷脂酰丙醇，二油酰磷脂酰丁醇和二油酰磷脂酰肌醇。制剂缓冲液中的灵敏度调节剂是γ-环糊精。将配制的试剂空气干燥，并在37℃下保持稳定至少3周。

10. 发明授权

US5797940A Adjustable skin incision device 失效
标题翻译：可调皮肤切开装置
公开(公告)号：US5797940A
公开(公告)日：1998-08-25
申请号：US866172
申请日：1997-05-30
申请人： James A. Mawhirt , Nikki S. Thompson
发明人： James A. Mawhirt , Nikki S. Thompson
IPC分类号： A61B17/32
CPC分类号： A61B17/32093 , A61B5/150022 , A61B5/15019 , A61B5/150259 , A61B5/150427 , A61B5/150916 , A61B5/15113 , A61B5/15128 , A61B5/15144
摘要： A device for making an adjustably sized incision in skin. The device comprises a housing having a slotted opening; a blade disposed within the housing for making an incision in skin; a blade triggering mechanism disposed within the housing, for propelling the blade through the slotted opening of the housing a given distance to make an incision of a predetermined size in the skin; and incision size adjusting mechanism associated with the housing for selectively adjusting the size of the incision. The incision size adjusting mechanism includes a cam disposed within the housing, the cam being manually movable relative to the housing for allowing the size of the incision to be adjusted by variably limiting the given distance the blade is propelled through the slotted opening of the housing according to the cam's position relative to the housing. In one embodiment, the cam adjusts the size of the incision by varying the incision's depth into the skin to produce blood sample volumes which are selectively increased or decreased according to a selected depth of the incision. This feature makes the device especially suitable for making skin incisions in adults or children. In another embodiment, the cam adjusts the size of the incision by varying the incision's depth into the skin and the incision's length in the skin to produce blood sample volumes which are selectively increased or decreased according to a selected depth and length of the incision. This feature makes the device especially suitable for making skin incisions in infants and toddlers.
摘要翻译：用于在皮肤中制作可调节尺寸的切口的装置。该装置包括具有开槽开口的壳体; 设置在所述壳体内用于在皮肤中形成切口的刀片; 刀片触发机构，其设置在所述壳体内，用于通过所述壳体的开槽开口推动所述刀片给定距离以在皮肤中切割预定尺寸; 以及与壳体相关联的切口尺寸调节机构，用于选择性地调节切口的尺寸。所述切口尺寸调节机构包括设置在所述壳体内的凸轮，所述凸轮可手动地相对于所述壳体移动，以允许通过可变地限制所述刀片通过所述壳体的开槽开口被推进的给定距离来调节所述切口的尺寸，到凸轮相对于壳体的位置。在一个实施例中，凸轮通过改变切口进入皮肤的深度来调节切口的尺寸，以产生根据切口的选定深度选择性地增加或减少的血液样本体积。该功能使得该装置特别适合于在成人或儿童中进行皮肤切口。在另一个实施例中，凸轮通过改变切口在皮肤中的深度和皮肤中的切口长度来调节切口的尺寸，以产生根据切口的所选深度和长度选择性地增加或减少的血液样本体积。该特征使得该装置特别适用于在婴儿和幼儿中进行皮肤切口。

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