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1. 发明授权

US09977019B2 Fluorous peptide microarray, detection process using a fluorous peptide microarray, and process of forming a fluorous peptide microarray 有权
公开(公告)号：US09977019B2
公开(公告)日：2018-05-22
申请号：US14394435
申请日：2013-04-16
申请人： MS2 ARRAY LLC
发明人： Marvin Yu
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N33/54386 , G01N33/54306 , G01N33/582 , G01N2333/90
摘要： A fluorous peptide microarray, a process of detecting information by using a fluorous peptide microarray, and a process of forming a fluorous peptide microarray are disclosed. The fluorous peptide microarray includes a covalently-modified conductive fluorous surface and fluorous-tagged peptides having natural amino acids positioned on the covalently-modified conductive fluorous surface. The fluorous-tagged peptides are configured for analysis of one or both of a protein and an enzyme. The process of detecting information includes using the fluorous peptide microarray. The process of forming the fluorous peptide microarray includes spotting the fluorous-modified composition to the fluorous surface after a solution phase reaction or transfer blotting the fluorous-modified composition.

2. 发明授权

US10443093B2 Fluorous oligonucleotide microarray 有权
公开(公告)号：US10443093B2
公开(公告)日：2019-10-15
申请号：US15360066
申请日：2016-11-23
申请人： MS² ARRAY LLC
发明人： Marvin Yu
IPC分类号： G01N33/543 , G01N33/58 , C12Q1/6837 , B01J19/00 , C40B50/18
摘要： A fluorous-modified composition, a fluorous nucleoside, nucleotide, or oligonucleotide microarray, a compositional detection process, a process of forming a fluorous nucleoside, nucleotide, or oligonucleotide microarray, and fluorous nucleoside, nucleotide, or oligonucleotide microarray processes are disclosed. The fluorous-modified composition includes a linker, a nucleoside, nucleotide, or oligonucleotide connected to the linker, and a fluorous domain connected to the linker. The fluorous-modified composition includes at least one terminal perfluoroalkyl group in the fluorous domain, a solid-phase attachment group connected to the linker, or a combination thereof. The compositional detection process includes using the fluorous microarray for compositional detection. The processes of forming a fluorous microarray include transfer blotting the fluorous-modified composition to form a fluorous microarray and the spotting of reaction mixtures containing a fluorous-modified nucleoside, nucleotide, or oligonucleotide. The fluorous microarray includes a fluorous-modified conductive surface and fluorous nucleoside, nucleotide, or oligonucleotides positioned on the fluorous-modified surface. The fluorous microarray process includes using information corresponding to a compositional detection process.

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